Up to date on the use of triptans for child and adolescent migraine: “the state of the art”

The introduction of triptans, in the early 1990s, has improved the therapy for acute migraine attack, offering a new quality of life for those patients who suffer from this disabling neurological disorder. Epidemiological data point out that about 10% of school–age children suffer from migraine, with a progressive increase in incidence and prevalence up to the threshold of adulthood. The increase in extent and prevalence of migraine from the years of growth stresses the importance of the application and adjustment of ad hoc therapeutic (either pharmacological or not) and diagnostic measures. Indeed, the peculiar neurobiological and psychological aspects which are typical of an “evolving” organism preclude the use, by simple “transposition” or “proportion”, of the knowledge acquired from adult–targeted studies. That requires the implementation of studies to analyze the specific responses of children and adolescents to the triptans. To date, the studies on such issues are absolutely insufficient to draw definitive conclusions and indications for the use of triptans for child and adolescent migraineurs

Headache and alexithymia in children and adolescents: what Is the connection?

Background: Headache is one of the most common complaints in children and adolescents and comorbidity rates are very high and the major associated diseases are depression, anxiety, atopic disorders, sleep, and behavioral disorders. In recent years, it has been highlighted that difficulties regulating emotions such as alexithymia have also been associated with diagnosis of somatization. Methods: We carried out a mini review analyzing the relation between alexithymia and primary headache (e.g., migraine and tension type headache) in children and adolescents by synthesizing the relevant studies in the literature on PubMed, PsycINFO, and Google Scholar. Search terms were "alexithymia" combined with the "primary headache," "migraine," "tension type headache," "children," and "adolescents." Results: All analyzed studies found higher levels of alexithymia in children and adolescents with headache than control groups but there are different opinions about the relationship between headache and alexithymia. For example, some studies suggest that the association between headache and alexithymia in children may be due to an incomplete development of emotive competency or a general immature cognitive development, instead other studies found a correlation between headache symptoms, insecure attachment, and alexithymia. There seems to be also differences between children with migraine compared to those with tension type headache (TTH). Conclusion: There are some studies on adults suffering from headache or migraine and alexithymia, but there is only a moderate amount of research on pediatric age with different opinions and theories about this relationship. Further studies on children and adolescents are necessary to effectively understand this relationship and to help children to reduce headache and improve emotional consciousness

Metacognition and headache: which Is the role in childhood and adolescence?

Headache, in particular migraine, is one of the most frequent neurological symptoms in children and adolescents and it affects about 60% of children and adolescents all over the world. Headache can affect several areas of child’s functioning, such as school, physical activities, peer, and family relationship. The global and severe burden of this disease requires a multidisciplinary strategy and an effective treatment addressed all of the patient’s needs and based on cutting-edge scientific research. In recent years, research has focused on cognitive factors specifically in functions called metacognitive processes. Metacognition can be defined as the knowledge, beliefs, and cognitive processes involved in monitoring, control, and assessment of cognition. Metacognition seems to be closely related to the ability of theory of mind, the ability to infer, and reason about the mental states of other people in order to predict and explain own behavior. Recent studies found a relationship between metacognitive skills and anxiety, depression, motivation, academic performance, human social interactions, and stress symptoms. This relationship is very interesting for headache treatment, because these factors are the most commonly reported triggers in this disorder and there is a high comorbidity with anxiety and depression in children and adolescents with headache. So, headache and these comorbidities, in particular anxiety and depression, may have in common persistent and maladaptive patterns of thinking which are related to maladaptive metacognitive beliefs. Further research should assess metacognitive processes of children and adolescents with headache in order to increase their ability to control their own cognitive processes and consequently monitor factors which may trigger the attacks

Location-aware Mobile Services for a Smart City: Design, Implementation and Deployment

A smart city is a high-performance urban context, where citizens are more aware of, and more integrated into the city life, thanks to an intelligent city information system. In this paper we design, implement and deploy a smart application that retrieves and conveys to the user relevant information on the user's surroundings. This case study application let us discuss the challenges involved in creating a location-aware mobile service based on live information coming from the city IT infrastructure. The service, that is currently being deployed in the Italian city of Cesena, has been designed with the goal of being a general model for future applications. In particular, we discuss location-aware and mobile development, cloud and cluster based geographical data storage, and spatial data computation. For each of these topics we provide implementation and deployment solutions based on currently available technology. In particular we propose an architecture based on a complex On-Line Transaction Processing (OLTP) infrastructure. Furthermore, this paper represents the first comprehensive, scientific study on the subject

From Sensing to Action: Quick and Reliable Access to Information in Cities Vulnerable to Heavy Rain

Cities need to constantly monitor weather to anticipate heavy storm events and reduce the impact of floods. Information describing precipitation and ground conditions at high spatio-temporal resolution is essential for taking timely action and preventing damages. Traditionally, rain gauges and weather radars are used to monitor rain events, but these sources provide low spatial resolutions and are subject to inaccuracy. Therefore, information needs to be complemented with data from other sources: from citizens' phone calls to the authorities, to relevant online media posts, which have the potential of providing timely and valuable information on weather conditions in the city. This information is often scattered through different, static, and not-publicly available databases. This makes it impossible to use it in an aggregate, standard way, and therefore hampers efficiency of emergency response. In this paper, we describe information sources relating to a heavy rain event in Rotterdam on October 12-14, 2013. Rotterdam weather monitoring infrastructure is composed of a number of rain gauges installed at different locations in the city, as well as a weather radar network. This sensing network is currently scarcely integrated and logged data are not easily accessible during an emergency. Therefore, we propose a reliable, efficient, and low-cost ICT infrastructure that takes information from all relevant sources, including sensors as well as social and user contributed information and integrates them into a unique, cloud-based interface. The proposed infrastructure will improve efficiency in emergency responses to extreme weather events and, ultimately, guarantee more safety to the urban population

Evaluation of chromosome microarray analysis in a large cohort of females with autism spectrum disorders: A single center Italian study

Autism spectrum disorders (ASD) encompass a heterogeneous group of neurodevelopmental disorders resulting from the complex interaction between genetic and environmental factors. Thanks to the chromosome microarray analysis (CMA) in clinical practice, the accurate identification and characterization of submicroscopic deletions/duplications (copy number variants, CNVs) associated with ASD was made possible. However, the widely acknowledged excess of males on the autism spectrum reflects on a paucity of CMA studies specifically focused on females with ASD (f-ASD). In this framework, we aim to evaluate the frequency of causative CNVs in a single-center cohort of idiopathic f-ASD. Among the 90 f-ASD analyzed, we found 20 patients with one or two potentially pathogenic CNVs, including those previously associated with ASD (located at 16p13.2 16p11.2, 15q11.2, and 22q11.21 regions). An exploratory genotype/phenotype analysis revealed that the f-ASD with causative CNVs had statistically significantly lower restrictive and repetitive behaviors than those without CNVs or with non-causative CNVs. Future work should focus on further understanding of f-ASD genetic underpinnings, taking advantage of next-generation sequencing technologies, with the ultimate goal of contributing to precision medicine in ASD

The European Legal Framework on Cybercrime

This article analyzes the European legal framework on cybercrime. Initially, it argues the challenges of cybercrime to traditional criminal justice systems. Subsequently, it focuses on the criminal law framework on cybercrime with a mainly European perspective. The European legal framework provides a three-path solution: the reduction of frictions among national legislations, the introduction of new investigative powers and the facilitation of international cooperation. The article presents and discusses each solution. Further, it argues that the effective implementation of the main legal instruments does not seem to depend on the legal enforceability of these international measures. Contrarily, other, non legal, factors such as national security, politics, the economy and the public opinion appear to stimulate the spontaneous implementation of the European legal framework. In this context, the added value of the EU action is rather low, although the Treaty of Lisbon and the Stockholm Programme may improve this situation in the long ter

Spatial Bloom Filters: Enabling Privacy in Location-Aware Applications

The wide availability of inexpensive positioning systems made it possible to embed them into smartphones and other personal devices. This marked the beginning of location-aware applications, where users request personalized services based on their geographic position. The location of a user is, however, highly sensitive information: the user's privacy can be preserved if only the minimum amount of information needed to provide the service is disclosed at any time. While some applications, such as navigation systems, are based on the users' movements and therefore require constant tracking, others only require knowledge of the user's position in relation to a set of points or areas of interest. In this paper we focus on the latter kind of services, where location information is essentially used to determine membership in one or more geographic sets. We address this problem using Bloom Filters (BF), a compact data structure for representing sets. In particular, we present an extension of the original Bloom filter idea: the Spatial Bloom Filter (SBF). SBF's are designed to manage spatial and geographical information in a space efficient way, and are well-suited for enabling privacy in location-aware applications. We show this by providing two multi-party protocols for privacy-preserving computation of location information, based on the known homomorphic properties of public key encryption schemes. The protocols keep the user's exact position private, but allow the provider of the service to learn when the user is close to specific points of interest, or inside predefined areas. At the same time, the points and areas of interest remain oblivious to the user

Burgers velocity fields and dynamical transport processes

We explore a connection of the forced Burgers equation with the Schr\"{o}dinger (diffusive) interpolating dynamics in the presence of deterministic external forces. This entails an exploration of the consistency conditions that allow to interpret dispersion of passive contaminants in the Burgers flow as a Markovian diffusion process. In general, the usage of a continuity equation $\partial_t\rho =-\nabla (\vec{v}\rho)$, where $\vec{v}=\vec{v}(\vec{x},t)$ stands for the Burgers field and $\rho$ is the density of transported matter, is at variance with the explicit diffusion scenario. Under these circumstances, we give a complete characterisation of the diffusive matter transport that is governed by Burgers velocity fields. The result extends both to the approximate description of the transport driven by an incompressible fluid and to motions in an infinitely compressible medium.Comment: Latex fil

A qualitative reading of the ecological (dis)organisation of criminal associations. The case of the ?Famiglia Basilischi? in Italy

This paper combines the theoretical foundations of organisational ecology - one of the most important approaches in economic sociology - with classic criminological theories to interpret the birth, evolution and death of criminal associations. This mixed approach will support the interpretation of organised crime groups as phenomena strictly linked to the environment as well as to other competitors in criminal markets. This paper analyses the birth, evolution and death of a criminal association in Basilicata, Southern Italy, known as the ?Famiglia Basilischi?. The case is exemplary of how ecological conditions affect the success or failure of a newly formed criminal association. These conditions can therefore be indicators to interpret organised criminal activities in similar environments