Human resource management system strength in times of crisis

In times of crisis, employees turn to their managers for information and guidance. When managers share distinctive, consistent, and consensual information (also known as human resource management [HRM] system strength), it is easier for employees to make sense of the information and understand what is expected from them. To date, research has mainly focused on the outcomes of HRM system strength but has remained silent on its antecedents. Thus, we know little about the factors that influence managers when sharing information with their employees. Drawing on insights from research on HRM system strength, attribution, and cross-cultural fields, we suggest that the interaction between managers’ motivation (i.e., the severity of a crisis and an organization's reputation) and their general beliefs (i.e., national cultural values: uncertainty avoidance and power distance) can explain HRM system strength in times of crisis. To test our hypotheses, we used HLM to analyze a three-level sample of 368 bi-weekly observations nested in 34 universities within 15 countries. Results show that the positive effects of crisis severity and an organization's reputation on the employment of HRM system strength were stronger in high uncertainty avoidance countries, but weaker in high power distance countries. Theoretical and practical implications are discussed

Lot-to-lot consistency of a tetravalent dengue vaccine in healthy adults in Australia: a randomised study

Background: The recombinant yellow fever-17D-dengue virus, live, attenuated, tetravalent dengue vac-cine (CYD-TDV) has undergone extensive clinical trials. Here safety and consistency of immunogenicityof phase III manufacturing lots of CYD-TDV were evaluated and compared with a phase II lot and placeboin a dengue-naïve population.Methods: Healthy 18–60 year-olds were randomly assigned in a 3:3:3:3:1 ratio to receive three sub-cutaneous doses of either CYD-TDV from any one of three phase III lots or a phase II lot, or placebo,respectively in a 0, 6, 12 month dosing schedule. Neutralising antibody geometric mean titres (PRNT50GMTs) for each of the four dengue serotypes were compared in sera collected 28 days after the thirdvaccination—equivalence among lots was demonstrated if the lower and upper limits of the two-sided95% CIs of the GMT ratio were ≥0.5 and ≤2.0, respectively.Results: 712 participants received vaccine or placebo and 614 (86%) completed the study; 17 (2.4%) par-ticipants withdrew after adverse events. Equivalence of phase III lots was demonstrated for 11 of 12pairwise comparisons. One of three comparisons for serotype 2 was not statistically equivalent. GMTsfor serotype 2 in phase III lots were close to each other (65.9, 44.1 and 58.1, respectively).Conclusions: Phase III lots can be produced in a consistent manner with predictable immune responseand acceptable safety profile similar to previously characterised phase II lots. The phase III lots maybe considered as not clinically different as statistical equivalence was shown for serotypes 1, 3 and 4across the phase III lots. For serotype 2, although equivalence was not shown between two lots, the GMTsobserved in the phase III lots were consistently higher than those for the phase II lot. As such, in our view,biological equivalence for all serotypes was demonstrated.Joseph Torresi, Leon G. Heron, Ming Qiao, Joanne Marjason, Laurent Chambonneau, Alain Bouckenooghe, Mark Boaz, Diane van der Vliet, Derek Wallace, Yanee Hutagalung, Michael D. Nissen, Peter C. Richmon

Metabolic responses to the acute ingestion of two commercially available carbonated beverages: A pilot study

<p>Abstract</p> <p>Background</p> <p>The purpose of this placebo-controlled, double-blind cross-over study was to compare the effects of two commercially available soft drinks on metabolic rate.</p> <p>Methods</p> <p>After giving informed consent, twenty healthy men and women were randomly assigned to ingest 12 ounces of Celsius™ and, on a separate day, 12 ounces of Diet Coke®. All subjects completed both trials using a randomized, counterbalanced design. Metabolic rate (via indirect calorimetry) and substrate oxidation (via respiratory exchange ratio) were measured at baseline (pre-ingestion) and at the end of each hour for 3 hours post-ingestion.</p> <p>Results</p> <p>Two-way ANOVA revealed a significant interaction (p < 0.001) between trials in metabolic rate. Scheffe post-hoc testing indicated that metabolic rate increased by 13.8% (+ 0.6 L/min, p < 0.001) 1 hr post, 14.4% (+0.63 L/min, p < 0.001) 2 hr post, and 8.5% (+0.37 L/min, p < 0.004) 3 hr post Celsius™ ingestion. In contrast, small (~4–6%) but statistically insignificant increases in metabolic rate were noted following Diet Coke^®ingestion. No differences in respiratory exchange ratio were noted between trials.</p> <p>Conclusion</p> <p>These preliminary findings indicate Celsius™ has thermogenic properties when ingested acutely. The effects of repeated, chronic ingestion of Celsius™ on body composition are unknown at this time.</p