84 research outputs found
Enhanced response of the fricke solution doped with hematoporphyrin under X-rays irradiation
Photodynamic therapy augments the efficacy of oncolytic vaccinia virus against primary and metastatic tumours in mice
in mic
In vivo fluorescence imaging of the transport of charged chlorine6 conjugates in a rat orthotopic prostate tumour
Polymeric drug conjugates are used in cancer therapy and, varying their molecular size and charge, will affect their in vivo transport and extravasation in tumours. Partitioning between tumour vasculature and tumour tissue will be of particular significance in the case of photosensitizer conjugates used in photodynamic therapy, where this partitioning can lead to different therapeutic effects. Poly-l-lysine chlorine6 conjugates (derived from polymers of averageMr 5000 and 25 000) were prepared both in a cationic state and by poly-succinylation in an anionic state. A fluorescence scanning laser microscope was used to follow the pharmacokinetics of these conjugates in vivo in an orthotopic rat prostate cancer model obtained with MatLyLu cells. Fluorescence was excited with the 454–528 nm group of lines of an argon laser and a 570 nm long pass filter used to isolate the emission. Results showed that the conjugates initially bound to the walls of the vasculature, before extravasating into the tissue, and eventually increasing in fluorescence. The anionic conjugates produced tissue fluorescence faster than the cationic ones, and surprisingly, the largerMr conjugates produced tissue fluorescence faster than the smaller ones with the same charge. These results are consistent with differences in aggregation state between conjugates. © 1999 Cancer Research Campaig
In Situ Polymerized Hollow Mesoporous Organosilica Biocatalysis Nanoreactor for Enhancing ROS‐Mediated Anticancer Therapy
Parabolic Quantitative Structure-Activity Relationships and Photodynamic Therapy: Application of a Three-Compartment Model with Clearance to the In Vivo Quantitative Structure-Activity Relationships of a Congeneric Series of Pyropheophorbide Derivatives Used as Photosensitizers for Photodynamic Therapy
Diblock Copolymer Micelles Deliver Hydrophobic Protoporphyrin IX for Photodynamic Therapy
INTRACELLULAR LOCALIZATION OF A CHALCOGENAPYRYLIUM DYE PROBED BY SPECTROSCOPY AND SITES OF PHOTODAMAGE
Nanoparticles to mediate X‐ray‐induced photodynamic therapy and Cherenkov radiation photodynamic therapy
GIANT CELL FORMATION IN BLADDER TUMOR CELLS FOLLOWING HEMATOPORPHYRIN DERIVATIVE-SENSITIZED PHOTOIRRADIATION
- …