27 research outputs found
Inheritance of quantitative expression of erythrocyte glucose-6-phosphate dehydrogenase activity in the Negro—a twin study
- Author
- B. Childs
- Curtis Hames
- D. Coulton
- D. R. London
- Donald C. Shreffler
- E. Beutler
- E. Beutler
- E. Essen-Moller
- F. Giannelli
- G. J. Brewer
- G. J. Brewer
- George J. Brewer
- H. N. Kirkman
- H. W. Siemens
- Henry Gershowitz
- I. H. Porter
- J. C. Gall
- J. C. Gall
- J. Rowley
- John C. Gall
- L. Atkins
- M. F. Lyon
- M. L. Barr
- M. M. Grumbach
- Merton Honeyman
- O. J. Miller
- P. A. Marks
- P. E. Carson
- R. G. Davidson
- R. G. Davidson
- Raymond J. Dern
- S. H. Boyer
- S. Muldal
- S. Ohno
- W. E. Zinkham
- W. W. Park
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/06/1967
- Field of study
Studies have been conducted on eight sets of monozygous and nine sets of dizygous female Negro twins, both members of whom were heterozygous for G-6-PD deficiency. Twins were studied both by assay of erythrocytic G-6-PD activity and by the methemoglobin elution test (MET). The MET is a procedure which identifies histochemically cells with appreciable G-6-PD activity and permits accurate determination of the percentage of such cells in heterozygotes. Monozygous twins showed significantly less “within-pair” variation than dizygous twins with both the MET and G-6-PD assay.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/44115/1/10528_2004_Article_BF00487735.pd
Effects of Anacetrapib in Patients with Atherosclerotic Vascular Disease
- Author
- Aaltonen M
- Abdur Rahman M
- Abell T
- Abide W. Jr
- Acheatel R
- Achiri P
- Acon J
- Adams T
- Affinito S
- Agarwal S
- Aggarwal K
- Aggarwal R
- Ahlström P
- Ahmad A
- Ahmed M
- Aillon C
- Airaksinen A
- Ait-sadi R
- Akers J
- Al-jumaily J
- Albers C
- Albert M
- Alberti A
- Alexander T
- Alford C
- Algotsson L
- Allen T
- Allworth M
- Almond E
- Aloisi A
- Alternburg C
- Alton M
- Amin J
- Amundson A
- Andersen K
- Andersen M
- Anderson E
- Anderson G
- Anderson R
- Anderson T
- Andersson H
- Andersson L
- Andreo J
- Andres C
- Andresen D
- Andrews G
- Andrews L
- Andrews R
- Andrioli V
- Angermann Ce
- Annas T
- Ansell V
- Antonio-drabek C
- Antonishen D
- Antonishen M
- Anuschek V
- Appel Kf
- Appel S
- Appleyard D
- Archer A
- Armitage J
- Armstrong L
- Armstrong M
- Arnesson K
- Arnold M
- Arora P
- Arp H
- Asbill B
- Ashbrook-raby C
- Ashton L
- Assarsson E
- Audet K
- Augenbraun C
- Aung HNIN THANDA
- Auscher S
- Ausner J
- Aviles R
- Awasty V
- Axelsson U
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- Banerjee S
- Bang Hansen M
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- Zuchelkowski A
- Zulauf N
- Ågårdh A
- Öner A
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
BACKGROUND:
Patients with atherosclerotic vascular disease remain at high risk for cardiovascular events despite effective statin-based treatment of low-density lipoprotein (LDL) cholesterol levels. The inhibition of cholesteryl ester transfer protein (CETP) by anacetrapib reduces LDL cholesterol levels and increases high-density lipoprotein (HDL) cholesterol levels. However, trials of other CETP inhibitors have shown neutral or adverse effects on cardiovascular outcomes.
METHODS:
We conducted a randomized, double-blind, placebo-controlled trial involving 30,449 adults with atherosclerotic vascular disease who were receiving intensive atorvastatin therapy and who had a mean LDL cholesterol level of 61 mg per deciliter (1.58 mmol per liter), a mean non-HDL cholesterol level of 92 mg per deciliter (2.38 mmol per liter), and a mean HDL cholesterol level of 40 mg per deciliter (1.03 mmol per liter). The patients were assigned to receive either 100 mg of anacetrapib once daily (15,225 patients) or matching placebo (15,224 patients). The primary outcome was the first major coronary event, a composite of coronary death, myocardial infarction, or coronary revascularization.
RESULTS:
During the median follow-up period of 4.1 years, the primary outcome occurred in significantly fewer patients in the anacetrapib group than in the placebo group (1640 of 15,225 patients [10.8%] vs. 1803 of 15,224 patients [11.8%]; rate ratio, 0.91; 95% confidence interval, 0.85 to 0.97; P=0.004). The relative difference in risk was similar across multiple prespecified subgroups. At the trial midpoint, the mean level of HDL cholesterol was higher by 43 mg per deciliter (1.12 mmol per liter) in the anacetrapib group than in the placebo group (a relative difference of 104%), and the mean level of non-HDL cholesterol was lower by 17 mg per deciliter (0.44 mmol per liter), a relative difference of -18%. There were no significant between-group differences in the risk of death, cancer, or other serious adverse events.
CONCLUSIONS:
Among patients with atherosclerotic vascular disease who were receiving intensive statin therapy, the use of anacetrapib resulted in a lower incidence of major coronary events than the use of placebo. (Funded by Merck and others; Current Controlled Trials number, ISRCTN48678192 ; ClinicalTrials.gov number, NCT01252953 ; and EudraCT number, 2010-023467-18 .)
Isolated systolic hypertension in Evans County—I. Prevalence and screening considerations
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Social status, physical activity, and coronary proneness
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Attempts to immunoprecipitate the LHRH precursor synthesized in cell free systems
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Personality traits and coronary heart disease
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Smoking habits and blood pressure change: A seven year follow-up
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
The relationship of weight change to changes in blood pressure, serum uric acid, cholesterol and glucose in the treatment of hypertension
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study