Zombie Shakespeare

The year 2016 has seen an unprecedented level of interest occasioned by the 400th anniversary of Shakespeare’s death. This interest is in marked contrast to the surviving information concerning the event: the cause, place and even date of Shakespeare’s demise are all unknown. Moreover, attention to the mere fact of death adds nothing to knowledge of Shakespeare’s work; rather it distracts attention. This article surveys the anniversary celebrations in relation to the contrasting life records, arguing that the Anniversary has produced a “Zombie Shakespeare”, a twenty-first century biographical fantasy indicative of commodification rather than literary or creative imagination. This article is published as part of a collection on Shakespeare studies

Revamping the Guitar Curriculum: Adapting Piano Methods and Theory to Apply to the Guitar

In this paper I will discuss the importance of a well rounded pedagogy for beginning guitar students. The existing piano pedagogy has courses outlining lessons and appropriate pieces correlated with lessons in technique, theory, ear training, sight reading, as well as other disciplines; the guitar has nothing like it to compare. I will also include a creative project including examples of piano lessons adapted for the guitar, including theory ideas using the fretboard, finding intervals on one string using half steps represented by the frets, and example pieces that offer a variety in genres, among other things. I will draw from the existing piano courses available to the young student and expand upon the already existing guitar lesson books. I will also draw on articles and publications advocating for a well rounded education in music. I hope to show that, as the popularity of the guitar continues, a pedagogical approach to the instrument should also evolve. Piano might be the more established discipline, but there’s no reason to take music education less seriously with the guitar. Many students get by without learning to read music, or get stuck learning just one style of music, even though the guitar is one of the most versatile instruments out there

Study of Fluid Experiment System (FES)/CAST/Holographic Ground System (HGS)

The use of holographic and schlieren optical techniques for studying the concentration gradients in solidification processes has been used by several investigators over the years. The HGS facility at MSFC has been primary resource in researching this capability. Consequently, scientific personnel have been able to utilize these techniques in both ground based research and in space experiments. An important event in the scientific utilization of the HGS facilities was the TGS Crystal Growth and the casting and solidification technology (CAST) experiments that were flown on the International Microgravity Laboratory (IML) mission in March of this year. The preparation and processing of these space observations are the primary experiments reported in this work. This project provides some ground-based studies to optimize on the holographic techniques used to acquire information about the crystal growth processes flown on IML. Since the ground-based studies will be compared with the space-based experimental results, it is necessary to conduct sufficient ground based studies to best determine how the experiment worked in space. The current capabilities in computer based systems for image processing and numerical computation have certainly assisted in those efforts. As anticipated, this study has certainly shown that these advanced computing capabilities are helpful in the data analysis of such experiments

Effect of cell- and species-differences in the expression of drug metabolism enzymes on chemical-induced injury to the rat and human kidney

Differences in the expression of drug metabolizing enzymes between cells of the rat and human kidney on chemical-induced nephrotoxicity were studied. Rat renal proximal tubular (rPT) and distal tubular (rDT) cells differed in their susceptibility to trichloroethylene (Tri) and thiophene-containing compounds. These differences were caused in part by differences in the activity of cytochrome P450 monooxygenase (P450) between the two cell types. rPT cells expressed cytochrome P450 (CYP) 2B1/2, CYP2C11, CYP2E1, CYP4A2/3, and GSTα, but not CYP3A1/2, GSTµ, GSTπ, or GSTτ. rDT cells expressed CYP2B1/2, CYP2E1, and CYP4A2/3, GSTα, and GSTµ, but not CYP2C11, CYP3A1/2, GSTπ, or GSTτ. Expression of CYP2E1 was significantly higher in rDT cells than in rPT cells. Pyridine induced CYP2E1 in both liver and kidney microsomes but not in rPT and rDT cells. Clofibrate induced CYP4A and CYP2B only in liver and kidney microsomes and also CYP2E1 and CYP2C11 in kidney microsomes. The GST isoforms responsible for GSH conjugation of Tri were also determined. Pyridine treatment increased CH formation in rat liver and kidney microsomes. Clofibrate treatment only increased CH formation in kidney microsomes. Primary cultures of rPT and rDT cells maintained their expression of GSH-dependent enzymes but not P450 isoforms. Freshly isolated human proximal tubular (hPT) cells expresses CYP4A11, GSTA, GSTP, and GSTT but not GSTM. Tri and DCVC were toxic to freshly isolated hPT cells in a manner not affected by P450 or cysteine S-conjugate β-lyase inhibition. Tri was metabolized to its GSH conjugate but not to CH in hPT cells. Primary cultures of hPT cells maintained their expression of GSH-dependent enzymes and CYP4A11. Treatment of cultures with ethanol or dexamethasone altered expression of CYP4A11. These data support the hypothesis that differences in the susceptibility of rPT, rDT, and hPT cells to chemical-induced nephrotoxicity are caused by difference in the expression of drug metabolism enzymes

Dissolved Oxygen Monitoring in Kings River and Leatherwood Creek

The Clean Water Act (CWA) establishes the basic structure used to regulate water quality. Under the CWA, States are required to assess water bodies relative to water‐quality standards and designated beneficial uses and then to submit lists of impaired bodies every other year to the US Environmental Protection Agency (USEPA). In 2015, at least 4,800 water bodies were listed as impaired by dissolved oxygen across the US (USEPA, 2015). Aquatic species like fish and macroinvertebrates depend on adequate dissolved oxygen for survival. Low dissolved oxygen can lead to fish kills, reduced aquatic diversity, and nuisance smells from anaerobic conditions – ultimately, low dissolved oxygen concentrations result in water bodies not being able to meet the aquatic life designated use

On a reformulation of the commutator subgroup

For semigroup $S$, a commutative congruence $\sigma_{orient}$ on $S$ and a subsemigroup Orientable($S$) of $S$ were introduced in "Two cancellative commutative congruences and group diagrams", Semigroup Forum (2011) 82: 338-353. Here we demonstrate that when the semigroup is in fact a group $G$, then Orientable($G$) is the commutator subgroup $[G,G]$ and $G / \sigma_{orient}$ is the abelian quotient group $G / [G,G]$.Comment: 4 pages, 0 figure

Modeling multiple human operators in the supervisory control of heterogeneous unmanned vehicles

In the near future, large, complex, time-critical missions, such as disaster relief, will likely require multiple unmanned vehicle (UV) operators, each controlling multiple vehicles, to combine their efforts as a team. However, is the effort of the team equal to the sum of the operator's individual efforts? To help answer this question, a discrete event simulation model of a team of human operators, each performing supervisory control of multiple unmanned vehicles, was developed. The model consists of exogenous and internal inputs, operator servers, and a task allocation mechanism that disseminates events to the operators according to the team structure and state of the system. To generate the data necessary for model building and validation, an experimental test-bed was developed where teams of three operators controlled multiple UVs by using a simulated ground control station software interface. The team structure and interarrival time of exogenous events were both varied in a 2×2 full factorial design to gather data on the impact on system performance that occurs as a result of changing both exogenous and internal inputs. From the data that was gathered, the model was able to replicate the empirical results within a 95% confidence interval for all four treatments, however more empirical data is needed to build confidence in the model's predictive ability.United States. Office of Naval ResearchUnited States. Air Force Office of Scientific Researc

MILO: Models of innovation in learning online at Key Stage 3 and 14-19: Final report executive summary

This summary report presents and analyses the key findings from eight case studies, which reflect a wide range of models of online learning, each of which has been developed for specific reasons, largely in relation to visions of how technology can transform learning, but also to solve practical problems such as re-engaging disaffected learners and coping with rising pupil numbers

MILO: Models of innovation in learning online at Key Stage 3 and 14-19: Final report appendices

This document contains the appendices to the main report, which presents case studies, which reflect a wide range of models of online learning, each of which has been developed for specific reasons, largely in relation to visions of how technology can transform learning, but also to solve practical problems such as re-engaging disaffected learners and coping with rising pupil numbers

MILO: Models of innovation in learning online at Key Stage 3 and 14-19: Final report

The report presents and analyses eight case studies, which reflect a wide range of models of online learning, each of which has been developed for specific reasons, largely in relation to visions of how technology can transform learning, but also to solve practical problems such as re-engaging disaffected learners and coping with rising pupil numbers