23 research outputs found

    Correction. Strong invariance principles for sequential Bahadur--Kiefer and Vervaat error processes of long-range dependent sequences

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    Correction to The Annals of Statistics (2006) 34, 1013--1044 [URL: http://projecteuclid.org/euclid.aos/1151418250]Comment: Published in at http://dx.doi.org/10.1214/009053607000000370 the Annals of Statistics (http://www.imstat.org/aos/) by the Institute of Mathematical Statistics (http://www.imstat.org

    Hydrodynamical analysis of single inclusive spectra and Bose-Einstein correlations for Pb+PbPb+Pb at 160 AGeV

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    We present the first analysis of preliminary data for Pb+PbPb+Pb at 160 AGeVAGeV using 3+1-dimensional relativistic hydrodynamics. We find excellent agreement with the rapidity spectra of negative hadrons and the correlation measurements. The data indicates a large amount of stopping; 65%65\% of the invariant energy of the collision is thermalized and 73%73\% of the baryons are contained in the central fireball. Within our model this implies that a quark-gluon-plasma of lifetime 3.4 fm/cfm/c was formed.Comment: 13 pages, 5 Postscript figures (attached to this file as compressed and uuencoded Postscript file

    Histidine Decarboxylase Expression in Human Melanoma

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    SummaryHistamine has been implicated as one of the mediators involved in regulation of proliferation in both normal and neoplastic tissues. Histidine decarboxylase, the only enzyme that catalyzes the formation of histamine from L-histidine, is an essential regulator of histamine levels. In this study, we investigated the gene and protein expression of histidine decarboxylase in melanoma. Reverse transcriptase polymerase chain reaction and in situ hybridization studies of WM-35, WM-983/B, HT-168, and M1 human melanoma cell lines both resulted in positive signals for histidine decarboxylase messenger RNA. A polyclonal chicken antibody was developed against human histidine decarboxylase and protein expression was confirmed by western blot analysis of the cell lysates, revealing a predominant immunoreactive band at approximately 54 kDa corresponding to monomeric histidine decarboxylase. Protein expression of histidine decarboxylase was also shown by flow cytometric analysis and strong punctate cytoplasmic staining of melanoma cell lines. Moreover, both primary and metastatic human melanoma tissues were brightly stained for histidine decarboxylase. When compared with the very weak or no reactions on cultivated human melanocytes both western blot and immunohistochemical studies showed much stronger histidine decarboxylase expression in melanoma cells. These findings suggest that expression of histidine decarboxylase is elevated in human melanoma

    Shifts in vegetation phenology along flyways entail varying risks of mistiming in a migratory songbird

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    Long-term shifts in vegetation phenology generally follow the pattern of global warming. Yet, topographical complexity and biome diversity cause uneven spatial trends in the phenological response of vegetation to climate change. If phenology changes similarly along migration routes, individuals may adequately respond by shifting the whole migration schedule to still time life history with local phenological events. On the contrary, phenological shifts that differ in direction or magnitude between sites can enhance the risk of mistiming, resulting in reduced survival and reproductive success and eventually population declines. We identified the direction and magnitude of long-term shifts in vegetation phenology along avian migration routes, using remotely sensed vegetation data over 29 yr (1982–2010) to estimate the risk of mistiming for different sets of assumptions concerning cues and adaptability of migration timing. For this study, we used individual series of non-breeding, spring stopover and breeding sites (determined by light-level geolocation) of three European populations of Luscinia megarhynchos (Common Nightingale), an insectivorous Palearctic long-distance migrant. The breeding populations in France, Italy, and Bulgaria are representatives for populations migrating on the western, central, and eastern flyway toward sub-Saharan Africa. The direction and magnitude of phenological shifts differed between migration stages and across flyways and under most sets of assumptions, the resulting risk of mistiming was higher in the Western compared to Central and Eastern flyway. We emphasize that estimates for the risk of mistiming as resulting from phenological shifts highly depend on the cues that migrants use to time migratory progression and on the adaptive potential of the particular migratory species to react to phenological shifts
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