22 research outputs found
Global age-sex-specific fertility, mortality, healthy life expectancy (HALE), and population estimates in 204 countries and territories, 1950-2019 : a comprehensive demographic analysis for the Global Burden of Disease Study 2019
- Author
- Abbafati Cristiana
- Abbas Kaja M.
- Abbasi Mohammad
- Abbasi-Kangevari Mohsen
- Abbasifard Mitra
- Abbastabar Hedayat
- Abd-Allah Foad
- Abdelalim Ahmed
- Abdollahi Mohammad
- Abdollahpour Ibrahim
- Abedi Aidin
- Abedi Parisa
- Abegaz Kedir H.
- Abolhassani Hassan
- Abosetugn Akine E.
- Aboyans Victor
- Abrams Elissa M.
- Abreu Lucas G.
- Abrigo Michael R. M.
- Abu Haimed Abdulaziz K.
- Abu-Gharbieh Eman
- Abu-Raddad Laith J.
- Abualhasan Ahmed
- Abushouk Abdelrahman I.
- Acebedo Alyssa
- Ackerman Ilana N.
- Adabi Maryam
- Adair Tim
- Adamu Abdu A.
- Adebayo Oladimeji M.
- Adedeji Isaac A.
- Adekanmbi Victor
- Adelson Jaimie D.
- Adeoye Abiodun M.
- Adetokunboh Olatunji O.
- Adham Davoud
- Advani Shailesh M.
- Afarideh Mohsen
- Afshari Mahdi
- Afshin Ashkan
- Agardh Emilie E.
- Agarwal Gina
- Agasthi Pradyumna
- Agesa Kareha M.
- Aghaali Mohammad
- Aghamir Seyed M.
- Agrawal Anurag
- Ahmad Tauseef
- Ahmadi Alireza
- Ahmadi Keivan
- Ahmadi Mehdi
- Ahmadieh Hamid
- Ahmadpour Ehsan
- Ahmed Muktar B.
- Aji Budi
- Akalu Temesgen Y.
- Akinyemi Rufus O.
- Akinyemiju Tomi
- Akombi Blessing J.
- Akunna Chisom J.
- Al-Aly Ziyad
- Al-Mekhlaf Hesham M.
- Al-Raddadi Rajaa
- Alahdab Fares
- Alam Khurshid
- Alam Noore
- Alam Samiah
- Alam Tahiya
- Alanezi Fahad M.
- Alanzi Turki M.
- Albertson Samuel B.
- Alcalde-Rabanal Jacqueline E.
- Alema Niguse M.
- Alemu Biresaw W.
- Alemu Yihun M.
- Alhabib Khalid F.
- Alhassan Robert K.
- Ali Muhammad
- Ali Saqib
- Alicandro Gianfranco
- Alijanzadeh Mehran
- Alinia Cyrus
- Alipour Vahid
- Alizade Hesam
- Aljunid Syed M.
- Alla François
- Allebeck Peter
- Almadi Majid A.
- Almasi Ali
- Almasi-Hashiani Amir
- Almasri Nihad A.
- Almulhim Abdulaziz M.
- Alonso Jordi
- Altirkawi Khalid A.
- Alumran Arwa K.
- Alvis-Guzman Nelson
- Alvis-Zakzuk Nelson J.
- Amare Azmeraw T.
- Amare Bekalu
- Amini Saeed
- Amini-Rarani Mostafa
- Aminorroaya Arya
- Amiri Fatemeh
- Amit Arianna M.
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- Ancuceanu Robert
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- Anderson Jason A.
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- Mathur Manu R.
- Matsushita Kunihiro
- Maulik Pallab K.
- May Erin A.
- Mazidi Mohsen
- McAlinden Colm
- McGrath John J.
- McKee Martin
- Medina-Solis Carlo E.
- Meharie Birhanu G.
- Mehndiratta Man M.
- Mehrabi Nasab Entezar
- Mehri Fereshteh
- Mehrotra Ravi
- Mehta Kala M.
- Meitei Wahengbam B.
- Mekonnen Teferi
- Melese Addisu
- Memiah Peter
- Memish Ziad A.
- Mendoza Walter
- Menezes Ritesh G.
- Mengesha Endalkachew W.
- Mengesha Meresa B.
- Mensah George A.
- Mereke Alibek
- Mereta Seid T.
- Meretoja Atte
- Meretoja Tuomo J.
- Mestrovic Tomislav
- Miazgowski Bartosz
- Miazgowski Tomasz
- Michalek Irmina M.
- Mihretie Kebadnew M.
- Miller Ted R.
- Mills Edward J.
- Milne George J.
- Mini G. K.
- Miri Mohammad
- Mirica Andreea
- Mirrakhimov Erkin M.
- Mirzaei Hamed
- Mirzaei Maryam
- Mirzaei Roya
- Mirzaei-Alavijeh Mehdi
- Misganaw Awoke
- Mitchell Philip B.
- Mithra Prasanna
- Moazen Babak
- Moghadaszadeh Masoud
- Mohajer Bahram
- Mohamad Osama
- Mohamadi Efat
- Mohammad Gholi Mezerji Naser
- Mohammad Dara K.
- Mohammad Yousef
- Mohammadbeigi Abolfazl
- Mohammadian-Hafshejani Abdollah
- Mohammadifard Noushin
- Mohammadpourhodki Reza
- Mohammed Ammas S.
- Mohammed Hussen
- Mohammed Jemal A.
- Mohammed Shafiu
- Mohebi Farnam
- Mohseni Bandpei Mohammad A.
- Mokari Amin
- Mokdad Ali H.
- Molokhia Mariam
- Momen Natalie C.
- Monasta Lorenzo
- Mondello Stefania
- Mooney Meghan D.
- Moosazadeh Mahmood
- Moradi Ghobad
- Moradi Masoud
- Moradi-Joo Mohammad
- Moradi-Lakeh Maziar
- Moradzadeh Rahmatollah
- Moraga Paula
- Morales Linda
- Morawska Lidia
- Moreno Velasquez Ilais
- Morgado-da-Costa Joana
- Morrison Shane D.
- Mosapour Abbas
- Mosser Jonathan F.
- Mouodi Simin
- Mousavi Khaneghah Amin
- Mousavi Seyyed M.
- Mueller Ulrich O.
- Mukhopadhyay Satinath
- Mullany Erin C.
- Mumford John E.
- Munro Sandra B.
- Muriithi Moses K.
- Musa Kamarul I.
- Mustafa Ghulam
- Muthupandian Saravanan
- Nabavizadeh Behnam
- Nabhan Ashraf F.
- Naderi Mehdi
- Nagarajan Ahamarshan J.
- Nagel Gabriele
- Naghavi Mohsen
- Naghshtabrizi Behshad
- Naik Gurudatta
- Naimzada Mukhammad D.
- Nair Sanjeev
- Najafi Farid
- Naldi Luigi
- Nandakumar Vishnu
- Nandi Anita K.
- Nangia Vinay
- Nansseu Jobert R.
- Naserbakht Morteza
- Nayak Vinod C.
- Nazari Javad
- Ndejjo Rawlance
- Ndwandwe Duduzile E.
- Negoi Ionut
- Negoi Ruxandra I.
- Netsere Henok B.
- Neupane Subas
- Ngari Kiirithio N.
- Nguefack-Tsague Georges
- Ngunjiri Josephine W.
- Nguyen Cuong T.
- Nguyen Diep N.
- Nguyen Huong L.
- Nguyen Jason Q.
- Nguyen Michele
- Nguyen Ming
- Nguyen Trang H.
- Nichols Emma
- Nigatu Dabere
- Nigatu Yeshambel T.
- Nikbakhsh Rajan
- Nikpoor Amin R.
- Nixon Molly R.
- Nnaji Chukwudi A.
- Nomura Shuhei
- Norheim Ole F.
- Norrving Bo
- Noubiap Jean J.
- Nouraei Motlagh Soraya
- Nowak Christoph
- Nsoesie Elaine
- Nunez-Samudio Virginia
- Oancea Bogdan
- Odell Christopher M.
- Ogbo Felix A. (R18978)
- Oghenetega Onome B.
- Oh In-Hwan
- Okunga Emmanuel W.
- Oladnabi Morteza
- Olagunju Andrew T.
- Olusanya Bolajoko O.
- Olusanya Jacob O.
- Oluwasanu Mojisola M.
- Omer Omer Muktar
- Ong Kanyin
- Ong Sokking
- Onwujekwe Obinna E.
- Oren Eyal
- Orji Aislyn U.
- Orpana Heather M.
- Ortega-Altamirano Doris V.
- Ortiz Alberto
- Osarenotor Osayomwanbo
- Osei Frank B.
- Ostojic Sergej M.
- Ostroff Samuel M.
- Otoiu Adrian
- Otstavnov Nikita
- Otstavnov Stanislav S.
- Owolabi Mayowa O.
- P. A. Mahesh
- Padubidri Jagadish R.
- Pakhale Smita
- Pakhare Abhijit P.
- Pakshir Keyvan
- Palladino Raffaele
- Pana Adrian
- Panda-Jonas Songhomitra
- Pandey Anamika
- Pangaribuan Helena U.
- Park Eun-Kee
- Park James
- Parmar Priya
- Parry Charles D.
- Pasovic Maja
- Pasupula Deepak K.
- Patel Jenil R.
- Patel Sangram K.
- Paternina-Caicedo Angel J.
- Pathak Ashish
- Pathak Mona
- Patten Scott B.
- Patton George C.
- Paudel Deepak
- Paudel Sagun
- Paulson Katherine
- Pazoki Toroudi Hamidreza
- Pease Spencer A.
- Peden Amy E.
- Pennini Alyssa
- Pepito Veincent C.
- Peprah Emmanuel K.
- Pereira Alexandre
- Pereira David M.
- Pereira Jeevan
- Perico Norberto
- Pescarini Julia M.
- Pesudovs Konrad
- Pham Hai Q.
- Phillips Michael R.
- Piccinelli Cristiano
- Pierce Maxwell
- Pigott David M.
- Pilgrim Thomas
- Pilz Tessa M.
- Piradov Michael A.
- Pirsaheb Meghdad
- Pishgar Farhad
- Plana-Ripoll Oleguer
- Plass Dietrich
- Pletche Martin
- Pokhrel Khem N.
- Polibin Roman V.
- Polinder Suzanne
- Polkinghorne Kevan R.
- Pond Constance D.
- Postma Maarten J.
- Pottoo Faheem H.
- Pourjafar Hadi
- Pourmalek Farshad
- Pourmirza Kalhori Reza
- Pourshams Akram
- Poznanska Anna
- Prada Sergio I.
- Prakash Sanjay
- Prakash V.
- Prasad Narayan
- Preotescu Liliana
- Pribadi Dimas R.
- Pupillo Elisabetta
- Quazi Syed Zahiruddin
- Rabiee Mohammad
- Rabiee Navid
- Radfar Amir
- Rafiee Ata
- Rafiei Alireza
- Raggi Alberto
- Rahim Fakher
- Rahimi-Movaghar Afarin
- Rahman Mohammad H.
- Rahman Muhammad A.
- Rajabpour-Sanati Ali
- Rajati Fatemeh
- Rakovac Ivo
- Ram Pradhum
- Ramezanzadeh Kiana
- Rana Saleem M.
- Ranabhat Chhabi L.
- Ranta Annemarei
- Rao Puja C.
- Rao Sowmya J.
- Rasella Davide
- Rashedi Vahid
- Rastogi Prateek
- Rath Goura K.
- Rathi Priya
- Rawaf David L.
- Rawaf Salman
- Rawal Lal
- Rawassizadeh Reza
- Rawat Ramu
- Razo Christian
- Redford Sofia B.
- Regassa Lemma D.
- Reiner Robert C.
- Reinig Nickolas
- Reitsma Marissa B.
- Remuzzi Giuseppe
- Renjith Vishnu
- Renzaho Andre M. N. (R17978)
- Ärnlöv Johan
- Øverland Simon
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2020
- Field of study
Background: Accurate and up-to-date assessment of demographic metrics is crucial for understanding a wide range of social, economic, and public health issues that affect populations worldwide. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 produced updated and comprehensive demographic assessments of the key indicators of fertility, mortality, migration, and population for 204 countries and territories and selected subnational locations from 1950 to 2019.
Methods: 8078 country-years of vital registration and sample registration data, 938 surveys, 349 censuses, and 238 other sources were identified and used to estimate age-specific fertility. Spatiotemporal Gaussian process regression (ST-GPR) was used to generate age-specific fertility rates for 5-year age groups between ages 15 and 49 years. With extensions to age groups 10–14 and 50–54 years, the total fertility rate (TFR) was then aggregated using the estimated age-specific fertility between ages 10 and 54 years. 7417 sources were used for under-5 mortality estimation and 7355 for adult mortality. ST-GPR was used to synthesise data sources after correction for known biases. Adult mortality was measured as the probability of death between ages 15 and 60 years based on vital registration, sample registration, and sibling histories, and was also estimated using ST-GPR. HIV-free life tables were then estimated using estimates of under-5 and adult mortality rates using a relational model life table system created for GBD, which closely tracks observed age-specific mortality rates from complete vital registration when available. Independent estimates of HIV-specific mortality generated by an epidemiological analysis of HIV prevalence surveys and antenatal clinic serosurveillance and other sources were incorporated into the estimates in countries with large epidemics. Annual and single-year age estimates of net migration and population for each country and territory were generated using a Bayesian hierarchical cohort component model that analysed estimated age-specific fertility and mortality rates along with 1250 censuses and 747 population registry years. We classified location-years into seven categories on the basis of the natural rate of increase in population (calculated by subtracting the crude death rate from the crude birth rate) and the net migration rate. We computed healthy life expectancy (HALE) using years lived with disability (YLDs) per capita, life tables, and standard demographic methods. Uncertainty was propagated throughout the demographic estimation process, including fertility, mortality, and population, with 1000 draw-level estimates produced for each metric. Findings: The global TFR decreased from 2·72 (95% uncertainty interval [UI] 2·66–2·79) in 2000 to 2·31 (2·17–2·46) in 2019. Global annual livebirths increased from 134·5 million (131·5–137·8) in 2000 to a peak of 139·6 million (133·0–146·9) in 2016. Global livebirths then declined to 135·3 million (127·2–144·1) in 2019. Of the 204 countries and territories included in this study, in 2019, 102 had a TFR lower than 2·1, which is considered a good approximation of replacement-level fertility. All countries in sub-Saharan Africa had TFRs above replacement level in 2019 and accounted for 27·1% (95% UI 26·4–27·8) of global livebirths. Global life expectancy at birth increased from 67·2 years (95% UI 66·8–67·6) in 2000 to 73·5 years (72·8–74·3) in 2019. The total number of deaths increased from 50·7 million (49·5–51·9) in 2000 to 56·5 million (53·7–59·2) in 2019. Under-5 deaths declined from 9·6 million (9·1–10·3) in 2000 to 5·0 million (4·3–6·0) in 2019. Global population increased by 25·7%, from 6·2 billion (6·0–6·3) in 2000 to 7·7 billion (7·5–8·0) in 2019. In 2019, 34 countries had negative natural rates of increase; in 17 of these, the population declined because immigration was not sufficient to counteract the negative rate of decline. Globally, HALE increased from 58·6 years (56·1–60·8) in 2000 to 63·5 years (60·8–66·1) in 2019. HALE increased in 202 of 204 countries and territories between 2000 and 2019
Peri-operative red blood cell transfusion in neonates and infants: NEonate and Children audiT of Anaesthesia pRactice IN Europe: A prospective European multicentre observational study
- Author
- Adelais Tsiotou
- Adriana Gurita
- Afroditi Karafotia
- Albert Castellheim
- Alberto Izquierdo
- Alena Zlámalová
- Alessandra Moscarelli
- Alessandra Verzelloni
- Alessandro Vittori
- Alessia Montaguti
- Aliaksandra Parashchanka
- Alice Miskovic
- Alicia Chamizo
- Alicja Bartkowska-Sniatkowska
- Alison Hare
- Ana Mandras
- Ana Markić
- Ana Peleteiro
- Anda Zundane
- Anders Bastholm Bille
- Andrea Cortegiani
- Andrea Wolfler
- Andreas Machotta
- Andreas Weyland
- Andrew Blevin
- Andrew Robertson
- András Petróczy
- Angela Pistorio
- Anita Reil
- Anja Diers
- Ann Kvarnström
- Anna Camporesi
- Anna Guddo
- Anna Malisiova
- Anna-Ursina Malär
- Anne Laffargue
- Anne Lesage
- Anne M Beukers
- Annemie Bauters
- Anouk Van der Knijff-van Dortmont
- Anthony R Absalom
- Antonella Cotoia
- Arash Afshari
- Armin Flinspach
- Arta Barzdina
- Artemis Polyzoi
- Artur Baranowski
- Aslı Sagun
- Aurélien Legrand
- Aurélien Zang
- Ayse Çiğdem Tutuncu
- Balázs Hauser
- Barbe Pieters
- Barbora Cabanová
- Bas Van Zaane
- Beate Kuppers
- Benjamin Urbina
- Bernard Coustets
- Bernd Schmitz
- Bernhard Koller
- Biljana Drašković
- Brendan O'Hare
- Brigitte Messerer
- Brita De Lorenzo
- Bruno Guido Locatelli
- Camilla Micalizzi
- Carine Marcucci
- Carmel Cassar
- Carmelo Minardi
- Carmen Scott
- Carol Bodlani
- Carolin Aehling
- Carolina Tormo de Las Heras
- Caroline Couchepin
- Caroline Lejus-Bourdeau
- Caroline Pregardien
- Catarina Cruz Esteves
- Catherine Amory
- Catherine Baujard
- Ceferina Suárez Castaño
- Celia Allison
- Celia Arbona
- Cesare Vezzoli
- Chiara Grasso
- Chris Perry
- Christa Boer
- Christiane Goeters
- Christoph Eisner
- Christoph Menzel
- Christophe Dadure
- Chrystelle Sola
- Chulananda Goonasekera
- Claudia Hoehne
- Claudia Neumann
- Clelia Zanaboni
- Clemens Schorer
- Cristina Agapiti
- Cristina Auli
- Cristina González Serrano
- Cécile Magne
- Dan Gilpin
- Daniel Richter
- Daniela Lerro
- Daniela Pupacic
- Daphne Michelet
- Dario Galante
- Darja Janjatovic
- David Alders
- David Artés
- David Barnes
- David Kahn
- David Pachter
- de Graaff J. C.
- Despoina Iordanidou
- Diana Butković
- Dilek Özcengiz
- Dina Bert
- Dina Emal
- Disma N.
- Dmytro Dmytriiev
- Dolores Méndez
- Dorota Lewandowska
- Dusica Simic
- Edgar Székely
- Edoardo Calderini
- Eleana Garini
- Elena Attanasi
- Elena Gordeva
- Elena Lenares
- Elena Vilardell Ortíz
- Eliane Khalil
- Elisa Reponen
- Ellie Walker
- Elvan Öçmen
- Emanuele Rossetti
- Emese Nyíri
- Emilie Druot
- Emma Meehan
- Emma Pontén
- Erik Ramon Isern
- Ernesto Martínez García
- Erzsebet Sapi
- Esther Ngan
- Eva Schafrat
- Evangelia Bali
- Fabio Caramelli
- Fabio Sbaraglia
- Fanny Fabre
- Federico Bilotta
- Florence Julien-Marsollier
- France Stevens
- Francesca Pinzoni
- Francis Veyckemans
- Francisco Escribá
- Frank Wappler
- Franz-Josef Kretz
- François de la Brière
- François Semjen
- Fuchs A.
- Gabor Erdoes
- Gabriel Mocioiu
- Gail Scoones
- Gema Pino
- Gerald Rogan Neba
- Gergely Göbl
- Gert-Jan Scheffer
- Gilda Cinnella
- Gilles Orliaguet
- Girolamo Mattioli
- Giulia Bottazzi
- Giulia Frasacco
- Giuliana Anna Porro
- Giuseppe Staiti
- Graham Bell
- Gregor Badelt
- Gulsen Keskin
- Guner Kaya
- Gyula Tövisházi
- Habre W.
- Hale Aksu Erdost
- Handan Birbiçer
- Hannah King
- Hannu Kokki
- Heiko Kaiser
- Helena Salgado
- Hervé Dupont
- Hilmi Ayanoglu
- Hugues Ludot
- Ilona Razlevice
- Inge De Liefde
- Inger Marie Drage
- Irena Maraulaite
- Irena Simic
- Irena Vulicevic
- Irene García Martínez
- Irina Milojevic
- Irina Trante
- Isabel Eggemann
- Isabelle Constant
- Isabelle Pichon
- Isole Edelman
- Iulia Cindea
- Ivan Kohn
- Ivana Budic
- Ivana Kerovec Sorić
- Ivana Petrov
- Jacqueline Mauch
- James Armstrong
- Jan Schreiber
- Janos Schnur
- Jarkko Harju
- Jarl Reinhard
- Jean-Paul Mission
- Jelena Berger
- Jenni Vieri
- Jeremy Tomas
- Jesús Cebrián
- Jiří Žurek
- Joanne Norman
- Johan Berghmans
- Johanes Eger
- Johanna Ulrici
- John Emery
- Joke De Ruiter
- Jordanka Ilic
- Joris Vundelinckx
- Josip Azman
- Josko Markic
- Jost Kaufmann
- Jowita Rosada-Kurasińska
- Joy Abbott
- Judit Csillag
- Juliet Wolfe Barry
- Juliette Godart
- Jurgen Dertinger
- Jurgen Van Limmen
- Jutta Scheffczik
- János Gál
- Kai Zacharowski
- Kariantti Kallio
- Karin Becke
- Karin Hochmuth
- Karin Jonckheer
- Karin Oeinck
- Karin Oppenrieder
- Karina Jakubowska
- Karine Nouette Gaulain
- Kathryn James
- Katy Nicholson
- Kerstin Sandström
- Kevin Goddard
- Khairi Shah
- Koen Lapage
- Kristoffer Stensrud
- L Amaki Sogbodjor
- Laszlo Vutskits
- Laura Brigitta Colantonio
- Laura Lukosiene
- Laurent Hertz
- Leila Mameli
- Leila Messroghli
- Lena Brunner
- Lenka Knoppová
- Lesley McKee
- Li-En Tan
- Lilica Ros
- Lindsay Crate
- Lisa Daniels
- Lonneke Staals
- Loredana Oana
- Luc De Baerdemaeker
- Luc Tielens
- Lucia Scordo
- Lucie Sabau
- Luminita Ilie
- Lynn Uhrig
- Lynne Waring
- Léa Petry
- Magdalena Juzwa-Sobieraj
- Magdalena Mierzewska-Schmidt
- Magdalena Urban-Lechowicz
- Maja Suica
- Malgorzata Grzeskowiak
- Mandy Jackson
- Manuela Platzer
- Margot Bergsma
- Marguerite Ellekvist
- Mari-Liis Ilmoja
- Maria Cristina Mondardini
- Maria Domingas Patuleia
- Maria Garcia
- Maria João Santos
- Maria Sammartino
- Maria Soares
- Maria Vittinghof
- Mariangela Giombini
- Marianne Veldhuizen
- Marieke Voet-Lindner
- Marielle Buitenhuis
- Marija Stevic
- Marina Pandurov
- Marinella Astuto
- Mark Hendriks
- Mark Ross
- Mark Worrall
- Markus Stevens
- Markus Weigand
- Markus Wilbs
- Martin Hölzle
- Martin Jöhr
- Martin Söhle
- Martin Vavřina
- Martin Volkers
- Martina Stichlberger
- Maryline Bordes
- Marzena Zielinska
- María Isabel Villalobos Rico
- Mathias Marchon
- Matthias Klages
- Mattias Casutt
- Maurizia Grazzini
- Mehdi Bennis
- Melanie Schäfer
- Merja Kokki
- Merle Väli
- Michael Laschat
- Michael Schöler
- Michaela Löffler
- Michal Frelich
- Michelle Casey
- Michelle Quinney
- Micol Maffioletti
- Mihai Morariu
- Miia Kokkonen
- Miloslav Hanula
- Mine Akin
- Miriam Ochsenreiter
- Mirjana Knezevic
- Mirko Dolci
- Monica Gandhi
- Montserrat Suarez Comas
- Moreno Favarato
- Mustafa Azizoglu
- Myriam Bellon
- Nada Sabourdin
- Nadia Najafi
- Nadine Dobby
- Nalini Malarkkan
- Nandor Kosik
- Nargis Ahmad
- Natalia Sierra Biddle
- Natalie Cooper
- NECTARINE Group of the European Society of Anaesthesiology and Intensive Care Clinical Trial Network: Christian Breschan
- Nicola Zadra
- Nicolas Leister
- Nikola Stankovic
- Nil Ekiz
- Noemie Audren
- Nurcan Doruk
- Nuria Masip
- Nuria Montferrer Estruch
- Olivier Jacqmarcq
- Osvaldo Pérez Pardo
- Pablo De la Arena
- Pablo Troncoso Montero
- Paloma Rubio
- Panagoula Mammi
- Paul Martin
- Paul Smith
- Paul Stevens
- Pedro Pina
- Pelagia Chloropoulou
- Pelin Corman Dincer
- Pertti Suominen
- Peter Brooks
- Peter Frykholm
- Peter Kranke
- Petr Reimer
- Petra Cajková
- Petronella Mari Vermeulen
- Philippa Dix
- Philippe Pirat
- Philippe Roulleau
- Piet Wyffels
- Pilar Del Rey de Diego
- Pinar Kendigelen
- Pinelopi Papagiannopoulou
- Piotr Sawicki
- Pomianek Przemyslaw
- Prakash Krishnan
- Rachele Bonfiglio
- Radu Tabacaru
- Rainer Dörenberg
- Raisa Vähätalo
- Rebecca Pad
- Reet Kikas
- Reet Moor
- René Urbanec
- Richard Ellerkmann
- Rients De Boer
- Rita Scalisi
- Riva T.
- Rob Bomont
- Roberto Leone
- Robin Sunderland
- Rodica Badeti
- Rodrigo Poves-Álvarez
- Rose Fesseau
- Rossella Garra
- Rudolf Likar
- Ruth Cohausz
- Ruth Kroess
- Sadia Adil
- Sam De Silva
- Sami Suvanto
- Sandra Kralik
- Sandra Lako
- Sandra Numan
- Sara Mele
- Sarah Bell
- Sarah Gallagher
- Sascha Haussmann
- Sascha Meier
- Sebastian Richter
- Sebastian Weiterer
- Selena Puric Racic
- Sergio Picardo
- Shahab Ghamari
- Sibel Baris
- Silvia López
- Silvia Serrano
- Simona Anna Finamore
- Simone Lindau
- Simonetta Tesoro
- Sinead Harte
- Sirin Yücetepe
- Sladjana Vasiljevic
- Sophie Childs
- Souhayl Dahmani
- Sporre Bengt
- Sridevi Kuchi
- Stefan De Hert
- Stefan Heschl
- Stefan Seiler
- Stefano Scalia Catenacci
- Stephanie Bew
- Stephanie Jinks
- Stephanie King
- Stephanie Mifsud
- Stuart Blain
- Suellen Walker
- Susana Manrique Muñoz
- Susanna Keilig
- Svetlana Kotzeva
- Sílvia Pinho
- Teresa Leal
- Thierry Pirotte
- Thomas Bruelisauer
- Thomas Descarpentries
- Thomas Erb
- Thomas Fischer
- Thomas Hurni
- Thomas Mueller
- Tjerk Zweers
- Tom Hansen
- Tom Terboven
- Torsten Baehner
- Tumay Umuroglu
- Tuula Manner
- Ulf Lindestam
- Ulmer F.
- Uwe Trieschmann
- Vagia Ntritsou
- Valentin Munteanu
- Valter Sonzogni
- Veronika Maráczi
- Veronique Depret-Donatien
- Vesna Marjanovic
- Victoria Barlow
- Vimmi Oshan
- Virag K.
- Vladimír Mixa
- Wenche B Boerk
- Wolfgang Buhre
- Yann Bögli
- Yann Hamonic
- Yesim Senayli
- Yvona Sedláčková
- Yvonne Jelting
- Zane Straume
- Zdenka Rados
- Zeenat Nawoor
- Zehra Hatipoğlu
- Çimen Olguner
- Špela Pirtovšek Štupnik
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- 01/01/2022
- Field of study
BACKGROUND: Little is known about current clinical practice concerning peri-operative red blood cell transfusion in neonates and small infants. Guidelines suggest transfusions based on haemoglobin thresholds ranging from 8.5 to 12 g dl-1, distinguishing between children from birth to day 7 (week 1), from day 8 to day 14 (week 2) or from day 15 (≥week 3) onwards. OBJECTIVE: To observe peri-operative red blood cell transfusion practice according to guidelines in relation to patient outcome. DESIGN: A multicentre observational study. SETTING: The NEonate-Children sTudy of Anaesthesia pRactice IN Europe (NECTARINE) trial recruited patients up to 60 weeks' postmenstrual age undergoing anaesthesia for surgical or diagnostic procedures from 165 centres in 31 European countries between March 2016 and January 2017. PATIENTS: The data included 5609 patients undergoing 6542 procedures. Inclusion criteria was a peri-operative red blood cell transfusion. MAIN OUTCOME MEASURES: The primary endpoint was the haemoglobin level triggering a transfusion for neonates in week 1, week 2 and week 3. Secondary endpoints were transfusion volumes, 'delta haemoglobin' (preprocedure - transfusion-triggering) and 30-day and 90-day morbidity and mortality. RESULTS: Peri-operative red blood cell transfusions were recorded during 447 procedures (6.9%). The median haemoglobin levels triggering a transfusion were 9.6 [IQR 8.7 to 10.9] g dl-1 for neonates in week 1, 9.6 [7.7 to 10.4] g dl-1 in week 2 and 8.0 [7.3 to 9.0] g dl-1 in week 3. The median transfusion volume was 17.1 [11.1 to 26.4] ml kg-1 with a median delta haemoglobin of 1.8 [0.0 to 3.6] g dl-1. Thirty-day morbidity was 47.8% with an overall mortality of 11.3%. CONCLUSIONS: Results indicate lower transfusion-triggering haemoglobin thresholds in clinical practice than suggested by current guidelines. The high morbidity and mortality of this NECTARINE sub-cohort calls for investigative action and evidence-based guidelines addressing peri-operative red blood cell transfusions strategies. TRIAL REGISTRATION: ClinicalTrials.gov, identifier: NCT02350348
Whole-genome sequencing reveals host factors underlying critical COVID-19
- Author
- Abd Elghafar M.S.
- Abdel-Aziz M.
- Abdelrazik M.
- Abdollahi H.
- Abdullah T.
- Abecasis G.R.
- Abecasis G.R.
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- Uitterlinden A.G.
- Underwood S.J.
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- Vaida M.
- Valente S.
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- Valentino F.
- van Blokland I.
- van Heel D.A.
- van Koutrik L.
- Varghese M.
- Vecchia M.
- Vedage D.
- Veerapen K.
- Venkatesh H.
- Venn L.D.
- Venturelli S.
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- Vizcaychipi M.P.
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- Waite A.A.C.
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- Walker R.
- Walker S.
- Walker S.
- Walker S.
- Wall A.
- Walsh T.
- Walsh T.
- Walters R.K.
- Walton O.
- Wang B.
- Wang J.
- Wang X.
- Wanying Z.
- Ward G.
- Ward L.
- Ward M.
- Warden S.
- Warmerdam R.
- Warren D.
- Wassall H.
- Wasson C.
- Watkins C.
- Watson E.
- Watson G.
- Watson J.
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- Waugh V.
- Weaver J.
- Webster A.
- Webster D.
- Webster K.
- Wei S.
- Weiss S.T.
- Weldon C.H.
- Wells C.
- Welters I.D.
- Weston H.
- Whileman A.
- Whitbread J.
- White D.
- White I.
- White K.
- White M.
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- White N.
- Whiteley S.
- Whiteside J.
- Whittle H.
- Whitton C.
- Whyte C.
- Wicks S.J.
- Wilby E.
- Wilcox L.
- Wilcox R.
- Wild H.
- Wild L.
- Wild L.
- Wilding L.
- Wiles M.
- Wilkins J.
- Wilkinson A.
- Wilkinson B.
- Willer C.
- Williams A.
- Williams A.
- Williams A.
- Williams A.T.
- Williams D.
- Williams E.
- Williams F.
- Williams G.
- Williams H.
- Williams K.
- Williams M.
- Williams P.
- Williams S.
- Williams T.
- Willis C.
- Willis H.
- Wills M.
- Willson J.
- Wilson A.
- Wilson D.J.
- Wilson J.
- Wilson J.F.
- Wilson J.F.
- Winnard S.
- Winter-Goodwin B.
- Wolf-Roberts R.
- Wolford B.
- Wong J.
- Wood D.
- Wood H.-L.
- Wood S.
- Wood T.
- Woodford C.
- Woodruff M.
- Woods L.
- Woodyatt W.
- Woolley A.E.
- Worner R.
- Worsley L.
- Wray G.
- Wren L.
- Wrey Brown C.
- Wright D.
- Wright J.
- Wright M.
- Wrobel N.
- Wu Y.
- Wulandari R.
- Wyllie D.H.
- Wynter I.
- Xavier K.
- Xue X.
- Yadav A.
- Yang J.
- Yassen A.M.
- Yates B.
- Ye C.
- Yun N.
- Zainy T.
- Zak A.
- Zaki A.
- Zamikula J.
- Zanella I.
- Zborowski A.C.
- Zeberg H.
- Zechner M.
- Zechner M.
- Zguro K.
- Zhang M.
- Zhao J.H.
- Zheng C.
- Zhou W.
- Zitter L.
- Zlatopolsky M.
- Zongo O.
- Zucchi P.
- Zyndorf M.
- Zöllner S.
- Åsvold B.O.
- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 07/07/2022
- Field of study
Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2,3,4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease
Multiancestry analysis of the HLA locus in Alzheimer’s and Parkinson’s diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes
- Author
- Aarsland Dag
- Aarsland Dag
- Abdelnour Carla
- Abraham Richard
- Abraham Richard
- Adarmes-Gómez A.D.
- Adarmes-Gómez Ad
- Aguilera N.
- Aguilera Nuria
- Ahmad Shahzad
- Al-Chalabi Ammar
- Al-Chalabi Ammar
- Alarcon E.
- Alarcón-Martín E.
- Alarcón-Martín Emilio
- Alcolea Daniel
- Alegret M.
- Alegret Montserrat
- Alonso M.D.
- Alvarez Ignacio
- Alvarez Victoria
- Ambati Aditya
- Amer-Ferrer G.
- Amin Najaf
- Amouyel Philippe
- Amouyel Philippe
- Amouyel Phillippe
- Anastasiou Anna
- Anastasiou Costas
- Andrade Victor
- Andreassen Ole A.
- Andreassen Ole A.
- Andreassen Ole A.
- Andreoni Simona
- Annuar Azlina Ahmad
- Antequera M.
- Anthoula Tsolaki
- Antikainen Riitta
- Antonell Anna
- Antúnez C.
- Appollonio Ildebrando
- Arcaro Marina
- Archetti Silvana
- Arfan Ikram M.
- Arias Pastor Alfonso
- Ariel Prestia Federico
- Armstrong Nicola J.
- Arosio Beatrice
- Arosio Beatrice
- Assogna Francesca
- Athanasiu Lavinia
- Athanasiu Lavinia
- Au Wing-Lok
- Bahrami Shahram
- Bailly Henri
- Banaj Nerisa
- Baquero M.
- Baquero Miquel
- Bass Nicholas J.
- Bass Nick
- Bastiani Patrizia
- Bayer Anthony
- Becker Tim
- Belezhanska Diyana
- Bellenguez Céline
- Bellenguez Céline
- Bellenguez Céline
- Belloy Michael E.
- Belén Pastor Ana
- Ben-Shlomo Yoav
- Benussi Alberto
- Benussi Luisa
- Benussi Luisa
- Bergh Sverre
- Bernal M.
- Bernardo-Harrington Mateus
- Berr Claudine
- Berr Claudine
- Besse Céline
- Bessi Valentina
- Binetti Giuliano
- Bizarro Alessandra
- Bjerke Maria
- Blennow Kaj
- Blesa R.
- Blesa Rafael
- Boada M.
- Boada M.
- Boada Mercè
- Boada Mercè
- Boecker Henning
- Boland Anne
- Boland Anne
- Borroni Barbara
- Borroni Barbara
- Boschi Silvia
- Bosnes Ingunn
- Bossù Paola
- Brayne Carol
- Brayne Carol
- Bresner Catherine
- Brice Alexis
- Brodaty Henry
- Brookes Keeley J.
- Brown Kristelle
- Brown Kristelle S.
- Bråthen Geir
- Bråthen Geir
- Buendia M.
- Buendia Mar
- Buiza-Rueda D.
- Buiza-Rueda Dolores
- Bullido M.J.
- Bullido María J.
- Bullido María J.
- Burguera J.A.
- Burholt Vanessa
- BÛrger Katharina
- Caffarra Paolo
- Calero M.
- Calero Miguel
- campion Dominique
- Campos-Martin Rafael
- Cano A.
- Carracedo A.
- Carracedo Ángel
- Carrillo F.
- Carrillo F.
- Carrion-Claro M.
- Carrión-Claro M.
- Casajeros M.J.
- Castaño Eduardo M.
- Castillo Morales Atahualpa
- Cañabate P.
- Cañabate Pilar
- Cecchetti Roberta
- Cervera-Carles Laura
- Chan Anne Y.Y.
- Chao Yinxia
- Chapuis Julien
- Charbonnier Camille
- Chen Ling
- Chen Yongping
- Chene Geneviève
- Chew Elaine Guo Yan
- Chillotti Caterina
- Chipi Elena
- Chung Sun Ju
- Ciccone Simona
- Ciullo Valentina
- Claassen Jurgen A.H.R.
- Clarimon Jordi
- Clarimon Jordi
- Clarimon Jordi
- Clarimón J.
- Clark Christopher
- Clarke Robert
- Collinge John
- Collinge John
- Conti Elisa
- Corbatón-Anchuelo A.
- Cores Valeria
- Corma-Gómez Anaïs
- Costa Marcos R
- Costantini Emanuele
- Craig David
- Craig David
- Cruz-Gamero J.M.
- Cuesta Carolina
- Custodero Carlo
- Daian Delphine
- Dalmasso Maria Carolina
- Damotte Vincent
- Damotte Vincent
- Daniele Antonio
- Daniele Antonio
- Dardiotis Efthimios
- Darling Daniel
- Dartigues Jean-Francois
- Dartigues Jean-François
- David Smith A.
- David Smith A.
- Davies Chloe
- de Deyn Peter Paul
- de Mendonça Alexandre
- de Mendonça Alexandre
- de Munain Adolfo Lopez
- de Pancorbo M.M.
- De Roeck Ellen
- de Rojas I.
- de Rojas I.
- de Rojas Itziar
- de Rojas Itziar
- Debette Stéphanie
- Debette Stéphanie
- Deckert Jürgen
- del Ser T.
- del Ser Teodoro
- Del Zompo Maria
- Deleuze Jean-François
- Deleuze Jean-François
- Deloukas Panagiotis
- Deloukas Pangiotis
- den Bussche Hendrik
- Denning Nicola
- Denning Nicola
- Deramecourt Vincent
- Dermecourt Vincent
- Dichgans Martin
- Dichgans Martin
- Dichgans Martin
- Diego S.
- Diego Susana
- Diehl-Schmid Janine
- Diez-Fairen M.
- Diez-Fairen Mónica
- Dionigi Rossi Paolo
- Djurovic Srdjan
- Djurovic Srdjan
- Dolores Alonso María
- Dowzell Kimberley
- Drichel Dmitriy
- Dubois Bruno
- Dufouil Carole
- Dufouil Carole
- Dufouil Carole
- During Emmanuel
- Duron Emmanuelle
- Düzel Emrah
- Düzel Emrah
- Engelborghs Sebastiaan
- Epelbaum Jacques
- Escott-Price Valentina
- Escott-Price Valentina
- Escuela R.
- Escuela R.
- Espinosa A.
- Espinosa Ana
- Etchepareborda Ignacio
- Eugenia Sáez María
- Ewers Michael
- Fabrizio Tagliavini
- Fallgaard Nielsen Sune
- Farotti Lucia
- Fenoglio Chiara
- Fernández-Fuertes Marta
- Ferrarese Carlo
- Ferreira Catarina B
- Ferri Evelyn
- Feulner Thomas
- Fievet Nathalie
- Fievet Nathalie
- Fin Bertrand
- Fischer Peter
- Fisher Elizabeth
- Fladby Tormod
- Fladby Tormod
- Fließbach Klaus
- Foo Jia Nee
- Foo Jia Nee
- Forsell Charlotte
- Fortea J.
- Fortea Juan
- Fostinelli Silvia
- Fox Nick
- Fox Nick C.
- Fox Nick C.
- Franco E.
- Franco-Macías Emlio
- Frank-García A.
- Frank-García Ana
- Frikke-Schmidt Ruth
- Frikke-Schmidt Ruth
- Froelich Lutz
- Frölich Lutz
- Gailhajenet A.
- Gailhajenet Anna
- Galeano Pablo
- Galimberti Daniela
- Galimberti Daniela
- Gan-Or Ziv
- Garcia Madrona S.
- Garcia-Gonzalez Pablo
- Garcia-Madrona Sebastian
- Garcia-Ribas G.
- Garcia-Ribas Guillermo
- Garcia-Ribas Guillermo
- García-Alberca J.M.
- García-Alberca José María
- García-González P.
- García-González Pablo
- García-González Pablo
- Garrote-Espina L.
- Garrote-Espina L.
- Germani Sandra
- Gerrish Amy
- Gerrish Amy
- Ghanbari Mohsen
- Ghidoni Roberta
- Giedraitis Vilmantas
- Giedraitis Vilmantas
- Giegling Ina
- Giegling Ina
- Gill Michael
- Gill Michael
- Gill Michael
- Gim Jungsoo
- Giorgio Giaccone
- Goldhardt Oliver
- Goldhardt Oliver
- González-Péerez A.
- González-Pérez Antonio
- Graff Caroline
- Graff Caroline
- Grande Giulia
- Green Emma
- Greicius Michael D.
- Grenier-Boley Benjamin
- Grenier-Boley Benjamin
- Grenier-Boley Benjamin
- Grimmer Timo
- Grünblatt Edna
- Grünblatt Edna
- Gu Wei
- Guerreiro Rita
- Guetta-Baranes Tamar
- Guitart M.
- Guitart Marina
- Gurling Hugh
- Gwilliam Rhian
- Gwilliam Rhian
- Gómez-Garre P.
- Gómez-Garre P.
- Haapasalo Annakaisa
- Hadjigeorgiou Georgios
- Hampel Harald
- Hampel Harald
- Hannequin Didier
- Hanon Olivier
- Hanon Olivier
- Hanon Olivier
- Hardy John
- Hardy John
- Hardy John
- Harold Denise
- Harold Denise
- Hartmann Annette M.
- Hartmann Annette M.
- Harwood Janet
- Hausner Lucrezia
- Hausner Lucrezia
- He Zihuai
- Heilmann-Heimbach Stefanie
- Heilmann-Heimbach Stefanie
- Helisalmi Seppo
- Heneka Michael T.
- Hernández Isabel
- Herold Christine
- Herrmann Martin J.
- Heun Reinhard
- Heuser Isabella
- Hevilla S.
- Hiltunen Mikko
- Hiltunen Mikko
- Hodges Angela
- Hoffmann Per
- Hoffmann Per
- Hollingworth Paul
- Hollingworth Paul
- Holmans Peter
- Holmans Peter A.
- Holmes Clive
- Holmes Clive
- Holstege Henne
- Holstege Henne
- Hooper Nigel M.
- Hort Jakub
- Hort Jakub
- Huerto Vilas Raquel
- Hulsman Marc
- Hüll Michael
- Ibarria M.
- Ibarria Marta
- Ignacio Bacha Juan
- Ignacio Brusco Luis
- Ikeuchi Takeshi
- Ingelsson Martin
- Ingelsson Martin
- Ingino Carlos
- Jan Biessels Geert
- Janowitz Daniel
- Jansen Iris
- Jansen Iris
- Jeon Beom S.
- Jessen Frank
- Jessen Frank
- Jessen Frank
- Jesús S.
- Jesús S.
- Jiang Lulu
- Johansson Charlotte
- Johnston Janet A.
- Johnston Jarret A.
- Jones Lesley
- Jones Lesley
- Jung Yoo Jin
- Jöckel Karl-Heinz
- Jürgen Deckert
- Kauwe John
- Kehoe Patrick
- Kehoe Patrick G.
- Kehoe Patrick G.
- Kern Silke
- Khor Chiea Chuen
- Kilander Lena
- Kinhult Ståhlbom Anne
- Kivipelto Miia
- Kleineidam Luca
- Klopp Norman
- Kochen Silvia
- Koh Woon-Puay
- Kohler Eduardo
- Kohler Matias
- Koivisto Anne
- Kornhuber Johannes
- Kornhuber Johannes
- Kosmidis Mary H.
- Kuulasmaa Teemu
- Kuulasmaa Teemu
- Kölsch Heike
- Küçükali Fahri
- Küçükali Fahri
- Laatikainen Tiina
- Labrador Espinosa M.A.
- Labrador Ma
- Lacidogna Giordano
- Lacour ndré
- Laczo Jan
- Lafuente A.
- Lafuente Asunción
- Lage C.
- Lage Carmen
- Lage Carmen
- Lambert Jean-Charles
- Lambert Jean-Charles
- Lambert Jean-Charles
- Laske Christoph
- Laukka Erika J
- Lauria Alessandra
- Lawlor Brian
- Lawlor Brian
- Le Guen Yann
- Lee Kun Ho
- Legaz A.
- Lehtisalo Jenni
- Lerch Ondrej
- Lian Michelle M.
- Lian Michelle Mulan
- Lim Jia Lun
- Lim Shen-Yang
- Lin Juei-Jueng
- Lin Ling
- Lindström Jaana
- Lis Palacio Dana
- Lisso Julieta
- Liu Chunfeng
- Liu Jianjun
- Livingston Gill
- Livingston Gill
- Lleó Alberto
- Lleóo A.
- Lord Jenny
- Love Seth
- Love Seth
- Lovestone Simon
- Lovestone Simon
- Luckcuck Lauren
- Luckcuck Lauren
- Luis Royo Jose
- Luo Guo
- Lupton Michelle
- Lupton Michelle
- Luís Royo Jose
- Lynch Aoibhinn
- Lynch Aoibhinn
- Lóopez de Munáin A.
- López-García S.
- López-García Sara
- Löwemark Malin
- Macias J.
- Macias-García D.
- Macias-García D.
- MacLeod Catherine A.
- Macías Juan
- Magda Tsolaki
- Maier Wolfgang
- Maier Wolfgang
- Malik Rainer
- Mangialasche Francesca
- Mangone Carlos
- Mann David
- Mann David
- Manzanares S.
- Mao Chengjie
- Marco Spallazzi
- Maria García-Alberca Jose
- Maroñas O.
- Marquié M.
- Marquié M.
- Marquié Marta
- Marshall Rachel
- Marshall Rachel
- Martín Montes A.
- Martín Montes Angel
- Martín E.
- Martín Elvira
- Martínez Rodríguez Carmen
- Martínez B.
- Martínez C.
- Martínez M.T.
- Martínez V.
- Martínez-Lage Álvarez A.
- Marín M.
- Marín M.
- Marín T.
- Marín-Muñoz J.
- Masullo Carlo
- Masullo Carlo
- Mata Ignacio
- Mather Karen
- Matoska Vaclav
- Mauleón Ana
- Mayhaus Manuel
- Mayo Kevin
- McGuinness Bernadette
- McGuinness Bernadette
- McQuillin Andrew
- McQuillin Andrew
- Mead Simon
- Mead Simon
- Meah Wee-Yang
- Mecocci Patrizia
- Mecocci Patrizia
- Medel Nancy
- Medina M.
- Medina Miguel
- Meggy Alun
- Meggy Alun
- Mehrabian Shima
- Mehrabian Shima
- Mendioroz Iriarte M.
- Mendoza Silvia
- Menéndez-González M.
- Menéndez-González Manuel
- Mignot Emmanuel
- Mir P.
- Mir Pablo
- Mir Pablo
- Miyashita Akinori
- Moebus Susanne
- Moebus Susanne
- Moebus Susanne
- Mok Shi Qi
- Mok Vincent
- Mol Merel
- Molina-Porcel Laura
- Montrreal L.
- Montrreal L.
- Montrreal Laura
- Morelli Laura
- Moreno Fermin
- Moreno Fermin
- Moreno M.
- Moreno Mariona
- Moreno-Grau S.
- Moreno-Grau Sonia
- Morgan Kevin
- Morgan Kevin
- Morizono Takashi
- Morris John
- Muchnik Carolina
- Mummery Catherine
- Möthen Markus M
- Nacmias Benedetta
- Nacmias Benedetta
- Naito Tatsuhiko
- Nash William
- Natunen Teemu
- Ng Ebonne Y.
- Ngandu Tiia
- Nicolas Aude
- Nicolas Gael
- Nicolas Gael
- Niida Shumpei
- Nordestgaard Børge G.
- Nordestgaard Børge G.
- Novack Gisela
- Nuñez-Llaves R.
- Nöthen Markus M.
- O'Donovan Michael
- O'Donovan Michael C.
- Okada Yukinori
- Olaso Robert
- Olivar Natividad
- Olivé C.
- Orellana A.
- Orellana A.
- Orellana Adelina
- Orsini Michela
- Ortega G.
- Ortega Gemma
- Ortiz Cecilia
- Owen Michael
- Owen Michael J.
- Ozaki Kouichi
- Pablo Tartan Juan
- Padovani Alessandro
- Pancho A.
- Pancho Ana
- Paola Zoia Chiara
- Paolo Caffarra
- Papenberg Goran
- Papenberg Goran
- Papma Janne
- Park Hyeonseul
- Parnetti Lucilla
- Parnetti Lucilla
- Parveen Kayenat
- Parveen Kayenat
- Pasquier Florence
- Pasquier Florence
- Pasquier Florence
- Passmore Peter
- Passmore Peter
- Pastor P.
- Pastor Pau
- Pastor Pau
- Patel Yogen
- Pei Zhong
- Peixoto Leal Thiago
- Pelejà E.
- Pelejà Esther
- Peltonen Markku
- Peng Rong
- Pericard Pierre
- Periñán Mt
- Periñán-Tocino T.
- Perneczky Robert
- Peters Oliver
- Peters Oliver
- Pickering-Brown Stuart
- Pijnenburg Yolande A. L.
- Pijnenburg Yolande A.L.
- Pinchler Sabrina
- Pineda J.A.
- Pineda Juan A.
- Pineda-Sánchez R.
- Pineda-Sánchez R.
- Piras Fabrizio
- Piras Federica
- Pisanu Claudia
- Piñol Ripoll G.
- Piñol-Ripoll Gerard
- Piñol-Ripoll Gerard
- Polak Thomas
- Politis Daniel G.
- Popp Julius
- Popp Julius
- Porcel Laura Molina
- Posthuma Danielle
- Powell John
- Powell John F.
- Prakash Kumar-M.
- Preckler S.
- Preckler Silvia
- Priller Josef
- Proitsi Petra
- Proitsi Petra
- Prokic Ivana
- Puerta R.
- Puerta Raquel
- Puerta Raquel
- Péerez Tur J.
- Pérez-Cordon A.
- Pérez-Cordón Alba
- Pérez-Tur Jordi
- Pérez-Tur Jordi
- Quenez Olivier
- Quintela I.
- Quintela Inés
- Qvist Thomassen Jesper
- Rainero Innocenzo
- Rainero Innocenzo
- Ramakers Inez
- Ramakers Inez
- Ramirez Alfredo
- Ramirez Alfredo
- Ramirez Alfredo
- Real de Asúa D.
- Real L.M.
- Real Luis M.
- Real Luis M.
- Reinders Marcel J.T.
- Reyes Toso Carlos
- Riedel-Heller Steffi
- Riedel-Heller Steffi
- Riedel-Heller Steffi
- Riederer Peter
- Riemenschneider Matthias
- Rios Mario
- Ritchie Karen
- Roberto Natalia
- Rodrigo S.
- Rodrigo-Herrero Silvia
- Rodriguez-Rodriguez Eloy
- Rodriguez-Rodriguez Eloy
- Rodríguez-Rodríguez E.
- Rojo Matias
- Rong Zhang Bao
- Rongve Arvid
- Rongve Arvid
- Rosas Allende Irene
- Rosende-Roca M.
- Rosende-Roca Maitée
- Ross Owen A.
- Rossi Giacomina
- Rossi Giacomina
- Rossor Martin
- Rossor Martin
- Roveta Fausto
- Royo J.L.
- Rubino Elisa
- Rubinsztein David C.
- Rubinsztein David C.
- Ruiz A.
- Ruiz A.
- Ruiz Agustín
- Ruiz Agustín
- Rujescu Dan
- Rujescu Dan
- Rujescu Dan
- Ryan Natalie S.
- Ryan Nathalie
- Ráabano A.
- Rábano Alberto
- Sachdev Perminder
- Saenz Aldo
- Sakka Paraskevi
- Sala Gessica
- Saltvedt Ingvild
- Saltvedt Ingvild
- Salvadori Nicola
- Sanabria A.
- Sanabria Ángela
- Sanchez Abalos Mariana
- Sanchez del Valle Díaz R.
- Sanchez-Garcia Florentino
- Sando Sigrid B.
- Sando Sigrid B.
- Sastre Merlín Isabel
- Sastre I.
- Satake Wataru
- Scamosci Michela
- Scarmeas Nikolaos
- Scarmeas Nikolaos
- Scarpini Elio
- Scheltens Philip
- Scheltens Philip
- Scherbaum Norbert
- Scherbaum Norbert
- Scherer Martin
- Scherer Martin
- Schmid Matthias
- Schneider Anja
- Schneider Anja
- Schott Jonathan M.
- Schott Jonathan M.
- Schürmann Britta
- Selbæk Geir
- Selbæk Geir
- Selnes Per
- Sempere Vicente
- Seripa Davide
- Seripa Davide
- Serpente Maria
- Serrano-Rios M.
- Sevillano Zulma
- Shadrin Alexey A.
- Shadrin Alexey A.
- Shang Hui-Fang
- Shaw Christopher E.
- Shaw Christopher E.
- Shi Chang-He
- Shofany Jacob
- Sims Rebecca
- Sims Rebecca
- Sims Rebecca
- Singleton Andrew B.
- Skoog Ingmar
- Skrobot Olivia
- Sleegers Kristel
- Sleegers Kristel
- Soininen Hilkka
- Solfrizzi Vincenzo
- Solfrizzi Vincenzo
- Solis Patricia
- Solomon Alina
- Song Kyuyoung
- Sorbi Sandro
- Sotolongo-Grau O.
- Sotolongo-Grau O.
- Sotolongo-Grau Oscar
- Spalletta Gianfranco
- Spalletta Gianfranco
- Spottke Annika
- Squassina Alessio
- Squassina Alessio
- Stordal Eystein
- Stordal Eystein
- Strandberg Timo
- Sussams Rebecca
- Sáez M.E.
- Sánchez Juan Pascual
- Sánchez-Arjona María Bernal
- Sánchez-Juan P.
- Sánchez-Juan Pascual
- Sánchez-Valle Raquel
- Sánchez-Valle Raquel
- Takalo Mari
- Talyansky Seth D.
- Tan Ai Huey
- Tan Eng-King
- Tan Eng-King
- Tan Louis C.S.
- Tandiono Moses
- Tegos Thomas
- Teipel Stefan
- Teresa Martínez-Larrad María
- Tesí Niccolo
- Teunissen Charlotte
- Thalamuthu Anbupalam
- Thomas Charlene
- Thomas Tegos
- Thomassen Jesper Qvist
- Thonberg Håkan
- Toda Tatsushi
- Todd Stephen
- Todd Stephen
- Traykov Latchezar
- Tremolizzo Lucio
- Tremolizzo Lucio
- Tsolaki Magda
- Tsolaki Magda
- Tuomilehto Jaakko
- Turton James
- Tybjærg-Hansen Anne
- Tzourio Christophe
- Táarraga L.
- Tárraga Lluís
- Uitterlinden Andre
- Ullgren Abbe
- Ulstein Ingun
- Ulstein Ingun
- Uphill James
- Vacca Alessandro
- Valero S.
- Valero S.
- Valero Sergi
- Van Broeckhoven Christine
- van der Flier Wiesje
- van der Flier Wiesje M.
- van der Lee Sven J.
- van der Lugt Aad
- Van Dongen Jasper
- van Duijn Cornelia M.
- Van Duin Cornelia
- van Rooij Jeroen
- van Swieten John
- van Swieten John
- Vandenberghe Rik
- Vardy Emma
- Vargas L.
- Vargas Liliana
- Verhey Frans
- Verhey Frans
- Vicente M.P.
- Vidal Jean-Sébastien
- Vigo-Ortega R.
- Vigo-Ortega R.
- Vivancos L.
- Vogelgsang Jonathan
- Vyhnalek Martin
- Vyhnalek Martin
- Waern Margda
- Wagner Michael
- Wallon David
- Wallon David
- Warden Donald
- Warner Nick
- Warren Jason D.
- Weber Heike
- Weinhold Leonie
- Wichmann H-Erich
- Wilcock Gordon
- Williams Amy
- Williams Julie
- Williams Julie
- Williams Julie
- Wiltfang Jens
- Wiltfang Jens
- Wiltfang Jens
- Windle Gill
- Woods Bob
- Wu Yih-Ru
- Xu Renshi
- Xu Yu-ming
- Yan Yaping
- Yang Jing
- Yannakoulia Mary
- Yaqub Amber
- Yogeshwar Selina Maria
- Yonkova Mihova Kalina
- Yu Eric
- Zetterberg Henrik
- Zettergren Anna
- Zhang Jing
- Zulaica Miren
- Álvarez I.
- Álvarez V.
- Álvarez Victoria
- Publication venue
- National Academy of Sciences
- Publication date
- 29/08/2023
- Field of study
Across multiancestry groups, we analyzed Human Leukocyte Antigen (HLA) associations in over 176,000 individuals with Parkinson’s disease (PD) and Alzheimer’s disease (AD) versus controls. We demonstrate that the two diseases share the same protective association at the HLA locus. HLA-specific fine-mapping showed that hierarchical protective effects of HLA-DRB1*04 subtypes best accounted for the association, strongest with HLA-DRB1*04:04 and HLA-DRB1*04:07, and intermediary with HLA-DRB1*04:01 and HLA-DRB1*04:03. The same signal was associated with decreased neurofibrillary tangles in postmortem brains and was associated with reduced tau levels in cerebrospinal fluid and to a lower extent with increased Aβ42. Protective HLA-DRB1*04 subtypes strongly bound the aggregation-prone tau PHF6 sequence, however only when acetylated at a lysine (K311), a common posttranslational modification central to tau aggregation. An HLA-DRB1*04-mediated adaptive immune response decreases PD and AD risks, potentially by acting against tau, offering the possibility of therapeutic avenues
Global, regional, and national burden of disorders affecting the nervous system, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021
- Author
- Abate Yohannes Habtegiorgis
- Abbas Jaffar
- Abbasi Madineh Akram
- Abbasian Mohammadreza
- Abbastabar Hedayat
- Abd-Rabu Rami
- Abdelmasseh Michael
- Abdollahi Mohammad
- Abdollahi Mozhan
- Abdollahifar Mohammad-Amin
- Abdulah Deldar Morad
- Abdullahi Auwal
- Abedi Aidin
- Abedi Vida
- Abeldaño Zuñiga Roberto Ariel
- Abidi Hassan
- Abiodun Olumide
- Aboagye Richard Gyan
- Abolhassani Hassan
- Aboyans Victor
- Abrha Woldu Aberhe
- Abu-Gharbieh Eman
- Abualhasan Ahmed
- Aburuz Salahdein
- Adamu Lawan Hassan
- Addo Isaac Yeboah
- Adebayo Oladimeji M
- Adekanmbi Victor
- Adekiya Tayo Alex
- Adikusuma Wirawan
- Adnani Qorinah Estiningtyas Sakilah
- Adra Saryia
- Afework Tsion
- Afolabi Aanuoluwapo Adeyimika
- Afraz Ali
- Afzal Saira
- Aghamiri Shahin
- Agodi Antonella
- Agyemang-Duah Williams
- Ahinkorah Bright Opoku
- Ahmad Aqeel
- Ahmad Danish
- Ahmad Sajjad
- Ahmadzade Amir Mahmoud
- Ahmed Ali
- Ahmed Ayman
- Ahmed Haroon
- Ahmed Jivan Qasim
- Ahmed Luai A
- Ahmed Muktar Beshir
- Ahmed Syed Anees
- Ajami Marjan
- Aji Budi
- Ajumobi Olufemi
- Akade Seyed Esma'il
- Akbari Morteza
- Akbarialiabad Hossein
- Akhlaghi Shiva
- Akinosoglou Karolina
- Akinyemi Rufus Olusola
- Akonde Maxwell
- Al Hasan Syed Mahfuz
- AL-Ahdal Tareq Mohammed Ali
- Al-amer Rasmieh Mustafa
- Al-Gheethi Adel Ali Saeed
- Al-Omari Basem
- Al-Shahi Salman Rustam
- Al-Tawfiq Jaffar A
- Al-Worafi Yaser Mohammed
- Alahdab Fares
- Albashtawy Mohammed
- AlBataineh Mohammad T
- Aldawsari Khalifah A
- Alemi Hediyeh
- Alemi Sharifullah
- Algammal Abdelazeem M
- Alhalaiqa Fadwa Alhalaiqa Naji
- Alhassan Robert Kaba
- Ali Abid
- Ali Endale Alemayehu
- Ali Liaqat
- Ali Mohammed Usman
- Ali Musa Mohammed
- Ali Rafat
- Ali Shahid
- Ali Syed Shujait Shujait
- Ali Zahid
- Alif Sheikh Mohammad
- Alimohamadi Yousef
- Aliyi Ahmednur Adem
- Aljofan Mohamad
- Aljunid Syed Mohamed
- Alladi Suvarna
- Almazan Joseph Uy
- Almustanyir Sami
- Alqahtani Jaber S
- Alqasmi Ibrahim
- Alqutaibi Ahmed Yaseen
- Altaany Zaid
- Altirkawi Khalid A
- Alvis-Guzman Nelson
- Aly Hany
- Aly Safwat
- Alzoubi Karem H
- Amani Reza
- Amindarolzarbi Alireza
- Amiri Sohrab
- Amirzade-Iranaq Mohammad Hosein
- Amu Hubert
- Amugsi Dickson A
- Amusa Ganiyu Adeniyi
- Amzat Jimoh
- Ancuceanu Robert
- Anderlini Deanna
- Anderson David B
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- Androudi Sofia
- Angappan Dhanalakshmi
- Angesom Teklit W
- Anil Abhishek
- Ansari-Moghaddam Alireza
- Anwer Razique
- Arafat Mosab
- Aravkin Aleksandr Y
- Areda Demelash
- Ariffin Hany
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- Arkew Mesay
- Arooj Mahwish
- Artamonov Anton A
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- Aruleba Raphael Taiwo
- Asadi-Pooya Ali A
- Asena Tilahun Ferede
- Asghari-Jafarabadi Mohammad
- Ashraf Muhammad
- Ashraf Tahira
- Atalell Kendalem Asmare
- Athari Seyyed Shamsadin
- Atinafu Bantalem Tilaye Tilaye
- Atorkey Prince
- Atout Maha Moh'd Wahbi
- Atreya Alok
- Aujayeb Avinash
- Avan Abolfazl
- Ayala Quintanilla Beatriz Paulina
- Ayatollahi Haleh
- Ayinde Olatunde O
- Ayyoubzadeh Seyed Mohammad
- Azadnajafabad Sina
- Azizi Zahra
- Azizian Khalil
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- Babaei Mahsa
- Badar Muhammad
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- Baghdadi Soroush
- Bagherieh Sara
- Bai Ruhai
- Baig Atif Amin
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- Balalla Shivanthi
- Baltatu Ovidiu Constantin
- Banach Maciej
- Bandyopadhyay Soham
- Banerjee Indrajit
- Baran Mehmet Firat
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- Barker-Collo Suzanne Lyn
- Barrow Amadou
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- Basu Sanjay
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- Batra Kavita
- Baune Bernhard T
- Bedi Neeraj
- Begde Ahmet
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- Bilalaga Mariah Malak
- Biswas Atanu
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- Bjørge Tone
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- Bärnighausen Till Winfried
- Béjot Yannick
- Cabral Lucas Scotta
- Caetano dos Santos Florentino Luciano
- Calina Daniela
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- Cao Bochen
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- Carreras Giulia
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- Casulli Adriano
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- Catapano Alberico L
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- Cerin Ester
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- Chanie Gashaw Sisay
- Charan Jaykaran
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- Chidambaram Saravana Babu
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- Chowdhury Enayet Karim
- Chowdhury Rajiv
- Christensen Hanne
- Chu Dinh-Toi
- Chukwu Isaac Sunday
- Chung Eric
- Coberly Kaleb
- Columbus Alyssa
- Comachio Josielli
- Conde Joao
- Cortesi Paolo Angelo
- Costa Vera Marisa
- Cousin Ewerton
- Couto Rosa A S
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- Cárdenas Rosario
- D'Amico Emanuele
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- Dai Xiaochen
- Dai Zhaoli
- Danawi Hadi A
- Dandona Lalit
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- Darwish Amira Hamed
- Das Saswati
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- Dash Nihar Ranjan
- Dashti Mohsen
- De la Hoz Fernando Pio
- de la Torre-Luque Alejandro
- De Leo Diego
- Dean Frances E
- Dehghan Amin
- Dehghan Azizallah
- Dejene Hiwot
- Demant Daniel
- Demetriades Andreas K
- Demissie Solomon
- Deng Xinlei
- Desai Hardik Dineshbhai
- Devanbu Vinoth Gnana Chellaiyan
- Dhama Kuldeep
- Dharmaratne Samath Dhamminda
- Dhimal Meghnath
- Dias da Silva Diana
- Diaz Daniel
- Dibas Mahmoud
- Ding Delaney D
- Dinu Monica
- Dirac M Ashworth
- Diress Mengistie
- Do Thanh Chi
- Do Thao Huynh Phuong
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- Dodangeh Milad
- Doheim Mohamed Fahmy
- Dokova Klara Georgieva
- Dongarwar Deepa
- Dsouza Haneil Larson
- Dua Tarun
- Dube John
- Duraisamy Senbagam
- Durojaiye Oyewole Christopher
- Dutta Sulagna
- Dziedzic Arkadiusz Marian
- Edinur Hisham Atan
- Eissazade Negin
- Ekholuenetale Michael
- Ekundayo Temitope Cyrus
- El Nahas Nevine
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- Elbarazi Iffat
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- Elhadi Muhammed
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- Elmeligy Omar Abdelsadek Abdou
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- Elshaer Mohammed
- Elsohaby Ibrahim
- Emamverdi Mehdi
- Emeto Theophilus I
- Endres Matthias
- Esezobor Christopher Imokhuede
- Eskandarieh Sharareh
- Fadaei Abdolmajid
- Fagbamigbe Adeniyi Francis
- Fahim Ayesha
- Faramarzi Ali
- Fares Jawad
- Farjoud Kouhanjani Mohsen
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- Fatehizadeh Ali
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- Gadanya Muktar A
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- Galali Yaseen
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- Gan Quan
- Gandhi Aravind P
- Ganesan Balasankar
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- Gau Shuo-Yan
- Gautam Rupesh K
- Gebre Teshome
- Gebrehiwot Mesfin
- Gebremeskel Gebreamlak Gebremedhn
- Gebreslassie Haftay Gebremedhin
- Getacher Lemma
- Ghaderi Yazdi Bardiya
- Ghadirian Fataneh
- Ghaffarpasand Fariborz
- Ghanbari Reza
- Ghasemi MohammadReza
- Ghazy Ramy Mohamed
- Ghimire Sailaja
- Gholami Ali
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- Ghotbi Elena
- Ghozy Sherief
- Gialluisi Alessandro
- Gill Paramjit Singh
- Glasstetter Logan M
- Gnedovskaya Elena V
- Golchin Ali
- Golechha Mahaveer
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- Golinelli Davide
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- Goyal Anmol
- Gray Richard J
- Grivna Michal
- Guadie Habtamu Alganeh
- Guan Bin
- Guarducci Giovanni
- Guicciardi Stefano
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- Guo Hanbing
- Gupta Bhawna
- Gupta Rajeev
- Gupta Sapna
- Gupta Veer Bala
- Gupta Vivek Kumar
- Gutiérrez Reyna Alma
- Habibzadeh Farrokh
- Hachinski Vladimir
- Haddadi Rasool
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- Haro Josep Maria
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- Hasaballah Ahmed I.
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- Hassan Amr
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- Hay Simon I
- Hayat Khezar
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- Kundu Satyajit
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- Kuttikkattu Ambily
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- Lahariya Chandrakant
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- Malik Ahmad Azam
- Malik Iram
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- Martini Santi
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- Nikolouzakis Taxiarchis Konstantinos
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- Okwute Patrick Godwin
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- Olatubi Matthew Idowu
- Oliveira Gláucia Maria Moraes
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- Palladino Raffaele
- Palma-Alvarez Raul Felipe
- Pan Feng
- Panagiotakos Demosthenes
- Panda-Jonas Songhomitra
- Pandey Anamika
- Pandey Ashok
- Pandian Jeyaraj Durai
- Pangaribuan Helena Ullyartha
- Pantazopoulos Ioannis
- Pardhan Shahina
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- Parikh Romil R
- Park Seoyeon
- Parthasarathi Ashwaghosha
- Pashaei Ava
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- Patoulias Dimitrios
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- Pouramini Alireza
- Pourbagher-Shahri Ali Mohammad
- Pourfridoni Mohammad
- Pourtaheri Naeimeh
- Prakash Peralam Yegneswaran
- Prakash Sanjay
- Prakash V
- Prates Elton Junio Sady
- Pritchett Natalie
- Purnobasuki Hery
- Qasim Nameer Hashim
- Qattea Ibrahim
- Qian Gangzhen
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- Rahimifard Mahban
- Rahman Md Obaidur
- Rahman Mohammad Hifz Ur
- Rahman Mosiur
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- Rahmani Amir Masoud
- Rahmani Shayan
- Rahmati Masoud
- Raj Moolambally Sheetal
- Rajabpour-Sanati Ali
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- Ramasubramani Premkumar
- Ramazanu Sheena
- Rancic Nemanja
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- Rapaka Deepthi
- Rashedi Vahid
- Rashid Ahmed Mustafa
- Rashidi Alavijeh Mehran
- Rashidi Mohammad-Mahdi
- Rasouli-Saravani Ashkan
- Rawaf Salman
- Razo Christian
- Redwan Elrashdy Moustafa Mohamed
- Rekabi Bana Atefe
- Remuzzi Giuseppe
- Rezaei Nazila
- Rezaei Negar
- Rezaei Nima
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- Rhee Taeho Gregory
- Riad Abanoub
- Robinson Stephen R
- Rodrigues Mónica
- Rodriguez Jefferson Antonio Buendia
- Roever Leonardo
- Rogowski Emma L B
- Romoli Michele
- Ronfani Luca
- Roy Pramanik Koushik
- Roy Priyanka
- Rubagotti Enrico
- Ruiz Milagros A
- Russ Tom C
- S Sunnerhagen Katharina
- Saad Aly M A
- Saadatian Zahra
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- Sacco Simona
- Saddik Basema
- Sadeghi Erfan
- Sadeghian Saeid
- Saeed Umar
- Saeed Usman
- Safdarian Mahdi
- Safi Sher Zaman
- Sagar Rajesh
- Sagoe Dominic
- Saheb Sharif-Askari Fatemeh
- Saheb Sharif-Askari Narjes
- Sahebkar Amirhossein
- Sahoo Soumya Swaroop
- Sahraian Mohammad Ali
- Sajedi Seyed Aidin
- Sakshaug Joseph W
- Saleh Mohamed A
- Salehi Omran Hossein
- Salem Marwa Rashad
- Salimi Sohrab
- Samadi Kafil Hossein
- Samadzadeh Sara
- Samargandy Saad
- Samodra Yoseph Leonardo
- Samuel Vijaya Paul
- Samy Abdallah M
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- Sanjeev Rama Krishna
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- Santri Ichtiarini Nurullita
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- Schiess Nicoline
- Schlaich Markus P
- Schuermans Art
- Schwarzinger Michaël
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- Selvaraj Siddharthan
- Sendekie Ashenafi Kibret
- Sengupta Pallav
- Senthilkumaran Subramanian
- Serban Dragos
- Sergindo Mihretu Tagesse
- Servili Chiara
- Sethi Yashendra
- SeyedAlinaghi SeyedAhmad
- Seylani Allen
- Shabani Mohammad
- Shabany Maryam
- Shafie Mahan
- Shahabi Saeed
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- Shahid Samiah
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- Shahsavari Hamid R
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- Sham Sunder
- Shama Adisu Tafari T
- Shamim Muhammad Aaqib
- Shams-Beyranvand Mehran
- Shamsi Mohammad Anas
- Shanawaz Mohd
- Sharath Medha
- Sharfaei Sadaf
- Sharifan Amin
- Sharma Manoj
- Sharma Rajesh
- Shashamo Bereket Beyene
- Shayan Maryam
- Sheikhi Rahim Ali
- Shekhar Shashank
- Shen Jiabin
- Shenoy Suchitra M
- Shetty Pavanchand H
- Shiferaw Desalegn Shiferaw
- Shigematsu Mika
- Shiri Rahman
- Shittu Aminu
- Shivakumar K M
- Shokri Fereshteh
- Shool Sina
- Shorofi Seyed Afshin
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- Siankam Tankwanchi Akhenaten Benjamin
- Siddig Emmanuel Edwar
- Sigfusdottir Inga Dora
- Silva João Pedro
- Silva Luís Manuel Lopes Rodrigues
- Sinaei Ehsan
- Singh Balbir Bagicha
- Singh Garima
- Singh Paramdeep
- Singh Surjit
- Sirota Sarah Brooke
- Sivakumar Shravan
- Sohag Abdullah Al Mamun
- Solanki Ranjan
- Soleimani Hamidreza
- Solikhah Solikhah
- Solomon Yerukneh
- Solomon Yonatan
- Song Suhang
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- Sotoudeh Houman
- Spartalis Michael
- Stark Benjamin A
- Starnes Joseph R
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- Stein Dan J
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- Stovner Lars Jacob
- Suleman Muhammad
- Suliankatchi Abdulkader Rizwan
- Sultana Abida
- Sun Jing
- Sunkersing David
- Sunny Angel
- Susianti Hani
- Swain Chandan Kumar
- Szeto Mindy D
- Tabarés-Seisdedos Rafael
- Tabatabaei Seyyed Mohammad
- Tabatabai Shima
- Tabish Mohammad
- Taheri Majid
- Tahvildari Azin
- Tajbakhsh Ardeshir
- Tampa Mircea
- Tamuzi Jacques JL Lukenze
- Tan Ker-Kan
- Tang Haosu
- Tareke Minale
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- Tat Nathan Y
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- Tavakoli Oliaee Razieh
- Tavangar Seyed Mohammad
- Tavasol Arian
- Tefera Yibekal Manaye
- Tehrani-Banihashemi Arash
- Temesgen Worku Animaw
- Temsah Mohamad-Hani
- Teramoto Masayuki
- Tesfaye Amensisa Hailu
- Tesfaye Edosa Geta
- Tesler Riki
- Thakali Ocean
- Thangaraju Pugazhenthan
- Thapa Rajshree
- Thapar Rekha
- Thomas Nikhil Kenny
- Thrift Amanda G
- Ticoalu Jansje Henny Vera
- Tillawi Tala
- Toghroli Razie
- Tonelli Marcello
- Tovani-Palone Marcos Roberto
- Traini Eugenio
- Tran Nghia Minh
- Tran Ngoc-Ha
- Tran Phu Van
- Tromans Samuel Joseph
- Truelsen Thomas Clement
- Truyen Thien Tan Tri Tai
- Tsatsakis Aristidis
- Tsegay Guesh Mebrahtom
- Tsermpini Evangelia Eirini
- Tualeka Abdul Rohim
- Tufa Derara Girma
- Ubah Chukwudi S
- Udoakang Aniefiok John
- Ulhaq Inam
- Umair Muhammad
- Umakanthan Srikanth
- Umapathi Krishna Kishore
- Unim Brigid
- Unnikrishnan Bhaskaran
- Vaithinathan Asokan Govindaraj
- Vakilian Alireza
- Valadan Tahbaz Sahel
- Valizadeh Rohollah
- Van den Eynde Jef
- Vart Priya
- Varthya Shoban Babu
- Vasankari Tommi Juhani
- Vaziri Siavash
- Vellingiri Balachandar
- Venketasubramanian Narayanaswamy
- Verras Georgios-Ioannis
- Vervoort Dominique
- Villafañe Jorge Hugo
- Villani Leonardo
- Vinueza Veloz Andres Fernando
- Viskadourou Maria
- Vladimirov Sergey Konstantinovitch
- Vlassov Vasily
- Volovat Simona Ruxandra
- Vos Theo
- Vu Loc Tri
- Vujcic Isidora S
- Wagaye Birhanu
- Waheed Yasir
- Wahood Waseem
- Walde Mandaras Tariku
- Wang Fang
- Wang Shu
- Wang Yanzhong
- Wang Yuan-Pang
- Waqas Muhammad
- Waris Abdul
- Weerakoon Kosala Gayan
- Weintraub Robert G
- Weldemariam Abrha Hailay
- Westerman Ronny
- Whisnant Joanna L
- Wickramasinghe Dakshitha Praneeth
- Wickramasinghe Nuwan Darshana
- Willekens Barbara
- Wilner Lauren B
- Winkler Andrea Sylvia
- Wolfe Charles D A
- Wu Ai-Min
- Wulf Hanson Sarah
- Xu Suowen
- Xu Xiaoyue
- Yadollahpour Ali
- Yaghoubi Sajad
- Yahya Galal
- Yamagishi Kazumasa
- Yang Lin
- Yano Yuichiro
- Yao Yao
- Yehualashet Sisay Shewasinad
- Yeshaneh Alex
- Yesiltepe Metin
- Yi Siyan
- Yiğit Arzu
- Yiğit Vahit
- Yon Dong Keon
- Yonemoto Naohiro
- You Yuyi
- Younis Mustafa Z
- Yu Chuanhua
- Yusuf Hadiza
- Zadey Siddhesh
- Zahedi Mohammad
- Zakham Fathiah
- Zaki Nazar
- Zali Alireza
- Zamagni Giulia
- Zand Ramin
- Zandieh Ghazal G Z
- Zangiabadian Moein
- Zarghami Amin
- Zastrozhin Mikhail Sergeevich
- Zeariya Mohammed G M
- Zegeye Zelalem Banjaw
- Zeukeng Francis
- Zhai Chunxia
- Zhang Chen
- Zhang Haijun
- Zhang Yunquan
- Zhang Zhi-Jiang
- Zhao Hanqing
- Zhao Yang
- Zheng Peng
- Zhou Hengxing
- Zhu Bin
- Zhumagaliuly Abzal
- Zielińska Magdalena
- Zikarg Yossef Teshome
- Zoladl Mohammad
- Ärnlöv Johan
- Publication venue
- Elsevier
- Publication date
- 01/04/2024
- Field of study
BackgroundDisorders affecting the nervous system are diverse and include neurodevelopmental disorders, late-life neurodegeneration, and newly emergent conditions, such as cognitive impairment following COVID-19. Previous publications from the Global Burden of Disease, Injuries, and Risk Factor Study estimated the burden of 15 neurological conditions in 2015 and 2016, but these analyses did not include neurodevelopmental disorders, as defined by the International Classification of Diseases (ICD)-11, or a subset of cases of congenital, neonatal, and infectious conditions that cause neurological damage. Here, we estimate nervous system health loss caused by 37 unique conditions and their associated risk factors globally, regionally, and nationally from 1990 to 2021.MethodsWe estimated mortality, prevalence, years lived with disability (YLDs), years of life lost (YLLs), and disability-adjusted life-years (DALYs), with corresponding 95% uncertainty intervals (UIs), by age and sex in 204 countries and territories, from 1990 to 2021. We included morbidity and deaths due to neurological conditions, for which health loss is directly due to damage to the CNS or peripheral nervous system. We also isolated neurological health loss from conditions for which nervous system morbidity is a consequence, but not the primary feature, including a subset of congenital conditions (ie, chromosomal anomalies and congenital birth defects), neonatal conditions (ie, jaundice, preterm birth, and sepsis), infectious diseases (ie, COVID-19, cystic echinococcosis, malaria, syphilis, and Zika virus disease), and diabetic neuropathy. By conducting a sequela-level analysis of the health outcomes for these conditions, only cases where nervous system damage occurred were included, and YLDs were recalculated to isolate the non-fatal burden directly attributable to nervous system health loss. A comorbidity correction was used to calculate total prevalence of all conditions that affect the nervous system combined.FindingsGlobally, the 37 conditions affecting the nervous system were collectively ranked as the leading group cause of DALYs in 2021 (443 million, 95% UI 378–521), affecting 3·40 billion (3·20–3·62) individuals (43·1%, 40·5–45·9 of the global population); global DALY counts attributed to these conditions increased by 18·2% (8·7–26·7) between 1990 and 2021. Age-standardised rates of deaths per 100 000 people attributed to these conditions decreased from 1990 to 2021 by 33·6% (27·6–38·8), and age-standardised rates of DALYs attributed to these conditions decreased by 27·0% (21·5–32·4). Age-standardised prevalence was almost stable, with a change of 1·5% (0·7–2·4). The ten conditions with the highest age-standardised DALYs in 2021 were stroke, neonatal encephalopathy, migraine, Alzheimer's disease and other dementias, diabetic neuropathy, meningitis, epilepsy, neurological complications due to preterm birth, autism spectrum disorder, and nervous system cancer.InterpretationAs the leading cause of overall disease burden in the world, with increasing global DALY counts, effective prevention, treatment, and rehabilitation strategies for disorders affecting the nervous system are needed
Bufete jurídico gratuito en Guadalajara
- Author
- Arias-Fletes Rafael
- Bermúdez-Murillo Greta
- Cruz-López Carol L.
- Franco-Valdez Rosa C.
- Hernández-Cruz Karen A.
- Lomelí-Ruiz Alan A.
- Mendoza-Silva Karina G.
- Michel-Talamantes Diana M.
- Montoya-Ramos Pablo A.
- Núñez-Navarro Fernando
- Pérez-DeAlba Andrea
- Romero-Casanova María G.
- Silva-Fletes Víctor M.
- Sánchez-Sánchez Jesús M.
- Ángel-Gámez Brenda
- Publication venue
- 'ITESO, A.C.'
- Publication date
- 01/07/2017
- Field of study
El objetivo del bufete jurídico del ITESO es construir de manera conjunta alternativas de solución a problemas de acceso a la justicia, con base en los derechos humanos, la cultura de paz y la pedagogía ignaciana. Para esto, se desarrolla todo un proceso de acompañamiento jurídico, cuya metodología sigue los siguientes pasos (que varían según el caso): se comienza con la asignación de casos y las asesorías jurídicas; después se realiza un dictamen; se da seguimiento a los casos y a los procesos jurídicos y administrativos pertinentes, como las visitas a los juzgados, la realización de mediaciones o conciliaciones o el acompañamiento a registros civiles; el proceso termina con la resolución de los casos o la asignación de estos a las autoridades pertinentes que les darán seguimiento. A su vez, se realiza trabajo de investigación y se participa en distintos escenarios - como el Instituto de Justicia Alternativa (IJA) y la atención a migrantes y refugiados - y en proyectos de justicia itinerante. Los resultados principales del PAP son: las asesorías integrales brindadas, en las que se dio atención a más de 184 personas; los dictámenes, y demás documentos elaborados pertinentes a los casos, como las demandas; la solución de diversos conflictos; una compilación de información sobre el tema de migración; documentos de difusión y promoción; y un taller impartido en el marco del trabajo con el IJA. Así, este PAP fue un espacio de aprendizaje, reflexión y crecimiento, donde el trabajo se realizó de manera horizontal y con base en los valores propios del proyecto
A second update on mapping the human genetic architecture of COVID-19
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- Abdel-Aziz M
- Abdelrazik M
- Abdullah MS
- Abe R
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- Abel L
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- Abernathy C
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- Wyllie DH
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- Yaspan B
- Yassen AM
- Yasui Y
- Yates B
- Yatomi M
- Ye C
- Yermakovich D
- Yeung RSM
- Yi X
- Yonekawa A
- Yoo S
- Yoon K
- Yoshida K
- Yoshida S
- Yoshida S
- Yoshida T
- Yoshihara T
- Yoshiya K
- Yoshiyama T
- Young M
- Yue F
- Yun N
- Yáñez CE
- Yáñez Z
- Zainulabid UA
- Zainy T
- Zak A
- Zaki A
- Zamikula J
- Zamudio IPM
- Zanella A
- Zapata-Contreras D
- Zapatamartinez M
- Zarate R
- Zarei N
- Zavaleta DAF
- Zawadzki P
- Zawati MH
- Zborowski AC
- Zeberg H
- Zechner M
- Zhang Q
- Zhao X
- Zheng C
- Zheng T
- Zhlawi HJ
- Zhlawi MWJ
- Zholdybayeva E
- Zhou W
- Zhu W
- Zitter L
- Zoller H
- Zongo O
- Zorloni C
- Zuñiga-Pacheco P
- Zárate RN
- Zúñiga-Ramos J
- Álvarez BG
- Ávila-Arcos MA
- Ávila-Arcos MC
- Özer O
- Überla K
- Þorsteinsdóttir U
- Publication venue
- Nature Research
- Publication date
- 21/06/2023
- Field of study
Presentation, care and outcomes of patients with NSTEMI according to World Bank country income classification: the ACVC-EAPCI EORP NSTEMI Registry of the European Society of Cardiology.
- Author
- Abdekader R
- Abdelhameed M
- Abdelhamid M
- Abdelmottaleb W
- Abdin A
- Abdrabou M
- Abid L
- Abraham J A
- Abraheem A
- Abras M
- Adam C
- Adamyan M
- Adel M
- Adlam D
- Aerts S
- Affleck D-C
- Afsar A
- Ageev F
- Aguiar C Tavares
- Ahangari F
- Ahmad W A Wan
- Ahmad Wan Azman Wan
- Ahmed A
- Ahmed A
- Ahmed F
- Ahmed I M
- Ahmed S
- Ahmed S Waqar
- Ailoaei S
- Akgun A
- Akhmatova F
- Akhtar N
- Al Mahmeed W A R
- Al-Kinani T
- Al-Mashari S
- Al-Obaidi F
- Al-Riyami A
- Al-Riyami H
- Al-Zaidi M
- Alegre O
- Alemzadeh-Ansari M J
- Aleti S
- Algamal H Mahrous
- Alhussein F
- Ali A
- Ali H Hameed
- Ali M
- Ali M
- Ali T
- Ali Y
- Alla M Dafa
- Almeida A Rocha
- Almeida I
- Almeida S
- Almubarak E
- Almyahi M Hashim
- Alrahimi J
- Alsina M
- Altaher S
- Altinier A
- Alvarado K
- Alyavi A
- Alyavi B
- Alyavi Baxrom
- Amadi C
- Amber K
- Ambroziak M
- Amen S
- Amirov B
- Andrade L A Fajardo
- Andrei C-L
- Aneel A
- Anguita M J Fernandez
- Anselmi M
- Antonijevic J
- Antoniou A
- Antovski A
- Appelman Y
- Appelman Yolande
- Appelman Yolande
- Appelman Yolande
- Arat-Ozkan A
- Ardelean A
- Arefin M M
- Arefyev M N
- Argyropoulos K
- Ari H
- Ari S
- Ariza-Solé A
- Arizcuren A Munarriz
- Armangau P
- Arroyo-Monino D F
- Asim A
- Assaf O
- Assembekov B
- Astarcioglu M A
- Atallah B
- Atanaskovic V
- Atkinson C
- Atos J S
- Atta A Radi
- Attia N
- Augagneur M
- Avanzas P
- Averkov O V
- Avraamides P
- Ayesta A
- Aytekin V
- Aytekin Vedat
- Azam J
- Azam M G
- Azaryan K
- Azzahhafi J
- Babaeva L
- Babes E Emilia
- Babinski W
- Bacic G
- Badariene J
- Badri M
- Baglikov A
- Bahaa H
- Bahloul A
- Bahon L
- Bajramovic N Sabanovic
- Bajramovic Nirvana Sabanovic
- Baker P
- Bakr K
- Bakracheski N
- Baksyte G
- Balachandran K
- Balciute S
- Balghith M
- Balghith Mohammed
- Balparda H
- Baluta M M
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- Banos J-L
- Baptista R
- Baptista S
- Barbato E
- Bardauskiene L
- Barillà F
- Barker J
- Barker L N
- Barman L
- Barrabes J A
- Bartoszewska D
- Basaran O
- Bashuroska E Kovacheska
- Basiero A Bonet
- Bastiancic L
- Batias-Moreau L
- Batin P
- Batjoens H
- Batrinac A
- Baydar O
- Bañeras J
- Beauloye C
- Beauloye Christophe
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- Beckers J
- Bednarek A
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- Been M
- Beesley K
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- Begic A
- Begic E
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- Beleslin B
- Belfiore R
- Bell S
- Beltrano C
- Benham L
- Benvenga R M
- Beranova M
- Bermúdez M Garcia
- Bernabò P
- Bernal F J Castillo
- Besli F
- Betiu A
- Betkier-Lipinska K
- Biccire F G
- Biddau M
- Birchall K
- Biria A
- Biron Y
- Biserka S
- Blachut A
- Black M
- Blasco A
- Blockmans M
- Blondelon A
- Boiffard E
- Bojovski I
- Bondare L
- Bonet G
- Bonfils L
- Bonnet G
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- Bosch X
- Bowers N
- Boyadjian S
- Bragagnini W
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- Brie D
- Brigic L
- Brinkworth E
- Brizida L
- Broadley A
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- Brozmannová D
- Brozmannová Denisa
- Brugaletta Salvatore
- Brugaletta Salvatore
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- Buckley C
- Buckman C
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- Budaj A
- Budaj A
- Budaj Andrzej
- Budaj Andrzej
- Budyak V
- Bueno H
- Bueno Hector
- Bueno Hector
- Bueno Héctor
- Bugajski J
- Burdeus M Vidal
- Burton J
- Busljetik O
- Bustinza I C Möller
- Buttigieg L-L
- Button H
- Buysse M
- Buzle A
- Cabeza M Martin
- Cacucci M
- Cader F A
- Cader Fathima Aaysha
- Caeiro D
- Caforio A L P
- Calleja A Gainza
- Cambra A Duran
- Camilleri W
- Campinas A
- Camus E
- Can C
- Can V
- Canciello G
- Cankovic M
- Cann E
- Canpolat U
- Capendeguy O
- Capodanno D
- Cardaniuc L
- Cardelli L S
- Cardona M
- Carias M
- Carlier S
- Carniel L
- Carrington M
- Cartasegna L
- Casado T
- Casella G
- Castilho B
- Casu G
- Celik A
- Cercek A Cerne
- Cercek M
- Cercek Miha
- Chalil S
- Chamero P Sanchez
- Chaplin J
- Charfeddine S
- Charles T
- Chavarria J
- Checco L
- Cheeseman M
- Chernokurova Y
- Chioncel O
- Choijiljav G
- Choudhary B
- Christenssen V
- Chuvarayan G
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- Cieslik-Guerra U
- Cigalini C
- Cigut M
- Cimadevilla O C Fernandez
- Ciobanu L
- Claeys M J
- Clark A
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- Clarkson N
- Clifford P
- Coelho C
- Cojocaru A
- Collard L
- Collier D
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- Cooper J
- Costa R
- Cotrim N
- Cottin M
- Coulding M
- Cozma A
- Cozma C
- Crespín M Crespín
- Crew A
- Crisan S
- Crncic D
- Crnomarkovic B
- Cruddas E
- Cruz C
- Cruz I
- Cubero-Gallego H
- Cuisset T
- Cullen K
- Cummins H
- Curcio A
- Currie J
- Curtis K
- Custodio P
- Custovic F
- Cvetanovic D
- D'Agostino A
- Da Gama F Fernandes
- Dabovic D
- Dagres N
- Dagres N
- Dagva M
- Dagva Mungunchimeg
- Daios S
- Dakhil Z
- Dan A-R
- Dan G-A
- Dan Gheorghe-Andrei
- Danchin N
- Danchin N
- Dandar E
- Dandy C
- Danila T
- Darabantiu D
- Davies C
- Davies K
- Dayer M
- De Coninck M
- de Figueiredo M Paralta
- De Jesus I
- De La Fuente B
- De Raedt H
- De Rosa S
- De Sousa D
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- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 03/02/2023
- Field of study
Cohort profile: the ESC EURObservational Research Programme Non-ST-segment elevation myocardial infraction (NSTEMI) Registry.
- Author
- Abdekader R
- Abdelhameed M
- Abdelhamid M
- Abdelmottaleb W
- Abdin A
- Abdrabou M
- Abid L
- Abraham J A
- Abraheem A
- Abras M
- Adam C
- Adamyan M
- Adel M
- Adlam D
- Aerts S
- Affleck D-C
- Afsar A
- Ageev F
- Aguiar C Tavares
- Ahangari F
- Ahmad W A Wan
- Ahmad Wan Azman Wan
- Ahmed A
- Ahmed A
- Ahmed F
- Ahmed I M
- Ahmed S
- Ahmed S Waqar
- Ailoaei S
- Akgun A
- Akhmatova F
- Akhtar N
- Al Mahmeed W A R
- Al Mahmeed Wael Abdul Rahman
- Al-Kinani T
- Al-Mashari S
- Al-Obaidi F
- Al-Riyami A
- Al-Riyami H
- Al-Zaidi M
- Alegre O
- Alemzadeh-Ansari M J
- Aleti S
- Algamal H Mahrous
- Alhussein F
- Ali A
- Ali H Hameed
- Ali M
- Ali M
- Ali T
- Ali Y
- Alla M Dafa
- Almeida A Rocha
- Almeida I
- Almeida S
- Almubarak E
- Almyahi M Hashim
- Alrahimi J
- Alsina M
- Altaher S
- Altinier A
- Alvarado K
- Alyavi A
- Alyavi B
- Alyavi Baxrom
- Amadi C
- Amber K
- Ambroziak M
- Amen S
- Amirov B
- Andrade L A Fajardo
- Andrei C-L
- Aneel A
- Anguita M J Fernandez
- Anselmi M
- Antonijevic J
- Antoniou A
- Antovski A
- Appelman Y
- Appelman Yolande
- Appelman Yolande
- Appelman Yolande
- Arat-Ozkan A
- Ardelean A
- Arefin M M
- Arefyev M N
- Argyropoulos K
- Ari H
- Ari S
- Ariza-Solé A
- Arizcuren A Munarriz
- Armangau P
- Arroyo-Monino D F
- Asim A
- Assaf O
- Assembekov B
- Astarcioglu M A
- Atallah B
- Atanaskovic V
- Atkinson C
- Atos J S
- Atta A Radi
- Attia N
- Augagneur M
- Avanzas P
- Averkov O V
- Avraamides P
- Ayesta A
- Aytekin V
- Aytekin Vedat
- Azam J
- Azam M G
- Azaryan K
- Azzahhafi J
- Babaeva L
- Babes E Emilia
- Babinski W
- Bacic G
- Badariene J
- Badri M
- Baglikov A
- Bahaa H
- Bahloul A
- Bahon L
- Bajramovic N Sabanovic
- Bajramovic Nirvana Sabanovic
- Baker P
- Bakr K
- Bakracheski N
- Baksyte G
- Balachandran K
- Balciute S
- Balghith M
- Balghith Mohammed
- Balparda H
- Baluta M M
- Ban E
- Banos J-L
- Baptista R
- Baptista S
- Barbato E
- Bardauskiene L
- Barillà F
- Barker J
- Barker L N
- Barman L
- Barrabes J A
- Bartoszewska D
- Basaran O
- Bashuroska E Kovacheska
- Basiero A Bonet
- Bastiancic L
- Batias-Moreau L
- Batin P
- Batjoens H
- Batrinac A
- Baydar O
- Bañeras J
- Beauloye C
- Beauloye Christophe
- Becker D
- Beckers J
- Bednarek A
- Beekes M
- Been M
- Beesley K
- Bega G
- Begic A
- Begic E
- Belahnech Y
- Beleslin B
- Belfiore R
- Bell S
- Beltrano C
- Benham L
- Benvenga R M
- Beranova M
- Bermúdez M Garcia
- Bernabò P
- Bernal F J Castillo
- Besli F
- Betiu A
- Betkier-Lipinska K
- Biccire F G
- Biddau M
- Birchall K
- Biria A
- Biron Y
- Biserka S
- Blachut A
- Black M
- Blasco A
- Blockmans M
- Blondelon A
- Boiffard E
- Bojovski I
- Bondare L
- Bonet G
- Bonfils L
- Bonnet G
- Bonnet J-L
- Bor W
- Bosch X
- Bowers N
- Boyadjian S
- Bragagnini W
- Bras M Le
- Brezeanu R
- Brie D
- Brigic L
- Brinkworth E
- Brizida L
- Broadley A
- Brown C
- Brown J
- Brozmannová D
- Brozmannová Denisa
- Brugaletta Salvatore
- Brugaletta Salvatore
- Brunner P
- Bruno N
- Brunton M
- Brust K
- Bs C
- Buckley C
- Buckman C
- Budaj A
- Budaj A
- Budaj A
- Budaj Andrzej
- Budaj Andrzej
- Budyak V
- Bueno H
- Bueno Hector
- Bueno Hector
- Bueno Héctor
- Bugajski J
- Burdeus M Vidal
- Burton J
- Busljetik O
- Bustinza I C Möller
- Buttigieg L-L
- Button H
- Buysse M
- Buzle A
- Cabeza M Martin
- Cacucci M
- Cader F A
- Cader Fathima Aaysha
- Caeiro D
- Caforio A L P
- Calleja A Gainza
- Cambra A Duran
- Camilleri W
- Campinas A
- Camus E
- Can C
- Can V
- Canciello G
- Cankovic M
- Cann E
- Canpolat U
- Capendeguy O
- Capodanno D
- Cardaniuc L
- Cardelli L S
- Cardona M
- Carias M
- Carlier S
- Carniel L
- Carrington M
- Cartasegna L
- Casado T
- Casella G
- Castilho B
- Casu G
- Celik A
- Cercek A Cerne
- Cercek M
- Cercek Miha
- Chalil S
- Chamero P Sanchez
- Chaplin J
- Charfeddine S
- Charles T
- Chavarria J
- Checco L
- Cheeseman M
- Chernokurova Y
- Chioncel O
- Choijiljav G
- Choudhary B
- Christenssen V
- Chuvarayan G
- Cibo M
- Cieslik-Guerra U
- Cigalini C
- Cigut M
- Cimadevilla O C Fernandez
- Ciobanu L
- Claeys M J
- Clark A
- Clark M
- Clark S
- Clarkson N
- Clifford P
- Coelho C
- Cojocaru A
- Collard L
- Collier D
- Collins S
- Conway D
- Cooper J
- Costa R
- Cotrim N
- Cottin M
- Coulding M
- Cozma A
- Cozma C
- Crespín Crespín M
- Crew A
- Crisan S
- Crncic D
- Crnomarkovic B
- Cruddas E
- Cruz C
- Cruz I
- Cubero-Gallego H
- Cuisset T
- Cullen K
- Cummins H
- Curcio A
- Currie J
- Curtis K
- Custodio P
- Custovic F
- Cvetanovic D
- D'Agostino A
- Da Gama F Fernandes
- Dabovic D
- Dagres N
- Dagres N
- Dagva M
- Dagva Mungunchimeg
- Daios S
- Dakhil Z
- Dan A-R
- Dan G-A
- Dan Gheorghe-Andrei
- Danchin N
- Danchin N
- Dandar E
- Dandy C
- Danila T
- Darabantiu D
- Davies C
- Davies K
- Dayer M
- De Coninck M
- de Figueiredo M Paralta
- De Jesus I
- De La Fuente B
- De Raedt H
- De Rosa S
- De Sousa D
- Decalf V
- Dechamps M
- Deery J
- Degrell P
- Deharo P
- Dejan M
- Delaney J
- Delarche N
- Delgado V
- Dellborg H
- Dellborg M
- Dementiev E
- Demeure F
- Demir A R
- Demirbag R
- Demirci Y
- Den Hartog A
- Denney H
- Derien A-S
- Derigay J
- Derntl M
- Desai H
- Desperak P
- Dewan M A-M
- Dharma S
- Dharma Surya
- Di Lisi D
- Di Palermo A
- Diakakis G
- Digne F
- Dimitriadis F
- Dirsiene R
- Dixon K
- Djokic I
- Djokic-Vejzovic A
- Dobranici M
- Dobreanu D
- Domange J
- Donaldson D
- Donazzan L
- Donnelly P
- Donoiu I
- Dos Santos R Carvalheira
- Dozic A
- Drakomathioulakis M
- Drapeau I
- Drnovsek B
- Druelles P
- Duarte R
- Dubreuil O
- Dugauquier C
- Dumanschi C
- Dumont C
- Dumont Carlos
- Dumonteil N
- Dumoulein M
- Duncan L
- Durak-Nalbantic A
- Durier C
- Dursun L
- Dweck M
- Dzubur A
- Dámaso E San
- Eftychiou C
- Eglinton C
- Eisen A
- Ejubovic M
- El Din A Alaa
- Elbasheer E
- Eldeeb F
- Elistratova O
- Elliott K
- Ellouze T
- Elshiekh A
- Eltayeb M
- Emberson J
- Emberson J
- Erglis A
- Erglis Andrejs
- Erimescu C
- Erlinge D
- Erlinge D
- Ermacora D
- Erturk M
- Escudier J M
- Esteve-Pastor M A
- Eteocleous N
- Evans D
- Evola S
- Evrard P
- Exley D
- Fabris E
- Faheem O
- Fajadet J
- Falnita L
- Farah B
- Farhan H Ali
- Farhan Hasan Ali
- Faria D
- Farto-Abreu P
- Fatema M-E
- Fedulaev Y
- Felmeden D
- Felmeden L
- Fernandes R
- Fernandes R
- Ferraioli D
- Ferrando J I Llao
- Ferrari I
- Ferreira C
- Ferreira J
- Ferreira J
- Ferreira-Gonzalez I
- Fetisova E
- Feusette P
- Filimon G
- Filimon S
- Filippini E
- Firoozan S
- Firouzi A
- Fleming C
- Fletcher A
- Fluttaz A
- Fofana A
- Fojt A
- Fotoglidis A
- Francis R
- Frea S
- French E
- Freshwater K
- Frias A
- Friberg O
- Frigo G M
- Fuertes D García
- Fuertes J
- Fuior S
- Furlan T
- Furnaz S
- Furukawa Y
- G S
- Gaita D
- Galasko G
- Galasso G
- Gale C P
- Gale C P
- Gale Chris P
- Gale Chris P
- Gale Christopher Peter
- Garau E
- Garcia-Rubira J C
- Garg S
- Garrod R
- Gasior M
- Gati S
- Gaudio C
- Gbur M
- Gelmaniene R
- George L
- Geppert A
- Geppert Alexander
- Gergis M N
- Gevaert S
- Ghadrdoost B
- Ghaly I
- Gheorghiu M
- Ghorbani A
- Ghosh J
- Giannadaki M
- Gibson C
- Gierlotka M
- Gierlotka Marek
- Gil-Pérez P
- Ginturi T
- Glen J
- Glikson M
- Glikson M
- Gljiva-Gogic Z
- Glowacki K
- Glowczynska R
- Gobic D
- Goddard W
- Golpira R
- Gomaa A
- Gomes R
- Gomez V Nomberto
- Goncalves F
- Goncalves L
- Gonzalez Gonzalez J
- Gonzalez M J Garcia
- Gonzalez P
- Good F
- Goodchild F
- Goreva L
- Goudis C
- Grammatikopoulos K
- Grandis U
- Gray A
- Grecu M
- Greig N
- Grgurevic M Vucijak
- Grib L
- Grilj V
- Groch L
- Grueva E
- Gudmundsdottir I
- Gudmundsdottir Ingibjorg
- Guedes J
- Guerreiro R Azevedo
- Guiatni A
- Guillard N
- Gunarathne A
- Gungor B
- Gungoren F
- Gustiene O
- Gustiene Olivija
- Guédès A
- Gürsoy E
- Haas M
- Habib A
- Habiba S
- Hadebe B
- Hadžibegic N
- Hafez B
- Haghighi S
- Hakme A
- Halilcevic M
- Halldorsdottir H
- Hamdan H
- Hamid E
- Hamm C
- Hamm C
- Hammami R
- Hammond L
- Hammond S
- Hamzic-Mehmedbasic A
- Hanet C
- Haq M M
- Harper P
- Harrison R
- Harvey S
- Hasan A S
- Hasun M
- Hausleiter J
- Hawranek M
- Hayes C
- Hayrapetyan H
- Hazelton T
- Hellyer C
- Hery P
- Heshmat-Ghahdarijani K
- Heyndrickx G
- Hidalgo-Urbano R
- Hill J
- Hiltrop N
- Hlinomaz O
- Hlinomaz Ota
- Hobson S
- Hodzic E
- Hoffer E
- Honton B
- Hood M
- Hope S
- Hossain R
- Houben V
- Housley K
- Howson J
- Hoye A
- Hoyle V
- Hrvat E
- Huber K
- Huber Kurt
- Huber Kurt
- Huchet F
- Huczek Z
- Hughes D
- Hujdur M
- Hultsberg-Olsson G
- Humida A
- Hurford F
- Hussein S
- Hutchinson D
- Hutton K
- Hyams B
- Ibragimova F
- Ibrahim A
- Ibraimova A
- Iglica A
- Imam A
- Immordino F
- Inanc I H
- Indolfi C
- Indolfi Ciro
- Ingabire P
- Ingabire Prossie
- Ioan O
- Ioannou A
- Iqbal N
- Islam M M
- Islamov R
- Istratoaie O
- Iung B
- Iung B
- Ivanov M
- Ivanov V
- Iyengar S
- Izquierdo M
- Izzat L
- Jacquet S
- Jahan J
- Jakljevic T
- James S
- Jamiel A A
- Jarakovic M
- Jedrzejczyk S
- Jenab Y
- Johnson L
- Jones E
- Jones K Vandesnepscheut
- Jones S
- Jones S
- Jordan P
- Jorge P
- Jose M
- Jourdan K
- Jovanoska J
- Jovanovski Z
- Junco-Vicente A
- Junejo S
- Kafkala K
- Kahraman F
- Kalenderoglu K
- Kalimullin D
- Kaljumäe H
- Kalpak O
- Kalpak Oliver
- Kamal A
- Kamal W
- Kandasamy S
- Kanellos I E
- Kapleriene L
- Kappetein A P
- Karacaglar E
- Karakanas A
- Karasek A
- Kardos A
- Karoudi R Al
- Karthikeyan V J
- Kasperski I
- Kasprzak J D
- Kassim Z Abu
- Kay A
- Kaya H
- Kayikcioglu M
- Kayikcioglu M
- Kayikcioglu M
- Kazimierczyk E
- Kazmi K
- Kazmierczak-Dziuk A
- Keeling P
- Keituqwa I
- Kent M
- Kereselidze Z
- Keric T
- Kfir H
- Khalaf H
- Khandoker F
- Khatiwada D
- Khurelbaatar M-U
- Kiitam U
- Kilasho M
- Kilic A
- Kilic S
- King R
- Kirk P
- Kirkup E
- Kitai T
- Kitai Takeshi
- Klosinska M
- Knight A
- Kocho S
- Kocijancic A
- Koerschgen T
- Kolakaluri L
- Kolste H Jan Te
- Kolyviras A
- Komissarova M S
- Kong W
- Kononen M
- Konsoah A
- Kontonassakis I
- Kornowski R
- Kosiak M
- Kostic T
- Kotakos C
- Kotnik G
- Koukis P
- Kourgiannidis G
- Kovacevic M
- Kovacic D
- Kowalik R
- Krakowian M
- Kramarikova P
- Kruchinkina E
- Krzesinski P
- Krzysiek M
- Kucukosmanoglu M
- Kukavica N
- Kukreja N
- Kumar A
- Kumar A
- Kunadian V
- Kunadian Vijay
- Kunadian Vijay
- Kundu S
- Kunhunny S
- Kupstyte-Kristapone N
- Kurbasic I
- Kurpesa M
- Kushimo O
- Kusinska A
- Kyavar M
- Kyriazopoulos K
- Kzhdryan H
- Kzhdryan Hovhannes
- Labeque J-N
- Labyk A
- Laghari A H
- Lagvilava D
- Lainscak M
- Lakshmana S
- Lamb K
- Lambrianidi C
- Lampropoulos K
- Lancaster N
- Landolina M
- Larina V
- Larisa R
- Larrieu M
- Law J
- Legutko J
- Leng K
- Leonardi Sergio
- Leonardi Sergio
- Leskovar B
- Lettino Maddalena
- Lettino Maddalena
- Levashov S
- Lewis T
- Libungan B
- Lidon R-M
- Liebetrau C
- Liebetrau Christoph
- Lindsay S
- Lipar L
- Litvinenco N
- Lizaitis M
- Liška D
- Loh P H
- Lopesdesousa G
- Lopez F
- Lopez-Garcia C
- Lopez-Sendon J L
- Lorenzoni G
- Lotman E-M
- Loubeyre C
- Loureiro J
- Lourenço C
- Lubi R
- Luca C
- Lucon A
- Ludman P
- Ludman P
- Ludman Peter
- Ludman Peter F
- Lulic D
- Lund L
- Lupu S
- Luz A
- Lynch M
- Macdonald S
- Machowski M
- Mackic D
- Mackie S
- Madiha F
- Maggioni A P
- Maggioni A P
- Maggioni A P
- Maghraby K
- Magno P
- Mahmoud H
- Mahmoud K
- Maier K
- Maisuradze D
- Maisuradze David
- Makia F
- Malagon L
- Mallinson J
- Malmendier D
- Mamaloukaki M
- Mamas M
- Mamdouh M
- Maniadakis N
- Manjavacas A M Iniesta
- Mano T
- Mansourati J
- Mansourati Jacques
- Mansouri P
- Marandi Toomas
- Marchetti M F
- Marcinkeviciene J
- Marin F
- Marin L A Martinez
- Marinkovic M
- Marino M
- Marinoski T
- Marinskiene J
- Marjeh Y Bani
- Markovski R
- Marsden K
- Martin K
- Martin M D
- Martin R
- Martinez L
- Martinez-Basterra J
- Martinovic S Salinger
- Martins V
- Maruri R
- Maruthanayagam R
- Masoumi G
- Massey I
- Massoz M
- Masumoto A
- Mateo V Martinez
- Matias F
- Matic D
- Matskeplishvili S
- Matsukawa R
- Matthews I G
- Mattia A Della
- Mavuri M
- Maxian R
- Maximov D
- Mayedah R
- Mayne D
- Mbakwem A
- Mccarrick A
- Mcdonald J
- Mcdonald S
- Mcgee C
- Mcgill Y
- Mcleod A
- Meder B
- Mellows K
- Meloni L
- Mendes D Espregueira
- Mendes M
- Mendonca C
- Meray I
- Mercea S
- Merella P
- Merlo M
- Mgazeel F
- Micklewright L
- Middle J
- Mielniczuk M
- Mihajlovic M
- Mijatovic Z
- Mila L
- Milasinovic Serbia Dejan
- Milasinovic Dejan
- Milkas A
- Mills H
- Milosevic A
- Mimoso J
- Miranda H
- Mirrakhimov E
- Mirrakhimov Erkin
- Mitchell M
- Mitic V
- Mitre A
- Miyoshi Y
- Mizia-Stec K
- Mkhitaryan S
- Mocilnik M
- Mohamed A
- Mohamed Awad
- Moisi M
- Mojsovska V
- Mondo C
- Mongiardo A
- Monteil B
- Monteiro C
- Monteiro P
- Monteiro S
- Monteiro Silvia
- Montisci R
- Moreno G
- Morgan M
- Moris C
- Morisco C
- Mornos C
- Moscalu V
- Mostafa A
- Mostafa A Magdy
- Mosteoru S
- Mota P
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- Motherwell N
- Mougenot E
- Moura A R
- Mouret J-P
- Mpatsouli A
- Mshengu E
- Muderrisoglu H
- Mujaric E
- Mujovic N
- Mujtaba M Shaikh
- Mulla A Al
- Munoz C Gallego
- Munt S
- Murataliev T
- Murray V
- Musija E
- Mussida M
- Nadar S K
- Nadar Sunil K
- Nadarajah Ramesh
- Naessens S
- Nageh T
- Nagy K V
- Nagy K V
- Nagy K V
- Nair R
- Nakad G
- Navickaite A
- Nawrotek B
- Neale T
- Nedoshivin A
- Nedoshivin A
- Negahban A Q
- Neglia D
- Neiva J
- Nejjari M
- Nembhard S
- Neykova A
- Nicholson A
- Nickenig G
- Nicolas-Franco S
- Nikitin I
- Nikojajevic I
- Nilsson A
- Nishino S
- Nizam S U
- Noori F
- Noorzadeh M
- Novas V
- Novitskii N
- Novo G
- Nowotta F
- Ntoliou P
- Nédio M
- Obaid D
- Obradovic I
- Oginetz N
- Ojeda F Bosa
- Oksul M
- Oliveira I
- Oliveira M
- Omar Z
- Omelanczuk-Wiech E
- Oney S
- Oommen A
- Opolski G
- Opris D
- Oprita O C
- Oronsaye E
- Ortega J
- Orvin K
- Orvin Katia
- Osmanagic A
- Paczynska M
- Padron A Lara
- Pais G
- Pais J
- Pamias R Freixa
- Panoulas V
- Pantic T
- Papadaki S T
- Papadopoulos C
- Papaioannou S
- Pape A Le
- Papoutsaki E
- Parati G
- Paravati V
- Parker E
- Parkinson V
- Parzakonis N
- Pascalau L
- Pascual I
- Pasquale G Di
- Pasquet A A
- Paterson P
- Patialiatos T
- Pavan D
- Peachey T
- Pejkov H
- Peluso A
- Pendlebury C
- Peovska I Mitevska
- Pereda D Cordero
- Perez L E
- Perez-Lopez C M Bianchi
- Perkan A
- Perret T
- Pesl L
- Peters G
- Petit F
- Petrescu L
- Petridou M
- Petronio A-P
- Petronio A-S
- Petrovic M
- Philippart R
- Philippe F
- Philippe François
- Phillips H
- Phillips S
- Picarra B
- Pierard S
- Pietila M
- Pilalidou A
- Pilkiene A
- Pinchuk T
- Pinto P
- Pipertzi A
- Pippard L
- Piquart A
- Pisaryuk A
- Pitt-Kerby T
- Pleskovic A
- Pllaha E
- Plugaru A
- Poghosyan H
- Poghosyan K
- Poh K-K
- Pojskic B
- Pojskic L
- Polimeni A
- Ponomareva E
- Pop D
- Pop-Moldovan A L
- Popescu B A
- Popescu M Ioachim
- Popescu R A
- Poposka L
- Popovic B
- Popovici I
- Popovici M
- Popovici Mihail
- Porter J
- Potapov P
- Potepa M
- Potpara T
- Pourbaix S
- Poznic N Glavnik
- Prendergast C
- Prescott E
- Preston S
- Price A
- Price C
- Prieur F
- Prior P
- Prokopczuk J
- Prota C
- Pruszczyk P
- Przybylo P
- Pupic L
- Pustjens T
- Pylarinou V
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- Yin D Chan Pin
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- Zaputovic L
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- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 13/12/2022
- Field of study
Whole-genome sequencing reveals host factors underlying critical COVID-19
- Author
- Abd Elghafar Mohamed S.
- Abdel-Aziz Mahmoud
- Abdelrazik Marwa
- Abdollahi Hamed
- Abdullah T.
- Abecasis Goncalo
- Abedalthagafi M.
- Abel Lynn
- Abernathy C.
- Abraheem Azmeralde
- Abul-Husn Noura S.
- Acquilini D.
- Adams C.
- Adams Emma L.
- Adams K.
- Adamsara Alireza
- Adanini Olurenke
- Adeleye O.
- Adra D.
- Afilalo J.
- Afilalo M.
- Afolabi D.
- Afrasiabi Z.
- Agasou A.
- Agrawal Shruti
- Agüero D.
- Ahmad N.
- Ahmadi Saeideh
- Ahmed A.
- Ahmed Cecilia
- Akeroyd L.
- Akhtar M.N.
- Akinkugbe O.
- Aksentijevich Alexandra
- Al-Afghani H.
- Al-Awdah L.
- Alaamery M.
- Alahmadey Z.Z.
- Alaverdian D.
- Alavere H.
- Albader A.
- Albaiceta G.M.
- Albakri J.K.
- AlBardis H.
- Albeladi M.
- Albesher N.
- Albrich W.
- AlDhawi N.
- Aldridge J.
- Aleagha Afshar Etemadi
- Alexander Peter.
- Alfonso J.
- Alghamdi B.
- Alghamdi J.
- Ali A.
- Ali Altaf
- Ali I.A.M.
- Ali Syamlan
- Aliannejad Rasoul
- Aljawini N.
- AlJohani S.
- Alkwai S.
- Allan A.
- Allan E.
- Allan J.
- Alldis Zoe
- Allen L.
- Allen Meryem
- Allen Schvearn
- Allibone S.
- Allison K.S.
- Allos R.
- Ally S.M.
- AlMalik A.
- Almalki F.
- Almohammed I.
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- Åsvold Bjørn Olav
- Publication venue
- Publication date
- 01/01/2022
- Field of study
Altres ajuts: Department of Health and Social Care (DHSC); Illumina; LifeArc; Medical Research Council (MRC); UKRI; Sepsis Research (the Fiona Elizabeth Agnew Trust); the Intensive Care Society, Wellcome Trust Senior Research Fellowship (223164/Z/21/Z); BBSRC Institute Program Support Grant to the Roslin Institute (BBS/E/D/20002172, BBS/E/D/10002070, BBS/E/D/30002275); UKRI grants (MC_PC_20004, MC_PC_19025, MC_PC_1905, MRNO2995X/1); UK Research and Innovation (MC_PC_20029); the Wellcome PhD training fellowship for clinicians (204979/Z/16/Z); the Edinburgh Clinical Academic Track (ECAT) programme; the National Institute for Health Research, the Wellcome Trust; the MRC; Cancer Research UK; the DHSC; NHS England; the Smilow family; the National Center for Advancing Translational Sciences of the National Institutes of Health (CTSA award number UL1TR001878); the Perelman School of Medicine at the University of Pennsylvania; National Institute on Aging (NIA U01AG009740); the National Institute on Aging (RC2 AG036495, RC4 AG039029); the Common Fund of the Office of the Director of the National Institutes of Health; NCI; NHGRI; NHLBI; NIDA; NIMH; NINDS.Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care or hospitalization after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes-including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)-in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease