21 research outputs found
Controllled release of metropolol tartrate from nanoporous silica matrices
A series of nanoporous silica matrices (a silica gel matrix and two ordered mesoporous silica)
have been investigated as potential carriers for the controlled release of metoporolol tartrate a
selective β1 receptor blocker used in the treatment of several diseases of the cardiovascular system.
Particular attention was devoted to the optimization of a reproducible and fast synthetic procedure.
The morphology, structure and chemical nature of the porous surfaces were characterized by N2
physisorption, X-ray diffraction, HR-TEM and FT-IR analyses. The delivery profiles were collected in
vitro in physiological solution a pH 7.4.
We have observed a close correlation between the drug release kinetic and the textural properties of
the carriers in particular with their pore size dimension