Bioactive compounds in childhood obesity and associated metabolic complications: Current evidence, controversies and perspectives

Obesity represents the most frequent chronic disease among children worldwide, with a significant global burden on society. Metabolically unhealthy obesity (MUO) can affect children since their first years of life, and novel therapeutic strategies to tackle metabolic complications are under investigation. This review focuses on bioactive compounds and their possible beneficial effects on obesity, particularly omega-3, docosahexaenoic acid, vitamin D, biotics, polysaccharide macromolecules, polyphenols, inositols, alpha lipoic acid, and bromelaine. Our aim is to summarize current evidence about bioactive compounds in the treatment of obesity, highlighting recent findings on their use in children and adolescents. Most studied molecules are omega-3 and vitamin D, despite the heterogeneity between the studies. Moreover, given the emerging interest in the gut-brain axis in the link between metabolic health and microbiota, various studies on prebiotics, probiotics, synbiotics, postbiotics and polysaccharide macromolecules have been considered. Some preclinical studies seem to highlight a possible role of the polyphenols, even if their clinical evidence is still discussed. Lastly, we describe possible effects of inositols and alpha-lipoic acid. Despite some dietary supplements seem to be promising in overweight subjects, only in a few of them a dose/response efficacy has been found in the pediatric age. Innovative, well-designed and targeted clinical trials are then needed to prove the beneficial effects of these compounds that could support the standard behavioral therapy for obesity

Comparison of the TaqMan and LightCycler systems in pharmacogenetic testing: evaluation of the CYP2C9*2/*3 polymorphisms.

Background: Pharmacogenetic testing for drugmetabolizing enzymes is not yet widely used in clinical practice. Methods: In an attempt to facilitate the application of this procedure, we have compared two real-time PCRbased methods, the TaqMan_ and the LightCycler_ for the pharmacogenetic evaluation of CYP2C9*2/*3 polymorphisms. Results and Conclusion: Both procedures are suitable for pharmacogenetic studies. The TaqMan procedure was less expensive in terms of cost per sample, but the TaqMan apparatus is more expensive than the LightCycler apparatus

Resource sharing efficiency in network slicing

The economic sustainability of future mobile networks will largely depend on the strong specialization of its offered services. Network operators will need to provide added value to their tenants, by moving from the traditional one-size-fits-all strategy to a set of virtual end-to-end instances of a common physical infrastructure, named network slices , which are especially tailored to the requirements of each application. Implementing network slicing has significant consequences in terms of resource management: service customization entails assigning to each slice fully dedicated resources, which may also be dynamically reassigned and overbooked in order to increase the cost-efficiency of the system. In this paper, we adopt a data-driven approach to quantify the efficiency of resource sharing in future sliced networks. Building on metropolitan-scale real-world traffic measurements, we carry out an extensive parametric analysis that highlights how diverse performance guarantees, technological settings, and slice configurations impact the resource utilization at different levels of the infrastructure in presence of network slicing. Our results provide insights on the achievable efficiency of network slicing architectures, their dimensioning, and their interplay with resource management algorithms at different locations and reconfiguration timescales.The work of University Carlos III of Madrid was supported by the H2020 5G-MoNArch project (Grant Agreement No. 761445) and the work of NEC Laboratories Europe by the 5GTransformer project (Grant Agreement No. 761536). The work of CNR-IEIIT was partially supported by the ANR CANCAN project (ANR-18-CE25-0011).Publicad

Mappatura della letteratura sulle soluzioni digitali e tecnologiche nell'assistenza infermieristica: un protocollo di scoping review

   INTRODUCTION: Digital and technological solutions (DTS) might have an impact on people’s personal and professional lives. These types of solutions, according to studies, have the potential to revolutionize and improve the quality and long-term sustainability of healthcare activities, with nurses playing a significant role. Although DTS appears to be intimately linked to the future of nursing, technology must be utilized as an active rather than passive tool. Nonetheless, understanding DTS appears to be difficult, and a scoping study can provide a thorough overview of such a complicated topic. As a result, the scoping study on this topic will map all of the important aspects of DTS and synthesize studies on the nursing workforce, as well as analyze and clarify knowledge gaps and aid future research and development. This article presents the study protocol.  METHODS: The Joanna Briggs Institute (JBI) scoping review methodology will be used for the proposed scoping review. It will include both quantitative and qualitative scientific research as well as grey literature on DTS in nursing. Only English-language works will be considered for inclusion. Two independent reviewers will take part in an iterative process of evaluating literature, choosing papers, and extracting data. Disagreements among reviewers will be resolved through debate until a consensus is reached or through consultation with the study team if necessary. Results will be presented using descriptive statistics, diagrammatic or tabular displayed information, and narrative summaries, as specified in the JBI guidelines.  DISCUSSION: This scoping review protocol explained why it is important to describe the literature on embracing DTS in the nursing field, how to approach the research process, and what the study's key implications will be. The protocol itself may be helpful to increase transparency in the research process, attract interested researchers to work with the group that developed the protocol and offer a practical methodological benchmark for researchers interested in performing scoping reviews by serving as an example of a scoping review protocol.  KEYWORDS: Digital solutions; Technological solutions; Nursing; Scoping review; Study protocol; Framework    INTRODUZIONE: Le soluzioni digitali e tecnologiche potrebbero avere un impatto sulla vita personale e professionale della popolazione. Questi tipi di soluzioni, secondo gli studi, hanno il potenziale per rivoluzionare e migliorare la qualità e la sostenibilità a lungo termine delle attività di salute, deve gli infermieri svolgono un ruolo significativo di innovatori, facilitatori e gestori dei processi. Sebbene le soluzioni digitali e tecnologiche sembrino essere intimamente legate al futuro dell’assistenza infermieristica, la tecnologia deve essere utilizzata come strumento attivo, piuttosto che passivo. Tuttavia, la comprensione del fenomeno sembra essere difficile e una scoping review può fornire una panoramica completa di un argomento di tale complessità. Di conseguenza, la presente scoping review mapperà tutti gli aspetti salienti legati alle soluzioni digitali e tecnologiche e sintetizzerà gli studi sul coinvolgimento della professione infermieristica, nonché analizzerà e chiarirà le lacune di conoscenza presenti e aiuterà la ricerca e i progetti futuri. Questo articolo presenta il protocollo di studio di scoping review per raggiungere l’obiettivo di mappatura della letteratura.  METODI: Il protocollo utilizza la metodologia di scoping review del Joanna Briggs Institute (JBI). Comprenderà sia la ricerca scientifica quantitativa che qualitativa, nonché la letteratura grigia sulle soluzioni digitali e tecnologiche nell’assistenza infermieristica. Solo i lavori in lingua inglese saranno presi in considerazione per l’inclusione. Due revisori indipendenti prenderanno parte a un processo iterativo di valutazione della letteratura, scelta dei documenti ed estrazione dei dati. I disaccordi tra i revisori saranno risolti attraverso il dibattito fino al raggiungimento di un consenso o attraverso la consultazione con il gruppo di studio, ove necessario. I risultati saranno presentati utilizzando statistiche descrittive, le informazioni presentate in forma grafica, tabulare o a mezzo narrativo, come specificato nelle linee guida JBI.  DISCUSSIONE: Questo protocollo di scoping review intende definire perché è importante descrivere la letteratura sull’adozione delle soluzioni digitali e tecnologiche in ambito infermieristico, come affrontare il processo di ricerca sottostante alla revisione e quali saranno le implicazioni chiave dello studio. Il protocollo stesso può essere utile per aumentare la trasparenza nel processo di ricerca, ingaggiare i ricercatori interessati a lavorare con il gruppo che ha sviluppato il protocollo (research engagement) e offrire un punto di riferimento metodologico e pratico per i ricercatori interessati a svolgere revisioni nel medesimo ambito.  PAROLE CHIAVE: Soluzioni digitali; Soluzioni tecnologiche; Infermieristica; Revisione della letteratura; Protocollo di studi

How should I slice my network? A multi-service empirical evaluation of resource sharing efficiency

Proceeding of: MobiCom '18: The 24th Annual International Conference on Mobile Computing and Networking, New Delhi, India, October 29 - November 2, 2018By providing especially tailored instances of a virtual network,network slicing allows for a strong specialization of the offered services on the same shared infrastructure. Network slicing has profound implications on resource management, as it entails an inherent trade-off between: (i) the need for fully dedicated resources to support service customization, and (ii) the dynamic resource sharing among services to increase resource efficiency and cost-effectiveness of the system. In this paper, we provide a first investigation of this trade-off via an empirical study of resource management efficiency in network slicing. Building on substantial measurement data collected in an operational mobile network (i) we quantify the efficiency gap introduced by non-reconfigurable allocation strategies of different kinds of resources, from radio access to the core of the network, and (ii) we quantify the advantages of their dynamic orchestration at different timescales. Our results provide insights on the achievable efficiency of network slicing architectures, their dimensioning, and their interplay with resource management algorithms.We would like to thank the shepherd and reviewers for their valuable comments and feedback. The work of University Carlos III of Madrid was supported by the H2020 5G-MoNArch project (grant agreement no. 761445), and the work of NEC Europe Ltd. was supported by the H2020 5GTransformer project (grant agreement no. 761536)

EATING DISORDERS: THE ROLE OF CHILDHOOD TRAUMA AND THE EMOTION DYSREGULATION

Background: The present retrospective case-control study is aimed at evaluating the presence of childhood traumatic factors and the difficulty in regulating emotions, within a sample of patients with eating disorders compared to the group of healthy controls. Subjects and methods: We included 65 people assessed for eating disorders, 40 patients and 25 healthy controls, who were given two tests: the Childhood Trauma Questionnaire-Short Form (CTQ-SF) to investigate the presence of traumatic events and the Difficulties in Emotion Regulation Scale (DERS) to assess the emotional regulation. Results: People with eating disorders showed higher average scores, and therefore greater severity than the control group, in all the domains explored, both considering traumatic experiences and emotional dysregulation. The domain emotional neglect showed the closest correlation with eating disorders (average scoring 15.9 vs 9.9 of healthy controls), followed by emotional abuse (12.2 vs 7.8), physical neglect (8.2 vs 6.6), physical abuse (8.3 vs 6.6) and sexual abuse (7.2 vs 5.6). In the same way, the emotional dysregulation was greater among people with eating disorder than healty controls, concerning every items explored by DERS, as clarity (average scoring 14.8 vs 11.4), awareness (17.1 vs 11.7), goals (16.3 vs 12.9), strategy (22.0 vs 14.7), non acceptance (17.4 vs 12.1) and impulse (16.5 vs 11.4). Conclusions: Childhood traumatic experiences and emotional dysregulation result significantly higher in people with eating disorders than healthy controls

Not all Apps are created equal: analysis of spatiotemporal heterogeneity in nationwide mobile service usage

Proceeding of: 13th International Conference on emerging Networking EXperiments and Technologies (CoNEXT '17)We investigate how individual mobile services are consumed at a national scale, by studying data collected in a 3G/4G mobile network deployed over a major European country. Through correlation and clustering analyses, our study unveils a strong heterogeneity in the demand for different mobile services, both in time and space. In particular, we show that: (i) somehow surprisingly, almost all considered services exhibit quite different temporal usage patterns; (ii) in contrast to such temporal behavior, spatial patterns are fairly uniform across all services; (iii) when looking at usage patterns at different locations, the average traffic volume per user is dependent on the urbanization level, yet its temporal dynamics are not. Our findings do not only have sociological implications, but are also relevant to the orchestration of network resources.This research work has been performed in the framework of the H2020-ICT-2014-2 project 5G NORMA (Grant Agreement No. 671584)