La novela corta en los catálogos del librero Alonso y Padilla

This article focuses on the presence of the seventeenth-century short novel in the catalogues that Pedro Joseph Alonso y Padilla handed out in his bookshop. Different versions of the catalogues that the bookseller compiled from 1720 to 1740 have been analyzed as well as the titles that he actually edited. The criteria for the selection of titles are difficult to guess, yet it is quite revealing that he drew particular attention to such prominent writers as Cervantes, Zayas, Carvajal, Castillo Solórzano or Salas Barbadillo.Este artículo sondea la presencia de la novela corta del siglo XVII en los catálogos que Pedro Joseph Alonso y Padilla fue distribuyendo en su librería. Se han tenido en cuenta las distintas versiones de lo que hizo desde 1720 a 1740, analizando después aquellos títulos que realmente editó. Por qué eligió unos y no otros se antoja difícil de averiguar, pero sí que es revelador el hecho de que se fijara en nombres tan representativos como Cervantes, Zayas, Carvajal, Castillo Solórzano o Salas Barbadillo

Imitar al que imita: Castillo Solórzano y el "Epítome a la historia de fray Tomás de Villanueva" de Quevedo

Alonso de Castillo Solórzano includes in his Sagrario de Valencia a compendium of seven stories of saints and blessed related to Valencia, including the brother Tomás de Villanueva. He confesses to have used the text written by Miguel Bartolomé Salón as a source, but nothing says about the Epítome a la vida of this Augustinian friar, written by Quevedo, which Solórzano is imitating in fact. The object of this article is to analyse this particular circumstance and the different ways of the rewriting of Castillo SolórzanoAlonso de Castillo Solórzano recoge en su Sagrario de Valencia un compedio de siete vidas de santos o beatos vinculados con esta ciudad, entre los que se encuentra fray Tomás de Villanueva. Confiesa haber tomado como fuente a Miguel Bartolomé Salón pero nada dice del Epítome a la vida de este agustino escrita por Quevedo, a quien realmente está siguiendo. Este artículo aborda esta particular circunstancia y los distintos modos de reescritura llevados a cabo por Castillo Solórzano

Population Structure of <i>Mycosphaerella graminicola</i> and Location of Genes for Resistance to the Pathogen: Recent Advances in Argentina

Leaf blotch of wheat (Septoria tritici Rob. ex Desm., teleomorph Mycosphaerella graminicola (Fückel) Schr¨ot. in Cohn) causes significant losses in wheat. During the last decades studies about the genetic variability of the pathogen and location of the resistance have been intensive around the world. The knowledge about the genetic variation of M. graminicola is very important because it could allow us to determine which genotypes predominate within a geographic area. It also can be used to evaluate the germplasm resistance of wheat cultivars with isolates with high genetic differences. In addition, the knowledge of the genes conditioning resistance in different genotypes allows getting precise combination in new germplasm. The incorporation of the known genes in new cultivars could contribute to broadening the resistance to the pathogen. A paper about genetic variability of the pathogen and location of the resistance, with special emphasis in the work carried out in Argentina, is presented.Facultad de Ciencias Agrarias y Forestale

La depresión infantojuvenil: prevención en un Instituto de Enseñanza Secundaria

La infancia se acorta por la actividad a que los adultos someten a los niños/as, y la adolescencia se prolonga artificialmente, porque el período de dependencia económica y psicosocial no coincide con el de autonomía física que se consolida en la pubertad. La sociedad, las familias, la escolaridad, las circunstancias... en muchas ocasiones hacen que los niños/as y adolescentes tengan dificultades de adaptación que se manifiestan en conductas de depresión, que se prolongan o surgen en la adultez. Se proponen las bases de un Programa de (Intervención desde la) Prevención, en un Instituto de Enseñanza Secundaria, desde el Departamento de Orientación, con la colaboración de los tutores del centro, las familias, y con la implicación de toda la comunidad educativa.Childhood is shortened by the activity that adults subject children and adolescence is extended artificially, because the period of psychological and economic dependency does not coincide with the physical autonomy which is consolidated at puberty. The society, families, schooling, the circumstances... on many occasions make that children and adolescents have difficulties of adaptation that is manifested in behavior of depression, which extend or arise in adulthood. We propose the bases of a program of (intervention from the) prevention, in an Institute of secondary education, from the guidance Department, with the collaboration of the Center, families, tutors and with the involvement of the entire educational communityEste trabajo pretende dar a conocer la importancia de la prevención de la depresión infantojuvenil en un Instituto de Enseñanza Secundaria, mediante la elaboración de las bases de un Programa de intervención desde el Departamento de Orientación, con la colaboración de los tutores del centro, las familias, y con la implicación de toda la comunidad educativa

Population Structure of <i>Mycosphaerella graminicola</i> and Location of Genes for Resistance to the Pathogen: Recent Advances in Argentina

Leaf blotch of wheat (Septoria tritici Rob. ex Desm., teleomorph Mycosphaerella graminicola (Fückel) Schr¨ot. in Cohn) causes significant losses in wheat. During the last decades studies about the genetic variability of the pathogen and location of the resistance have been intensive around the world. The knowledge about the genetic variation of M. graminicola is very important because it could allow us to determine which genotypes predominate within a geographic area. It also can be used to evaluate the germplasm resistance of wheat cultivars with isolates with high genetic differences. In addition, the knowledge of the genes conditioning resistance in different genotypes allows getting precise combination in new germplasm. The incorporation of the known genes in new cultivars could contribute to broadening the resistance to the pathogen. A paper about genetic variability of the pathogen and location of the resistance, with special emphasis in the work carried out in Argentina, is presented.Facultad de Ciencias Agrarias y Forestale

Interacting resident epicardium-derived fibroblasts and recruited bone marrow cells form myocardial infarction scar

Background: Although efforts continue to find new therapies to regenerate infarcted heart tissue, knowledge of the cellular and molecular mechanisms involved remains poor. Objectives: This study sought to identify the origin of cardiac fibroblasts (CFs) in the infarcted heart to better understand the pathophysiology of ventricular remodeling following myocardial infarction (MI). Methods: Permanent genetic tracing of epicardium-derived cell (EPDC) and bone marrow-derived blood cell (BMC) lineages was established using Cre/LoxP technology. In vivo gene and protein expression studies, as well as in vitro cell culture assays, were developed to characterize EPDC and BMC interaction and properties. Results: EPDCs, which colonize the cardiac interstitium during embryogenesis, massively differentiate into CFs after MI. This response is disease-specific, because angiotensin II-induced pressure overload does not trigger significant EPDC fibroblastic differentiation. The expansion of epicardial-derived CFs follows BMC infiltration into the infarct site; the number of EPDCs equals that of BMCs 1 week post-infarction. BMC-EPDC interaction leads to cell polarization, packing, massive collagen deposition, and scar formation. Moreover, epicardium-derived CFs display stromal properties with respect to BMCs, contributing to the sustained recruitment of circulating cells to the damaged zone and the cardiac persistence of hematopoietic progenitors/stem cells after MI. Conclusions: EPDCs, but not BMCs, are the main origin of CFs in the ischemic heart. Adult resident EPDC contribution to the CF compartment is time- and disease-dependent. Our findings are relevant to the understanding of post-MI ventricular remodeling and may contribute to the development of new therapies to treat this disease.1. Instituto de Salud Carlos III: ISCIII PI13/02144, CP09/00333, RD12/0019-0023, RD12/0019-0032, RD12/0019-0022 2. MINECO: BFU2012-35799 3. Junta de Andalucía: CTS-7564 4. EU FP7-Marie Curie-ITN actions PITN-GA-2011-28960

Iberian cured-ham consumption improves endothelial function in healthy subjects

Objectives: Previous studies have shown that dietary components such as oleic acid or polyphenols exert beneficial effects on endothelium. We aimed to assess the impact of regular consumption of Iberian cured-ham (ICH) on endothelial function. Design: An open-label, randomized controlled parallel study. Setting: Volunteers recruited through advertisements at a hospital in Madrid, Spain. Participants: 102 Caucasian adults (76.8% females) aged 25-55 years, and free from cardiometabolic disease. Intervention: Participants were randomized to an ICH-enriched ad libitum diet or an ad libitum diet without ICH for 6 weeks. Subjects in ICH group were randomly provided with either acorn- or mixed-fed ICH, and followed up for an additional 6-week period under their usual diet. Measurements: Clinical parameters, biomarkers of endothelial function and oxidative stress, microvascular vasodilatory response to hyperemia and arterial stiffness were measured before and after the intervention. Results: After 6 weeks, a larger decrease in PAI-1 was observed in subjects consuming ICH compared to the Control group (-6.2±17.7 vs. 0.3±1.4 ng/ml; p=0.020). Similarly, microvascular vasodilatory response to hyperemia showed a significant increase (112.4±391.7 vs. -56.0±327.9%; p=0.007). However, neither oxidative stress, hemodynamic nor clinical parameters differed significantly over the study. Additionally, after stopping ICH consumption, improvements in PAI-1 remained for 6 additional weeks with respect to baseline (p=0.006). Conclusion: The present study demonstrates, for the first time, that regular consumption of ICH improves endothelial function in healthy adults. Strategies aimed to preserve or improve the endothelial function may have implications in vascular aging beyond the prevention of the atherothrombotic disease

Factibilidad de servicio de env?o de carga de art?culos grandes en Lima Metropolitana para clientes finales administrados a trav?s de una plataforma virtual

El presente plan de negocio, tiene como finalidad presentar la factibilidad de brindar el servicio de transporte de carga grande, a trav?s de una plataforma virtual, de una forma sostenible y rentable. Esta idea nace de las entrevistas realizadas a los transportistas informales, inmersi?n de campo y comparaci?n de realidades actuales en otros pa?ses. A trav?s de esta plataforma virtual, los transportistas que se encuentren debidamente asociados, podr?n contactarse con los clientes que habitualmente utilizan el servicio de carga grande, estos clientes pueden ser 50% personas naturales y 50% micro, medianas y peque?as empresas, y que en la actualidad asisten a los centros de acopio, el tiempo que les toma contratar transportistas desde que salen de su oficina hasta que cierran el trato, puede ser entre 2 a 4 horas, y en el caso de los transportistas no es diferente, ellos pueden estar hasta 1 d?a entero sin realizar alg?n servicio de transporte, ya sea por la falta de clientes o por que los jaladores (personas que reciben una comisi?n por ubicar clientes), no han podido encontrar nuevos clientes

Advancing Key Gaps in the Knowledge of Plasmodium vivax Cryptic Infections Using Humanized Mouse Models and Organs-on-Chips

Plasmodium vivax is the most widely distributed human malaria parasite representing 36.3% of disease burden in the South-East Asia region and the most predominant species in the region of the Americas. Recent estimates indicate that 3.3 billion of people are under risk of infection with circa 7 million clinical cases reported each year. This burden is certainly underestimated as the vast majority of chronic infections are asymptomatic. For centuries, it has been widely accepted that the only source of cryptic parasites is the liver dormant stages known as hypnozoites. However, recent evidence indicates that niches outside the liver, in particular in the spleen and the bone marrow, can represent a major source of cryptic chronic erythrocytic infections. The origin of such chronic infections is highly controversial as many key knowledge gaps remain unanswered. Yet, as parasites in these niches seem to be sheltered from immune response and antimalarial drugs, research on this area should be reinforced if elimination of malaria is to be achieved. Due to ethical and technical considerations, working with the liver, bone marrow and spleen from natural infections is very difficult. Recent advances in the development of humanized mouse models and organs-on-a-chip models, offer novel technological frontiers to study human diseases, vaccine validation and drug discovery. Here, we review current data of these frontier technologies in malaria, highlighting major challenges ahead to study P. vivax cryptic niches, which perpetuate transmission and burden