Recent trends and climatic perspectives of hailstorms frequency and intensity in Tuscany and Central Italy

International audienceThe damages from climatic extremes have dramatically increased in the last decades in Europe, as likely outcomes of climate change: floods, droughts, heat waves and hailstorms have brought local as well as widespread damages to farmers, industry, infrastructures and society, to insurance and reinsurance companies; in this work we deal with the hailstorm hazard. The NCEP-NCAR Reanalysis (2.5 by 2.5° lat-lon) over the Italian area and the hailstorm reports at several sites are used to identify few forcings for hailstorms; statistical relationships linking forcings and hailstorm frequencies are derived. Such relationships are applied to the same forcings derived from the CGCM2-A2 climate scenario provided by the Canadian Centre for Climate modeling and analysis (CCCma; resolution approximately 3.75 by 3.75° lat-lon), to evaluate the expected changes of the frequency of hailstorms. The time series of the forcings from the NCEP-NCAR Reanalysis and the CCCma climate scenario in the past decades are compared in order to assess the reliability and accuracy of the predictions of the future hailstorm hazard. It is shown that the climate scenario provides a fairly faithful representation of the past trends of the forcings relevant to the hailstorms frequency and that such quantity, hence the hailstorm hazard, is growing and will likely grow in the future over the limited area taken into consideration in this study

The Use of Six Sigma to Assess Two Prostheses for Immediate Breast Reconstruction

Breast reconstruction is fundamental and urgent for patients in order to avoid future psychological and physical issues. That’s why immediate breast reconstruction has been requested increasingly in the last years. In this study two prosthesis with different structures and properties were compared according the aesthetic appearance (BREAST-Q© was employed) and five complications (seroma, hematoma, infections, dehiscence and red breast syndrome). The overall population was composed by 56 patients: 24 received a Tutomesh prosthesis and 32 received a Surgimend prosthesis. The DMAIC (define, measure, analyse, improve and control) cycle was implemented as a problem-solving strategy of the Six Sigma to compare the prostheses. While statistically significant difference between the two groups wasn’t found according to the overall BREAST-Q© (p-value = 0.674), the number of complications of the two groups resulted statistically different (p-value of chi-square test less than 0.001). Although it is not possible to understand from this study the reasons of the differences between the complications, this research proved that Surgimend and Tutomesh prostheses can be both implanted safely for immediate breast reconstruction since the higher costs of Surgimend could be neutralized with its lower hospitalization compared to Tutomesh. © 2021, Springer Nature Switzerland AG

Seismic vulnerability assessment of existing Italian hospitals: The case study of the national cancer institute “G. Pascale foundation” of Naples

Introduction: A large portion of the Italian built heritage is characterized by a significant seismic vulnerability since many structures were designed with outdated criteria, i.e., without accounting for seismic actions. This aspect is particularly relevant for strategic structures and infrastructures, whose functionalities are crucial in case of seismic events. Objective: The main aim of the present paper is to share the key findings related to the seismic vulnerability assessment of the National Institute for the Study and Treatment of Cancer (IRCCS) “Giovanni Pascale Foundation” in Naples. In particular, the main evidences could be easily extended to existing hospitals realized in the last century, with the main reference to: construction techniques, quality of constructional material, overt and convert seismic vulnerabilities and possible intervention strategies for risk mitigation. Methods: In the present paper, the assessment methodologies adopted for such a strategic hospital complex are provided, focusing in particular on: i. preliminary research of original design documents and on-site investigation for determining constructional details; ii. material tests on structural elements; iii. vulnerability seismic assessment by means of non-linear FE analyses (push-over and capacity spectrum method); iv. recommendations on retrofitting measures and cost estimations. Results: The conducted study puts into clear evidence the inadequacy of the investigated buildings to face the design seismic actions provided by the current Italian code and thus showed the significant seismic vulnerabilities affecting the Institute “G. Pascale Foundation” of Naples. Among these, particular attention has also been focused on the so-called intrinsic vulnerabilities, namely the ones not measurable explicitly and interesting non-structural elements (e.g., connection of shelves, stained glass windows, facilities, etc.). Conclusion: The presented case study highlights the strong seismic vulnerability affecting structures realized in the past century, despite their strategic functions. On the whole, the examined structures can be considered as representative of this building typology, and the adopted calculation criteria, as well as the assumptions of the assessment process, could be easily extended to similar case studies

Public crowdsensing of heat waves by social media data

Abstract. Investigating on society-related heat wave hazards is a global issue concerning the people health. In the last two decades, Europe experienced several severe heat wave episodes with catastrophic effects in term of human mortality (2003, 2010 and 2015). Recent climate investigations confirm that this threat will represent a key issue for the resiliency of urban communities in next decades. Several important mitigation actions (Heat-Health Action Plans) against heat hazards have been already implemented in some WHO (World Health Organization) European region member states to encourage preparedness and response to extreme heat events. Nowadays, social media (SM) offer new opportunities to indirectly measure the impact of heat waves on society. Using the crowdsensing concept, a micro-blogging platform like Twitter may be used as a distributed network of mobile sensors that react to external events by exchanging messages (tweets). This work presents a preliminary analysis of tweets related to heat waves that occurred in Italy in summer 2015. Using TwitterVigilance dashboard, developed by the University of Florence, a sample of tweets related to heat conditions was retrieved, stored and analyzed for main features. Significant associations between the daily increase in tweets and extreme temperatures were presented. The daily volume of Twitter users and messages revealed to be a valuable indicator of heat wave impact at the local level, in urban areas. Furthermore, with the help of Generalized Additive Model (GAM), the volume of tweets in certain locations has been used to estimate thresholds of local discomfort conditions. These city-specific thresholds are the result of dissimilar climatic conditions and risk cultures

The Catania 1669 lava eruptive crisis: simulation of a new possible eruption

SCIARA (Smart Cellular Interactive Automata for modeling the Rheology of Aetnean lava flows, to be read as “shea’rah”), our first two-dimensional Cellular Automata model for the simulation of lava flows, was tested and validated with success on several lava events like the 1986/87 Etnean eruption and the last phase of the 1991/93 Etnean one. Real and simulated events are satisfying within limits to forecast the surface covered by the lava flow. Moreover, improved versions have been adopted in testing other real lava flows of Mount Etna and of Reunion Island (Indian Ocean). The model has been applied with success in the determination of risk zones in the inhabited areas of Nicolosi, Pedara, S. Alfio and Zafferana (Sicily). The main goal of the present work has been the verification of the effects, in volcanic risk terms, in the Etnean area from Nicolosi to Catania, of a eruptive crisis similar to the event that occurred in 1669, as if the episode would happen nowadays. Catania has been severely interested in some major Etnean events in history, the most famous one being, namely, the 1669 eruption, involving 1 km3 of lava during 130 days. The simulation of lava tubes and the usage of different histories within the experiments have been crucial in the determination of a new risk area for Catania. In fact, simulations carried out without the introduction of lava tubes, never involved the city, proving the fact that lava tubes, played a fundamental role in the 1669 Catania lava crisis

Stromboli: a natural laboratory of environmental science

The science of environment is per se multi- and inter-disciplinary. It is not possible to separate the role of the physical, chemical, biological, and anthropic factors, respectively. Research must therefore rely on suitable natural laboratories, where all different effects can be simultaneously monitored and investigated. Stromboli is a volcanic island slightly North of Sicily, within a tectonic setting characterised by a Benioff zone, curved like a Greek theatre, opened towards the Tyrrhenian Sea, with deep earthquakes. Moreover, it is a unique volcano in the world in that since at least ~ 3000 years ago, it has exploded very regularly, about every 15^20 min. Hence, it is possible to monitor statistically phenomena occurring prior, during, and after every explosion. The Istituto Nazionale di Geofisica e Vulcanologia (INGV) has recently established a permanent Laboratory and an extensive interdisciplinary programme is being planned. A few main classes of items are to be considered including: (1) matter exchange (solid, liquid, gas, chemistry); (2) thermal and/or radiative coupling; (3) electromagnetic coupling; (4) deformation; (5) biospheric implications; and (6) anthropic relations since either the times of the Neolithic Revolution. Such an entire multidisciplinary perspective is discussed, being much beyond a mere volcanological concern. We present here the great heuristic potential of such a unique facility, much like a natural laboratory devoted to the investigation of the environment and climate.Published429-442JCR Journalreserve

Atypical COVID-19 dynamics in a patient with mantle cell lymphoma exposed to rituximab

Patients with non-hodgkin lymphomas (NHL) represent a population of special interest during the current Coronavirus disease-19 (COVID-19) pandemics. NHLs are associated with disease- and treatment-related immunodeficiencies which may generate unusual COVID-19 dynamics and pose unique management challenges. We report the unusual clinical course of COVID-19 in a patient with mantle cell lymphoma (MCL) exposed to nine doses of Rituximab shortly before infection with severe acute respiratory syndrome corona virus 2 (SARS-CoV-2). He had a prolonged asymptomatic phase, with negative molecular and antibody testing for SARS-CoV-2, followed by a rapidly progressive evolution to severe COVID-19. Despite detection of viral RNA overlapped with first symptoms occurrence, anti-SARS-CoV-2 antibodies displayed an asynchronous pattern, with IgG first appearing 2 days after RNA positivity and IgM never being detected throughout the entire clinical course. While disease-associated immune derangements and/or previous treatments involving anti-CD20 antibodies might have contributed to COVID-19 dynamics in our patient, data suggests that antibody testings, without concurrent molecular assessment for SARS-CoV-2, may turn inadequate for monitoring of MCL patients, and in general NHL patients heavily exposed to anti-CD20 antibodies, during the current pandemics. We suggest that repeated molecular testing of nasopharyngeal swab should be implemented in these subjects despite a negative serology and absence of symptoms of SARS-CoV-2 infection. For the same reasons, a customized strategy needs to be developed for patients exposed to anti-CD20 antibodies, based on different features and mechanism of action of available SARS-CoV-2 vaccines and novel vaccinomics developments

Response and toxicity to cytarabine therapy in leukemia and lymphoma: From dose puzzle to pharmacogenomic biomarkers

Cytarabine is a pyrimidine nucleoside analog, commonly used in multiagent chemotherapy regimens for the treatment of leukemia and lymphoma, as well as for neoplastic meningitis. Ara‐C‐based chemotherapy regimens can induce a suboptimal clinical outcome in a fraction of patients. Several studies suggest that the individual variability in clinical response to Leukemia & Lymphoma treatments among patients, underlying either Ara‐C mechanism resistance or toxicity, appears to be associated with the intracellular accumulation and retention of Ara‐CTP due to genetic variants related to metabolic enzymes. Herein, we reported (a) the latest Pharmacogenomics biomarkers associated with the response to cytarabine and (b) the new drug formulations with optimized pharmacokinetics. The purpose of this review is to provide readers with detailed and comprehensive information on the effects of Ara‐C‐based therapies, from biological to clinical practice, maintaining high the interest of both researcher and clinical hematologist. This review could help clinicians in predicting the response to cytarabine‐based treatments

Archaeometric approach for the study of mortars from the underwater archaeological site of Baia (Naples) Italy: Preliminary results

This work was aimed to evaluate the features of mortar samples taken from the underwater archaeological area of Baia (Naples, Italy), an important site, where the remains of the ancient Roman city of Baiae and Portus Iulius are submerged after bradyseism events, started from 4th century AD. Several architectural structures are still preserved into the submerged environment, such as: luxurious maritime villas, imperial buildings, private houses, thermae, tabernae and warehouses. In particular, some samples were collected from the masonry walls belonging to a building of the underwater area called Villa a Protiro. A first archaeometric approach has been applied to analyse twelve archaeological mortars samples in order to define: textural features, chemical composition and raw materials used for their production. For this purpose different analytical methods were used, such as, polarizing optical microscope (POM) and scanning electron microscopy (SEM-EDS).This work was financially supported by national national research project “COMAS” (Planned COnservation, “in situ”, of underwater archaeological artifacts), funded by the Italian Ministry of Education, Universities and Research (MIUR).Peer reviewe