Reception Grand March

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In Defense of the Lone Wolf: Collaboration in Language Documentation

Collaboration has become a hot topic in the field of language documentation, with many authors insisting that lone wolf research is unethical research. We take issue with the viewpoints that documentary linguists must collaborate with the community, that the linguist’s goals should be subordinate to the goals of community members, and that solo research is necessarily unethical research. Collaborating with community members in language documentation projects is not the only method of treating the community fairly and reciprocating their generosity. There will not always be community members interested in language documentation, nor will there always be community members capable of participation. Even in cases where community members are interested, capable, and willing, both the researcher and the community should be allowed to decide when, where, how, and whether to collaborate. Moreover, we suggest that the insistence on collaboration can cause guilt when collaboration is difficult, or can lead researchers into unproductive or even dangerous situations. On the other hand, we welcome collaboration if both parties retain autonomy in decision-making and both truly want to work collaboratively. There is nothing unethical about setting one’s own research agenda and conducting linguistic fieldwork alone. Lone wolf linguistics isn’t necessarily unethical linguistics.National Foreign Language Resource Cente

Improved Visualization of Alphitobius diaperinus

The lesser mealworm, Alphitobius diaperinus (Panzer), is a perennial pest of poultry facilities and known to transmit pathogens of poultry and humans. Ongoing research examining reservoir potential of A. diaperinus revealed the need for a comprehensive, user-friendly guide for determining sex of A. diaperinus at different stadia. This paper is unique in providing a comprehensive illustrated guide of characters used for differentiation of sexes in A. diaperinus

Permeation Fill-Tube Design for Inertial Confinement Fusion Target Capsules

A unique approach for permeation filling of nonpermeable inertial confinement fusion target capsules with deuterium— tritium (DT) is presented. This process uses a permeable capsule coupled into the final target capsule with a 0.03-mm-diameter fill tube. Leak free permeation filling of glow-discharge polymerization (GDP) targets using this method have been successfully demonstrated, as well as ice layering of the target, yielding an inner ice surface roughness of 1-µm rms (root mean square). Finally, the measured DT ice-thickness profile for this experiment was used to validate a thermal model’s prediction of the same thickness profile

Amateur Paleontological Societies and Fossil Clubs, Interactions with Professional Paleontologists, and Social Paleontology in the United States

Considerable interest exists among lifelong learners in the USA about fossils and the science of paleontology. Unlike some other science-related groups, e.g., astronomy and ornithology, interest in fossils among amateur paleontologists is primarily focused within local clubs and societies with little national coordination. This paper presents the results of formative evaluation of the FOSSIL project, conducted after the project “Kickoff” meeting held at the NAPC (North American Paleontological Convention) in 2014. FOSSIL is developing a national networked community of practice that includes amateur and professional paleontologists. Our research indicates that more than 60 amateur fossil clubs and societies exist in the USA, of which almost 40 have elected to be part of the FOSSIL network. Overarching goals of this program include enhanced collaborations between amateurs and professionals, knowledge-building about paleontology, access to resources for lifelong learning, and development a viable learning community of practice focused on topics of common and societal interest, such as collections (including digitization), evolution, climate change, and K-12 outreach. In addition to more traditional means such as list-serves and newsletters, FOSSIL is developing an online community (myFOSSIL) and using social media (Facebook and Twitter) to foster communication and interactions among stakeholders, and thus promoting the concept of “social paleontology”

The Belgrade PaleoBlitz: A Pilot Project to Engage Amateur Paleontologists

Paleontology is an interdisciplinary field that attracts a range of individuals, from hobbyists to professionals. A primary goal of the NSF-funded FOSSIL Project is to establish a unified community of paleontologists and promote best practices in the field of paleontology. The Belgrade PaleoBlitz was a pilot effort to meet these goals by guiding participants through the museum curation process via a rapid two-day immersion. The objectives of the PaleoBlitz event were to: 1) educate participants in best practices associated with the museum curation process, and 2) catalog specimens collected from the Belgrade Quarry into the Florida Museum of Natural History vertebrate paleontology collections. These objectives seek to find a balance between educating participants and contributing to science. A pre-event application dispersed to amateur paleontology clubs throughout the United States determined applicants’ baseline content knowledge and practices. To facilitate learning and promote networking, we selected 13 participants who varied in expertise from six different paleontology organizations. Immediate and delayed post-event surveys assessed acceptance and implementation of best practices, confidence related to specific aspects of the museum curation process, and expansion of individuals’ personal paleontology network. Responses showed that all participants made changes to their existing collections, felt more confident in specific aspects of the museum curation process, and had continued connections with other participants after this event

Ethics roundtable: 'Open-ended ICU care: Can we afford it?'

The patient is a 27-year-old previously healthy male with a diagnosis of viral encephalitis with a lymphocytic pleocytosis on cerebrospinal fluid examination. For 3 months, he has been in status epilepticus (SE) on high doses of barbiturates, benzodiazepines, and ketamine and a ketogenic feeding-tube formula. He remains in burst suppression on continuous electroencephalography (EEG). He is trached and has a percutaneous endoscopic gastrostomy (PEG) feeding tube. He has been treated several times for pneumonia, and he is on a warming blanket and is on vasopressors to maintain his blood pressure. His vitals are stable and his lab work is within limits. The sedation is decreased under EEG guidance every 72 hours, after which he goes back into SE and heavy sedation is resumed. The latest magnetic resonance imaging (MRI) shows edema but otherwise no obvious permanent cortical damage. The family wants a realistic assessment of the likely outcome. The neurologist tells them the literature suggests the outlook is poor but not 100% fatal. As long as all of his other organs are functioning on life support, there is always a chance the seizures will stop at some time in the future, and so the neurologist recommends an open-ended intensive care unit (ICU) plan and hopes for that outcome. © 2010 BioMed Central Ltd

The measurement of molecular diversity by receptor site interaction simulation

The assembly of large compound libraries for the purpose of screening against various receptor targets to identify chemical leads for drug discovery programs has created a need for methods to measure the molecular diversity of such libraries. The method described here, for which we propose the acronym RESIS (for Receptor Site Interaction Simulation), relates directly to this use. A database is built of three-dimensional representations of the compounds in the library and a set of three-point three-dimensional theoretical receptor sites is generated based on putative hydrophobic and polar interactions. A series of flexible, three-dimensional searches is then performed over the database, using each of the theoretical sites as the basis for one such search. The resulting pattern of hits across the grid of theoretical receptor sites provides a measure of the molecular diversity of the compound library. This can be conveniently displayed as a density map which provides a readily comprehensible visual impression of the library diversity characteristics. A library of 7500 drug compounds derived from the CIPSLINEPC databases was characterized with respect to molecular diversity using the RESIS method. Some specific uses for the information obtained from application of the method are discussed. A comparison was made of the results from the RESIS method with those from a recently published two-dimensional approach for assessing molecular diversity using sets of compounds from the Maybridge database (MAY).Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/42964/1/10822_2004_Article_165958.pd

Molecular dynamics simulation of polymer helix formation using rigid-link methods

Molecular dynamics simulations are used to study structure formation in simple model polymer chains that are subject to excluded volume and torsional interactions. The changing conformations exhibited by chains of different lengths under gradual cooling are followed until each reaches a state from which no further change is possible. The interactions are chosen so that the true ground state is a helix, and a high proportion of simulation runs succeed in reaching this state; the fraction that manage to form defect-free helices is a function of both chain length and cooling rate. In order to demonstrate behavior analogous to the formation of protein tertiary structure, additional attractive interactions are introduced into the model, leading to the appearance of aligned, antiparallel helix pairs. The simulations employ a computational approach that deals directly with the internal coordinates in a recursive manner; this representation is able to maintain constant bond lengths and angles without the necessity of treating them as an algebraic constraint problem supplementary to the equations of motion.Comment: 15 pages, 14 figure