Stepping out of the Chinese Room: Word meaning with and without consciousness

What is the role of consciousness in language processing? Unconscious priming experiments show that words can prime other words with related meanings (cat \u2013 dog), and these priming effects are assumed to reflect the activation of conceptual knowledge in semantic memory. Alternatively, however, unconscious priming effects could reflect predictive relationships between the words\u2019 forms, since words that are semantically related are also statistically related in language use. Therefore, unconscious \u201csemantic\u201d priming effects could be due to relationships between words\u2019 forms mimicking conceptual relationships, as in Searle\u2019s Chinese Room thought experiment. To distinguish wordform-based and semantics-based accounts of priming we conducted an experiment in which temporal words (e.g., earlier, later) were preceded by spatial words that were processed either consciously or unconsciously. Time is typically conceptualized as a spatial continuum extending along either the sagittal (front-back) or the lateral (left-right) axis, but only the sagittal space-time mapping is encoded in language (e.g. the future is ahead, not to the right). Results showed that temporal words were primed both by sagittal words (back, front) and lateral words (left, right) when primes were perceived consciously, as predicted by both wordformbased and semantics-based accounts. Yet, only sagittal words produced an unconscious priming effect, as predicted by the wordform-based account. Unconscious word processing appears to be limited to relationships between words\u2019 forms, and consciousness may be needed to activate words\u2019 meanings

A Multi-One Instruction Set Computer for Microcontroller Applications

This work presents a simple integer-only instruction set architecture and microarchitecture derived from One Instruction Set Computers (OISCs) and embedding multiple execution modes ( ${m}$ OISC), capable of running at a reasonable performance level to enable basic usability in microcontroller applications. The purpose of ${m}$ OISC is to enable simple data transfer tasks and run small programs while maintaining ultimate simplicity. We present the internal organization for a computer architecture including an 8bit I/O register, and 64kB central Random Access Memory (RAM), organized in two-bytes words. The processor can run code generated assuming an OISC or a Complex Instruction Set Computer (CISC) scheme (op-code based), depending on the programmer’s demands and based on the initial setting of a register during start-up. To enable practical applications and demonstrate successful exploitation of ${m}$ OISC in view of integration in a compiler back-end, we designed a custom Proof-of-Concept (PoC) software design toolchain based on LLVM and clang. Although not targeting all the features of commercial ISA, the toolchain is capable of compiling C code from LLVM intermediate representation or generating ${m}$ OISC code translated from ARM, x86, RISC-V, and MIPS assembly. The toolchain also enables practical Value Change Dump (VCD) simulations output with graphical plots of the CPU state and associated symbols. A PoC microcontroller system has been synthesized in a low power Field Programmable Gate Array (FPGA) and verified in a basic wireless telemetry application including a Synchronous Peripheral Interface (SPI) RFM9x Long RAnge (LoRA) transceiver and a MAX30205 Inter Integrated Circuit (I2C) temperature sensor, using its 8bit I/O port, with software bus interface implementation. ${m}$ OISC occupies ~6% of resources on a Cyclone 10LP FPGA, for 1397 Adaptive Look-Up Tables (ALUTs) and 461 dedicated logic registers. The measured dynamic current consumption of the complete FPGA board with synthesized ${m}$ OISC is 12mA at 100MHz clock

Genomic Differences Between the Sexes in a Fish Species Seen Through Satellite DNAs

Neotropical fishes have highly diversified karyotypic and genomic characteristics and present many diverse sex chromosome systems, with various degrees of sex chromosome differentiation. Knowledge on their sex-specific composition and evolution, however, is still limited. Satellite DNAs (satDNAs) are tandemly repeated sequences with pervasive genomic distribution and distinctive evolutionary pathways, and investigating satDNA content might shed light into how genome architecture is organized in fishes and in their sex chromosomes. The present study investigated the satellitome of Megaleporinus elongatus, a freshwater fish with a proposed Z1Z1Z2Z2/Z1W1Z2W2 multiple sex chromosome system that encompasses a highly heterochromatic and differentiated W1 chromosome. The species satellitome comprises of 140 different satDNA families, including previously isolated sequences and new families found in this study. This diversity is remarkable considering the relatively low proportion that satDNAs generally account for the M. elongatus genome (around only 5%). Differences between the sexes in regards of satDNA content were also evidenced, as these sequences are 14% more abundant in the female genome. The occurrence of sex-biased signatures of satDNA evolution in the species is tightly linked to satellite enrichment associated with W1 in females. Although both sexes share practically all satDNAs, the overall massive amplification of only a few of them accompanied the W1 differentiation. We also investigated the expansion and diversification of the two most abundant satDNAs of M. elongatus, MelSat01-36 and MelSat02-26, both highly amplified sequences in W1 and, in MelSat02-26’s case, also harbored by Z2 and W2 chromosomes. We compared their occurrences in M. elongatus and the sister species M. macrocephalus (with a standard ZW sex chromosome system) and concluded that both satDNAs have led to the formation of highly amplified arrays in both species; however, they formed species-specific organization on female-restricted sex chromosomes. Our results show how satDNA composition is highly diversified in M. elongatus, in which their accumulation is significantly contributing to W1 differentiation and not satDNA diversity per se. Also, the evolutionary behavior of these repeats may be associated with genome plasticity and satDNA variability between the sexes and between closely related species, influencing how seemingly homeologous heteromorphic sex chromosomes undergo independent satDNA evolution.Fil: Crepaldi, Carolina. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilFil: Martí, Emiliano. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilFil: Gonçalves, Évelin Mariani. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilFil: Marti, Dardo Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Biología Subtropical. Universidad Nacional de Misiones. Instituto de Biología Subtropical; ArgentinaFil: Parise Maltempi, Patricia Pasquali. Universidade Estadual Paulista Julio de Mesquita Filho; Brasi

Genomic variability of Cirneco dell’Etna and the genetic distance with other dog breeds

Cirneco dell’Etna is an old Italian breed of scent hunting dogs. Commonly used genomic measures such as heterozygosity, fixation indexes, and runs of homozygosity can help to improve knowledge about its genetic diversity. This study aimed to: (i) investigate Cirneco’s genomic background, (ii) quantify its genomic inbreeding, and (iii) detect genomic regions differentiating the Cirneco’s two allowed coat colours, self-coloured fawn and tan and white. Canine 230K SNP BeadChips was used to investigate 24 Cirneco (19 self-coloured fawn, and 5 tan and white) and other 106 dogs from eight phylogenetically and historically related breeds. The genetic distance, ancestry, and relationship among breeds were explored by multidimensional scaling, Reynolds distances, phylogenetic tree, and admixture analysis. The genomic inbreeding (FROH) was calculated for each breed. Averaged Wright’s fixation index FST was used to identify the genes that most differentiated the two groups of Cirneco. All analyses highlighted that Segugio Italiano and Kelb tal Fenek are the closest breeds to Cirneco. Within the breed, tan and white subjects showed a more heterogeneous genetic background and a lower inbreeding in comparison with self-coloured fawn ones, even though more than half of the latter presented a superimposable admixture. The gene that most differentiated these two groups is Microphthalmia-Associated Transcription Factor (MITF), previously associated with white spotting in other breeds. Given the small size of the Cirneco population and its open registry, its management should carefully combine morphological and genealogical evaluations with genetic tools to identify the best breeders while maintaining an acceptable genetic pool.peer-reviewe

Statins, antihypertensive treatment, and blood pressure control in clinic and over 24 hours: evidence from PHYLLIS randomised double blind trial

Objective To investigate the possibility that statins reduce blood pressure as well as cholesterol concentrations through clinic and 24 hour ambulatory blood pressure monitoring

Potential application of pre-harvest LED interlighting to improve tomato quality and storability

Unidad de excelencia María de Maeztu CEX2019-000940-MGrowing conditions and agronomical inputs play a key role in determining fruit qualitative and nutraceutical traits at harvest and post-harvest. The hereby presented research investigated the effects of pre-harvest supplemental LED interlighting on post-harvest quality of hydroponically grown tomatoes (Solanum lycopersicum "Siranzo"). Three LED treatments, applied for 16 h d-1 (h 8.00-00.00), were added to natural sunlight and consisted of Red and Blue (RB), Red and Blue + Far-Red (FR), and Red and Blue + Far-Red at the end-of-day for 30 min (EOD), with an intensity of 180 µmol m-2 s-1 for Red and Blue, plus 44 µmol m-2 s-1 for Far-Red. A control treatment (CK), where plants were grown only with sunlight, was also considered. Fruits at red stage were selected and placed in a storage room at 13 °C in darkness. Fruit quality assessment was performed at harvest time and after one week of storage. RB and FR increased fruit firmness compared to CK, opening possible benefits toward reducing fruit losses during post-harvest handling. RB treated fruits also maintained a higher content of lycopene and β-carotene after the first week of storage. The study demonstrates that supplementary LED interlighting during greenhouse tomato cultivation may enhance storability and help preserve fruit nutritional properties during post-harvest

Modelling environmental burdens of indoor-grown vegetables and herbs as affected by red and blue LED lighting

Notwithstanding that indoor farming is claimed to reduce the environmental pressures of food systems, electricity needs are elevated and mainly associated with lighting. To date, however, no studies have quantified the environmental and economic profile of Light Emitting Diodes (LED) lighting in indoor farming systems. The goal of this study is to quantify the effect of varying the red (R) and blue (B) LED spectral components (RB ratios of 0.5, 1, 2, 3 and 4) on the eco-effciency of indoor production of lettuce, chicory, rocket and sweet basil from a life cycle perspective. The functional unit of the assessment was 1 kg of harvested fresh plant edible product, and the International Reference Life Cycle Data System (ILCD) method was employed for impact assessment. Even though most of the materials of the LED lamp and electronic elements were imported from long distances (14,400 km), electricity consumption was the largest contributor to the environmental impacts (with the LED lamps being the main electricity consumers, approximately 70%), apart from the resources use indicator, where the materials of the lamps and the mineral nutrients were also relevant. RB0.5 was the most energy-effcient light treatment but had the lowest eco-effciency scores due to the lower crop yields.This project received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No. 708672. The elaboration of the manuscript was also supported by a grant from the Fundacion Séneca (reference 20555/IV/18, Call for Fellowships for Guest Researcher Stays at Universities and OPIS of the Region of Murcia) awarded to Francesco Orsini