Nonperturbative corrections to moments of the decay B -> X_s l^+ l^-

We study nonperturbative corrections to the inclusive rare decay B -> X_s l^+ l^- by performing an operator product expansion (OPE) to O(1/m_b^3). The values of the matrix elements entering at this order are unknown and introduce uncertainties into physical quantities. We study uncertainties introduced into the partially integrated rate, moments of the hadronic spectrum, as well as the forward-backward asymmetry. We find that for large dilepton invariant mass q^2 > M_{\psi'}^2 these uncertainties are large. We also assess the possibility of extracting the HQET parameters \lambda_1 and \bar{\Lambda} using data from this process.Comment: 24 pages, revtex, 4 figures, added an appendix with details, results unchange

Nonperturbative corrections to B -> X_s l^+ l^- with phase space restrictions

We study nonperturbative corrections up to O(1/m_b^3) in the inclusive rare B decay B -> X_s l^+ l^- by performing an operator product expansion. The values of the matrix elements entering at this order are unknown and introduce uncertainties into physical quantities. Imposing a phase space cut to eliminate the $c \bar{c}$ resonances we find that the O(1/m_b^3) corrections introduce an O(10%) uncertainty in the measured rate. We also find that the contributions arising at O(1/m_b^3) are comparable to the ones arising at O(1/m_b^2) over the entire region of phase space.Comment: 7 pages, 2 figures, revte

Phenomenology of B -> pi pi, pi K Decays at O(alpha^2 beta_0) in QCD Factorization

We study O(alpha^2 beta_0) perturbative corrections to matrix elements entering two-body exclusive decays of the form B -> pi pi, pi K in the QCD factorization formalism, including chirally enhanced power corrections, and discuss the effect of these corrections on direct CP asymmetries, which receive their first contribution at O(alpha). We find that the O(alpha^2 beta_0) corrections are often as large as the O(alpha) corrections. We find large uncertainties due to renormalization scale dependence as well as poor knowledge of the non-perturbative parameters. We assess the effect of the perturbative corrections on the direct CP violation parameters of B -> pi^+ pi^-.Comment: 27 pages, 5 figures. Updated input parameters and added citations; expanded discussio

A united statement of the global chiropractic research community against the pseudoscientific claim that chiropractic care boosts immunity.

BACKGROUND: In the midst of the coronavirus pandemic, the International Chiropractors Association (ICA) posted reports claiming that chiropractic care can impact the immune system. These claims clash with recommendations from the World Health Organization and World Federation of Chiropractic. We discuss the scientific validity of the claims made in these ICA reports. MAIN BODY: We reviewed the two reports posted by the ICA on their website on March 20 and March 28, 2020. We explored the method used to develop the claim that chiropractic adjustments impact the immune system and discuss the scientific merit of that claim. We provide a response to the ICA reports and explain why this claim lacks scientific credibility and is dangerous to the public. More than 150 researchers from 11 countries reviewed and endorsed our response. CONCLUSION: In their reports, the ICA provided no valid clinical scientific evidence that chiropractic care can impact the immune system. We call on regulatory authorities and professional leaders to take robust political and regulatory action against those claiming that chiropractic adjustments have a clinical impact on the immune system

Drilling their own graves:How the European oil and gas supermajors avoid sustainability tensions through mythmaking

This study explores how paradoxical tensions between economic growth and environmental protection are avoided through organizational mythmaking. By examining the European oil and gas supermajors’ ‘‘CEOspeak’’ about climate change, we show how mythmaking facilitates the disregarding, diverting, and/or displacing of sustainability tensions. In doing so, our findings further illustrate how certain defensive responses are employed: (1) regression, or retreating to the comforts of past familiarities, (2) fantasy, or escaping the harsh reality that fossil fuels and climate change are indeed irreconcilable, and (3) projecting, or shifting blame to external actors for failing to address climate change. By highlighting the discursive effects of enacting these responses, we illustrate how the European oil and gas supermajors self-determine their inability to substantively address the complexities of climate change. We thus argue that defensive responses are not merely a form of mismanagement as the paradox and corporate sustainability literature commonly suggests, but a strategic resource that poses serious ethical concerns given the imminent danger of issues such as climate change

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Identification of research communities in cited and uncited publications using a co-authorship network

Patterns of co-authorship provide an effective means of probing the structures of research communities. In this paper, we use the CiteSpace social network tool and co-authorship data from the Web of Science to analyse two such types of community. The first type is based on the cited publications of a group of highly productive authors in a particular discipline, and the second on the uncited publications of those highly productive authors. These pairs of communities were generated for three different countries—the People’s Republic of China (PRC), the United Kingdom (UK) and the United States of America (USA)—and for four different disciplines (as denoted by Web of Science subject categories)—Chemistry Organic, Engineering Environmental, Economics, and Management. In the case of the UK and USA, the structures of the cited and uncited communities in each of the four disciplines were markedly different from each other; in the case of the PRC, conversely, the cited and uncited PRC communities had broadly similar structures that were characterised by large groups of connected authors. We suggest that this may arise from a greater degree of guest or honorary authorship in the PRC than in the UK or the USA

Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19

IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19. Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19. DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022). INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days. MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes. RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively). CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes. TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570