7 research outputs found
Translocation t(3;8)(p14.2;q24.1) in renal cell carcinoma affects expression of the common fragile site at 3p14(FRA3B) in lymphocytes
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/03/1988
- Field of study
The common fragile site at 3p14(FRA3B) is cytogenetically close to the positions of translocation and deletion breakpoints frequently observed in renal cell carcinoma (RCC) and small cell carcinoma of the lung. Possible involvement of this fragile site in the familial RCC t(3;8)(p14.2;q24.1) was investigated. Expression of FRA3B, induced by treatment of lymphocytes with aphidicolin, is altered by the translocation. These results suggest that the fragile site is very close to, if not coincident with, the translocation breakpoint.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/27374/1/0000401.pd
Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans
- Author
- Abbasi Z
- Abdul-Hamid M Akhlil
- Abel Paul D
- Abrams Paul H
- Adab Fawzi A
- Adamson Andrew
- Adeyoju A
- Adolfson Jan
- Afzal Naveed
- Ahiaku Ernest K N
- Ahmed Munir
- Al Sudani Mohammed L
- Al-Samarraie Amir S M
- Al-Samerraie [Unknown]
- Al-Singary Waleed
- Al-Sudani [Unknown]
- Alcock Christopher
- Alexander Kimberly
- Ali Zulfiqar
- Almond David J
- Alonzi Roberto
- Aly Markus
- Amin Al Olama Ali
- Anderson John
- Andrews Henry
- Andrews Steven
- Anjum Iqbal
- Anson Ken
- Anyamene Nicola A
- Apakama Ike
- Aparcia F
- Archbold J A A
- Arndt Volker
- Ash D
- Ashford Richard F U
- Auvinen Anssi
- Azzabi A
- Badenoch David
- Bahl Amit
- Bailey Karen
- Bailey M J
- Ball Andrew J
- Banerjee G
- Barber Jim
- Barber N
- Baria [Unknown]
- Barnes Douglas G
- Barros-Silva Joao
- Barwell Julian
- Bashir J
- Basu Pradip
- Bates Christopher A
- Batra Jyotsna
- Bax N A
- Baxter-Smith D
- Bdesha Amar
- Beacock Christopher J M
- Beaney Ronald P
- Beard Ralph
- Beatty John D
- Beck Rupert
- Beese Gail
- Beesley Sharon
- Bell C Richard W
- Bellringer James
- Benlloch Garcia Sara
- Benson Richard
- Beresford [Unknown]
- Bevis Christopher R A
- Bhana Rajanee
- Bhanot S
- Bhatnagar A
- Bhatt R I
- Birch Brian
- Birtle Alison
- Bishop M
- Biyani C Shekhar
- Blacklock A R E
- Blades Rosemary
- Bliss Peter
- Bloomfield David J
- Boddy S
- Bollina Prasad
- Bonnington Sue
- Booth C M
- Bose Pradeep
- Bott Michael C
- Bottomley David
- Boucher Nigel R
- Bowen J
- Bower Mark
- Bowsher W G
- Boyd P J R
- Bradshaw Lynne
- Bramble F James
- Brenner Hermann
- Brewster Simon F
- Briggs Tim
- Brock Cathryn
- Brock Sue
- Bromage Stephen
- Broms Michael
- Brough Richard
- Brown Andrew A
- Brown Paul
- Brown Paul M
- Brown Richard
- Brown Stephen
- Browning Tony J
- Bryan N
- Burgess Neil A
- Burns-Cox Nicholas
- Butterbach Katja
- Butterworth Paul C
- Cahill D
- Callaghan P S
- Calleary John
- Calleja M
- Calman Frances
- Camilleri Philip
- Campbell Alister
- Cannon Andrea
- Cannon-Albright Lisa
- Carnell Dawn M
- Carr T W
- Carter Adam C
- Carter Charles J M
- Carter Simon
- Castle Bruce M
- Catto James
- Cavalli-Bjoerkman Carin
- Chadwick David
- Chahal Rohit
- Chakraborti P
- Chappell [Unknown]
- Charig C
- Chetiyawardana Anula D
- Chilton Christopher
- Chinegwundoh F I
- Chong Irene
- Choudhury Ananya
- Chow Wai-Man
- Christmas Timothy J
- Christova Svetlana
- Churn Mark J
- Cieza-Borrella Clara
- Clarke Noel W
- Clavijo-Eisele Jorge
- Clements Judith A
- Coe M
- Coetzee Gerhard A
- Cohen N P
- Coker C
- Cole David J
- Cole O
- Cole Trevor
- Collins Angus
- Collins Gerald
- Collinson Matthew
- Conn I
- Connell C
- Conti David V
- Cook Audrey
- Cook Margaret
- Cooke Peter
- Cooksey Graeme
- Coombs L
- Cooper Debbie
- Copland Robert F
- Cornaby Andrew J
- Cornford P A
- Corolis [Unknown]
- Corr John
- Costello C B
- Coull Mrs N
- Cowan Richard
- Cox Angela
- Cox Robert
- Coyle C
- Crew Jeremy
- Crisp John C
- Cross W
- Cruger Dorthe
- Crundwell Malcolm
- Cummings [Unknown]
- Cybulski Cezary
- Dadaev Tokhir
- Dahar Nazeer
- Daniel Francis N
- Darrad J
- Daruwala Pallon
- Das Gautam
- Datta Shibendra
- Davidson S
- Davies Joseph
- Davis Michael
- Davison Owen W
- Dawkins Guy
- Dawson Chris
- De Bolla Alan R
- Dearnaley David
- Desai Ken M
- Deutsch George P
- Dick John
- Dickinson Andrew J
- Dickson Jeanette
- Dikov Tihomir
- Dinneen Michael
- Dixit Sanjay
- Dobbs H Jane
- Doble A
- Doble Andrew
- Dodds David
- Doherty Alan
- Donaldson P
- Donovan Jenny L
- Dooldeniya M
- Douglas S Fiona
- Down Liz
- Drake [Unknown]
- Duchesne Gill M
- Duffy Peter
- Dunn Michael
- Dunsmuir W D
- Durkan Garrett
- Durrani Sajid K
- Easton Douglas
- Eaton Alan C
- Eccles Diane
- Eckert Allison
- Eddy B
- Eden C D
- Edwards J
- Eeles Rosalind A
- El-Modir A
- Elkabir Jeremy
- Elliott Emma
- Elliott P Tony
- Ellis B W
- Ellis R
- Elves Andrew W S
- Elwell Christine
- Emberton Mark
- Emmerson Louise
- England Roland C D
- Errington R D
- Evans D Gareth
- Falconer Alison
- Fawcett Derek
- Featherston C
- Featherstone Carolyn J
- Feggetter Jeremy
- Ferguson C
- Fermont D
- Ferro Michael
- Fisher Cyril
- Fitzgerald Liesel
- Fitzgerlad Liesel M
- Fletcher Matthew
- Folkes A
- Ford Trevor F
- Foster Paul W
- Franks Kevin N
- Freedman Mathew
- Frim Olivera
- Gale Joanna
- Gallegos Christopher
- Gelister James S
- George Anne
- Ghana [Unknown]
- Gibbs Stephanie
- Gilbert Hugh
- Giles Graham G
- Gillatt David
- Glaholm John
- Glass Jonathan M
- Glenister James
- Goode Thomas D
- Gordon E M
- Govindasami Koveela
- Gower Richard L
- Graham John
- Green Damian
- Greenland Jonathan
- Grieve Robert
- Griffiths Thomas R L
- Gronberg Henrik
- Gujral Sandy
- Gupta Nishi
- Gurun Riza Murat
- Gustafsson Sven
- Guy Michelle
- Guy Peter J
- Haiman Christopher A
- Haldar Neil
- Halder N
- Haley James
- Hamdy F C
- Hamdy Freddie
- Hamilton C
- Hammonds John
- Hampson S J
- Hanbury Damien C
- Hardman P D John
- Harland Stephen J
- Harney John M
- Harper Peter
- Harris D
- Harris Sarah
- Harrison G S M
- Harriss D R
- Harvey-Hills N
- Hawkyard Simon
- Hazel Steve
- Hazelett Dennis J
- Heath Catherine M
- Heathcote Peter
- Hehir Michael
- Hellawell Giles O
- Henderson Brian E
- Hendry David
- Henley Mike
- Henrique Rui
- Henry Ann
- Herbert Pippa
- Herkommer Kathleen
- Hetherington John
- Hickish Tamas
- Hicks James A
- Hilman Serena
- Hindley Richard
- Hindmarsh John R
- Hines John
- Hingorani M
- Ho Edwin T S
- Hodgson Shirley
- Hoffman U
- Holden David
- Holding Peter
- Hollingdale A
- Hollins Graham W
- Holmes Simon A V
- Holt Sarah
- Hopper John L
- Horan Gail
- Horwich Alan
- Hoskin Peter
- Howell Graham P
- Howson Joanne
- Hrouda D
- Huddart Robert
- Hudson Liz
- Hughes Michael
- Hughes Owen
- Hughes Rob
- Humber Caroline
- Iacovou John W
- Ibrahim A
- Inglis John A
- Irving Stuart
- Irwin C
- Iversen Peter
- Izatt Louise
- Izegbu Victor
- Jameel Basharat
- James Michael J
- James N
- James R Lester
- Javle Pradip
- Jenkins P
- Jhavar Sameer
- Johansson Jan-Erik
- Jones Chris R
- Jones David A
- Jones Gareth
- Jones Mandy
- Joseph J
- Joss Shelagh
- Jugurnauth-Little Sara
- Kachakova Darina
- Kaisary Amir
- Kaliski Alexandre L
- Kaneva Radka
- Kapur G
- Karim O
- Karlsson Ami
- Karp Stephen J
- Kedda Mary-Anne
- Keeley F X
- Kelkar Anand R
- Kelleher J P
- Kelly John
- Kenwrick Sue
- Kerr Kris
- Key Tim J
- Khan F
- Khaw Kay-Tee
- Khoo Vincent
- Kibel Adam S
- Kierzek Andrzej
- Kimber Rachel M
- Kinder R
- Kirby Roger S
- Kirk David
- Kirkbride Peter
- Kirollos Magdi M
- Klarskov Peter
- Kluzniak Wojciech
- Kockelbergh Roger
- Koenig Philip C W C
- Kooiman Gordon G
- Koreich O
- Kote-Jarai Zsofia
- Koupparis Anthony
- Kourah Mohamed
- Kraus Sigurd
- Kujala Paula
- Kujawa Magda L
- Kulkarni Ravi
- Kumar M
- Kumar Rajeev
- Kunkler Ian H
- Kynaston H
- Kynaston Howard
- Lachlan Katherine L
- Laing Robert
- Lalloo Fiona
- Lancashire M
- Lane Athene
- Langley Stephen E M
- Laniado Marc
- Larner T R
- Lau Maurice W
- Lawrence W T
- Lawson Anne
- Le Roux Pieter J
- Leader Mary
- Lee A
- Lee J O
- Lee L
- Lemburger R John
- Lennon Teresa
- Leone Priscilla
- Leongamornlert Daniel
- Lester Jason
- Leung Hing
- Lewis D Christopher
- Lewis J
- Li Qiuyan
- Lim Hui-Yi
- Lin Hui-Yi
- Liston Thomas
- Livni Naomi
- Livsey Jacqueline
- Lloyd S
- Locke Imogen
- Lodge Richard
- Logue John
- Longmuir Mark
- Lophatananon Artitaya
- Lophatonanon Artitaya
- Lubinski Jan
- Lucas Malcolm G
- Luedeke Manuel
- Luscombe C J
- Lydon Anna
- Lynch Michael
- Lynn Naing N K
- Lyons Norma
- MacDermott James P A
- Macdonagh Ruaraidh P
- Macdonald [Unknown]
- Madaan Sanjeev
- Madhava Kudingila R
- Maeaettaenen Liisa
- Maguire Joseph
- Maher E R
- Mahmood Rana
- Maia Sofia
- Maier Christiane
- Mair Graeme H M
- Malone Greg
- Malone Peter R
- Mangar Stephen A
- Mantle Mark
- Mark I
- Marsden Gemma
- Mason M D
- Mason Malcolm
- Mason Robert
- Matanhelia [Unknown]
- Matenhelia Shyam
- Matthews Philip N
- McAleese J
- McBride Donna
- Mcdonnell Shannon K
- McDonnell Shannon K
- McFarlane Jonathan
- McGrath [Unknown]
- McIlhenny Craig
- McInerney Paul
- McIntosh Gregor
- McKinna F
- McLaren Duncan
- McLarty Esther
- McMenemin Rhona
- McNeill Alan
- McNicholas T A
- Meddings Robert N
- Mee A David
- Melcher Lucinda
- Memon [Unknown]
- Menzes Pravin
- Michael Agnieszka
- Miller Marek
- Mills Robert
- Mitchell S
- Mitev Vanio
- Mithal Natasha
- Mitkova Atanaska
- Mitra Anita
- Mobb Gillian E
- Moffat Leslie E F
- Mokete [Unknown]
- Money-Kyrle Julian
- Montgomery Bruce
- Moody Hilary
- Moody Martin P
- Morgan Angela
- Morley Roland
- Morris Sean B
- Morrison Patrick
- Mort Diana
- Mostafid Amir H
- Motiwala Hanif
- Mufti Gulzar
- Muir Gordon
- Muir Kenneth
- Mumtaz Faiz
- Murphy Michael
- Murray Alexandra
- Murray Keith W
- Murrell Shirley
- Murtola Teemu
- Muthukumar D
- Naerger Harry
- Namasivayam Siva
- Nargund Vinod
- Nawrocki [Unknown]
- Neal David E
- Neilson Donald
- Nethersell A
- Newby Jacqueline C
- Newman Hugh
- Newton R
- Nielsen Sune F
- Nordestgaard Børge G
- O'Boyle P J
- O'Brien J
- O'Brien Tim S
- O'Donnell H
- O'Donoghue E
- O'Donoghue Neil
- O'Reilly P
- O'Rourke J S
- O'Sullivan Joe
- O'Sullivan Patricia
- Oakley Neil
- Ogden Chris
- Ohja Hemant
- Oliver Tim
- Omara Tracy
- Ong Eng K
- Osborn David
- Ostler Peter
- Owen J
- Palfrey Edward
- Panades Miguel
- Panakis Niki
- Pancharatnam M
- Pandha Hardev
- Pantelides Michalakis L
- Panwar U
- Parikh Omi
- Park Hyun
- Park Jong Y
- Parker Chris
- Parker Christopher H
- Parys Bohdan T
- Pascoe Sarah
- Pashayan Nora
- Patel Anup
- Paterson Joan
- Pathack S
- Pati Jhumur
- Patterson Helen
- Pattu [Unknown]
- Paul A
- Paul Alan
- Paulo Paula
- Payne Heather
- Peake David
- Pedersen John
- Pedley I
- Pengelly A
- Peracha Amjad M
- Perry Matthew
- Persad Raj
- Peters John
- Pharoah Paul
- Philp N H
- Philp T
- Pickering Lisa M
- Pigott Katharine
- Pinto Pedro
- Plail R
- Plowman P Nicholas
- Pocock Richard D
- Pope A J
- Popert Rick
- Popov Elenko
- Porter Tim
- Potter John M
- Pow-Sang Julio
- Powell Christopher
- Powell Philip
- Powles Thomas B
- Prasad Krishna
- Prasad Seshadri Sri
- Prejbisz J W
- Prescott Stephen
- Protheroe Andrew
- Qureshi Khaver N
- Raby Nigel
- Radlein Selina
- Ragavan Narasimhan
- Raju Palaniappa G S
- Ramachandra Prakash B
- Raman R
- Rane Abhay
- Rankin Julia
- Rao Y
- Ratan Hari L
- Ravi Ramachandran
- Ravishankar K
- Read [Unknown]
- Reddy Paul J
- Rimington Peter R
- Rinckleb Antje
- Rincon Maria
- Riska Shaun
- Ritchie Peter A
- Roberts J Trevor
- Robertson Andrew
- Robinson Angus
- Robinson Anne C
- Robinson Lee Q
- Rochester Mark A
- Roder Andreas
- Rogers P B
- Rosario Derek
- Rosenbaum Tomas P
- Rothwell Neil
- Rowbotham Carl
- Rowe [Unknown]
- Rowley Kathryn
- Ruddy Deborah
- Rundle John
- Russell John M
- Ryan P G
- Sabharwal A
- Saggar Anand K
- Samanci Ali
- Sangar Vijay K
- Santos Joana
- Saunders Edward J
- Saunders Pamela
- Sawyer Emma J
- Saxby M F
- Schaid Daniel J
- Schleutker Johanna
- Schumacher Fredrick
- Schwaibold Hartwig
- Scoble John E
- Scrase Christopher
- Selim [Unknown]
- Sellers Thomas
- Sells Henry
- Sethia Krishna K
- Severi Gianluca
- Shackley David C
- Shaffer [Unknown]
- Shah Nihil
- Shakespeare D
- Shanley Sue
- Sharma Neerah K
- Sheehan Denise J
- Sherwin Elizabeth
- Shum Poh Lin
- Side Lucy
- Sidek Norma
- Signorello Lisa B
- Sikora Karol
- Simcock R
- Sinclair Andrew M
- Singh Pravin
- Siva M
- Slavov Chavdar
- Smith James
- Smith Michael F
- Sokal Michael
- Sole Graham M
- Southey Melissa C
- Speakman Mark J
- Spiers Alexander
- Spurdle Amanda
- Sreenivasan Thiagarajan
- Srihari Narayanan N
- Srinivasan [Unknown]
- Sriram Rajagopalan
- Staffurth John N
- Stanford Janet L
- Stattin Paer
- Stegmaier Christa
- Stephens Sarah
- Stewart D
- Stockdale Andrew
- Stott Mark A
- Stower M J
- Strachan John R
- Stuart Nicholas S A
- Sugden Elaine
- Summerton Duncan
- Sundar Santhanam
- Sundaram S K
- Suresh Gokarakonda
- Susnerwala Shabbir
- Swami Kuchibhotla S
- Symons Stephanie J
- Syndikus Isabel
- Taari Kimmo
- Tahir Saad
- Tammela Teuvo L
- Tammela Teuvo L J
- Tanquay J
- Taylor J W
- Taylor John W
- Teixeira Manuel R
- Terry T
- Thibodeau Stephen N
- Thomas Robert J
- Thomas Stephen A
- Thompson Alan
- Thompson Pauline
- Thomson Alastair H
- Thurston A
- Tidball Sarah
- Tillmans Lori
- Tilsley Owen
- Tindall Stuart F
- Tipples K
- Tong [Unknown]
- Toussi Hamid
- Toy Elizabeth W
- Travis Ruth C
- Trembath Richard C
- Tulloch David N
- Turner Kevin J
- Turner Megan
- Tweedle James
- Tymrakiewicz Malgorzata
- Tyrell C J
- Umez-Eronini N
- Urwin Graeme H
- Vale Justin A
- Van As [Unknown]
- Van As Nicholas
- Vasanthan Subramaniam
- Vesey Sean
- Vilarino-Varela Maria
- Violet John
- Virdi Jaspal
- Viñuela Ana
- Vlahova Aleksandrina
- Vogel Walther
- Wade Robert
- Wahlfors Tiina
- Waite Katherine
- Walker E M
- Walker Roger
- Wallace David M A
- Wallinder Hans
- Wang Liang
- Watkin Nicholas A
- Watson M E
- Waxman J H
- Waymont Brian
- Weaver Andrew
- Webb Ralph J
- Wedderburn Andrew
- Weischer Maren
- Wells Paula
- Wemyss-Holden G D
- Weston P M T
- Wheatley Duncan
- Whelan P
- Whillis D
- Whitmore Ian
- Wiklund Fredrik
- Wilde Adam D
- Wiles Vicki
- Wilkins Marie
- Wilkinson Rosemary
- Williams John H
- Williams Simon
- Willis Michael
- Wills Michael I
- Wilson J R
- Wilson Richard
- Winkler Mathias H
- Wise Marcus
- Wokozorczyk Dominika
- Wokołorczyk Dominika
- Wood Glenn
- Woodhams Simon
- Woodhouse C
- Woodward Cathryn
- Woolf [Unknown]
- Woolfenden K A
- Worlding Jane
- Wright Mark
- Wu Huihai
- WYLIE [Unknown]
- Wylie James P
- Wynne Chris
- Yeadon Trina
- Zachariah Babu
- Zang Angelika
- Zarkar A
- Zheng Wei
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2015
- Field of study
Genome-wide association studies (GWAS) have identified numerous common prostate cancer (PrCa) susceptibility loci. We have
fine-mapped 64 GWAS regions known at the conclusion of the iCOGS study using large-scale genotyping and imputation in
25 723 PrCa cases and 26 274 controls of European ancestry. We detected evidence for multiple independent signals at 16
regions, 12 of which contained additional newly identified significant associations. A single signal comprising a spectrum of
correlated variation was observed at 39 regions; 35 of which are now described by a novel more significantly associated lead SNP,
while the originally reported variant remained as the lead SNP only in 4 regions. We also confirmed two association signals in
Europeans that had been previously reported only in East-Asian GWAS. Based on statistical evidence and linkage disequilibrium
(LD) structure, we have curated and narrowed down the list of the most likely candidate causal variants for each region.
Functional annotation using data from ENCODE filtered for PrCa cell lines and eQTL analysis demonstrated significant
enrichment for overlap with bio-features within this set. By incorporating the novel risk variants identified here alongside the
refined data for existing association signals, we estimate that these loci now explain ∼38.9% of the familial relative risk of PrCa,
an 8.9% improvement over the previously reported GWAS tag SNPs. This suggests that a significant fraction of the heritability of
PrCa may have been hidden during the discovery phase of GWAS, in particular due to the presence of multiple independent
signals within the same regio
Finishing the euchromatic sequence of the human genome
- Author
- . Haifeng
- . Magner
- . Yin
- Abbott Scott
- Abbott-Ozersky Amanda
- Abdellah Zahra
- Abouelleil Amr
- Abrajano Anne
- Adachi Tamami
- Adam Catherine
- Adams Charles Q.
- Adamson Aaron
- Adekoya Emmanuel
- Adio-Oduola Babajide
- Aerts Andrea
- Aggarwal Arun
- Ahmadi Alireza
- Ahmed Shahana
- Aimable Matthew
- Ainscough Rachael
- Ait-Zahra Mostafa
- Aizu Tomoyuki
- Alcivare Dana
- Alegria Michelle
- Ali Alla
- Ali Johar
- Allegria-hartmann Michelle
- Alleman Jennifer
- Allen Carlana C.
- Allen Heather
- Allen Nicole R.
- Allen Susan
- Allen Thaddeus
- Almeida Jeff
- Almond Claire
- Alsbrooks Stephen L.
- Altherr Michael R.
- Amaratunge Harshinie C.
- Ambler Andrew
- Ambrose Karen
- Ambrose Kerrie
- Amemiya Chris
- Amico-Keller Gina
- Amin Amita G.
- Anderson Mechele
- Anderson Scott
- Anderson Scott
- Andora Janice
- Andredesz Carol
- Andrew Robert
- Andrews Dan
- Andrews Daniel
- Andrews Neil
- Andrews Stephanie
- Andriese Tim
- Anthouard Véronique
- Antonarakis Stylianos E.
- Anyalebechi Vivian
- Aoki Norie
- Apostolou Sinoula
- Apweiler Eva
- Arachchi Harindra
- Arai Rie
- Arbery Hazel
- Arcaina Marlon
- Arcaina Terisita
- Archer Beth
- Arellano Andre
- Arellano-Jones Perry
- Armbruster Jeff
- Armstrong Jon
- Arredondo Dilrukshi P.
- Arredondo Heather Hope
- Artiguenave François
- Asakawa Shuichi
- Asakawa Teruyo
- Ash Gareth
- Ashcroft Kevin
- Ashurst Jennifer
- Ashwell Robert
- Ashworth Linda K.
- Aslanidis Cara
- Asomugha Chinwe O.
- Asuncion Lawreen
- Atkin Deborah
- Atkinson Andrea
- Atkinson Barry
- Attix Cristina
- Attwood John
- Aubin Keith
- Auger Katherine
- Austin Shannon Michelle
- Avila Aaron
- Avis Terry
- Ayele Mulu
- Babayan Primo
- Babbage Anne
- Babbage Sarah
- Bach Phil
- Bachatsang Pasang
- Bacon Joanne
- Badri Hummy
- Baertsch Robert
- Bagguley Claire
- Bailey Jonathan
- Bajorek Eva
- Baker Andrew
- Baker Dan
- Baker M.
- Baker Richard
- Bakis Michele
- Baldwin Jennifer
- Banda Michael
- Banerjee Ruby
- Bao Jingyue
- Bao Qiyu
- Bao Weidong
- Bao Weidong
- Baptiste Pertrice
- Barbaria Joseph A.
- Barbe Valérie
- Bardill Simon
- Barker Daniel
- Barker Darren
- Barker Gary
- Barlow Karen
- Baron Laurent
- Barrett Anika
- Bartlett Rebecca
- Basham Victoria
- Bashman David
- Basu Suba
- Bateman Alex
- Bates Karen
- Battles John
- Batzer Mark
- Baumgart Cornelia
- Baumohl Jason
- Baynes Caroline
- Bayul Tashi
- Beall Keith
- Beard Lisa
- Beard Susan
- Beare David
- Beasley Alastair
- Beasley Helen
- Beasley Oliver
- Beaucham Leslie
- Beaudet Arthur
- Beck Alfred
- Beck Stephen
- Becker Michael
- Bell Emma
- Bell George I.
- Bellard Terell M.
- Bellerby Damian
- Bellerby Tristram
- Belter Edward A., Jr.
- Bemrose Richard
- Benard Michael Anthony
- BenKahla Alia
- Benke J
- Benner William
- Bennett James
- Bensasson Douda
- Bentley Andrew
- Bentley Dan
- Bentley David
- Berardinis Véronique de
- Bercovitz John
- Berghoff Amy
- Bergmann Anne
- Berkowicz Nicolas
- Berks Mary
- Berks Michael
- Bethel Graeme
- Beugelsdijk Tony J.
- Bhakta Rita
- Bhuchar Venita
- Bi Shihua
- Bian Xuemeng
- Bieri Tamberlyn
- Bimage Kesha E.
- Bird Christine
- Birditt Brian
- Birney Ewan
- Birney Ewan
- Birren Bruce
- Bissell Helen
- Biswalo Kaneza
- Bituin Aleksandr
- Black Stacey
- Blackburne-Maze Suzanne
- Blair Jessica Anne
- Blakey Sarah
- Blanks Tia
- Blasiar Darin
- Blazej Robert
- Blitshsteyn Berta
- Blomstrom David B.
- Bloom Scott
- Bloom Toby
- Blumer Heather
- Blye Jason
- Blyth Peter R.
- Blöcker Helmut
- Boatright Elizabeth
- Boehm John
- Boen Juanan
- Boguslavskiy Leonid
- Bolton Christel
- Bolund Lars
- Bondoc Marnel
- Bonfield James
- Bonnett Ralph
- Bonnin David
- Border Richard
- Borowsky Mark
- Borzym Katja
- Boukhgalter Boris
- Bowen Eric
- Bradley Amanda
- Bradshaw-Cordum Holly
- Brady Nicola
- Brandriff Brigitte F.
- Brannon Wade
- Branscomb Elbert
- Bray Jason
- Bray-Allen Sarah
- Brettin Thomas
- Bridgeman Anne
- Bridgers Michael
- Brimhall Angela K.
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- Hitchens Matthew Edward
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- Krawczyk Marie-Claude
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- Kremmidiotis Gabriel
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- Kruchowski Scott S.
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- Mariano Marisa
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- Mark Graham A.
- Marquis-Homeyer Catherine
- Marr Thomas G.
- Marra Marco
- Marriott Neil
- Marrone Anne
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- Matthews Charles D.
- Matthews Lucy
- Matthews Nick
- Matthews Paul
- Matthews Sterling D.
- Mauceli Evan
- Maunes Cynthia
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- McLay Kirsten
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- McMurray Amanda
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- Mejima Mio
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- Mercer Simon
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- Mungall Andy
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- Murayama Yuji
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- Yoon Vivienne
- Yoshida Satoru
- You Bo
- Young Geneva
- Young Louise
- Young Shelia
- Younger Ruth
- Yu Bing
- Yu Charles
- Yu Fuli
- Yu Jun
- Yu Jun
- Yu Jun
- Yuan Kaiwen
- Yuan Ye
- Yuan Yida
- Yue Shujie
- Yumae Brian
- Yun Rui
- Zainoun Joanne
- Zembeck Lisa
- Zeng Yixin
- Zhai Dong
- Zhan Guoping
- Zhang Bo
- Zhang Caimin
- Zhang Fengmei
- Zhang Guangyu
- Zhang Guohua
- Zhang Guohua
- Zhang Haiqing
- Zhang Haiqing
- Zhang Haiqing
- Zhang Hongbo
- Zhang Hongbo
- Zhang Jingjing
- Zhang Jingjing
- Zhang Jingkun
- Zhang Jiuchun
- Zhang Jiuchun
- Zhang Lanzhi
- Zhang Li
- Zhang Li
- Zhang Meihua
- Zhang Meng
- Zhang Ming
- Zhang Qing
- Zhang Ruhua
- Zhang Shaojie
- Zhang Tiezhen
- Zhang Wei
- Zhang Wei
- Zhang Xianglin
- Zhang Xianglin
- Zhang Xiaoliang
- Zhang Xiuqing
- Zhang Yan
- Zhang Yi
- Zhang Yilin
- Zhang Yilin
- Zhang Ying
- Zhang Yuansen
- Zhang Yuzhi
- Zhang Zhengdong
- Zhao Hongmei
- Zhao Lijian
- Zhao Shenru
- Zhao Zhijing
- Zhen Zhicheng
- Zheng Haibo
- Zhong Ming
- Zhou Carol
- Zhou Haixia
- Zhou Jianling
- Zhou Nannan
- Zhou Xinfeng
- Zhou Yan
- Zhou Yang
- Zhou Yi
- Zhu Bingying
- Zhu Bofeng
- Zhu Fenghua
- Zhu Genfeng
- Zhu Genfeng
- Zhu Miao
- Zhu Ning
- Zhu Yongge
- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
Multiple loci on 8q24 associated with prostate cancer susceptibility
- Author
- Abrams Paul H
- Adamson Andrew
- Adeyoju A
- Afzal N
- Ahiaku Ernest K. N
- Ahmed Munir
- Al Olama Ali Amin
- Al-Samerraie
- Alcock Christopher
- Anderson John
- Andrews Henry
- Andrews Steven
- Anjum Iqbal
- Anson Ken
- Apakama Ike
- Aparcia F
- Archbold J. A. A
- Ardern-Jones Audrey T
- Ash D
- Ashford Richard F. U
- Badenoch David
- Bahl Amit
- Bailey Karen
- Bailey M. J
- Ball Andrew J
- Bancroft E
- Banerjee G
- Barber Jim
- Barber N
- Baria
- Barnes Douglas G
- Barwell Julian
- Basu Pradip
- Bates Christopher A
- Bax N. A
- Baxter-Smith D
- Beacock Christopher
- Beaney Ronald P
- Beard Ralph
- Beck Rupert
- Beese Gail
- Beesley Sharon
- Bellringer James
- Benson Richard
- Bhatt R. I
- Birch Brian
- Birtle Alison
- Bishop M
- Biyani C. Shekhar
- Blacklock A. R. E
- Blades Rosemary
- Bloomfield David J
- Bollina Prasad
- Bonnington Sue
- Booth C. M
- Bose Pradeep
- Bottomley David
- Boucher Nigel R
- Bower Mark
- Bowsher W. G
- Boyd P. J. R
- Bramble F. James
- Brewster Simon F
- Briggs Tim
- Brock Cathryn
- Brock Sue
- Brough Richard
- Brown Paul M
- Brown Richard
- Brown Stephen
- Browning Tony J
- Butterworth Paul C
- Cahill D
- Callaghan P. S
- Calman Frances
- Campbell Alister
- Carnell Dawn M
- Carr T. W
- Carter Adam
- Carter Charles J. M
- Carter Simon
- Castle Bruce M
- Chadwick David
- Chakraborti P
- Charig C
- Chetiyawardana Anula D
- Chilton Christopher
- Chinegwundoh Francis I
- Chong Irene
- Chow Wai-Man
- Christmas Timothy J
- Churn Mark J
- Clarke Noel W
- Coe M
- Cohen N. P
- Coker C
- Cole David J
- Cole O
- Cole Trevor
- Collins Gerald
- Collinson Matthew
- Conn I
- Connell C
- Cooke Peter
- Coombs L
- Cooper Colin
- Cooper Debbie
- Copland Robert F
- Cornaby Andrew J
- Cornford P. A
- Corolis
- Corr John
- Costello C. B
- Cowan Richard
- Cox Robert
- Coyle C
- Crisp John C
- Cruger Dorthe
- Crundwell Malcolm
- Cummings
- Dahar Nazeer
- Daruwala Pallon
- Datta Shibendra
- Davidson S
- Davies Joseph
- Davis Michael
- Davison Owen W
- Dawkins Guy
- Dawson Chris
- De Bolla Alan R
- Dearnaley David P
- Desai Ken M
- Deutsch George P
- Dick John
- Dickinson Andrew J
- Dickson Jeanette
- Dinneen Michael
- Dixit Sanjay
- Dobbs H. Jane
- Doble Andrew
- Dodds David
- Doherty Alan
- Donaldson P
- Donovan Jenny L
- Douglas S. Fiona
- Drake
- Duchesne Gill M
- Duffy Peter
- Dunn Michael
- Dunsmuir W. D
- Durkan Garrett
- Easton Douglas F
- Eccles Diana
- Eden C. D
- Eeles Rosalind A
- El-Modir A
- Elkabir Jeremy
- Elliott Emma
- Ellis B. W
- Ellis R
- Elves Andrew W. S
- Elwell Christine
- Emberton Mark
- Emmerson Louise
- English Dallas R
- Errington R. D
- Evans D. Gareth
- Falconer Alison
- Fawcett Derek
- Featherston C
- Feggetter Jeremy
- Ferguson C
- Fermont D
- Ferro Michael
- Fletcher Matthew
- Folkes A
- Ford Trevor F
- Frim Olivera
- Gallegos Christopher
- Gelister James S
- George Anne
- Gibbs Stephanie
- Gilbert Hugh
- Giles Graham G
- Gillatt David
- Glaholm John
- Glass Jonathan M
- Glenister James
- Goode Thomas D
- Gordon E. M
- Gower Richard L
- Graham John
- Green Damian
- Greenland Jonathan
- Grieve Robert
- Griffiths Thomas R. L
- Gurun Riza Murat
- Guy Michelle
- Guy Peter J
- Hall Amanda L
- Hamdy F. C
- Hamilton C
- Hammonds John
- Hampson S. J
- Hanbury Damien C
- Hardman P. D. John
- Harland Stephen J
- Harney John M
- Harper Peter
- Harrison G. S. M
- Harriss D. R
- Harvey-Hills N
- Hawkyard Simon
- Heath Catherine M
- Hehir Michael
- Hendry David
- Henley Mike
- Herbert Pippa
- Hickish Tamas
- Hindmarsh John R
- Ho Edwin T. S
- Hodgson Shirley
- Holden David
- Holding Peter
- Hollins Graham W
- Holmes Simon A. V
- Hopper John L
- Horwich Alan
- Hoskin Peter
- Howell Graham P
- Howson Joanne
- Hrouda D
- Huddart Robert
- Hudson Liz
- Hughes Michael
- Hughes Owen
- Hughes Rob
- Humber Caroline
- Iacovou John W
- Ibrahim A
- Inglis John A
- Irving Stuart
- Irwin C
- Izatt Louise
- Izegbu Victor
- James Michael J
- James Michael J
- James R. Lester
- Javle Pradip
- Jenkins P
- Jhavar Sameer
- Jones Chris R
- Jones David A
- Jones Gareth
- Jones Mandy
- Joss Shelagh
- Kaisary Amir
- Karim O
- Karp Stephen J
- Keeley F. X
- Kelkar Anand R
- Kelleher J. P
- Kenwrick Sue
- Khan F
- Khoo Vincent
- Kirby Roger S
- Kirk David
- Kirkbride Peter
- Kirollos Magdi M
- Kockelbergh Roger
- Koreich O
- Kote-Jarai Zsofia
- Kourah Mohamed
- Kulkarni Ravi
- Kumar M
- Kunkler Ian H
- Kynaston Howard
- Laing Robert
- Lalloo Fiona
- Lancashire M
- Langley Stephen E. M
- Laniado Marc
- Larner T. R
- Lau Maurice W
- Lawrence W. T
- Lawson Anne
- Le Roux Pieter J
- Leader Mary
- Lee A
- Lee J. O
- Lee L
- Lemburger R. John
- Lennon Teresa
- Leone Priscilla
- Leongamornlert Daniel A
- Lester Jason
- Leung Hing
- Lewis D. Christopher
- Lewis J
- Liston Thomas
- Livsey Jacqueline
- Lloyd S
- Locke Imogen
- Lodge Richard
- Logue John
- Longmuir Mark
- Lophatananon Artitaya
- Lucas Malcolm G
- Luscombe C. J
- Lydon Anna
- Lynch Michael
- Lyons Norma
- MacDermott James P. A
- Macdonagh Ruaraidh P
- Maher E. R
- Mahmood Rana
- Mair Graeme H. M
- Malone Peter R
- Mark I
- Marsden Gemma
- Mason M. D
- Mason Robert
- Matenhelia Shyam
- Matthews Philip N
- McBride Donna
- McFarlane Jonathan
- McGrath John
- McInerney Paul
- McIntosh Gregor
- McKinna F
- McLaren Duncan
- McMenemin Rhona
- McNicholas T. A
- Meddings Robert N
- Mee A. David
- Memon
- Menzes Pravin
- Mills Robert
- Mitchell S
- Mithal Natasha
- Mitra Anita
- Mobb Gillian E
- Moffat Leslie E. F
- Mokete Moeketsi
- Money-Kyrle Julian
- Montgomery Bruce
- Moody Hilary
- Morley Roland
- Morris Sean B
- Morrison Jonathan
- Morrison Patrick
- Mort Diana
- Mostafid Amir H
- Motiwala Hanif
- Mufti Gulzar
- Muir Gordon
- Muir Kenneth R
- Mumtaz Faiz
- Murphy Michael
- Murray Alexandra
- Murray Keith W
- Murrell Shirley
- Muthukumar D
- Naerger Harry
- Namasivayam Siva
- Nargund Vinod
- Nawrocki Jan
- Neal David E
- Neilson Donald
- Nethersell A
- Newman Hugh
- Newton R
- O'Boyle P. J
- O'Brien J
- O'Brien Tim S
- O'Donoghue E
- O'Donoghue Neil
- O'Reilly P
- O'Rourke J. S
- O'Sullivan Joe
- Oakley Neil
- Ogden Chris
- Ohja Hemant
- Oliver Tim
- Osborn David
- Ostler Peter
- O’Brien Lynne T
- Palfrey Edward
- Panades Miguel
- Pancharatnam M
- Pantelides Michalakis L
- Parikh Omi
- Parker Chris
- Parker Christopher C
- Parker Christopher H
- Parys Bohdan T
- Pascoe Sarah
- Patel Anup
- Patterson Helen
- Payne Heather
- Peake David
- Pedley I
- Pengelly A
- Peracha A. M
- Perry Matthew
- Persad Raj
- Philp N. H
- Philp T
- Pigott Katharine
- Plail R
- Plowman P. Nicholas
- Pocock Richard D
- Pope A. J
- Popert Rick
- Porter Tim
- Powell Christopher
- Powell Philip
- Prasad Krishna
- Prejbisz J. W
- Prescott Stephen
- Protheroe Andrew
- Qureshi Khaver N
- Ragavan Narasimhan
- Rankin Julia
- Rao Y
- Ravi Ramachandran
- Read Graham
- Reddy Paul J
- Rimington Peter R
- Roberts J. Trevor
- Robertson Andrew
- Robinson Angus
- Robinson Anne C
- Robinson Lee Q
- Rogers P. B
- Rowbotham Carl
- Rowe Edward
- Rowley Kathryn
- Rundle John
- Russell John M
- Ryan P. G
- Saggar Anand K
- Samanci Ali
- Saunders Ed
- Sawyer Emma
- Saxby M. F
- Schwaibold Hartwig
- Scoble John E
- Scrase Christopher
- Sells Henry
- Sethia Krishna K
- Severi Gianluca
- Shah Nihil
- Shanley Sue
- Sharma Neerah K
- Sheehan Denise J
- Sherwin Elizabeth
- Shum L
- Simcock R
- Singh Pravin
- Siva M
- Smith James
- Smith Michael F
- Sokal Michael
- Sole Graham M
- Southey Melissa C
- Speakman Mark J
- Sreenivasan Thiagarajan
- Srihari Narayana N
- Srinivasan
- Sriram Rajagopalan
- Stewart D
- Stockdale Andrew
- Stott Mark A
- Stower M. J
- Strachan John R
- Subramonian K
- Sugden Elaine
- Sundar Santhanam
- Sundaram S. K
- Suresh Gokarakonda
- Susnerwala Shabbir
- Swami Kuchibhotla S
- Syndikus Isabel
- Tahir Saad
- Taylor John W
- Terry T
- Thomas Robert J
- Thomas Stephen A
- Thompson Alan
- Thompson Pauline
- Thomson Alastair H
- Thurston A
- Tilsley Owen
- Tindall Stuart F
- Tong
- Trembath Richard C
- Tulloch David N
- Tweedle James
- Tymrakiewicz Malgorzata
- Tyrell C. J
- Urwin Graeme H
- Van As Nicholas
- Vesey Sean
- Violet John
- Virdi Jaspal
- Waite Katherine
- Walker E. M
- Walker Roger
- Wallace David M. A
- Watkin Nicholas A
- Watson M. E
- Waxman J. H
- Waymont Brian
- Weaver Andrew
- Webb Ralph, J
- Wedderburn Andrew
- Wells Paula
- Wemyss-Holden G. D
- Weston P. M. T
- Wheatley Duncan
- Whelan P
- Whillis D
- Wiles Vicki
- Wilkins Marie
- Wilkinson Rosemary A
- Williams John H
- Williams Simon
- Willis Michael
- Wilson J. R
- Wilson Richard
- Wise Marcus
- Woodhams Simon
- Woodhouse C
- Woolfenden K. A
- Worlding Jane
- Wright Mark
- Wylie James P
- Wynne Chris
- Zang Angelika
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2009
- Field of study
Previous studies have identified multiple loci on 8q24 associated with prostate cancer risk. We performed a comprehensive analysis of SNP associations across 8q24 by genotyping tag SNPs in 5,504 prostate cancer cases and 5,834 controls. We confirmed associations at three previously reported loci and identified additional loci in two other linkage disequilibrium blocks (rs1006908: per-allele OR = 0.87, P = 7.9 x 10(-8); rs620861: OR = 0.90, P = 4.8 x 10(-8)). Eight SNPs in five linkage disequilibrium blocks were independently associated with prostate cancer susceptibility
Identification of seven new prostate cancer susceptibility loci through a genome-wide association study
- Author
- Abrams Paul H
- Adamson Andrew
- Adeyoju A
- Afzal N
- Ahiaku Ernest K. N
- Ahmed Munir
- Aitken Joanne
- Al Olama Ali Amin
- Al-Samerraie Dr
- Alcock Christopher
- Anderson John
- Andrews Henry
- Andrews Steven
- Anjum Iqbal
- Anson Ken
- Apakama Ike
- Aparcia F
- Archbold J. A. A
- Ardern-Jones Audrey T
- Arrand John
- Ash D
- Ashford Richard F. U
- Auvinen Anssi
- Badenoch David
- Bagnato Melisa
- Bahl Amit
- Bailey Karen
- Bailey M. J
- Ball Andrew J
- Bancroft E
- Banerjee G
- Banks Annette
- Barber Jim
- Barber N
- Baria Dr
- Barnes Douglas G
- Barrett Sandra
- Barwell Julian
- Basu Pradip
- Bates Christopher A
- Batra Jyotsna
- Bax N. A
- Baxter-Smith D
- Beacock Christopher
- Beaney Ronald P
- Beard Ralph
- Beck Rupert
- Beese Gail
- Beesley Sharon
- Belcheva Olga
- Bellringer James
- Benson Richard
- Bhatt R. I
- Biedermann Cédric
- Bieri Sabine
- Birch Brian
- Birtle Alison
- Bishop M
- Biyani C. Shekhar
- Blacklock A. R. E
- Blades Rosemary
- Blizzard Leigh
- Bloomfield David J
- Bollina Prasad
- Bonnington Sue
- Booth C. M
- Bose Pradeep
- Bottomley David
- Boucher Nigel R
- Bower Mark
- Bowsher W. G
- Boyd P. J. R
- Bradley Sita Ann
- Bramble F. James
- Bremer Michael
- Brewster Simon F
- Briggs Tim
- Brock Cathryn
- Brock Sue
- Brough Richard
- Brown Paul M
- Brown Richard
- Brown Stephen
- Browning Tony J
- Brugger Margot
- Butorac Kate
- Butterworth Paul C
- Cahill D
- Callaghan P. S
- Calman Frances
- Campbell Alister
- Cannon-Albright Lisa
- Cao Guangwen
- Carnell Dawn M
- Carr T. W
- Carter Adam C
- Carter Charles J. M
- Carter Simon
- Castle Bruce M
- Chadwick David
- Chakraborti P
- Challis David
- Chambers Suzanne
- Chang Wen-Jun
- Chappuis Pierre O
- Charig C
- Chetiyawardana Anula D
- Chilton Christopher
- Chinegwundoh F. I
- Chong Irene
- Chow Wai-Man
- Christmas Tim
- Christova Svetlana
- Churn Mark J
- Clarke Noel W
- Clements Judith
- Coe M
- Cohen N. P
- Coker C
- Cole David J
- Cole O
- Cole Trevor
- Collins Gerald
- Collinson Matthew
- Conn I
- Connell C
- Cooke Peter
- Coombs L
- Coomes Margerie
- Cooney Kathleen A
- Cooper Colin S
- Cooper Debbie
- Copland Robert F
- Cornaby Andrew J
- Cornford P. A
- Corolis Mr
- Corr John
- Corral Roman
- Costello C. B
- Cowan Richard
- Cox Angela
- Cox Robert
- Coyle C
- Crisp John C
- Cruger Dorthe
- Crundwell Malcolm
- Cummings Mr
- Cunningham Julie
- Dahar Nazeer
- Daruwala Pallon
- Datta Shibendra
- Davidson S
- Davies Joseph
- Davis Michael
- Davison Owen W
- Dawkins Guy
- Dawson Chris
- De Bolla Alan R
- Dearnaley David P
- Defabiani Nicolas
- Desai Ken M
- Deutsch George P
- Dick John
- Dickinson Andrew J
- Dickinson Joanne L
- Dickson Jeanette
- Dikov Tihomir
- Dinneen Michael
- Dixit Sanjay
- Dobbs H. Jane
- Doble Andrew
- Dodds David
- Dodova Rumjana
- Doherty Alan
- Donaldson P
- Donovan Jenny L
- Dork Thilo
- Douglas S. Fiona
- Drake Mr
- Dubrowinskaja Natalia
- Duchesne Gill M
- Duffy Peter
- Dunn Michael
- Dunsmuir W. D
- Durkan Garrett
- Easton Douglas F
- Eccles Diana
- Eden C. D
- Edwards Stephen M
- Eeles Rosalind A
- El-Modir A
- Elkabir Jeremy
- Elliott Emma
- Ellis B. W
- Ellis R
- Elves Andrew W. S
- Elwell Christine
- Emberton Mark
- Emmerson Louise
- English Dallas R
- Errington R. D
- Evans D. Gareth
- Falconer Alison
- Farnham Jim
- Fawcett Derek
- Featherston C
- Feggetter Jeremy
- Ferguson C
- Ferguson Megan
- Fermont D
- Ferro Michael
- Fisher Cyril
- Fitzgerald Liesel M
- Flanagan Louise
- Fletcher Matthew
- Folkes A
- Foote Simon
- Ford Trevor F
- Foulkes William D
- Frim Olivera
- Gallagher Stephen
- Gallegos Christopher
- Gardiner R. A. (Frank)
- Gelister James S
- George Anne
- Gibbs Stephanie
- Gilbert Hugh
- Giles Graham G
- Gillatt David
- Girardet Christophe
- Glaholm John
- Glass Jonathan M
- Glenister James
- Goode Thomas D
- Gordon E. M
- Gower Richard L
- Graham John
- Green Damian
- Greenland Jonathan
- Grieve Robert
- Griffiths Thomas R. L
- Gurun Riza Murat
- Guy Michelle
- Guy Peter J
- Haiman Christopher A
- Hall Amanda L
- Hamdy Freddie C
- Hamel Nancy
- Hamilton C
- Hammonds John
- Hampson S. J
- Hanbury Damien C
- Hardman P. D. John
- Harland Stephen J
- Harney John M
- Harper Peter
- Harrison G. S. M
- Harriss D. R
- Harvey-Hills N
- Hawkyard Simon
- Heath Catherine M
- Hehir Michael
- Henderson Brian E
- Hendry David
- Henley Mike
- Herbert Pippa
- Herkommer Kathleen
- Hickish Tamas
- Hillemanns Peter
- Hindmarsh John R
- Hinze Kimberly
- Ho Edwin T. S
- Hodgson Shirley
- Holden David
- Holding Peter
- Hollins Graham W
- Holmes Simon A. V
- Hopper John L
- Horwich Alan
- Hoskin Peter
- Hou Jian-Guo
- Howell Graham P
- Howson Joanne
- Hrouda D
- Huddart Robert A
- Hudson Liz
- Hughes Michael
- Hughes Owen
- Hughes Rob
- Humber Caroline
- Hutter Pierre
- Iacovou John W
- Ibrahim A
- Ingles Sue A
- Inglis John A
- Irving Stuart
- Irwin C
- Isotalo Jarkko
- Izatt Louise
- Izegbu Victor
- James Michael J
- James N
- James R. Lester
- Jameson Charles
- Javle Pradip
- Jenkins P
- Jhavar Sameer
- John Esther M
- Johnson Emilie K
- Jones Chris R
- Jones David A
- Jones Gareth
- Jones Mandy
- Joshi Amit D
- Joss Shelagh
- Kachakova Darina
- Kaisary Amir
- Kaneva Radka
- Karim O
- Karp Stephen J
- Karstens Johann H
- Karyadi Danielle M
- Kedda Mary Anne
- Keeley F. X
- Kelham Penelope
- Kelkar Anand R
- Kelleher J. P
- Kenwrick Sue
- Khan F
- Khan Humera
- Khoo Vincent S
- Kirby Roger S
- Kirk David
- Kirkbride Peter
- Kirollos Magdi M
- Kockelbergh Roger
- Kolonel Laurence N
- Konzelmann Isabelle
- Koopmeiners Joseph S
- Koreich O
- Kotar Kimberley
- Kote-Jarai Zsofia
- Kourah Mohamed
- Kuczyk Markus
- Kuefer Rainer
- Kulkarni Ravi
- Kumar M
- Kunkler Ian H
- Kwon Erika M
- Kynaston Howard
- Laing Robert
- Lalloo Fiona
- Lancashire M
- Lange Ethan M
- Langley Stephen E. M
- Laniado Marc
- Larner T. R
- Lau Maurice W
- Lawrence W. T
- Lawson Anne
- Le Marchand Loic
- Le Roux Pieter J
- Leader Mary
- Lee A
- Lee J. O
- Lee L
- Lemburger R .John
- Lennon Teresa
- Leone Priscilla
- Leongamornlert Daniel A
- Lester Jason
- Leung Hing
- Lewis D. Christopher
- Lewis J
- Lewis Sarah J
- Liston Thomas
- Liu Jo-Fen
- Livsey Jacqueline
- Lloyd S
- Locke Imogen
- Lodge Richard
- Logue John
- Longmuir Mark
- Lophatananon Artitaya
- Lose Felicity
- Lu Yong-Jie
- Lucas Malcolm G
- Luedeke Manuel
- Luscombe C. J
- Lydon Anna
- Lynch Michael
- Lyons Norma
- MacDermott James P. A
- Macdonagh Ruaraidh P
- Machtens Stefan
- Maher E. R
- Mahmood Rana
- Maier Christiane
- Mair Graeme H. M
- Malone Peter R
- Mark I
- Marsden Gemma
- Mason M. D
- Mason Robert
- Matenhelia Shyam
- Matikainen Mika
- Matthews Philip N
- Mattila Henna
- McArdle John
- McBride Donna
- McDonnell Shannon K
- McFarlane Jonathan
- McGrath John
- McInerney Paul
- McIntosh Gregor
- McKay James
- McKinna F
- McLaren Duncan
- McMenemin Rhona
- McNicholas T. A
- McWhirter Rebekah
- Meddings Robert N
- Mee A. David
- Meier Marie-Mathilde
- Memon Mr
- Menzes Pravin
- Meyer Andreas
- Mills Robert
- Mitchell S
- Mitev Vanio
- Mithal Natasha
- Mitkova Atanaska
- Mitra Anita
- Mobb Gillian E
- Moffat Leslie E. F
- Mokete Moeketsi
- Money-Kyrle Julian
- Montgomery Bruce
- Montie James E
- Moody Hilary
- Morley Roland
- Morris Sean B
- Morrison Jonathan
- Morrison Patrick
- Mort Diana
- Mostafid Amir H
- Motiwala Hanif
- Mufti Gulzar
- Muir Gordon
- Muir Kenneth
- Mumtaz Faiz
- Murphy Michael
- Murray Alexandra
- Murray Keith W
- Murrell Shirley
- Muthukumar D
- Naerger Harry
- Namasivayam Siva
- Nargund Vinod
- Nawrocki Jan
- Neal David E
- Neilson Donald
- Nelson Colleen
- Nethersell A
- Newman Beth
- Newman Hugh
- Newton R
- Nicol David
- Nikolov Momchil
- O'Boyle P. J
- O'Brien J
- O'Brien Lynne T
- O'Brien Tim S
- O'Donoghue E
- O'Donoghue Neil
- O'Mara Tracy
- O'Reilly P
- O'Rourke J. S
- O'Sullivan Joe
- Oakley Neil
- Ogden Chris
- Ohja Hemant
- Oliver Tim
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- Spurdle Amanda
- Sreenivasan Thiagarajan
- Srihari Narayanan N
- Srinivasan Mr
- Sriram Rajagopalan
- Stalder Michèle
- Stanford Janet L
- Stankovich James
- Stefflova Klara
- Stenman Ulf-Håkan
- Stern Mariana C
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- Stockdale Andrew
- Stott Mark A
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- Strachan John R
- Subramonian K
- Sugden Elaine
- Sundar Santhanam
- Sundaram S. K
- Suresh Gokarakonda
- Surowy Harald
- Susnerwala Shabbir
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- Syndikus Isabel
- Tahir Saad
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- Thomson Russell
- Thurston A
- Tilsley Owen
- Tindall Stuart F
- Tong Dr
- Trembath Richard C
- Tulloch David N
- Tweedle James
- Tymrakiewicz Malgorzata
- Tyrell C. J
- Urwin Graeme H
- Van As Nicholas
- VandenBergh Patrica
- Vesey Sean
- Violet John
- Virdi Jaspal
- Vlahova Aleksandrina
- Vogel Walther
- von Klot Christoph
- Wahlfors Tiina
- Waite Katherine
- Walker Amy
- Walker E. M
- Walker Roger
- Wallace David M. A
- Wang Liang
- Watkin Nicholas A
- Watson M. E
- Waxman J. H
- Waymont Brian
- Weaver Andrew
- Webb Ralph J
- Weber Bärbel
- Wedderburn Andrew
- Wells Paula
- Wemyss-Holden G. D
- Weston P. M. T
- Wheatley Duncan
- Whelan P
- Whillis D
- Wiest Irina
- Wiles Vicki
- Wilkins Marie
- Wilkinson Rosemary A
- Williams John H
- Williams Simon
- Willis Michael
- Wilson J. R
- Wilson Richard
- Wise Marcus
- Woodhams Simon
- Woodhouse Christopher J
- Woolfenden K. A
- Worlding Jane
- Wright Mark
- Wylie James P
- Wynne Chris
- Xu Dan-Feng
- Xu Xing-Xing
- Yaxley John
- Zachariah Babu
- Zakariah Babu
- Zang Angelika
- Zeegers Maurice
- Zeigler-Johnson Charnita
- Zhang Hong-Wei
- Zuhlke Kimberly A
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2009
- Field of study
Prostate cancer (PrCa) is the most frequently diagnosed male cancer in developed countries. To identify common PrCa susceptibility alleles, we have previously conducted a genome-wide association study in which 541, 129 SNPs were genotyped in 1,854 PrCa cases with clinically detected disease and 1,894 controls. We have now evaluated promising associations in a second stage, in which we genotyped 43,671 SNPs in 3,650 PrCa cases and 3,940 controls, and a third stage, involving an additional 16,229 cases and 14,821 controls from 21 studies. In addition to previously identified loci, we identified a further seven new prostate cancer susceptibility loci on chromosomes 2, 4, 8, 11, and 22 (P=1.6×10−8 to P=2.7×10−33)
Whole-genome sequencing reveals host factors underlying critical COVID-19
- Author
- Abd Elghafar Mohamed S.
- Abdel-Aziz Mahmoud
- Abdelrazik Marwa
- Abdollahi Hamed
- Abdullah T.
- Abecasis Goncalo
- Abedalthagafi M.
- Abel Lynn
- Abernathy C.
- Abraheem Azmeralde
- Abul-Husn Noura S.
- Acquilini D.
- Adams C.
- Adams Emma L.
- Adams K.
- Adamsara Alireza
- Adanini Olurenke
- Adeleye O.
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- Afilalo J.
- Afilalo M.
- Afolabi D.
- Afrasiabi Z.
- Agasou A.
- Agrawal Shruti
- Agüero D.
- Ahmad N.
- Ahmadi Saeideh
- Ahmed A.
- Ahmed Cecilia
- Akeroyd L.
- Akhtar M.N.
- Akinkugbe O.
- Aksentijevich Alexandra
- Al-Afghani H.
- Al-Awdah L.
- Alaamery M.
- Alahmadey Z.Z.
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- Aleagha Afshar Etemadi
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- Ali Altaf
- Ali I.A.M.
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- Publication venue
- Publication date
- 01/01/2022
- Field of study
Altres ajuts: Department of Health and Social Care (DHSC); Illumina; LifeArc; Medical Research Council (MRC); UKRI; Sepsis Research (the Fiona Elizabeth Agnew Trust); the Intensive Care Society, Wellcome Trust Senior Research Fellowship (223164/Z/21/Z); BBSRC Institute Program Support Grant to the Roslin Institute (BBS/E/D/20002172, BBS/E/D/10002070, BBS/E/D/30002275); UKRI grants (MC_PC_20004, MC_PC_19025, MC_PC_1905, MRNO2995X/1); UK Research and Innovation (MC_PC_20029); the Wellcome PhD training fellowship for clinicians (204979/Z/16/Z); the Edinburgh Clinical Academic Track (ECAT) programme; the National Institute for Health Research, the Wellcome Trust; the MRC; Cancer Research UK; the DHSC; NHS England; the Smilow family; the National Center for Advancing Translational Sciences of the National Institutes of Health (CTSA award number UL1TR001878); the Perelman School of Medicine at the University of Pennsylvania; National Institute on Aging (NIA U01AG009740); the National Institute on Aging (RC2 AG036495, RC4 AG039029); the Common Fund of the Office of the Director of the National Institutes of Health; NCI; NHGRI; NHLBI; NIDA; NIMH; NINDS.Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care or hospitalization after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes-including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)-in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease
Subretinal Hyperreflective Material in the Comparison of Age-Related Macular Degeneration Treatments Trials
- Author
- A. Tom Ghuman
- Aaron Towe
- Abby Brotherton
- Adam Brooks
- Adam Specker
- Adam Zamboni
- Adrienne Brower-Lingsch
- Aida Ayyad
- Alan Letson
- Alan Margherio
- Alan Ruby
- Albert Edwards
- Albert Frederick
- Alecia Travis
- Alessandro Castellarin
- Alex S. Willoughby
- Alex Schlosser
- Alexander Ho
- Alexander Khvatov
- Alexander Melamud
- Allen Ho
- Allison Cassidy
- Allison Guidry
- Allison Schnader
- Alysia Cronise
- Amanda Barnett
- Amanda Battcher
- Amanda Butt
- Amanda Bye
- Amanda Dinatale
- Amanda Fec
- Amanda Milliron
- Amanda Palomo
- Ames Munden
- Amy Dilback
- Amy Harris
- Amy Leviton
- Amy Martir
- Amy Noffke
- Amy Schultz
- Andreas Lauer
- Andrew Barkmeier
- Andrew N. Antoszyk
- Angela Price
- Angela Wealti
- Angie Karow
- Ann Arnold
- Ann Borthwick
- Ann Lundquist
- Anna Fagan
- Anne Lindblad
- Annette Vaughn
- AnnMarie Lavorna
- Antonio Capone
- April E. Harris
- Arthur D. Fu
- Arthur Willis
- Arun Patel
- Ashish Sharma
- Ashley Lester
- Avni Vyas
- Baker Hubbard
- Barbara Blodi
- Barbara Connell
- Barbara J. Ciscato
- Barbara Soderling
- Barbara Taylor
- Barry Golub
- Beau Richter
- Belinda Kosinski
- Bernard H. Doft
- Bertha Luevano
- Beth Daniels
- Beth Winder
- Bethany Sink
- Betsy Hendrix
- Blaine Cribbs
- Bob Boleman
- Brad Terry
- Bradley Jost
- Brandi Teske
- Brandon Busbee
- Brandon J. Lujan
- Brannon Balsley
- Brenda Branchaud
- Brenda Sanchez
- Brenda VanHoose
- Brett Rosenblatt
- Brian Fernandez
- Brian Reed
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- Brittany Ross
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- Brown
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- Bruce Keyser
- Bryan Schwent
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- Roy Trent Wallace
- Ruchira Glaser
- Russ Burris
- Russell Burns
- Russell E. Burns
- Ryan Neist
- Ryan Shultz
- Saba Mukarram
- Sally Arceneaux
- Sandra Arenas
- Sandra Harkins
- Sandra Reed
- Sandra Sall
- Sandra Stinnett
- Sandy Chong
- Sandy Lash
- Sandy Lewis
- Sandy Parker
- Sara Beardsley
- Sara Crowell
- Sara Downs
- Sarah Brett
- Sarah Buckley
- Sarah Ennis
- Sarah Gach
- Sarah Hines
- Sarah Jones
- Sarah Mobley
- Sarah Nolte
- Sarah Oelrich
- Sarah Pachman
- Sarah Risard
- Sarita Scott
- Sashi Kaur
- Saxena
- Scheleen Dickens
- Scott Pendergast
- Scott Pickell
- Scott Savage
- Scott Sneed
- Sean Grout
- Sepideh Hami
- Serena Neal
- Shamekia Newton
- Shannon Goddard
- Shannon Howard
- Shannya Townsend-Patrick
- Shantia Shears
- Sharon Fekrat
- Shashi Kini
- Shawnique Latham
- Shayla Hay
- Sheila Smith-Brewer
- Shelly Olson
- Shelly Valardi
- Sheri Carbon
- Shirley Ira
- Silvia Linares
- Sohail Hasan
- Solomon
- Sonny Icks
- Sophia Griffin
- Sophie J. Bakri
- Sophie J. Bakri
- Srilaxmi Bearelly
- Stacey Andelman
- Stacy McGilvra
- Starr Muscle
- Stefani Karakas
- Stephanie Morrow
- Stephanie Schindeldecker
- Stephen Couvillion
- Stephen Fransen
- Stephen Hobbs
- Stephen L. Perkins
- Stephen Petty
- Stephen Russell
- Stephen Shelley
- Stephen Young
- Steve Bennett
- Steven Bailey
- Steven Bennett
- Steven Leff
- Steven Schremp
- Stuart Green
- Stuart L. Fine
- Stuart L. Fine
- Stuart L. Fine
- Sujatha Subramaniam
- Sundeep Dev
- Sunil Srivastava
- Sunir Garg
- Suresh R. Chandra
- Susan B. Bressler
- Susan Brown
- Susan K. Nolte
- Susan K. Nolte
- Susan K. Nolte
- Susan Pope
- Susan Rath
- Susan Ryan
- Susanna S. Park
- Susannah Held
- Susie Chang
- Svetlana Reznichenko
- T. Michael Nork
- Tammy Butcher
- Tammy Ressel
- Taneika Howard
- Tanya Marsh
- Tarek Hassan
- Teresa Coffey
- Teresa Liesegang
- Terri Kidd
- Terry Hawks
- Thea Tantum
- Theodossiadis
- Theresa Cain
- Theresa Jeffers
- Thomas A. Ciulla
- Thomas Aaberg
- Thomas Hwang
- Thomas Link
- Thomas Stevens
- Thomas W. Stone
- Tien Wong
- Tiffany Guerrero
- Tiffany Swinford
- Tim Wright
- Timothy Crew
- Timothy Olsen
- Tina Bell
- Tina Bell
- Tina Cleary
- Tina T. Higdon
- Todd Blevins
- Todd Petrin
- Tom Shannon
- Tom Steele
- Tony Tsai
- Tonya Harrington
- Tori Jones
- Torsten Wiegand
- Tracey Brady
- Tracy Aly
- Tracy Grooten
- Travis A. Meredith
- Travis A. Meredith
- Trenise Steele
- Trexler M. Topping
- Troy Kieser
- Uma Balasubramaniam
- Ursula Lord
- Valerie Kirschner
- Valerie Lazarte
- Vanessa Bergman
- Vanessa Denny
- Vasanti Sookhai
- Veronica Sneed
- Vicky Seitz
- Virginia R. Regan
- Vivian Tanner
- W. Lloyd Clark
- Wanda Heath
- Wayne Solley
- Willia Ingram
- William Carli
- William Gilbert
- William Snyder
- William Wood
- Witmer
- Yesmin Urias
- Ying
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study