The Convergence of Ricoeur’s and Von Wright’s Complex Models of History

The relationship between the structural identity of narrative and the truth claim of the historical narrative work is one of importance to Ricœur. He considers the attempts of two interwoven models of history emerging from analytic philosophy—explanatory and narrative—to articulate this relationship. This paper explores the trajectories of these models as well as the epistemological and ontological crises culminating from the “simple” theses of each model. The solution to these crises requires a more complex method to account for the nature of the connections underlying historical understanding. Georg Henrik von Wright’s provisional or “hybrid” model of explanation and understanding revises the simple explanatory model and is foundational for Ricœur’s own complex revision of narrativist models through his notion of questioning back. The present paper argues that the structure of this hybrid model was unsatisfactory for von Wright, and leads in the direction of Ricœur’s own narrative method. Keywords: Ricœur, von Wright, Narrative, History, Questioning back. Résumé La relation entre l’identité structurale du récit et la prétention à la vérité de l’œuvre de récit historique est fondamentale chez Ricœur. Il considère que les deux modèles historiographiques de provenance analytique – le modèle explicatif et le modèle narratif – peuvent s’articuler. Cet article explore les trajectoires de ces modèles autant que les crises épistémologiques et ontologiques qui culminent dans chacune des thèses prise dans un sens unilatéral. La solution pour remédier à ces crises requiert une méthode plus complexe pour tenir compte de la nature des liens qui sous-tendent la compréhension historique. Le modèle d’explication et de compréhension, provisoire et “hybride,” de Georg Henrik von Wright permet de réviser le simple modèle explicatif. Ceci est fondamental pour comprendre  la révision complexe que Ricœur apporte aux modèles narrativistes à travers la reprise de la notion de “questionnement à rebours.” La présente contribution fait valoir que la structure de ce modèle hybride n’est pas satisfaisante pour von Wright, et débouche dans le sens de la méthode narrative proposée par Ricœur.Mots-clés: Ricœur, von Wright, Narrative, Histoire, Questionnenement à rebours

The Convergence of Ricoeur’s and Von Wright’s Complex Models of History

The relationship between the structural identity of narrative and the truth claim of the historical narrative work is one of importance to Ricœur. He considers the attempts of two interwoven models of history emerging from analytic philosophy—explanatory and narrative—to articulate this relationship. This paper explores the trajectories of these models as well as the epistemological and ontological crises culminating from the “simple” theses of each model. The solution to these crises requires a more complex method to account for the nature of the connections underlying historical understanding. Georg Henrik von Wright’s provisional or “hybrid” model of explanation and understanding revises the simple explanatory model and is foundational for Ricœur’s own complex revision of narrativist models through his notion of questioning back. The present paper argues that the structure of this hybrid model was unsatisfactory for von Wright, and leads in the direction of Ricœur’s own narrative method. Keywords: Ricœur, von Wright, Narrative, History, Questioning back.   Résumé La relation entre l’identité structurale du récit et la prétention à la vérité de l’œuvre de récit historique est fondamentale chez Ricœur. Il considère que les deux modèles historiographiques de provenance analytique – le modèle explicatif et le modèle narratif – peuvent s’articuler. Cet article explore les trajectoires de ces modèles autant que les crises épistémologiques et ontologiques qui culminent dans chacune des thèses prise dans un sens unilatéral. La solution pour remédier à ces crises requiert une méthode plus complexe pour tenir compte de la nature des liens qui sous-tendent la compréhension historique. Le modèle d’explication et de compréhension, provisoire et “hybride,” de Georg Henrik von Wright permet de réviser le simple modèle explicatif. Ceci est fondamental pour comprendre  la révision complexe que Ricœur apporte aux modèles narrativistes à travers la reprise de la notion de “questionnement à rebours.” La présente contribution fait valoir que la structure de ce modèle hybride n’est pas satisfaisante pour von Wright, et débouche dans le sens de la méthode narrative proposée par Ricœur. Mots-clés: Ricœur, von Wright, Narrative, Histoire, Questionnenement à rebours

Cryo-Electron Tomography Elucidates the Molecular Architecture of Treponema pallidum, the Syphilis Spirochete

Cryo-electron tomography (CET) was used to examine the native cellular organization of Treponema pallidum, the syphilis spirochete. T. pallidum cells appeared to form flat waves, did not contain an outer coat and, except for bulges over the basal bodies and widening in the vicinity of flagellar filaments, displayed a uniform periplasmic space. Although the outer membrane (OM) generally was smooth in contour, OM extrusions and blebs frequently were observed, highlighting the structure’s fluidity and lack of attachment to underlying periplasmic constituents. Cytoplasmic filaments converged from their attachment points opposite the basal bodies to form arrays that ran roughly parallel to the flagellar filaments along the inner surface of the cytoplasmic membrane (CM). Motile treponemes stably attached to rabbit epithelial cells predominantly via their tips. CET revealed that T. pallidum cell ends have a complex morphology and assume at least four distinct morphotypes. Images of dividing treponemes and organisms shedding cell envelope-derived blebs provided evidence for the spirochete’s complex membrane biology. In the regions without flagellar filaments, peptidoglycan (PG) was visualized as a thin layer that divided the periplasmic space into zones of higher and lower electron densities adjacent to the CM and OM, respectively. Flagellar filaments were observed overlying the PG layer, while image modeling placed the PG-basal body contact site in the vicinity of the stator–P-collar junction. Bioinformatics and homology modeling indicated that the MotB proteins of T. pallidum, Treponema denticola, and Borrelia burgdorferi have membrane topologies and PG binding sites highly similar to those of their well-characterized Escherichia coli and Helicobacter pylori orthologs. Collectively, our results help to clarify fundamental differences in cell envelope ultrastructure between spirochetes and gram-negative bacteria. They also confirm that PG stabilizes the flagellar motor and enable us to propose that in most spirochetes motility results from rotation of the flagellar filaments against the PG

Conditional loss of IKKα in Osterix + cells has no effect on bone but leads to age-related loss of peripheral fat

NF-κB has been reported to both promote and inhibit bone formation. To explore its role in osteolineage cells, we conditionally deleted IKKα, an upstream kinase required for non-canonical NF-κB activation, using Osterix (Osx)-Cre. Surprisingly, we found no effect on either cancellous or cortical bone, even following mechanical loading. However, we noted that IKKα conditional knockout (cKO) mice began to lose body weight after 6 months of age with severe reductions in fat mass and lower adipocyte size in geriatric animals. qPCR analysis of adipogenic markers in fat pads of cKO mice indicated no difference in early differentiation, but instead markedly lower leptin with age. We challenged young mice with a high fat diet finding that cKO mice gained less weight and showed improved glucose metabolism. Low levels of recombination at the IKKα locus were detected in fat pads isolated from old cKO mice. To determine whether recombination occurs in adipocytes, we examined fat pads in Osx-Cre;TdT reporter mice; these showed increasing Osx-Cre-mediated expression in peripheral adipocytes from 6 weeks to 18 months. Since Osx-Cre drives recombination in peripheral adipocytes with age, we conclude that fat loss in cKO mice is most likely caused by progressive deficits of IKKα in adipocytes

Make Research Data Public? -- Not Always so Simple: A Dialogue for Statisticians and Science Editors

Putting data into the public domain is not the same thing as making those data accessible for intelligent analysis. A distinguished group of editors and experts who were already engaged in one way or another with the issues inherent in making research data public came together with statisticians to initiate a dialogue about policies and practicalities of requiring published research to be accompanied by publication of the research data. This dialogue carried beyond the broad issues of the advisability, the intellectual integrity, the scientific exigencies to the relevance of these issues to statistics as a discipline and the relevance of statistics, from inference to modeling to data exploration, to science and social science policies on these issues.Comment: Published in at http://dx.doi.org/10.1214/10-STS320 the Statistical Science (http://www.imstat.org/sts/) by the Institute of Mathematical Statistics (http://www.imstat.org

Tumor-infiltrating lymphocytes: Streamlining a complex manufacturing process

Adoptive cell therapy of tumor-infiltrating lymphocytes has shown promise for treatment of refractory melanoma and other solid malignancies; however, challenges to manufacturing have limited its widespread use. Traditional manufacturing efforts were lengthy, cumbersome and used open culture systems. We describe changes in testing and manufacturing that decreased the process cycle time, enhanced the robustness of critical quality attribute testing and facilitated a functionally closed system. These changes have enabled export of the manufacturing process to support multi-center clinical trials

Sodium Regulation of Agonist Binding at Opioid Receptors. I. Effects of Sodium Replacement on Binding at and #{244}-Type Receptors in 731 5c and NG1 08-15 Cells and Cell Membranes

SUMMARY The effects of varying the sodium concentration (at constant ionic strength) on oploid binding at -and #{244}-opioid receptors in 731 5c and NG1 08-1 5 cells has been examined

Exile Vol. XIX No. 2

POETRY speckled day by Richard Carothers 3 Looking-Glass by Doug Cox 3 February fog scooves in by H. 8 Surface Tension by Glenn Bard 9 Closing by Doug Cox 10 southwest bazaar by Val Evans 16 Haiku sequence By Suzanne B. Dean 17 summertime by Richard Carothers 18 The Desirability of Being a Line by Laurie Wharton 18 The Blatant Morning by Phil Mercurio 23 sweet nothings by Linda Anderson 23 Alone In Bed by Val Evans 24 Walls and the Fallen Woman by H. 26-27 A Victim of Need by Suzanne B. Dean 28 PHOTOGRAPHY by Tamera Iverson 1, 18 by John Bildahl 9, 15 by Anne G. English 25 by Richard E. Bergen 27 by Bruce Andre 28 ARTWORK The Road to Calvary by Sheila Rollit 4 Norwegian Sadness by Tamera Iverson 11 by Ann Merrill 16 by Jude Hasel 17 by Pat Victory 22 by Wilson R. Baldridge 26 FICTION To My Grandmother by Robb Knuepfer 5-8 First Monday in July by Joe L. Bolster III 12-14 Glad About A Lot Today by John Fergus 19-22 A city stands by Suzanne B. Dean 24-2

Xpert MTB/RIF versus sputum microscopy as the initial diagnostic test for tuberculosis: a cluster-randomised trial embedded in South African roll-out of Xpert MTB/RIF

Background In South Africa, sputum smear microscopy has been replaced with Xpert MTB/RIF as the initial diagnostic test for tuberculosis. In a pragmatic parallel cluster-randomised trial, we evaluated the eff ect on patient and programme outcomes. Methods We randomly allocated 20 laboratories (clusters) in medium-burden districts of South Africa to either an Xpert (immediate Xpert) or microscopy (Xpert deferred) group (1:1), stratifi ed by province. At two primary care clinics per laboratory, a systematic sample of adults giving sputum for tuberculosis investigation was assessed for eligibility. The primary outcome was mortality at 6 months from enrolment. Masking of participants’ group allocation was not possible because of the pragmatic trial design. The trial is registered with the ISRCTN registry (ISRCTN68905568) and the South African Clinical Trial Register (DOH-27-1011-3849). Findings Between June and November, 2012, 4972 people were screened, and 4656 (93·6%) enrolled (median age 36 years; 2891 [62%] female; 2212 [62%] reported being HIV-positive). There was no diff erence between the Xpert and microscopy groups with respect to mortality at 6 months (91/2324 [3·9%] vs 116/2332 [5·0%], respectively; adjusted risk ratio [aRR] 1·10, 95% CI 0·75–1·62]). Interpretation Xpert did not reduce mortality at 6 months compared with sputum microscopy. Improving outcomes in drug-sensitive tuberculosis programmes might require not only better diagnostic tests but also better linkage to care