Púrpura em paciente com estrongiloidíase disseminada Purpura in patient with disseminated strongiloidiasis

A infecção pelo Strongyloides stercoralis em associação com imunosupressão pode manifestar-se com lesões em múltiplos órgãos e sistemas, caracterizando a forma disseminada da doença. Lesões cutâneas não são freqüentemente relatadas e, se presentes, manifestam-se como rash e petéquias. Púrpuras bem definidas são pouco descritas. No presente trabalho é descrito um caso de estrongiloidíase disseminada, com acometimento cutâneo em forma de púrpura, que se desenvolveu em um paciente timectomizado e usuário crônico de corticosteróide devido à miastenia gravis.<br>The association of systemic corticosteroid therapy and dissemination of Strongyloides stercoralis has been increasingly documented in the literature. Skin involvement in disseminated strongyloidiasis has been reported and the most commonly described cutaneous manifestations are rash and petechial eruptions. We present a case of an immunosuppressed man that developed disseminated strongyloidiasis with extensive purpura

When Joy Matters: The Importance of Hedonic Stimulation in Collocated Collaboration with Large-Displays

Hedonic aspects are increasingly considered as an important factor in user acceptance of information systems, especially for activities with high self-fulfilling value for the users. In this paper we report on the results of an experiment investigating the hedonic qualities of an interactive large-display workspace for collocated collaboration in sales-oriented travel advisory. The results show a higher hedonic stimulation quality of a touch-based large-display travel advisory workspace than that of a traditional workspace with catalogues. Together with the feedback of both customers and travel agents this suggests the adequacy of using touch-based large-displays with visual workspaces for supporting the hedonic stimulation of user experience in collocated collaboration settings. The relation of high perception of hedonic quality to positive emotional attitudes towards the use of a large-display workspace indicates that even in utilitarian activities (e.g. reaching sales goals for travel agents) hedonic aspects can play an important role. This calls for reconsidering the traditional divide of hedonic vs. utilitarian systems in current literature, to a more balanced view towards systems which provide both utilitarian and hedonic sources of value to the user

Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus

BACKGROUND: Coronary artery disease (CAD) is accelerated in subjects with type 2 diabetes mellitus (T2D). METHODS: To test whether this reflects differential genetic influences on CAD risk in subjects with T2D, we performed a systematic assessment of genetic overlap between CAD and T2D in 66 643 subjects (27 708 with CAD and 24 259 with T2D). Variants showing apparent association with CAD in stratified analyses or evidence of interaction were evaluated in a further 117 787 subjects (16 694 with CAD and 11 537 with T2D). RESULTS: None of the previously characterized CAD loci was found to have specific effects on CAD in T2D individuals, and a genome-wide interaction analysis found no new variants for CAD that could be considered T2D specific. When we considered the overall genetic correlations between CAD and its risk factors, we found no substantial differences in these relationships by T2D background. CONCLUSIONS: This study found no evidence that the genetic architecture of CAD differs in those with T2D compared with those without T2D.Peer reviewe