International law and land rights in Africa: the shift from states’ territorial possessions to indigenous peoples' ownership rights

This is a pre-copyedited, author-produced PDF of a chapter published in Home, Robert, (ed.) Essays in African Land Law. Pretoria University Press, pp. 47-68. ISBN 9781920538002 Availiable at : http://www.pulp.up.ac.za/cat_2011_15.htm

Effectiveness of adjuvant carboplatin-based chemotherapy compared to cisplatin in non-small cell lung cancer

Background: Cisplatin and vinorelbine given intravenously is a well-established adjuvant chemotherapy regimen after surgery for early non-small cell lung cancer. However, few validated alternatives exist when cisplatin is not indicated or tolerated. Carboplatin is frequently used in this setting. We evaluated the 5-year overall survival, progression-free survival and toxicity in patients treated for stage IB to IIIB resected non-small cell lung cancer receiving adjuvant carboplatin-based chemotherapy compared to cisplatin in association with vinorelbine. Methods: Single-center retrospective study of patients having received adjuvant chemotherapy between January 2004 and December 2013 at the oncology clinic at Institut Universitaire de Cardiologie et de Pneumologie de Québec (Canada). Three sub-groups, cisplatin/vinorelbine, carboplatin/vinorelbine and the substitution of cisplatin/vinorelbine for carboplatin/vinorelbine (cisplatin/vinorelbine/carboplatin/vinorelbine), were studied during treatment. Results: One hundred twenty-seven patients were included in this study. The median PFS was not significantly different, with 50.4 months for cisplatin/vinorelbine, 57.3 months for cisplatin/vinorelbine/carboplatin/vinorelbine and not yet achieved for the carboplatin/vinorelbine group (p = 0.80). Overall survival also did not differ significantly between the three groups. The 5-year overall survival rates were 66% in cisplatin/vinorelbine group, 55% in carboplatin/vinorelbine group and 70% in cisplatin/vinorelbine/carboplatin/vinorelbine group (p = 0, 95). No differences were noted between groups concerning high-grade hematologic toxicity. Conclusions: Although the effectiveness and hematologic toxicity are comparable between cisplat in and carboplatin in the adjuvant treatment of resected non-small cell lung cancer, the results obtained corroborate the practice used at our oncology clinic. Nevertheless, more prospective studies would be needed to confirm these results

Least-Squares Based Adaptive Source Localization with Biomedical Applications

In this thesis, we study certain aspects of signal source/target localization by sensory agents and their biomedical applications. We first focus on a generic distance measurement based problem: Estimation of the location of a signal source by a sensory agent equiped with a distance measurement unit or a team of such a sensory agent. This problem was addressed in some recent studies using a gradient based adaptive algorithm. In this study, we design a least-squares based adaptive algorithm with forgetting factor for the same task. Besides its mathematical background, we perform some simulations for both stationary and drifting target cases. The least-squares based algorithm we propose bears the same asymptotic stability and convergence properties as the gradient algorithm previously studied. It is further demonstrated via simulation studies that the proposed least-squares algorithm converges significantly faster to the resultant location estimates than the gradient algorithm for high values of the forgetting factor, and significantly reduces the noise effects for small values of the forgetting factor. We also focus on the problem of localizing a medical device/implant in human body by a mobile sensor unit (MSU) using distance measurements. As the particular distance measurement method, time of flight (TOF) based approach involving ultra wide-band signals is used, noting the important effects of the medium characteristics on this measurement method. Since human body consists of different organs and tissues, each with a different signal permittivity coefficient and hence a different signal propagation speed, one cannot assume a constant signal propagation speed environment for the aforementioned medical localization problem. Furthermore, the propagation speed is unknown. Considering all the above factors and utilizing a TOF based distance measurement mechanism, we use the proposed adaptive least-square algorithm to estimate the 3-D location of a medical device/implant in the human body. In the design of the adaptive algorithm, we first derive a linear parametric model with the unknown 3-D coordinates of the device/implant and the current signal propagation speed of the medium as its parameters. Then, based on this parametric model, we design the proposed adaptive algorithm, which uses the measured 3-D position of the MSU and the measured TOF as regressor signals. After providing a formal analysis of convergence properties of the proposed localization algorithm, we implement numerical tests to analyze the properties of the localization algorithm, considering two types of scenarios: (1) A priori information regarding the region, e.g quadrant (among upper-left, upper-right, lower-left, lower-right of the human body), of the implant location is available and (2) such a priori information is not available. In (1), assuming knowledge of fixed average relative permittivity for each region, we established that the proposed algorithm converges to an estimate with zero estimation error. Moreover, different white Gaussian noises are added to emulate the TOF measurement disturbances, and it is observed that the proposed algorithm is robust to such noises/disturbances. In (2), although perfect estimation is not achieved, the estimation error is at a low admissible level. In addition, for both cases (1) and (2), forgetting factor effects have been investigated and results show that use of small forgetting factor values reduces noise effects significantly, while use of high forgetting factor values speeds up convergence of the estimation

Land Rights and the Forest Peoples of Africa: Historical, Legal and Anthropological Perspectives

This composite publication presents and complements a study conducted on the land rights of indigenous peoples in five countries of the forested region of Africa, namely Burundi, Cameroon, Democratic Republic of Congo (DRC), Rwanda and Uganda. Building on historical facts and legal developments, the study highlights indigenous peoples’ loss of resources and land to colonists, commercial enter- prises and conservation initiatives. It also de scribes how, having been dispossessed of their ancestral lands and, in many cases, not alloca ted alternative land, indi genous forest peoples in Africa today live in extremely vulnerable conditions and experience marginalisation and poverty

Perception of Bronchoconstriction Following Methacholine and Eucapnic Voluntary Hyperpnea Challenges in Elite Athletes

International audienceObjective: Self-reported respiratory symptoms are poor predictors of exercise-induced bronchoconstriction (EIB) in athletes. The objective of this study was to determine whether athletes have an inadequate perception of bronchoconstriction.Methods: One hundred thirty athletes and 32 nonathletes completed a standardized questionnaire and underwent eucapnic voluntary hyperpnea (EVH) and methacholine inhalation test. Perception scores were quoted on a modified Borg scale before each spirometry measurement for cough, breathlessness, chest tightness, and wheezing. Perception slope values were also obtained by plotting the variation of perception scores before and after the challenges against the fall in FEV1 expressed as a percentage of the initial value [(perception scores after - before)/FEV1].Results: Up to 76% of athletes and 68% of nonathletes had a perception score of ≤0.5 at 20% fall in FEV1 following methacholine. Athletes with EIB/airway hyperresponsiveness (AHR) had lower perception slopes to methacholine than nonathletes with asthma for breathlessness only (P=.02). Among athletes, those with EIB/AHR had a greater perception slope to EVH for breathlessness and wheezing (P=.02). Female athletes had a higher perception slope for breathlessness after EVH and cough after methacholine compared with men (P<.05). The age of athletes correlated significantly with the perception slope to EVH for each symptom (P<.05).Conclusions: Minimal differences in perception of bronchoconstriction-related symptoms between athletes and nonathletes were observed. Among athletes, the presence of EIB/AHR, older age, and female sex were associated with slightly higher perception scores

Effects of daily raspberry consumption on immune-metabolic health in subjects at risk of metabolic syndrome : a randomized controlled trial

Consumption of red raspberries has been reported to exert acute beneficial effects on postprandial glycemia, insulinemia, triglyceridemia, and cytokine levels in metabolically disturbed subjects. In a two-arm parallel-group, randomized, controlled trial, 59 subjects with overweight or abdominal obesity and with slight hyperinsulinemia or hypertriglyceridemia were randomized to consume 280 g/day of frozen raspberries or to maintain their usual diet for 8 weeks. Primary analyses measured metabolic differences between the groups. Secondary analyses performed with omics tools in the intervention group assessed blood gene expression and plasma metabolomic changes following the raspberry supplementation. The intervention did not significantly affect plasma insulin, glucose, inflammatory marker concentrations, nor blood pressure. Following the supplementation, 43 genes were differentially expressed, and several functional pathways were enriched, a major portion of which were involved in the regulation of cytotoxicity, immune cell trafficking, protein signal transduction, and interleukin production. In addition, 10 serum metabolites were found significantly altered, among which β-alanine, trimethylamine N-oxide, and bioactive lipids. Although the supplementation had no meaningful metabolic effects, these results highlight the impact of a diet rich in raspberry on the immune function and phospholipid metabolism, thus providing novel insights into potential immune-metabolic pathways influenced by regular raspberry consumptio

Effect of general anaesthesia on functional outcome in patients with anterior circulation ischaemic stroke having endovascular thrombectomy versus standard care: a meta-analysis of individual patient data

Background: General anaesthesia (GA) during endovascular thrombectomy has been associated with worse patient outcomes in observational studies compared with patients treated without GA. We assessed functional outcome in ischaemic stroke patients with large vessel anterior circulation occlusion undergoing endovascular thrombectomy under GA, versus thrombectomy not under GA (with or without sedation) versus standard care (ie, no thrombectomy), stratified by the use of GA versus standard care. Methods: For this meta-analysis, patient-level data were pooled from all patients included in randomised trials in PuMed published between Jan 1, 2010, and May 31, 2017, that compared endovascular thrombectomy predominantly done with stent retrievers with standard care in anterior circulation ischaemic stroke patients (HERMES Collaboration). The primary outcome was functional outcome assessed by ordinal analysis of the modified Rankin scale (mRS) at 90 days in the GA and non-GA subgroups of patients treated with endovascular therapy versus those patients treated with standard care, adjusted for baseline prognostic variables. To account for between-trial variance we used mixed-effects modelling with a random effect for trials incorporated in all models. Bias was assessed using the Cochrane method. The meta-analysis was prospectively designed, but not registered. Findings: Seven trials were identified by our search; of 1764 patients included in these trials, 871 were allocated to endovascular thrombectomy and 893 were assigned standard care. After exclusion of 74 patients (72 did not undergo the procedure and two had missing data on anaesthetic strategy), 236 (30%) of 797 patients who had endovascular procedures were treated under GA. At baseline, patients receiving GA were younger and had a shorter delay between stroke onset and randomisation but they had similar pre-treatment clinical severity compared with patients who did not have GA. Endovascular thrombectomy improved functional outcome at 3 months both in patients who had GA (adjusted common odds ratio (cOR) 1·52, 95% CI 1·09–2·11, p=0·014) and in those who did not have GA (adjusted cOR 2·33, 95% CI 1·75–3·10, p&lt;0·0001) versus standard care. However, outcomes were significantly better for patients who did not receive GA versus those who received GA (covariate-adjusted cOR 1·53, 95% CI 1·14–2·04, p=0·0044). The risk of bias and variability between studies was assessed to be low. Interpretation: Worse outcomes after endovascular thrombectomy were associated with GA, after adjustment for baseline prognostic variables. These data support avoidance of GA whenever possible. The procedure did, however, remain effective versus standard care in patients treated under GA, indicating that treatment should not be withheld in those who require anaesthesia for medical reasons