Tests of General Relativity with Gravitational-Wave Observations using a Flexible--Theory-Independent Method

We perform tests of General Relativity (GR) with gravitational waves (GWs) from the inspiral stage of compact binaries using a theory-independent framework, which adds generic phase corrections to each multipole of a GR waveform model in frequency domain. This method has been demonstrated on LIGO-Virgo observations to provide stringent constraints on post-Newtonian predictions of the inspiral and to assess systematic biases that may arise in such parameterized tests. Here, we detail the anatomy of our framework for aligned-spin waveform models. We explore the effects of higher modes in the underlying signal on tests of GR through analyses of two unequal-mass, simulated binary signals similar to GW190412 and GW190814. We show that the inclusion of higher modes improves both the precision and the accuracy of the measurement of the deviation parameters. Our testing framework also allows us to vary the underlying baseline GR waveform model and the frequency at which the non-GR inspiral corrections are tapered off. We find that to optimize the GR test of high-mass binaries, comprehensive studies would need to be done to determine the best choice of the tapering frequency as a function of the binary's properties. We also carry out an analysis on the binary neutron-star event GW170817 to set bounds on the coupling constant $\alpha_0$ of Jordan-Fierz-Brans-Dicke gravity. We take two plausible approaches; in the first \emph{theory-agnostic} approach we find a bound $\alpha_0 \lesssim 2\times 10^{-1}$ from measuring the dipole-radiation for different neutron-star equations of state, while in the second \emph{theory-specific} approach we obtain $\alpha_0 \lesssim 4\times 10^{-1}$, both at $68\%$ credible level. These differences arise mainly due to different statistical hypotheses used for the analysis

High-Resolution Genetics Identifies the Lipid Transfer Protein Sec14p as Target for Antifungal Ergolines.

Invasive infections by fungal pathogens cause more deaths than malaria worldwide. We found the ergoline compound NGx04 in an antifungal screen, with selectivity over mammalian cells. High-resolution chemogenomics identified the lipid transfer protein Sec14p as the target of NGx04 and compound-resistant mutations in Sec14p define compound-target interactions in the substrate binding pocket of the protein. Beyond its essential lipid transfer function in a variety of pathogenic fungi, Sec14p is also involved in secretion of virulence determinants essential for the pathogenicity of fungi such as Cryptococcus neoformans, making Sec14p an attractive antifungal target. Consistent with this dual function, we demonstrate that NGx04 inhibits the growth of two clinical isolates of C. neoformans and that NGx04-related compounds have equal and even higher potency against C. neoformans. Furthermore NGx04 analogues showed fungicidal activity against a fluconazole resistant C. neoformans strain. In summary, we present genetic evidence that NGx04 inhibits fungal Sec14p and initial data supporting NGx04 as a novel antifungal starting point

Delay in breast cancer treatments during the first COVID-19 lockdown. a multicentric analysis of 432 patients

Background/Aim: Extraordinary restrictions aimed to limit Sars-CoV-2 spreading; they imposed a total reorganization of the health-system. Oncological treatments experienced a significant slowdown. The aim of our multicentric retrospective study was to evaluate screening suspension and surgical treatment delay during COVID-19 and the impact on breast cancer presentation. Patients and Methods: All patients who underwent breast surgery from March 11, 2020 to May 30, 2020 were evaluated and considered as the Lockdown group. These patients were compared with similar patients of the previous year, the Pre-Lockdown group. Results: A total of 432 patients were evaluated; n=223 and n=209 in the Lockdown

Laying the foundation of the effective-one-body waveform models SEOBNRv5: improved accuracy and efficiency for spinning non-precessing binary black holes

We present SEOBNRv5HM, a more accurate and faster inspiral-merger-ringdown gravitational waveform model for quasi-circular, spinning, nonprecessing binary black holes within the effective-one-body (EOB) formalism. Compared to its predecessor, SEOBNRv4HM, the waveform model i) incorporates recent high-order post- Newtonian results in the inspiral, with improved resummations, ii) includes the gravitational modes (l, |m|) = (3, 2), (4, 3), in addition to the (2, 2), (3, 3), (2, 1), (4, 4), (5, 5) modes already implemented in SEOBNRv4HM, iii) is calibrated to larger mass-ratios and spins using a catalog of 442 numerical-relativity (NR) simulations and 13 additional waveforms from black-hole perturbation theory, iv) incorporates information from second-order gravitational self-force (2GSF) in the nonspinning modes and radiation-reaction force. Computing the unfaithfulness against NR simulations, we find that for the dominant (2, 2) mode the maximum unfaithfulness in the total mass range $10-300 M_{\odot}$ is below $10^{-3}$ for 90% of the cases (38% for SEOBNRv4HM). When including all modes up to l = 5 we find 98% (49%) of the cases with unfaithfulness below $10^{-2} (10^{-3})$, while these numbers reduce to 88% (5%) when using SEOBNRv4HM. Furthermore, the model shows improved agreement with NR in other dynamical quantities (e.g., the angular momentum flux and binding energy), providing a powerful check of its physical robustness. We implemented the waveform model in a high-performance Python package (pySEOBNR), which leads to evaluation times faster than SEOBNRv4HM by a factor 10 to 50, depending on the configuration, and provides the flexibility to easily include spin-precession and eccentric effects, thus making it the starting point for a new generation of EOBNR waveform models (SEOBNRv5) to be employed for upcoming observing runs of the LIGO-Virgo-KAGRA detectors

Bayesian inference for compact binary coalescences with BILBY:Validation and application to the first LIGO-Virgo gravitational-wave transient catalogue

Gravitational waves provide a unique tool for observational astronomy. While the first LIGO–Virgo catalogue of gravitational-wave transients (GWTC-1) contains eleven signals from black hole and neutron star binaries, the number of observations is increasing rapidly as detector sensitivity improves. To extract information from the observed signals, it is imperative to have fast, flexible, and scalable inference techniques. In a previous paper, we introduced BILBY: a modular and user-friendly Bayesian inference library adapted to address the needs of gravitational-wave inference. In this work, we demonstrate that BILBY produces reliable results for simulated gravitational-wave signals from compact binary mergers, and verify that it accurately reproduces results reported for the eleven GWTC-1 signals. Additionally, we provide configuration and output files for all analyses to allow for easy reproduction, modification, and future use. This work establishes that BILBY is primed and ready to analyse the rapidly growing population of compact binary coalescence gravitational-wave signals

First measurement of the Hubble Constant from a Dark Standard Siren using the Dark Energy Survey Galaxies and the LIGO/Virgo Binary–Black-hole Merger GW170814

International audienceWe present a multi-messenger measurement of the Hubble constant H 0 using the binary–black-hole merger GW170814 as a standard siren, combined with a photometric redshift catalog from the Dark Energy Survey (DES). The luminosity distance is obtained from the gravitational wave signal detected by the Laser Interferometer Gravitational-Wave Observatory (LIGO)/Virgo Collaboration (LVC) on 2017 August 14, and the redshift information is provided by the DES Year 3 data. Black hole mergers such as GW170814 are expected to lack bright electromagnetic emission to uniquely identify their host galaxies and build an object-by-object Hubble diagram. However, they are suitable for a statistical measurement, provided that a galaxy catalog of adequate depth and redshift completion is available. Here we present the first Hubble parameter measurement using a black hole merger. Our analysis results in , which is consistent with both SN Ia and cosmic microwave background measurements of the Hubble constant. The quoted 68% credible region comprises 60% of the uniform prior range [20, 140] km s−1 Mpc−1, and it depends on the assumed prior range. If we take a broader prior of [10, 220] km s−1 Mpc−1, we find (57% of the prior range). Although a weak constraint on the Hubble constant from a single event is expected using the dark siren method, a multifold increase in the LVC event rate is anticipated in the coming years and combinations of many sirens will lead to improved constraints on H 0

GW190412: Observation of a Binary-Black-Hole Coalescence with Asymmetric Masses

We report the observation of gravitational waves from a binary-black-hole coalescence during the first two weeks of LIGO’s and Virgo’s third observing run. The signal was recorded on April 12, 2019 at 05∶30∶44 UTC with a network signal-to-noise ratio of 19. The binary is different from observations during the first two observing runs most notably due to its asymmetric masses: a ∼30 M_⊙ black hole merged with a ∼8 M_⊙ black hole companion. The more massive black hole rotated with a dimensionless spin magnitude between 0.22 and 0.60 (90% probability). Asymmetric systems are predicted to emit gravitational waves with stronger contributions from higher multipoles, and indeed we find strong evidence for gravitational radiation beyond the leading quadrupolar order in the observed signal. A suite of tests performed on GW190412 indicates consistency with Einstein’s general theory of relativity. While the mass ratio of this system differs from all previous detections, we show that it is consistent with the population model of stellar binary black holes inferred from the first two observing runs

GWTC-1: A Gravitational-Wave Transient Catalog of Compact Binary Mergers Observed by LIGO and Virgo during the First and Second Observing Runs

We present the results from three gravitational-wave searches for coalescing compact binaries with component masses above 1  M⊙ during the first and second observing runs of the advanced gravitational-wave detector network. During the first observing run (O1), from September 12, 2015 to January 19, 2016, gravitational waves from three binary black hole mergers were detected. The second observing run (O2), which ran from November 30, 2016 to August 25, 2017, saw the first detection of gravitational waves from a binary neutron star inspiral, in addition to the observation of gravitational waves from a total of seven binary black hole mergers, four of which we report here for the first time: GW170729, GW170809, GW170818, and GW170823. For all significant gravitational-wave events, we provide estimates of the source properties. The detected binary black holes have total masses between 18.6−0.7+3.2  M⊙ and 84.4−11.1+15.8  M⊙ and range in distance between 320−110+120 and 2840−1360+1400  Mpc. No neutron star-black hole mergers were detected. In addition to highly significant gravitational-wave events, we also provide a list of marginal event candidates with an estimated false-alarm rate less than 1 per 30 days. From these results over the first two observing runs, which include approximately one gravitational-wave detection per 15 days of data searched, we infer merger rates at the 90% confidence intervals of 110−3840  Gpc−3 y−1 for binary neutron stars and 9.7−101  Gpc−3 y−1 for binary black holes assuming fixed population distributions and determine a neutron star-black hole merger rate 90% upper limit of 610  Gpc−3 y−1

A joint fermi-gbm and ligo/virgo analysis of compact binary mergers from the first and second gravitational-wave observing runs

We present results from offline searches of Fermi Gamma-ray Burst Monitor (GBM) data for gamma-ray transients coincident with the compact binary coalescences observed by the gravitational-wave (GW) detectors Advanced LIGO and Advanced Virgo during their first and second observing runs. In particular, we perform follow-up for both confirmed events and low significance candidates reported in the LIGO/Virgo catalog GWTC-1. We search for temporal coincidences between these GW signals and GBM-triggered gamma-ray bursts (GRBs). We also use the GBM Untargeted and Targeted subthreshold searches to find coincident gamma-rays below the onboard triggering threshold. This work implements a refined statistical approach by incorporating GW astrophysical source probabilities and GBM visibilities of LIGO/Virgo sky localizations to search for cumulative signatures of coincident subthreshold gamma-rays. All search methods recover the short gamma-ray burst GRB 170817A occurring ∼1.7 s after the binary neutron-star merger GW170817. We also present results from a new search seeking GBM counterparts to LIGO single-interferometer triggers. This search finds a candidate joint event, but given the nature of the GBM signal and localization, as well as the high joint false alarm rate of 1.1 10-6 Hz, we do not consider it an astrophysical association. We find no additional coincidences

Search for the isotropic stochastic background using data from Advanced LIGO's second observing run

The stochastic gravitational-wave background is a superposition of sources that are either too weak or too numerous to detect individually. In this study, we present the results from a cross-correlation analysis on data from Advanced LIGO’s second observing run (O2), which we combine with the results of the first observing run (O1). We do not find evidence for a stochastic background, so we place upper limits on the normalized energy density in gravitational waves at the 95% credible level of Ω GW < 6.0 × 10 − 8 for a frequency-independent (flat) background and Ω GW < 4.8 × 10 − 8 at 25 Hz for a background of compact binary coalescences. The upper limit improves over the O1 result by a factor of 2.8. Additionally, we place upper limits on the energy density in an isotropic background of scalar- and vector-polarized gravitational waves, and we discuss the implication of these results for models of compact binaries and cosmic string backgrounds. Finally, we present a conservative estimate of the correlated broadband noise due to the magnetic Schumann resonances in O2, based on magnetometer measurements at both the LIGO Hanford and LIGO Livingston observatories. We find that correlated noise is well below the O2 sensitivity