Integrated surveying for the archaeological documentation of a neolithic site

It has been tested the applicability of integrated surveys (remote sensing, digital photogrammetry and terrestrial laser scanning (TLS)) in order to verify, through gradual and successive steps, how geomatic techniques can get 3D results with metric value combined with a quality content for an archaeological site. In particular, the data have been collected during the excavation campaign of Neolithic archaeological site in Taranto. The possibilities to scan articulated forms, in the presence of curve, concavity and convexity, and jutting parts rotate, characterized by alterations, through the acquisition of a dense points cloud makes the technique TLS needed in archaeology. Through the photogrammetric technique the laser data has been integrated concerning some details found on the site for which it has been required a higher degree of detail. The photogrammetric data has been acquired with the calibrated camera. The processing of the acquired data and their integration has been made possible to study an important archeological site, in its totality, from small scale (general site framework) to large scale (3D model with a high degree of detail) and to structure a multi-temporal database for simplified data management

Studio e sperimentazione di un sistema dosimetrico per campi RF durante MRI

In questo lavoro di tesi, partendo da risultati ottenuti da particolari sperimentazioni in vitro, si evidenzia la possibilità che l’esposizione ad esame MRI induca un danno alla struttura del DNA, ossia che l’esposizione a radiazioni elettromagnetiche RF (Radio Frequenza) possa essere considerata un fattore di rischio per lo sviluppo di neoplasie. Al fine di confermare queste evidenze anche da un punto di vista scientifico, si affrontano studi di dosimetria teorica e sperimentale, utilizzando come grandezza dosimetrica il SAR ("Specific Absorption Rate"); ossia, ci si propone di misurare e stimare la quantità di potenza rilasciata dal campo a radiofrequenza nella massa unitaria di campione biologico irradiato durante un esame MRI, per poi poter ottenere una corrispondenza effettiva tra la dose di radiazione assorbita ed effetto biologico da esso derivante

The Contemporary Fitted Kitchen: Object, Space, and Sign

This article offers an examination of the contemporary kitchen: firstly, as an object that continues to draw on the forms established by the Modernists in the early 20th century. Using 'real' kitchens alongside contemporary media representations, the 'signs' of kitchens for their meaning, along with a consideration of the contemporary kitchen as a physical space in relation to some of the prevailing ideas about, and attitudes towards, space in both the economic and cultural realms. The aim was to reveal something of the cultural significance of the contemporary kitchen, not only as a reflection of the dominant ideologies of functionality and efficiency; of productive activity and as 'the heart of the home', but to propose that the contemporary kitchen is significant for its articulation through its appearance, size, materials (as well as in its fixed nature) and in marketing and media representations, of a much wider range of messages and meanings that may include, but are not limited to, the concepts of cultural capital, the spectacle, of gender identity and gender roles, as well as articulating our fears of impermanency, social alienation and even perhaps, homelessness

Social Responsibility as a Driver for Local Sustainable Development

The increased interconnection among local and global players induced by globalization, as well as the need for a complete application of the “subsidiarity principle”, calls for a re-thinking of the “corporate social responsibility” concept. This new concept broadens the perspective of the single company interacting with its own stakeholders in relation to specific social and environmental impacts, to a network of organizations, with different aims and natures, collaborating on relevant sustainability issues. In this paper, the authors will provide a definition of “Territorial Social Responsibility”, sustaining the multi-stakeholder approach as a driver toward local sustainable development. Firstly, theoretical approaches to sustainable development at the territorial level will be examined, identifying the most innovative ideas about governance, network relation and development theories. The idea of development focuses not only on the economic aspects, but on the structural and institutional factors. The existence of cooperative territorial networks is essential to fulfil the creation of tangible and intangible assets at the local level. At the same time, the effectiveness of the decision-making and rules’ system can stimulate and empower territorial networks to tackle sustainable development. An analytical framework, scheme-shaped, will be set in order to identify the main aspects, indicators and practices characterizing the territorial social responsibility concept. It will represent a first attempt to create a feasible instrument aimed at understanding how cooperative social responsible actors, operating in the same territory, could direct the path toward sustainable development.Local Sustainable Development, Territorial Social Responsibility, Participation, Local Governance, Accountability, Sustainability Reporting, Multi-Stakeholder Approach, Networks

Immunization against Hepatitis B Surface Antigen (HBsAg) in a Cohort of Nursing Students Two Decades after Vaccination: Surprising Feedback

Health-care students can be exposed to biological risks during university training. The persistence of long-term immunogenicity against hepatitis B virus (HBV) was analyzed in a cohort of nursing students two decades after primary vaccination. A total of 520 students were enrolled at the University of Palermo and were evaluated for levels of anti-HBsAg antibodies. ThestudentswereexaminedduringthefirstyearoftheirDegreeCourseandwerecheckedtwoyears later. All students with anti-HBsAg <10 mIU/mL during their first or third year were boosted within onemonth. Theproportionofstudentsthatwerevaccinatedduringadolescenceshowinganti-HBsAg ≥10 mIU/mL was higher than that observed in students who were vaccinated during infancy (69% versus31.7%;p-value<0.001). ReceivingHBVvaccinationatadolescencewassignificantlyassociated with a fourfold increased possibility of having anti-HBsAg titers≥10 mIU/mL (adj-OR = 4.21, 95% CI: 2.43–7.30). Among the students who were checked at the third year and boosted after the first year (n = 279), those who were vaccinated during infancy showed a higher percentage of antibody titers <10 mIU/mL (20.3% versus 8.7% among vaccinated during adolescence; p < 0.01). This study confirms that HBV vaccination at adolescence might determine a higher long-term persistence of anti-HBsAg titers≥10 mIU/mL and that anti-HBV booster could increase levels of anti-HBsAg over a relatively short period, especially in subjects who were vaccinated during infancy

Nickel binding sites in histone proteins

Nickel compounds are well known as human carcinogens, though the molecular events that are responsible for this are not well understood. It has been proposed that a crucial element in the mechanism of carcinogenesis is the binding of Ni(II) ions within the cell nucleus. It is known that DNA polymer binds Ni(II) only weakly, leaving the proteins of the cell nucleus as the likely Ni(II) targets. Being histone proteins the most abundant among them, they can be considered the primary sites for nickel binding. Here we describe the interactions of nickel with histone H4, core tetramer (H3-H4)2 and several peptide fragments which have been selected as the candidates for specific binding sites in the histone octamer. The results allowed us to propose several mechanisms of nickel induced damage resulting from metal coordination, including structural changes of histone proteins, as well as nucleobase oxidation and sequence-specific histone hydrolysis. The aim of the present work is to provide a comprehensive overview of literature dealing with nickel coordination to histone proteins and its link with nickel involvement in toxicity and carcinogenicity

Integrated survey for the reconstruction of the Papal Basilica and the Sacred Convent of St. Francis in Assisi, Italy

The Papal Basilica and the Sacred Convent of Saint Francis in Assisi in Italy are characterized by unique and composite particularities that need an exhaustive knowledge of the sites themselves to guarantee visitor's security and safety, considering all the people and personnel normally present in the site, visitors with disabilities and finally the needs for cultural heritage preservation and protection. This aim can be reached using integrated systems and innovative technologies, such as Internet of Everything (IoE), which can connect people, things (smart sensors, devices and actuators; mobile terminals; wearable devices; etc.), data/information/knowledge and processes to reach the wanted objectives. The IoE system must implement and support an Integrated Multidisciplinary Model for Security and Safety Management (IMMSSM) for the specific context, using a multidisciplinary approach. The purpose of the paper is to illustrate the integrated survey for the reconstruction of the considered site that was necessary to obtain all the necessary information to start to set up the considered IMMSSM and the related IoE based technological system

Surface Plasmon Excitation of Second Harmonic light: Emission and Absorption

We aim to clarify the role that absorption plays in nonlinear optical processes in a variety of metallic nanostructures and show how it relates to emission and conversion efficiency. We define a figure of merit that establishes the structure's ability to either favor or impede second harmonic generation. Our findings suggest that, despite the best efforts embarked upon to enhance local fields and light coupling via plasmon excitation, nearly always the absorbed harmonic energy far surpasses the harmonic energy emitted in the far field. Qualitative and quantitative understanding of absorption processes is crucial in the evaluation of practical designs of plasmonic nanostructures for the purpose of frequency mixing

Extraversion and neuroticism in sexually dysfunctional men suffering from erectile dysfunction and premature ejaculation: a cross-sectional study

The role of personality traits in sexual complaints and dysfunctions is ever more evident. However, the literature is very scarce as to the possible relationships between such personality traits and specific sexual dysfunctions like ED, PE or both, their subtypes as to time of onset and severity levels. The main aim of the present study was to investigate if Neuroticism and Extraversion have different roles and trends in men suffering from PE and/or ED, both lifelong and acquired. Moreover, we verified if, by adopting DSM-IV-TR and DSM-5 criteria for diagnosing PE, some differences emerged in percentages of diagnosed cases. The sample consisted of 222 patients aged 18-70. The International Index of Erectile Function (IIEF-15) was used to assess erectile function, and the Premature Ejaculation Severity Index (PESI) was used to assess the severity of PE dysfunction. Neuroticism and Extraversion were measured with the Eysenck Personality Questionnaire-Revised (EPQ-R). In our results, Neuroticism and Extraversion were dependent on the kind of sexual dysfunction and its severity. These results suggest that type, time of onset and severity of sexual dysfunctions should be considered as related to specific personality characteristics and vice versa

Interaction of divalent cations with protein PARK9

Metals have been shown to play a role in the genesis and development of many neurodegenerative diseases. Park9 encoded protein can protect cells from manganese poisoning, an environmental risk factor for a Parkinson’s disease- like syndrome. Park9 belongs to a family of ATP-ases involved in metal coordination and transportation; familial mutations of this gene may result in early development of PD. We tested two peptide sequences from Park9, -P1D2E3K4H5E6L7- (1) and -F1C2G3D4G5A6N7D8C9G10- (2), for Mn(II), Zn(II) and Cu(II) binding. These fragments are located from 1165 to 1171 and from 1184 to 1193 residues in Park9 sequence, and are highly conserved in a number of organisms, from yeasts to humans. Experiments have been carried out at different pH values and ligand/metal molar ratios with both potentiometric and spectroscopic (NMR, UV-vis) techniques, showing that the three metals are able to effectively bind the examined peptides. Mn(II) and Zn(II) coordination with peptide (1) involves imidazol of His5 and carboxyl γ-O of Asp2, Glu3 and Glu6 residues, in a distorted octahedral geometry, possibly involving bidentate interaction of carboxyl groups; four donor atoms participate in Zn(II) binding, resulting in a tetracoordinated geometry. Mn(II) and Zn(II) coordination involves the two cysteines in peptide (2); Mn(II) accepts additional ligand bonds from D4 and D8 to complete the coordination sphere, together with some water molecules. Details of Cu(II) coordination are under study