2020-06-19/20/21 DAILY UNM GLOBAL HEALTH COVID-19 BRIEFING

Executive Summary: NM Highlights: Dr. Scrase on-line briefing. NM cases. Campgrounds closed through July 4th. Otero prison reports. Navajo nation’s first police dies. Santa Fe cancels 4th July fireworks. Face coverings donated. NM infection rate drops. US Highlights: AZ Governor issues Exec Order. Economics, Workforce, Supply Chain, PPE: Epidemiology Highlights: Reopening hospitals metric. Comparison of mask effectiveness. Private practices suffer. Healthcare Policy Recommendations: Maternal mortality. Practice Guidelines: Recommendations on hepatobiliary surgery and neonate management. Drugs, Vaccines, Therapies, Clinical Trials: Animal studies generate new vaccine candidates and vaccine platform. 16 new clinical trials registered. Other Science: Respiratory secretions detected by trained dogs. MRI findings show brain lesions in non-survivors. Healthy blood vessels may protect children. Meta-analysis on pneumonia severity. Smoking and COVID-19 severity meta-analysis

2020-06-29/30 DAILY UNM GLOBAL HEALTH COVID-19 BRIEFING

Executive Summary: NM Highlights: NM cases update. ABQ nursing home hit hard. UNM student family housing closure. White Sands National Park reopening. 52% of federal COVID-19 relief money for tribal communities. Bill signed to help NM taxpayers. US Highlights: Polarization of political elite response on Twitter. International Highlights: China’s military to use Ad5-nCoV vaccine in trials. Economics, Workforce, Supply Chain, PPE: Decontaminate N95 respirators using a microwave. Epidemiology Highlights: Mask-wearing prevents transmission. Face-masks associated with Italy’s declining epidemic. Healthcare Policy Recommendations: Social distancing reassessed? Lessons learned from previous pandemics. Digital tools against COVID-19. Investigating cultural and psychological factors to reduce spread. Practice Guidelines: Preserving couple relationships during COVID-19. Testing: No difference in viral load between symptomatic and asymptomatic individuals. A new fast point-of-care virus detection test. Few patient serum samples have virus RNA (at low viral load) and these are not associated with infectious disease. Symptoms and temperature reports are informative to screen health care workers. Drugs, Vaccines, Therapies, Clinical Trials: 37 new trials registered June 29-30. Other Science: Multisystem pediatric inflammatory syndrome. Hazardous postoperative outcomes. Childhood immunization in Africa. Citizen science and protein folding

2020-05-22 DAILY UNM GLOBAL HEALTH COVID-19 BRIEFING

Executive Summary: NM Highlights: 12 positive cases at NMSU. Short-term rentals restrictions. Dine-in reopening. US Highlights: Models to forecast COVID-19 deaths. Places of worship reopening. Contact tracing at University of Alabama. International Highlights: More deaths among poor. Mortality data in Italy. High death toll in Brazil. Global vaccines fall behind. Italy cases drop. Vaccines to go through India. Epidemiology Highlights: Children not pandemic drivers. Healthcare Policy Recommendations: Burnout of HCWs. NYC surgeons’ response. Foggy glasses tips. Practice Guidelines: Recommendations are provided on surgical strategies during COVID-19, management of hypertension, anesthesia practice, avoiding drug-induced cardiovascular impairments, arrhythmia management, elective surgery reboot, nutritional management, stroke care, neurointerventional surgery, blood management. Testing: Unregulated tests identified. Interpreting test results. Drugs, Vaccines, Therapies, Clinical Trials: Vaccine trials results. Vaccine moves to trials. Monoclonal antibody identified. Hydroxychloroquine no benefit. Adjuvant corticosteroid therapy. Old drugs may benefit. Vaccines inducing antibodies. Other Science: Mortality and CKD/liver disease. Transmission in pregnancy. Pathophysiology insights. Readmission characteristics. Sodium and severity. Simulated sunlight disinfects

2020-05-02/03 DAILY UNM GLOBAL HEALTH COVID-19 BRIEFING

Executive Summary: More NM cases. Free Shiprock testing. Prison release demands. 8 state parks reopen. Higher US deaths. NY PPE case dismissed. Orthopedic Tx down. European deaths down. UK mortality factors. People leaving large cities. Ending lockdown strategies. Public mask impact. Taiwan tracing. Homeless shelter prevalence. Homeless shelter outbreak. 50-state R0. COVID-19 decades later. US county tracking site. Hospital management model. COVID-19 behavioral transformation. Practice guidelines for: cardiology, IBD surgery, and rheumatic physical inactivity. Roche antibody test approved. Abbott antibody test EU-certified. Home anosmia assessment. CVD and ACE/ARBs. Tocilizumab early evidence. Tocilizumab systematic review. WHO vaccines trial. HCQ slower viral clearance. CBC predicts severity. Kidney disease meta-analysis. Innate/adaptive immunity timing. Combating misinformation. Mental health living reviews

2020-04-30 DAILY UNM GLOBAL HEALTH COVID-19 BRIEFING

Executive Summary: NM residential facility deaths. NM case update. NM TriCore testing antibodies. Navajo nation cases. May 10 Navajo peak. Udall funding push. El Paso shopping discouraged. NM budget shortfall. Santa Fe furlough. Ethanol sanitizer safety. LA free testing for all. Michigan protest. NM Batelle N95 decontamination. Hospital revenue decline. Wastewater early detection. German herd immunity. 60-day viral shedding possible. Temporary infected “ark”. Prison release preparedness. Low quality research. Phased long-term care. Suicide prevention. Corticosteroid tradeoffs. Cloth mask guidelines. SARS-CoV-2 assays compared. IgG and viral loads. Better testing reporting. Dubious testing vendors. Promising oral drug. Hydroxychloroquine prophylaxis dosing. Umifenovir ineffective. Multi-drug nanoparticles. Drug discovery new targets. 38 new COVID-19 trials. Cancer research review. Attenuated SARS-CoV-2

2020-05-04 DAILY UNM GLOBAL HEALTH COVID-19 BRIEFING

Executive Summary: NM convalescent plasma call. NM case counts. Gallup lockdown continues. Tribal federal relief delay. Childcare demand drops. Polling open for primaries. Non-US world funds R&D. South Korea eases more. Soft quarantine inefficiency. Chinese interventions. Transmission window. December French case. CDC on law enforcement, essential errands. NEJM on telemedicine. Practice guidelines for: ECMO, pneumonia, nuclear medicine SOP. FDA antibody test restrictions. Africa testing differences. PCR assay sensitivity. Wuhan antibody tracking. Hydroxychloroquine toxicity. Remdesivir mechanism. Tocilzumab study inconclusive. SARs-CoV-2 structure. 28 new trials. Immunology and exercise. Synthetic SARS-CoV-2. IgM and IgG responses. Bacterial and fungal coinfection. Youth mental health challenges

2020-05-09/10 DAILY UNM GLOBAL HEALTH COVID-19 BRIEFING

Executive Summary: NM gets remdesivir. NM case update. Dental services resume. NM prison testing. Educator age risk. Stuart Kauffman dashboard. Long-term care fatalities. Fauci in quarantine. US farmer support. US vaccinations down. South Korea bar shutdown. German rebound lockdown easing. Managing glove skin reactions. Neurosurgery down 70%. Impact airline travel ban. CDC meat packing report. UK distancing impact. 9-day incubation. Low fatality rate estimates. Improving social connection. Social distancing and mask use effective. Parents under stress. Nurse psychological stress. Israel Internal Medicine Tx strategies. Education management. Recommendations are given on endoscopy procedures, management of adrenal insufficiency and of IBD, on re-introduction of cardiovascular services, and respiratory PPE for healthcare workers. Guidelines for medical examiners, coroners, and pathologists. Successful GI department re-opening in China. FDA: serology testing performance. First antigen test approved. FFPE SARS-CoV-2 detection. Triple antiviral therapy effective. Respiratory rehabilitation effective. Targeting inflammatory cascade. Negative HCQ observational study. Chloroquine G6PD risk. Interferon inhibits replication – mouse. Tocilizumab benefit: uncontrolled study. Most trials in HCQ, remdesivir. NKG2A treatment target. In silico antiviral peptides. Chinese medicine review. Cell entry mechanisms. Olfactory viral entry. Higher female immune response. Immune checkpoints. Metagenomic analysis. ¼ hospitalized no risk factors. High RDW mortality. Mortality: vitamin D. Deaths of despair. Optimism and exercise

2020-06-10/11 DAILY UNM GLOBAL HEALTH COVID-19 BRIEFING

Executive Summary: NM Highlights: Governer’s update on COVID-19 efforts. NM case count. Testing for food industry workers. Testing for lawmakers and staffers. Face coverings mandatory in Santa Fe. Lawmakers prepare to $2.4B budget hole. Learning loss due to lockdown. US Highlights: EPA orders unsafe products removed. Cases on the rise after roll back. Economics, Workforce, Supply Chain, PPE: Governments need more money. Study on masks. Hearing impaired masks. Fast spread in Africa. Kenya’s economic slowdown. Epidemiology Highlights: White House Task Force warns of spikes. Mortality risk factors. Higher mortality in cancer patients. UV-C disinfection of mobile phones. Practice Guidelines: Benefits of non-invasive ventilation and prone positioning demonstrated in 15 patient case-series. Canadian Thoracic Society\u27s statement on management of sleep disordered breathing. Experience of providing ketogenic diet in two US epilepsy centers. A review on personalized cardiometabolic approach to reduce COVID-19 complications and costs. Asian guidelines on inflammatory bowel diseases management. Testing: False negative rate in COVID-19 testing. Patients testing negative with subsequent positive test results. IgG and IgM antibody response. SARS-CoV-2 receptor binding domain potential antigen for use in antibody testing. Drugs, Vaccines, Therapies, Clinical Trials: Drug repositioning. Hydroxychloroquine toxicity. Multifaceted immunosuppression described. HCQ not effective for prophylaxis. 63 new trials. Other Science: Containment vs mitigation strategy affects mortality. Prehospital pulse oximetry in detection of silent hypoxemia. Normal D-dimer associated with inpatient survival. Family support and risk of depression, anxiety, PTSD. Limited airborne transmission. Stay-at-home orders and weight

2020-05-18 DAILY UNM GLOBAL HEALTH COVID-19 BRIEFING

Executive Summary: NM Highlights: NM COVID safety guidelines. NM case count. Navajo Nation case count. Gadsden school district kitchens closures. ABQ non-COVID patient treatment delay. NM factory shutdowns. US Highlights: Moderna Inc. vaccine shows promise. US cases exceed 1.5 million. US states reopen. NY slowly reopening. Michigan vaccines decrease. CDC antibody study. International Highlights: WHO independent review. Economics, Workforce, Supply Chain, PPE Highlights: Maxillofacial surgeries down. PPE skin damage. Epidemiology Highlights: Infections may overwhelm ICE facilities. High estimated US infections. LA antibody testing results. Super-spreader in church. Hospital staff antibody response. No effect of climate. Healthcare Policy Recommendations: Pairing assistance to alleviate health system failure. Exercise recommendations. CDC funeral guidance. Practice Guidelines: Emergency Dept. Patient isolation triage tool. Gynecology ward rearrangement. Guidelines for nuclear cardiology labs. Testing: PCR without RNA extraction. Comparison of PCR kits. Comparison of IgG assays. Sequencing for screening. Drugs, Vaccines, Therapies, Clinical Trials: Subcutaneous tocilizumab. Five new antivirals. 28 new COVID-19 trials. Other Science: PTSD in healthcare workers. Antibody neutralizes virus. Good pregnancy outcomes. Males at risk. CDC: hospitalization and mortality rates. News makes people sad. African green monkey model. Air is cleaner

2020-05-01 DAILY UNM GLOBAL HEALTH COVID-19 BRIEFING

Executive Summary: Relaxing emergency orders. UNMH remdesivir patient. NM case update. Gallup lockdown. Aid for arts. Nursing facility boost. More NM layoffs. Public relief programs. Insurance call center. Capturing COVID-19 stories. More NYT NM praise. Belief enhances compliance. Italy cardiac arrests. Non-COVID vaccine backlog. Africa investments. US airlines require facemasks. Pandemic timeline prediction. Convalescent plasma. Viral shedding. Laboratory information systems. Internet searches. Practice guidelines for: skull surgery, cardiac electrophysiology, blood purification, electroconvulsive therapy, quantitative CT. Testing methods review. FDA authorizes remdesivir. Stillbenoid analogs. Favipiravir. HCQ reanalysis. Hypercoagulation and antithrombotic. ChAdOx1 MERS and animal immunity. New drug trials. Enterocytes infections. Cardiovascular disease. ACEi/ARBs. Common antihypertensives. Comprehensive COVID-19 review