4 research outputs found
Detection of Urinary Molecular Marker Test in Urothelial Cell Carcinoma: A Review of Methods and Accuracy
- Author
- Publication venue
- MDPI AG
- Publication date
- 01/11/2022
- Field of study
Early detection of bladder cancer has a positive impact on prognosis. A variety of biomarkers have been developed to detect bladder tumors in urine early and reduce the need for cystoscopy. To detect bladder cancer, several methods are available, but their accuracy varies according to the sensitivity and specificity of each method. This review aims to highlight the established detection methods for bladder cancer based on the available literature. In addition, we aim to identify the combination of different effective detection methods that provides the highest degree of accuracy. In our study, a keyword retrieval method was used to search for appropriate English-language references. This bibliography has been indexed in PubMed and Scopus or has been found through systematic searches from 2015 to 2022. Based on an analysis of international guidelines, it has been revealed that there are numerous discrepancies and unresolved issues. The discovery of an ideal detection method for urothelial cell carcinoma biomarkers has been the subject of numerous efforts. In recent years, a wide range of off-label, experimental, novel, and combined approaches have been published on this topic. This review can contribute to the identification of accurate methods of detecting bladder cancer and highlight areas for future research that can be improved
Chronic Kidney Disease—An Underestimated Risk Factor for Antimicrobial Resistance in Patients with Urinary Tract Infections
- Author
- Publication venue
- 'MDPI AG'
- Publication date
- 22/09/2022
- Field of study
(1) Background: Chronic kidney disease (CKD), as well as antimicrobial resistance (AMR) represent major global health problems, with important social and economic implications. It was reported that CKD is a risk factor for antimicrobial resistance, but evidence is scarce. In addition, CKD is recognized to be a risk factor for complicated urinary tract infections (UTIs). (2) Methods: We conducted an observational study on 564 adult in-hospital patients diagnosed with urinary tract infections. The aim of the study was to identify the risk factors for AMR, as well as multiple drug resistance (MDR) and the implicated resistance patterns. (3) Results: The mean age was 68.63 ± 17.2 years. The most frequently isolated uropathogens were Escherichia coli strains (68.3%) followed by Klebsiella species (spp. (11.2%). In 307 cases (54.4%)), the UTIs were determined by antibiotic-resistant bacteria (ARBs) and 169 cases (30%) were UTIs with MDR strains. Increased age (≥65) OR 2.156 (95% CI: 1.404–3.311), upper urinary tract obstruction OR 1.666 (1.083–2.564), indwelling urinary catheters OR 6.066 (3.919–9.390), chronic kidney disease OR 2.696 (1.832–3.969), chronic hemodialysis OR 4.955 (1.828–13.435) and active malignancies OR 1.962 (1.087–3.540) were independent risk factors for MDR UTIs. In a multivariate logistic regression model, only indwelling urinary catheters (OR 5.388, 95% CI: 3.294–8.814, p < 0.001), CKD (OR 1.779, 95% CI: 1.153–2.745, p = 0.009) and chronic hemodialysis (OR 4.068, 95% 1.413–11.715, p = 0.009) were risk factors for UTIs caused by MDR uropathogens. (4) Conclusions: CKD is an important risk factor for overall antimicrobial resistance, but also for multiple-drug resistance
Evaluation of a quality improvement intervention to reduce anastomotic leak following right colectomy (EAGLE): pragmatic, batched stepped-wedge, cluster-randomized trial in 64 countries
- Author
- Aarts Frits
- Ababneh Hazim
- Abad-Motos Ane
- Abaidalla Ahmed
- Abbakar Malaz
- Abd El Aal Ahmed
- Abd-Errazik Mohammad Ahmad
- Abdalradiy Abdalrahmman G
- Abdelkhalek Mohamed
- Abdelkhalek Mostafa
- Abdellatif Ahmed
- Abdellatif Mohamed
- Abdelsaid Kirolas
- Abdou Khaled
- Abdulfatah Mustapha
- Abdullah Mohammad Amer
- Abdullahi Mustapha Miko Mohammed
- Abellán Antonio Melero
- Abeysinghe Nayana
- Abiyere Henry
- Achimas-Cadariu Patriciu Andrei
- Adakaya Sıla
- Adam Nicolas
- Adams Benita
- Adams Ferdinand
- Adegboye Kazeem
- Adeyeye Ademola
- Adra Lama
- Adu-Poku Patricia
- Afuwape Oludolapo
- Afzal Ameer
- Afzal Muhammad Farooq
- Agapov Mihail
- Agara Daniel
- Aggarwal Manisha
- Agger Erika
- Aghadi Ifeanyi Kene
- Ahmed Amjed Yassir
- Ahmed Haleemasahdia
- Ahmed Khalil
- Ahmed Manar
- Ahmed Masood
- Ahmed Safia
- Ahn Hong Min
- Aibe Raquel
- Aigner Felix
- Aissat Abdenour
- Aitbaeva Arai
- Akay Omer
- Akbar Ali
- Akbas Ahmet
- Akere Abidemi
- Akesen Selcan
- Akgun Erhan
- Akhtar Naseem
- Akın Emrah
- Akova Elif
- Aktas Serhat
- Akçay Özlem
- Al Masri Mahmoud
- Al-Alnsi Ahmed
- Al-Hutheifi Roqia'A
- Al-Jarrah Amar
- Al-Naggar Hamza
- Al-Shehari Mohammed
- Alamin Nadeen
- Alawi Raneen
- Alawlaqi Dina
- Alawneh Fade
- Alberola Maria José
- Albers Michael
- Alcolea Natalia González
- Aleem Muhammad
- Alegre Inês
- Alegre Javier Martinez
- Alexandre Flavia
- Alexandrescu Corina
- Alexnder Abelevich
- Alexopoulou Kalliopi
- Alfonso Beatriz Amorós
- Ali Ahmed
- Ali Che Saniati Che
- Ali Danish
- Ali Madeeha
- Ali Mahmoud Abdelwahab
- Ali Manhal Hashim
- Ali Noura Al
- Alikhanli Jhale
- Aliyeva Zumrud
- Aliyu Mohammed
- Aljawder Hasan
- Allen Kate
- Almahmeed Ebrahim
- Alonso Alfredo
- Alonso Javier Etreros
- Alsamneh Muneer
- Alsayadi Ramzi
- Altinel Yuksel
- Altintoprak Fatih
- Altomare Donato F
- Alvarenga Isabella
- Alvarez Laura Jimenez
- Alvarez-Bautista Francisco Emmanuel
- Alvarez-Díez Marcos
- Alves Brenda Chayanny
- Amadigwe Rita
- Amado Andreia
- Amado Fabíola
- Amador Cristina García
- Amanullah Nazli
- Amaral Hélida Aline Tomacheski
- Amaral Luis
- Amin-Tai Hizami
- Aminu Bashiru
- Amir Ahmad Suhaimi
- Ammar Ahmed Siddique
- Ammar Mona Ahmed
- Ammendola Michele
- Ammerata Giorgio
- Amorim Edgar
- Ancans Guntis
- Anderson Tom
- Andrade Diogo
- Andrejevic Predrag
- Andrés Beatriz Díaz San
- Anestiadou Elissavet
- Ang Chin Wee
- Angelo Franceschi
- Anokhin Evgeny
- Anoldo Pietro
- Antakia Ramez
- Anton Majd
- Antonelli Serena
- Antropoli Carmine
- Anula Rocio
- Anwar Jamal
- Anyadike Florence
- Apostolakidou Magda
- Apostolidi Eirini
- Aprea Giovanni
- Arabadzhiev Angel
- Arakawa Satoshi
- Arauz Jazmin
- Aravindan U
- Aremu Abdurrahman
- Aremu Isiaka
- Argawy Osama
- Arican Can
- Arida Zahed Abu
- Armellin Claudia
- Arnaoutoglou Eleni
- Arreguy-Borges Kanthya
- Artigot Mariano
- Arturi Alessandro
- Arulappan Nirupama
- Arya Shobhit
- Arynov Ardak
- Asaad Peter
- Asano Yukio
- Ascari Francesca
- Asgarov Mohsum
- Ashmawy Soad
- Aslam Muhammad Imran
- Assimakopoulou Elena
- Assis Ana
- Astilleta Romina
- Atanasov Boyko
- Atendido Tiffany
- Athanasakis Elias
- Atici Semra Demirli
- Avellaneda Nicholas
- Avellaneda Nicolas
- Avseren Goksu
- Awead Marwa
- Ayandipo Omobolaji
- Aybar Engin
- Aydin Funda
- Aydin Gaye
- Ayoub Kusay
- Aytac Erman
- Aytaç Erman
- Azevedo Jose
- Azevedo Patricia
- Azhar Najia
- Aziz Gowhar
- Azman Zairul Azwan Mohd
- Aşkar Ahmet
- Babatunde Olanrewaju
- Badawi Marwa
- Baek Jeong-Heum
- Baez Noelia Fernández
- Baeza-Murcia Melody
- Bagnardi Francesco
- Baharom Salahudin
- Baik Seung Hyuk
- Baimakhanov Abylai
- Bains Lovenish
- Baker Aleksandra
- Bakmaz Bernarda
- Bala Abubakar Muhammad
- Balaban Vladimir
- Balalis Dimitrios
- Balasubramaniam Dinesh
- Balathayalan Yathev
- Baldi Claudio
- Balestri Riccardo
- Balfour James
- Ballah Abubakar
- Ballian Nikiforos
- Balooshi Iman Al
- Baloyiannis Ioannis
- Bamford Richard
- Bandar Mahdi Al
- Banham Gail
- Bannoud Mohammad Hassan
- Baptista Victor
- Baral Jörg
- Barbalace Nicolas
- Barbato Giuseppe
- Barbosa Anderson
- Bareka Metaxia
- Baris Baver
- Barradas Renato
- Barreda Sara Castillo
- Barrena-Blazquez Silvestra
- Barton Jess
- Bartosiak Katarzyna
- Bashilkina Olga
- Bashir Mohammed
- Basile Raffaele
- Basnyat Pradeep
- Batool Sana
- Bautista Wilson Manuel Sánchez
- Bayhan Zülfü
- Bayo José Manuel Muros
- Bayón Raquel Álvaro
- Baños Pedro Antonio Parra
- Beard David
- Bedzhanyan Arkady
- Behilil Chakib
- Bekele Kebebe
- Belarmino Armin
- Belay Million
- Belev Nikolay
- Bellato Vittoria
- Beltrán de Heredia Juan
- Belvedere Angela
- Benetti Emilio
- Benetti Sara
- Bengueddach Aicha
- Benjelloun El Bachir
- Benkabbou Amine
- Bennett James
- Bensafir Salim
- Bergamini Carlo
- Bernotaite Vlada
- Beron Reinaldo Isaacs
- Bethune Robert
- Bezede Cosmin
- Beznosenko Andriy
- Bhangu Aneel
- Bhargava Aman
- Bhat Rama Rani Krishna
- Bianchi Romina
- Bianco Francesco
- Bigoni Irene
- Binetti Margherita
- Bintintan Vasile
- Biondi Alberto
- Biondo Santino Antonio
- Bisgin Tayfun
- Bisheet George
- Bissett Ian
- Biswas Jyotirmoy
- Blackwell Sue
- Blanco Pablo
- Blanco Raquel Ríos
- Blanco-Colino Ruth
- Blasco Laura Fraile
- Blazquez-Martin Alma
- Bobadilla Billy Jimenez
- Bocancia Raluca
- Boccia Giuseppe
- Bogatikov Alexander
- Bolanle Olajide Edward
- Bomfa-Barbosa Alysson
- Bompou Effrosyni
- Bonardello Michela
- Bonci Eduard-Alexandru
- Bordom Daniel Osei
- Borges Filipe
- Borghi Felice
- Boschiero Matheus Negri
- Bose Bodhisattva
- Bouchagier Konstantinos
- Boudjenan-Serradj Nabil
- Boudoux Sabrina
- Bourazani Maria
- Boyce Stephen
- Bozbiyik Osman
- Bracale Umberto
- Brachini Gioia
- Bradulskis Saulius
- Brainsa Eneida
- Brandström Gustav
- Braumille Markus
- Bravo Ana Minaya
- Bravo Raquel
- Bredikhin Mikhail
- Brito Noelia
- Bruni Andrea
- Buccianti Piero
- Buchs Nicolas
- Buchwald Pamela
- Budnikova Ina
- Budrikienė Rima
- Buey Lourdes
- Buijs Louis
- Buleje Jorge Alejandro Benavides
- Burlov Nikita
- Butt Anam
- Byshetty Rajendar
- Bywater Edward
- Bzikha Ilham
- Bánky Balázs
- Bælum Jens Kristian
- Caballero-Delgado Javier
- Cabrera Claudia
- Cafranga Estíbaliz Gutiérrez
- Cagnazzo Federica
- Calabria Mariangela
- Calabro' Marcello
- Caliendo Domenico
- Calin Camelia
- Caliskan Cemil
- Callan Rory
- Callari Cosimo
- Caltea Mihaela
- Calvo Almudena Castro
- Camacho Amparo
- Cammarata Francesco
- Campanati Renato
- Campanelli Michela
- Campbell Marion
- Canals Lucía Otazu
- Canda Aras Emre
- Cano-Matias Auxiliadora
- Cao Victor Hugo Bruno
- Capolupo Gabriella Teresa
- Cappiello Antonio
- Capuano Marianna
- Capusan Alina
- Carannante Filippo
- Carbone Ludovico
- Cardelli Stefano
- Carden Claire
- Cardoso Diogo
- Caricato Marco
- Carlin Patricia Saez
- Carlini Massimo
- Carlos Sandra
- Carneros Virginia Jimenez
- Carosso Fabio
- Caroço Teresa Vieira
- Carpelan Anu
- Carpenter Holly
- Carrascosa-Morales Irene
- Carrie Augusto
- Carrizo Claudia
- Carta Giuseppina
- Carvalho Alexandre
- Carvello Michele
- Casanova Daniel
- Cascais Raquel
- Cassia Gabriela
- Castaldi Antonio
- Castaño Renata
- Castiglioni Simone
- Castillo Enrique Roca
- Castro Marta Cuartero
- Catalano Pablo
- Cato Liam
- Caz Esra
- Cebolla Elena Sagarra
- Cecchini Ilaria
- Celdrán Rebeca González
- Celik Hale Kefeli
- Ceretti Andrea Pisani
- Ceron Silvia Ferrer
- Cervellera Maurizio
- Cervone Carmela
- Chacko Anil
- Chandrasinghe Pramodh
- Charakopoulou Alexandra
- Chardalias Leonidas
- Chaturvedi Arun
- Chatzikomnitsa Paraskevi
- Chaudhari Abhishek
- Chaudhry Sanjay
- Chawla Tabish
- Chee Corissa
- Chen Nevin
- Cheng Kuang I
- Chiarugi Massimo
- Chisthi Meer
- Chitnis Abhishek
- Chitul Andrei
- Chmielewski Gaspard
- Cholewa Hanna
- Chornet Marta Roselló
- Chowdhary Manish
- Chowdhury Sharfuddin
- Chowdhury Sharfuddin M
- Chowdri Nisar
- Christensen Peter
- Christodoulidis Grigorios
- Chrysos Emmanuel
- Chua Lorna
- Chubukova Natlia
- Chung Jun Seong
- Church Robert
- Chwat Carina
- Ciabattari Paula
- Cianchi Fabio
- Cianci Pasquale
- Ciccarese Angelo Antonio
- Ciftci Ahmet Burak
- Cigagna Luca
- Cini Charles
- Ciotarla Danut Constantin
- Cirocchi Nicholas
- Ciubotaru Cezar
- Ciulli Cristina
- Ck Harikumar
- Clark Thomas
- Clarke Nicola
- Coccolini Federico
- Codes Lina
- Coelho Ana Margarida
- Cois Alessandro
- Coladonato Massimiliano
- Colak Elif
- Coldwell Chris
- Collins Jen
- Colombo Francesco
- Colás-Ruiz Enrique
- Conceição Luis
- Conde Juan Guillermo Ais
- Connolly Lewis
- Conversano Ivana
- Convertini Ornella
- Cook Esther
- Cooke Fiachra
- Coppolino Francesco
- Coratti Francesco
- Cordeiro Lisbete
- Correia Angela
- Correia Débora
- Cortes Bruno Giusti Werneck
- Cortés Guillermo Felipe Valderas
- Coskun Nurcan
- Costa Breno Xaia Martins
- Costa Susana
- Costa Sílvia
- Cour Kenn La
- Crabtree Nicholas
- Creavin Ben
- Cremonini Camilla
- Crescentini Giacomo
- Cricrì Michele
- Crisan Dana
- Cristian Daniel
- Croce Gianni Di
- Cruz Isabela
- Cucinotta Eugenio
- Cuichan Marco Vinicio Yugsi
- Cullinane Carolyn
- Cuneo Davide
- Cunha Miguel
- Curbelo Jacqueline
- Curcio Silvia
- Curro Giuseppe
- Currà Maria Cristina
- Currás Rosana Pérez
- Custódio Pedro
- Cutellè Clelia
- Czarnecki Roman
- D'Angelo Salvatore
- D'Ugo Stefano
- da Luz Magda
- da Silveira Sete Alexandre
- Dainius Edvinas
- Dalton Richard
- Damieta Marta Pascual
- Danassi Despoina
- Danelli Piergiorgio
- Danial Aghyad Kudra
- Daniels Ian R
- Daniyan Muhammad
- Danna Riccardo
- Danys Donatas
- Dardanov Dragomir
- Daryanani Deepu
- Dassanayake Vihara
- Daugėla Edvardas
- Dauri Mario
- Davidovskaja Larisa
- Davies Emma
- Davis Cian
- Dawson Brett E
- Dawson Carmel
- de Andrés-Asenjo Beatriz
- de Deken Julie
- de Franciscis Silvia
- de Kort Chantal
- de La Plaza Llamas Roberto
- de Lacy Antonio Maria
- de Lebrusant Fernández Sara
- de León Rendón Jorge Luis
- de Luca Michele
- de Lucia Chiara
- de Miranda Silvestre Simone Chaves
- de Oliveira Góes Igor Arantes
- de Oliveira Flávia Gomes
- de Oliveira João Carlos Costa
- de Palma Giovanni Domenico
- de Paoli Massimo
- de Queiroz Fábio Lopes
- de San Pío Carvajal Eduardo
- de Silva Dulantha
- de Simone Giuseppe
- de Souza Artioli Luana Maria
- de Souza Pires Bruno Lucena
- de Stefano Mauro
- de Zoysa Ishan
- Deac Vasile
- Debono Marianne
- Dedeu-Bastardas Imma
- Degiuli Maurizio
- Del Carmen Casas García Maria
- Del Castillo Vanesa Crespo Garcia
- Del Olmo Maria Inmaculada Ureña
- Del Pueblo Cristina Sanchez
- Del-Rio-Lafuente Francisco-Javier
- Delgado Eduardo
- Delgado Marina
- Delibegovic Samir
- Delimpalta Christina
- Delrio Paolo
- Demir Mehmet
- Demirel Emel
- Demirgan Serdar
- Dempsy Charlotte
- Deniz Nuri
- Depalma Norma
- Desai Neha
- Deus Ana Cláudia
- Devesa Helena
- Dhali Arkadeep
- Dhali Gopal Krishna
- Dhar Puneet
- Diaconescu Cati
- Diego Alejandro Romero-De
- Diez-Alonso Manuel
- Dijan Emilio
- Dilawar Maha
- Dimitriou Nikoletta
- Dimitrov Dobromir
- Dimitrova Slavina
- Dimofte Mihail-Gabriel
- Dindelegan George
- Dindri Franco
- Dinkci Mustafa Deniz
- Diéguez Beatriz
- Djumabayev Khasan
- Dobkowski Grzegorz
- Dodhy Afia Arshed
- Dolhai Erika
- Domanskiy Andrei
- Domingos Hugo
- Dominguez Fabiana
- Dominguez Sara Hernández
- Dominioni Tommaso
- Donatiello Valerio
- Doniquian Alejandro Marcelo
- Doree Nicholas
- Dorovinis Panagiotis
- Dos Santos José Mauro
- Dos Santos Marco Antônio Miranda
- Dos Santos Maria Beatriz Alves
- Douba Zain
- Drissi Farouk
- Drozdov Evgeniy
- Duarte Maria José
- Duchalais Emilie
- Dudas Gabor
- Dudric Vlad
- Dulskas Audrius
- Dupret Luc
- Durai Sheela
- Dushimova Zaure
- Duzgun Ozgul
- Dychko Aleksander
- Dzharov Georgi
- Dzhumabekov Berik
- Dziakova Jana
- Díez Miguel Cuende
- Earley Helen
- Ebdewi Hamdi
- Ebrahem Aamal
- Edington John
- Egwuonwu Ochonma Amobi
- Ejiofor Gloria
- Ekepil Anna
- Ekwesianya Andrew
- Ekwunife Okechukwu
- El Ahmadi Brahim
- El Jamali Faek
- El Metwally Aziza
- El Sorogy Mohamed
- El-Hussuna Alaa
- El-Wafa Yahya Abou
- Elbahrawy Khaled
- Eldakroury Israa
- Eldin Sami Jalal
- Elena Fanti
- Elfallal Ahmed
- Elfeki Hossam
- Elhadi Muhammed
- Elisiario Luisa
- Ellebæk Mark Bremholm
- Elmore Ugo
- Elrefai Mohamad
- Elshami Mohamedraed
- Emar Mohammed
- Emegoakor Chiemelu
- Emhareb Abdalla
- Emile Sameh
- en Siew Bei
- Ene-Cocis Mihaela-Valentina
- Eng Stanley Chee Ren
- Eraslan Huseyin
- Erdmann Thomas Rolf
- Erginöz Ergin
- Ergün Sefa
- Eriksen Niels Damgaard
- Erturk Candeniz
- Espin-Basany Eloy
- Espinha Daniela Roncoletta
- Espino Julieta
- Espino Pablo Calvo
- Esposito Giuseppe
- Esposito Rosario
- Espí-Macías Alejandro
- Estevão Pedro
- Estudillo Marta Copano
- Etelka Santo
- Evans Jonathan
- Ewah Richard
- Ewedah Moataz
- Fabbri Nicolò
- Fagan Paul
- Fagarasan Vlad
- Fakhradiyev Ildar
- Fakoya Adegbolahan
- Falenius Ville
- Farah José Francisco
- Farkašová Martina
- Farrés Laia Pagés
- Fathi Nik Qisti
- Fatudimu Samuel
- Faustino Ana
- Favacho Bernard Costa
- Feiss Anna
- Felix Michael Shalzim
- Feo Carlo V
- Ferlengez Aysegul
- Fermani Claudio
- Fernandes Andre
- Fernandes Vania
- Fernandez Eugenia
- Fernandez Laura
- Fernández Begoña Fadrique
- Fernández Ignacio Ortega
- Fernández-Arias Sebastian
- Fernández-Hevia Maria
- Fernández-Martínez Daniel
- Ferrario Luca
- Ferraz Teresa
- Ferreira Andreia
- Ferreira Cátia
- Ferro Ezequiel
- Ferroni Andrea Felice
- Fidelis Flávia
- Fiedziuk Agnieszka
- Filardo Matteo
- Filho Antônio Lacerda
- Filipová Lenka
- Filippou Jana
- Finch David
- Fiorenza Juan Maria
- Fiori Enrico
- Fiorito Pablo
- Fiume Diego
- Flandoli Claudia
- Fleres Francesco
- Fletcher Juliette
- Flores Natalia
- Flynn Collette
- Foppa Caterina
- Forero-Torres Alexander
- Fortuna Laura
- Fortunato Crescenza
- Fraj Victoria
- Franceschill Marzia
- Frasson Matteo
- Freitas Antonio Hilário
- Freitas António
- Frolova Yulia
- Frongia Federica
- Frontali Alice
- Fuenmayor-Valera Maria Luisa
- Futaba Kaori
- Fuzari Jamile
- Fütterer Carsten
- Galetti Ken
- Galimberti Andrea
- Gallardo Alfredo
- Galliamov Eduard
- Gallo Gaetano
- Galmes Carla
- Galvez Sandra Torres
- Galván-Pérez Armando
- Garau Alessandra Grazia Giuseppina
- Garay Lorena
- Garcia-Flórez Luis Joaquin
- García-Botello Stephanie
- García-Conde María
- García-Señoráns Marta Paniagua
- García-Ureña Miguel Ángel
- Garg Lalit
- Garmanova Tatiana
- Garoufalia Zoe
- Garrido Pilar Garcia
- Garritano Stefano
- Garzali Ibrahim Umar
- Gascon Isabel
- Gaspa Ilaria
- Gata Vlad Alexandru
- Gates Zoe
- Gava Guilherme
- Gbadegesin Peter
- Gemes Geza
- George Gejoe
- Gerald Seitinger
- Gerber Marlus Tavares
- Gezahegn Habtamu
- Gezer Turna
- Gharbi Akram
- Ghose Tapas
- Ghosh Anil
- Ghosh Dhruv
- Ghouali Amine Khayreddine
- Giacomini Giovanni
- Giakoustidis Dimitris
- Giannaraki Styliani
- Gili Simona
- Gill Aun Jamal
- Gillissen Freek
- Giuffrida Maria Carmela
- Giulino Giuseppina
- Giuseppina Forte
- Gklavas Antonios
- Glasbey James C
- Golub József
- Gomendio Maria Dolores Picardo
- Gomes Carina
- Gomes Diogo Carrola
- Gomes Gabriel
- Gomez-Rosado Juan-Carlos
- Gomila-Sanso Joan Andreu
- Gondal Khalid Masud
- Gonullu Emre
- Gonzabay Victor
- Gonzalez Carla Mariela
- Gonzalez Felix
- Gonzalez Tomás Elosua
- Gonzalez-Diaz Maria Jose
- Gonzalez-Gonzalez Enrique
- González Pilar Martínez
- Gonçalves Vera
- Gonçalvez Sandra Alonso
- Gordeyev Sergey
- Gorrela Kalyani
- Gosselink Martijn Pieter
- Goyal Laxmi
- Grama Florin
- Grasso Salvatore
- Greco Massimilano
- Gribnev Petar
- Grimes Lisa
- Grinblat Ariel
- Grintescu Ioana
- Grischott Marco
- Grolich Tomáš
- Grossi Ugo
- Guarino Rita
- Guatteri Luca
- Gudisa Zewude
- Guedes Xavier
- Guest Francesca
- Gulcu Baris
- Guler Ozkan
- Gultekin Fatma Ayca
- Gunetilleke Bhagya
- Gupta Lalit
- Gupta Rahul
- Gupta Sameer
- Gurbulak Esin Kabul
- Gurcoo Showkat
- Gutierrez Elsa
- Gutierrez Victor Manuel Maciel
- Gómez Luis Miguel Jimenez
- Gökay Banu Vural
- Güler Sertaç Ata
- Gülmez Mehmet
- Gümbelek Gülnur
- Güreşin Alican
- Hacim Adnan
- Hallam Sally
- Hallett Abigail
- Halliwell Gail
- Hallworth Stephen
- Hamdan Alaa
- Hamdan Fatima
- Hamed Hosam
- Hameed Malika
- Hamid Hytham K S
- Hamilton Vida
- Hammed Amane
- Hamza Amr
- Hanan Bernardo
- Handa Siddhartha
- Hannouf Sawsan
- Hansdotter Pernilla
- Hanson Matthew
- Haque Parvez David
- Hardt Julia
- Harrison Ewen
- Harshen Raj
- Hasan Wisam
- Hashim Norhayati Mohd
- Hassan Mohamed
- Hawkin Paul
- Hayirlioglu Mehmet Bilhan
- Heino Riitta
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- Yilmazlar Tuncay
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- Yoldas Tayfun
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- Yoshino Kenji
- Younes Lina
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- Yule Michael
- Yusoff Zakiah Mohd
- Zaari Fatimazahraa
- Zabiyaka Mikhail
- Zadrożna Monika
- Zafar Madiha
- Zagaynov Eugeny
- Zaidi Syed-Nadeem
- Zaimis Tilemachos
- Zain Wan Zainira Wan
- Zainy Rhendra Hardy Mohamad
- Zakaria Andee Dzulkarnaen
- Zakaria Maheen
- Zakaria Zaidi
- Zamudio-Bautista Jorge Luis
- Zanc Loredana
- Zanoni Andrea
- Zanus Giacomo
- Zapparoli Alessandro
- Zappone Anna
- Zarzava Eirini
- Zatari Dirar
- Zawadzki Marek
- Zayakov Georgi
- Zaycev Andrey
- Zazo Aya
- Zazo Rama
- Zdravkovic Maja
- Zengin Abdullah Kağan
- Zeringa Georgia
- Zimmerman David D E
- Zuhdy Mohammad
- Zvirych Vitalii
- Zywicka Ewa
- Álvarez-Llano Laura
- Ângelo Miguel Duarte
- ÓSullivan Sara Nuñez
- Özçelik Mehmet Faik
- Ćoza Ivo
- Şanlı Ahmet Necati
- Publication venue
- Publication date
- 01/01/2023
- Field of study
Background
Anastomotic leak affects 8 per cent of patients after right colectomy with a 10-fold increased risk of postoperative death. The EAGLE study aimed to develop and test whether an international, standardized quality improvement intervention could reduce anastomotic leaks.
Methods
The internationally intended protocol, iteratively co-developed by a multistage Delphi process, comprised an online educational module introducing risk stratification, an intraoperative checklist, and harmonized surgical techniques. Clusters (hospital teams) were randomized to one of three arms with varied sequences of intervention/data collection by a derived stepped-wedge batch design (at least 18 hospital teams per batch). Patients were blinded to the study allocation. Low- and middle-income country enrolment was encouraged. The primary outcome (assessed by intention to treat) was anastomotic leak rate, and subgroup analyses by module completion (at least 80 per cent of surgeons, high engagement; less than 50 per cent, low engagement) were preplanned.
Results
A total 355 hospital teams registered, with 332 from 64 countries (39.2 per cent low and middle income) included in the final analysis. The online modules were completed by half of the surgeons (2143 of 4411). The primary analysis included 3039 of the 3268 patients recruited (206 patients had no anastomosis and 23 were lost to follow-up), with anastomotic leaks arising before and after the intervention in 10.1 and 9.6 per cent respectively (adjusted OR 0.87, 95 per cent c.i. 0.59 to 1.30; P = 0.498). The proportion of surgeons completing the educational modules was an influence: the leak rate decreased from 12.2 per cent (61 of 500) before intervention to 5.1 per cent (24 of 473) after intervention in high-engagement centres (adjusted OR 0.36, 0.20 to 0.64; P < 0.001), but this was not observed in low-engagement hospitals (8.3 per cent (59 of 714) and 13.8 per cent (61 of 443) respectively; adjusted OR 2.09, 1.31 to 3.31).
Conclusion
Completion of globally available digital training by engaged teams can alter anastomotic leak rates. Registration number: NCT04270721 (http://www.clinicaltrials.gov)
The 12th Edition of the Scientific Days of the National Institute for Infectious Diseases “Prof. Dr. Matei Bals” and the 12th National Infectious Diseases Conference
- Author
- Adelina Raluca Marinescu
- Adelina Raluca Marinescu
- Adelina-Raluca Marinescu
- Adelina-Raluca Marinescu
- Adina Elena Ilie
- Adina Ilie
- Adina Ilie
- Adina Stăncescu
- Adina Stăncescu
- Adrian Abagiu
- Adrian Abagiu
- Adrian Bancescu
- Adrian Octavian Abagiu
- Adrian Streinu-Cercel
- Adrian Streinu-Cercel
- Adrian Streinu-Cercel
- Adrian Streinu-Cercel
- Adrian Streinu-Cercel
- Adrian Streinu-Cercel
- Adrian Streinu-Cercel
- Adrian Streinu-Cercel
- Adrian Streinu-Cercel
- Adrian Streinu-Cercel
- Adrian Streinu-Cercel
- Adrian Streinu-Cercel
- Adrian Streinu-Cercel
- Adrian Streinu-Cercel
- Adrian Streinu-Cercel
- Adrian Streinu-Cercel
- Adriana Hristea
- Adriana Hristea
- Adriana Hristea
- Adriana Hristea
- Adriana Hristea
- Adriana Hristea
- Adriana Hristea
- Adriana Hristea
- Adriana Slavcovici
- Alena Andreea Popa
- Alena-Andreea Popa
- Alexandra Badea
- Alexandra Badea
- Alexandra Badea
- Alexandra Badea
- Alexandra Badea
- Alexandra Badea
- Alexandra Badea
- Alexandra Badea
- Alexandra Badea
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- Alexandru Crișan
- Alexandru Crișan
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- Alexandru Mihai
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- Alexandru Rafila
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- Letitia Toma
- Liana Cătălina Gavriliu
- Liana Cătălina Gavriliu
- Liana Gavriliu
- Liana Gavriliu
- Ligia Ionescu
- Ligia Rodina
- Lilia Cojuhari
- Liliana Ion
- Liliana Lucia Preoțescu
- Liliana Lucia Preoțescu
- Livia Dragonu
- Livia Dragonu
- Livia Dragonu
- Livia Trașcă
- Liviu Tazlavanu
- Livius Tirnea
- Livius Tirnea
- Loredana Ionescu
- Loredana Mitran
- Loredana Nicoleta Stoica
- Lucia Tudor
- Lucian Cristian Petcu
- Lucian Giubelan
- Lucian Giubelan
- Lucian Giubelan
- Luciana Nichita
- Lucreția Dulgheru
- Luminița Bradu
- Luminița Bradu
- Luminița Marin
- Luminița Marin
- Madalina Popazu
- Magda Constantin
- Magda Vasile
- Magda Vasile
- Magdalena Lorena Andrei
- Magdalena Vasile
- Magdalena Vasile
- Manole Cojocaru
- Manuela Arbune
- Manuela Curescu
- Manuela Nica
- Manuela Podani
- Manuela Podani
- Mara Carsote
- Mara Carsote
- Marcela Popa
- Maria Elena Cocuz
- Maria Elena Mihai
- Maria Elena Mihai
- Maria Magdalena Moțoi
- Maria Magdalena Moțoi
- Maria Magdalena Moțoi
- Maria Nițescu
- Maria Nițescu
- Maria-Cristina Sîrbu
- Maria-Elena Mihai
- Maria-Sabina Tache
- Mariana Mărdărescu
- Mariana Pagute
- Marieta Iancu
- Marilena Ciortea
- Marilena Palaghiță
- Marilyse Vallée
- Marincu Iosif
- Marioara Neacșu
- Marius Niculescu
- Marius-Dan Ionescu
- Meilin Omer
- Michaela Oana
- Michel G. Bergeron
- Mihaela Anca Benea
- Mihaela Baciu
- Mihaela Cătălina Luca
- Mihaela Gheorghe
- Mihaela Ionica
- Mihaela Ionica
- Mihaela Ionică
- Mihaela Ionică
- Mihaela Lazar
- Mihaela Lazăr
- Mihaela Rădulescu
- Mihaela Rădulescu
- Mihaela Rădulescu
- Mihaela Rădulescu
- Mihaela Rădulescu
- Mihaela Rădulescu
- Mihaela Rădulescu
- Mihaela Rădulescu
- Mihaela Sabou
- Mihai Mitran
- Mihai Săndulescu
- Mihnea Hurmuzache
- Mioara Predescu
- Mirandolina Prisca
- Mircea Bararu
- Mircea Ioan Popa
- Mircea Ioan Popa
- Mircea Ioan Popa
- Mircea Tampa
- Mircea Tampa
- Mircea Tampa
- Mirela Ciucu
- Mirela Paliu
- Mona Popoiu
- Mona Popoiu
- Mona Popoiu
- Monica Andreea Stoica
- Monica Andreea Stoica
- Monica Cialma
- Monica Cîrstoiu
- Monica Luminița Luminos
- Monica Luminos
- Monica Luminos
- Monica Luminos
- Monica Luminos
- Monica Luminos
- Monica Luminos
- Monica Luminos
- Monica Luminos
- Monica Muntean
- Mădălina Georgescu
- Mădălina Irina Mitran
- Mădălina Merișescu
- Mădălina Merișescu
- Mădălina Merișescu
- Mădălina Merișescu
- Mădălina Merișescu
- Mădălina Popazu
- Mădălina Simoiu
- Narcisa Nicolescu
- Narcisa Nicolescu
- Nicoleta Irimescu
- Nina-Ioana Bodnar
- Nurcan Baydaroglu
- Oana Săndulescu
- Oana Săndulescu
- Oana Săndulescu
- Oana Săndulescu
- Oana Săndulescu
- Oana Săndulescu
- Oana Săndulescu
- Oana Săndulescu
- Oana Săndulescu
- Oana Săndulescu
- Oana Săndulescu
- Oana Săndulescu
- Octavian Munteanu
- Oleg Dmitriev
- Olga Adriana Caliman-Sturdza
- Olga Dorobăț
- Olga Dorobăț
- Olga Dorobăț
- Olga Mihaela Dorobăț
- Olga Mihaela Dorobăț
- Olivera Lupescu
- Opreanu Radu
- Otilia Benea
- Otilia Elisabeta Benea
- Otilia Elisabeta Benea
- Otilia Elisabeta Benea
- Otilia Elisabeta Benea
- Otilia-Elisabeta Benea
- Ovidiu Rosca
- Patricia Poptelecan
- Patricia Poptelecan
- Paulina Jimbei
- Radu Opreanu
- Radu Orfanu
- Raisa Popovici
- Raluca E. Jipa
- Raluca Jipa
- Raluca Jipa
- Raluca Jipa
- Raluca Jipa
- Raluca Jipa
- Raluca Jipa
- Raluca M. Hrișcă
- Raluca Mihaela Năstase
- Raluca Mihaela Năstase
- Raluca Mihăilescu
- Raluca Mihăilescu
- Raluca Năstase
- Raluca Năstase
- Raluca Năstase
- Raluca Năstase
- Raluca Năstase
- Raluca Năstase
- Raluca Năstase
- Raluca Năstase
- Raluca Tripon
- Ramona Georgiana Stanculete
- Ramona Georgiana Stanculete
- Ramona Zamfir
- Ramona Zamfir
- Ramona Ștefania Popescu
- Ramona Ștefania Popescu
- Ramona-Alexandra Zamfir
- Ramona-Alexandra Zamfir
- Ramona-Alexandra Zamfir
- Remulus Catană
- Remulus Catană
- Remulus Catană
- Remulus Catană
- Remulus Catană
- Remulus Catană
- Remulus Catană
- Remulus Catană
- Remulus Catană
- Remulus Catană
- Remulus Catană
- Remulus Catană
- Remulus Catană
- Remulus Catană
- Richard Giroux
- Rodica Bacruban
- Rodica Bacruban
- Rodica Bacruban
- Rodica Marinescu
- Rodica Olteanu
- Rodica Ungurianu
- Rosca Ovidiu
- Roxana Bohâlțea
- Roxana Cernat
- Roxana Duda
- Roxana Dumitriu
- Roxana Dumitriu
- Roxana Ion
- Roxana Iubu
- Roxana Nemescu
- Roxana Simona Georgescu
- Roxana Simona Georgescu
- Roxana Ștefănescu
- Ruxandra Drăghicenoiu
- Ruxandra Laza
- Ruxandra Laza
- Ruxandra Moroti
- Ruxandra Moroti
- Ruxandra Moroti
- Ruxandra Moroti-Constantinescu
- Ruxandra V. Moroti
- Sabina Sandu
- Sabina Vintila
- Sabina Vintilă
- Sabina Vintilă
- Sabina Vintilă
- Sabina Vintilă
- Sabina Șchiopu
- Serban Benea
- Sergiu Fendrihan
- Simin A. Florescu
- Simin-Aysel Florescu
- Simona Alexandra Iacob
- Simona Alexandra Iacob
- Simona Alexandra Iacob
- Simona Alexandra Iacob
- Simona Claudia Cambrea
- Simona Costin
- Simona Elena Albu
- Simona Elena Albu
- Simona Merisor
- Simona Merisor
- Simona Merișor
- Simona Puiu
- Simona Roxana Georgescu
- Simona Roxana Georgescu
- Simona Roxana Georgescu
- Simona Vladareanu
- Sorin Aramă
- Sorin Petrea
- Sorin Rugină
- Sorin Rugină
- Sorina Claudia Boldeanu
- Sorina Mitrescu
- Sorina Mitrescu
- Stela Halichidis
- Stela Semeniuc
- Sînziana Dumitru
- Săftica-Mariana Pohrib
- Tatiana Pantilimonov
- Teodora Ionescu
- Teodora Ionescu
- Teodora Moisil
- Tiberiu Holban
- Tiberiu Holban
- Tiberiu Holban
- Trinca Bogdan
- Tudor Gheorghe Vladoiu
- Tudor Gheorghe Vladoiu
- Tudor Vladoiu
- Tudor Vladoiu
- Tudor Vladoiu
- Valentin Cebotarescu
- Valentina Barbu
- Vasile Benea
- Vasile Benea
- Vasile Benea
- Veronica Ilie
- Victor Daniel Miron
- Victor Pantea
- Victoria Aramă
- Victoria Aramă
- Victoria Aramă
- Victoria Aramă
- Victoria Aramă
- Victoria Aramă
- Victoria Aramă
- Victoria Aramă
- Victoria Aramă
- Victoria Aramă
- Victoria Aramă
- Victoria Aramă
- Victoria Aramă
- Victoria Aramă
- Victoria Aramă
- Victoria Aramă
- Victoria Aramă
- Violeta Molagic
- Violeta Molagic
- Violeta Molagic
- Violeta Molagic
- Violeta Molagic
- Violeta Molagic
- Violeta Molagic
- Violeta Molagic
- Violeta Molagic
- Violeta Molagic
- Violeta Niță
- Violeta Niță
- Violeta Niță
- Violeta Niță
- Violeta Niță
- Violeta Niță
- Viorica Andreev
- Viorica Andreev
- Viorica Daniela Mitescu
- Viorica Daniela Mitescu
- Viorica Ispas
- Viorica Mitescu
- Viorica Mitescu
- Viorica Mitescu
- Viorica Mitescu
- Virgil Musta
- Virgil Musta
- Vlad Murărescu
- Vlad Predescu
- Vochita Andreia
- Vochita Laurențiu
- Voichita Elena Lazureanu
- Voichita Lazureanu
- Voichița Lăzureanu
- Voichița Lăzureanu
- Yagmur Erturk
- Yves Longtin
- Ève Bérubé
- Ştefan Sorin Aramă
- Ştefan Sorin Aramă
- Șerban Benea
- Șerban Benea
- Șerban Benea
- Șerban Benea
- Șerban Benea
- Șerban N. Benea
- Ștefan Sorin Aramă
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study