Influenza A triggered status asthmaticus requiring emergency ECMO

We describe a case of acute respiratory failure due to severe pneumonia triggered by the influenza A virus, rapidly evolving into a refractory status asthmaticus requiring emergent ECMO assistance, in order to facilitate the clinical management of patients suffering from this rare but life-threatening condition. This case report demonstrates that infection with influenza A virus can present with severe pneumonia and status asthmaticus refractory to medical and ventilatory treatment. When medical treatment and mechanical ventilation fail, extracorporeal membrane oxygenation therapy should not be delayed as it will avoid injury resulting from inadequate mechanical ventilation and lung hyperinflation

Ascorbic acid pre-treated quartz stimulates TNF-α release in RAW 264.7 murine macrophages through ROS production and membrane lipid peroxidation

<p>Abstract</p> <p>Background</p> <p>Inhalation of crystalline silica induces a pulmonary fibrotic degeneration called silicosis caused by the inability of alveolar macrophages to dissolve the crystalline structure of phagocytosed quartz particles. Ascorbic acid is capable of partially dissolving quartz crystals, leading to an increase of soluble silica concentration and to the generation of new radical sites on the quartz surface. The reaction is specific for the crystalline forms of silica. It has been already demonstrated an increased cytotoxicity and stronger induction of pro-inflammatory cyclooxygenase-2 (COX-2) by ascorbic acid pre-treated quartz (QA) compared to untreated quartz (Q) in the murine macrophage cell line RAW 264.7.</p> <p>Methods</p> <p>Taking advantage of the enhanced macrophage response to QA as compared to Q particles, we investigated the first steps of cell activation and the contribution of early signals generated directly from the plasma membrane to the production of TNF-α, a cytokine that activates both inflammatory and fibrogenic pathways.</p> <p>Results</p> <p>Here we demonstrate that TNF-α mRNA synthesis and protein secretion are significantly increased in RAW 264.7 macrophages challenged with QA as compared to Q particles, and that the enhanced response is due to an increase of intracellular ROS. Plasma membrane-particle contact, in the absence of phagocytosis, is sufficient to trigger TNF-α production through a mechanism involving membrane lipid peroxidation and this appears to be even more detrimental to macrophage survival than particle phagocytosis itself.</p> <p>Conclusion</p> <p>Taken together these data suggest that an impairment of pulmonary macrophage phagocytosis, i.e. in the case of alcoholic subjects, could potentiate lung disease in silica-exposed individuals.</p

3-D Imaging of surfaces for industrial applications: integration of structured light projection, Gray code projection and projector-camera calibration for improved performance

In this paper, two measurement procedures, aimed at the improvement of the performance of an optical whole field profilometer based on grating projection, are presented. The first procedure is based on the Gray code method. It performs a space encoding of the measurement area and yields 3-D range images in which even sharp discontinuities of the object shape can be measured. The second procedure performs the calibration of the optical components of the system, in order to describe the 3-D profile in a global coordinate system, and limiting the use of a reference surface only during the calibration of the profilometer. In the paper, the two procedures are detailed and some interesting experimental results are reported

Three-dimensional imaging based on gray-code light projection: characterization of the measuring algorithm and development of measuring system for industrial applications

A three-dimensional ͑3-D͒ imaging system based on Gray-code projection is described; it is thought to be used as an integration to the already developed profilometer based on the projection of multifrequency gratings. The Gray-code method allows us to evaluate the 3-D profile of objects that present even marked discontinuities of the surface, thus increasing the flexibility of the measuring system as to the topology of the objects that can be measured. The basic aspects of Gray-code projection for 3-D imaging and profiling are discussed, with particular emphasis devoted to the study of the resolution of the method and to the analysis of the systematic errors. The results of this study allow us to determine the optimal setting of the parameters of the measurement and to develop a suitable calibration procedure. The procedures for implementing the Gray-code method are presented, and some interesting experimental results are reported. Calibration of the system reveals an accuracy of 0.2 mm, corresponding to 0.1% of the field of view

Three dimensional Imaging based on Gray Code projection: Characterization of the the measuring algorithm and development of a measuring system for industrial applications

A three-dimensional (3-D) imaging system based on Gray-code projection is described; it is thought to be used as an integration to the already developed profilometer based on the projection of multifrequency gratings. The Gray-code method allows us to evaluate the 3-D profile of objects that present even marked discontinuities of the surface, thus increasing the flexibility of the measuring system as to the topology of the objects that can be measured. The basic aspects of Gray-code projection for 3-D imaging and profiling are discussed, with particular emphasis devoted to the study of the resolution of the method and to the analysis of the systematic errors. The results of this study allow us to determine the optimal setting of the parameters of the measurement and to develop a suitable calibration procedure. The procedures for implementing the Gray-code method are presented, and some interesting experimental results are reported. Calibration of the system reveals an accuracy of 0.2 mm, corresponding to 0.1% of the field of view

Correlazione tra modificazioni cervicali ed infezioni cervico-vaginali nella gravidanza singola e gemellare.

Corso di aggiornamento “Madre & Feto”, Numana (AN), 27/28/29 giugno 200