887 research outputs found
Mathematical framework for simulations of quantum fields in complex interferometers using the two-photon formalism
We present a mathematical framework for simulation of optical fields in complex gravitational-wave interferometers. The simulation framework uses the two-photon formalism for optical fields and includes radiation pressure effects, an important addition required for simulating signal and noise fields in next-generation interferometers with high circulating power. We present a comparison of results from the simulation with analytical calculation and show that accurate agreement is achieved
An all-optical trap for a gram-scale mirror
We report on a stable optical trap suitable for a macroscopic mirror, wherein
the dynamics of the mirror are fully dominated by radiation pressure. The
technique employs two frequency-offset laser fields to simultaneously create a
stiff optical restoring force and a viscous optical damping force. We show how
these forces may be used to optically trap a free mass without introducing
thermal noise; and we demonstrate the technique experimentally with a 1 gram
mirror. The observed optical spring has an inferred Young's modulus of 1.2 TPa,
20% stiffer than diamond. The trap is intrinsically cold and reaches an
effective temperature of 0.8 K, limited by technical noise in our apparatus.Comment: Major revision. Replacement is version that appears in Phy. Rev.
Lett. 98, 150802 (2007
Achieving ground state and enhancing entanglement by recovering information
For cavity-assisted optomechanical cooling experiments, it has been shown in
the literature that the cavity bandwidth needs to be smaller than the
mechanical frequency in order to achieve the quantum ground state of the
mechanical oscillator, which is the so-called resolved-sideband or good-cavity
limit. We provide a new but physically equivalent insight into the origin of
such a limit: that is information loss due to a finite cavity bandwidth. With
an optimal feedback control to recover those information, we can surpass the
resolved-sideband limit and achieve the quantum ground state. Interestingly,
recovering those information can also significantly enhance the optomechanical
entanglement. Especially when the environmental temperature is high, the
entanglement will either exist or vanish critically depending on whether
information is recovered or not, which is a vivid example of a quantum eraser.Comment: 9 figures, 18 page
SPRR2A enhances p53 deacetylation through HDAC1 and down regulates p21 promoter activity
Background: Small proline rich protein (SPRR) 2A is one of 14 SPRR genes that encodes for a skin cross-linking protein, which confers structural integrity to the cornified keratinocyte cell envelope. New evidence, however, shows that SPRR2A is also a critical stress and wound repair modulator: it enables a variety of barrier epithelia to transiently acquire mesenchymal characteristics (EMT) and simultaneously quench reactive oxygen species during wound repair responses. p53 is also widely recognized as the node in cellular stress responses that inhibits EMT and triggers cell-cycle arrest, apoptosis, and cellular senescence. Since some p53-directed processes would seem to impede wound repair of barrier epithelia, we hypothesized that SPRR2A up regulation might counteract these effects and enable/promote wound repair under stressful environmental conditions.Results: Using a well characterized cholangiocarcinoma cell line we show that levels of SPRR2A expression, similar to that seen during stressful biliary wound repair responses, disrupts acetylation and subsequent p53 transcriptional activity. p53 deacetylation is accomplished via two distinct, but possibly related, mechanisms: 1) a reduction of p300 acetylation, thereby interfering with p300-p53 binding and subsequent p300 acetylation of K382 in p53; and 2) an increase in histone deacetylase 1 (HDAC1) mRNA and protein expression. The p300 CH3 domain is essential for both the autoacetylation of p300 and transference of the acetyl group to p53 and HDAC1 is a component of several non-p300 complexes that enhance p53 deacetylation, ubiquitination, and proteosomal degradation. HDAC1 can also bind the p300-CH3 domain, regulating p300 acetylation and interfering with p300 mediated p53 acetylation. The importance of this pathway is illustrated by showing complete restoration of p53 acetylation and partial restoration of p300 acetylation by treating SPRR2A expressing cells with HDAC1 siRNA.Conclusion: Up-regulation of SPRR2A, similar to that seen during barrier epithelia wound repair responses reduces p53 acetylation by interfering with p300-p53 interactions and by increasing HDAC1 expression. SPRR2A, therefore, functions as a suppressor of p53-dependent transcriptional activity, which otherwise might impede cellular processes needed for epithelial wound repair responses such as EMT. © 2012 Mizuguchi et al.; licensee BioMed Central Ltd
A microchip optomechanical accelerometer
The monitoring of accelerations is essential for a variety of applications
ranging from inertial navigation to consumer electronics. The basic operation
principle of an accelerometer is to measure the displacement of a flexibly
mounted test mass; sensitive displacement measurement can be realized using
capacitive, piezo-electric, tunnel-current, or optical methods. While optical
readout provides superior displacement resolution and resilience to
electromagnetic interference, current optical accelerometers either do not
allow for chip-scale integration or require bulky test masses. Here we
demonstrate an optomechanical accelerometer that employs ultra-sensitive
all-optical displacement read-out using a planar photonic crystal cavity
monolithically integrated with a nano-tethered test mass of high mechanical
Q-factor. This device architecture allows for full on-chip integration and
achieves a broadband acceleration resolution of 10 \mu g/rt-Hz, a bandwidth
greater than 20 kHz, and a dynamic range of 50 dB with sub-milliwatt optical
power requirements. Moreover, the nano-gram test masses used here allow for
optomechanical back-action in the form of cooling or the optical spring effect,
setting the stage for a new class of motional sensors.Comment: 16 pages, 9 figure
Radiation-pressure-mediated control of an optomechanical cavity
We describe and demonstrate a method to control a detuned movable-mirror Fabry-Pérot cavity using radiation pressure in the presence of a strong optical spring. At frequencies below the optical spring resonance, self-locking of the cavity is achieved intrinsically by the optomechanical (OM) interaction between the cavity field and the movable end mirror. The OM interaction results in a high rigidity and reduced susceptibility of the mirror to external forces. However, due to a finite delay time in the cavity, this enhanced rigidity is accompanied by an antidamping force, which destabilizes the cavity. The cavity is stabilized by applying external feedback in a frequency band around the optical spring resonance. The error signal is sensed in the amplitude quadrature of the transmitted beam with a photodetector. An amplitude modulator in the input path to the cavity modulates the light intensity to provide the stabilizing radiation pressure force.This work was supported by the National Science Foundation CAREER Grants No. PHY-1150531, as well as No. PHY1707840 and No. PHY-1404245. M.J.Y. and D.E.M. receive support from the Australian Research Council through Project
No. CE170100004 (OzGrav)
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