Does the combination of resistance training and stretching increase cardiac overload?

OBJECTIVES: To compare the effects of combinations of resistance training (RT) and static stretching (SS) on heart rate (HR), systolic pressure (SBP), diastolic pressure (DBP), rate pressure product (RPP), oxygen saturation (SpO2), rating of perceived effort (RPE), and heart rate variability (HRV) in men. METHODS: Twelve normotensive healthy men participated in four protocols: a) SS+RT, b) RT+SS, c) RT, and d) SS. Variables were measured before, immediately after, and 15, 30, and 45 min after the sessions. RESULTS: The combination of SS and RT increased (po0.001) HR when compared to the effects of the noncombined protocols (from 2.38 to 11.02%), and this result indicated metabolic compensation. Regarding DBP, there were differences (po0.001) between the RT and SS groups (53.93±8.59 vs. 67.00±7.01 mmHg). SS has been shown to be able to reduce (po0.001) SpO2 (4.67%) due to the occlusion caused by a reduction in the caliber of the blood vessels during SS compared to during rest. The increase in RPP (6.88% between RT and SS+RT) along with the HR results indicated higher metabolic stress than that reflected by the RPE (combined protocols increased RPE from 21.63 to 43.25%). The HRV analysis confirmed these results, showing increases (po0.01) in the LF index between the combined and noncombined protocols. Compared to the effect of RT, the combination of SS and RT promoted a vagal suppression root mean square of the successive differences (RMSSD) index (from 9.51 to 21.52%) between the RT and SS+RT groups (po0.01) and between the RT and RT+SS groups (po0.001). CONCLUSION: Static stretching increases cardiac overload and RPE, reducing oxygen supply, especially when performed in combination with RT

Heart failure and treatment with Sodium-glucose Co-transporter Inhibitor (SGLT2): dapagliflozin and its effects on the cardiac system

This article thoroughly examines the effectiveness of treatment with dapagliflozin, a sodium-glucose co-transporter inhibitor, in the context of heart failure. The primary focus of this analysis lies in evaluating patients' clinical condition, the diagnostic procedures employed, and the various medications used as part of the treatment regimen. The objective of this investigation is based on a meticulous analysis of relevant scientific articles. Classified as documentary research within the field of Applied Linguistics, this study draws upon research covering classification, pathophysiology, clinical presentation, diagnosis, pharmacological treatment, and the role of SGLT2 inhibitors in heart failure as its primary theoretical framework. The findings indicate dapagliflozin's efficacy in reducing the heart's ejection fraction, regardless of the presence of diabetes. However, it emphasizes the importance of a comprehensive medical assessment before initiating the use of this medication, highlighting the need for caution and appropriate professional supervision

A produção textual e sua avaliação no material didático de Língua Portuguesa do Programa Brasil na Escola: da perspectiva teórica à utilização em contexto escolar

Neste trabalho, enfoca-se o eixo da produção textual no material didático de Língua Portuguesa do Programa Brasil na Escola, com um duplo objetivo: identificar a abordagem teórica subjacente às propostas de produção de texto, incluindo a forma de avaliação prevista; averiguar as possibilidades de utilização desse material, a partir das perspectivas de monitores voluntários, considerando o contexto educacional em que as práticas textuais se inserem na realidade das escolas estaduais e municipais onde atuam. Para isso, realizou-se um estudo do referido documento, bem como um levantamento de dados por meio da aplicação de questionário a três monitores que atuam no programa, em diferentes instituições de ensino do município de Capanema, PA, a partir da sua experiência com a utilização do material. Verificou-se que as concepções de língua e de texto adotadas na abordagem da produção textual e de sua avaliação, no material didático analisado, conflituam com as concepções emergentes no contexto escolar e com as condições estruturais das instituições em que atuam os monitores, o que gera dificuldades na sua efetiva orientação e aplicação

Síndromes anêmicas: uma abordagem fisiopatológica sobre as principais considerações clínicas / Anemic syndromes: a pathophysiological approach to key clinical considerations

O seguinte artigo é uma revisão narrativa de literatura fundamentada nas plataformas do SciELO, LILACS, Pubmed, Google Acadêmico e Brazilian Journal of Health Review no período de janeiro a março de 2022. Atualmente, a anemia é algo que não é investigado sobre a sua etiologia e  sujeita a negligência, muitos pacientes são vítimas dos riscos de hemotransfusão e até privados de tratarem doenças que seriam possivelmente de manejo mais simples se detectadas precocemente. O seguinte artigo objetivou descrever as principais considerações sobre as síndrome anêmicas, em especial em sua  fisiopatologia e implicações clínicas. A temática de síndromes anêmicas é um tema complexo, que possui várias etiologias, apresentações clínicas, sintomatologias e meios diagnósticos. A terapêutica é focada em investigar o fator etiológico de base e simultaneamente tratar as implicações e aliviar o quadro clínico. Logo, o estudo em questão narra de modo detalhado a fisiopatologia da anemia e aborda as principais síndromes anêmicas para a clínica médica.

Neuroprotective effects of crude extracts, compounds, and isolated molecules obtained from plants in the central nervous system injuries: a systematic review

The number of people with central nervous system (CNS) injuries increases worldwide and only a few therapies are used to mitigate neurological damage. Crude extracts, compounds, and isolated molecules obtained from plants have neuroprotective effects; however, their actions on the central nervous system are still not fully understood. This systematic review investigated the neuroprotective effects of crude extracts, compound, and isolated molecules obtained from plants in different CNS lesions. This PICO (Population/Problem, Intervention, Control, Outcome) systematic review included in vivo and in vitro studies that used small rodents as experimental models of CNS injuries (P) treated with crude extracts, compounds, and/or isolated molecules obtained from plants (I), compared to non-intervention conditions (C), and that showed a neuroprotective effect (O). Fourteen out of 5,521 studies were selected for qualitative analysis. Several neuroprotective effects (improvement of antioxidant activity, modulation of the inflammatory response, tissue preservation, motor and cognitive recovery) in the brain and spinal cord were reported after treatment with different doses of crude extracts (10 studies), compounds (2 studies), and isolated molecules (2 studies). Crude extracts, compounds, or isolated molecules obtained from plants showed promising neuroprotective effects against several CNS injuries in both the brain and spinal cord, regardless of gender and age, through the modulation of inflammatory activity and oxidative biochemistry, tissue preservation, and recovery of motor and cognitive activity

A divulgação científica para prevenção de doenças endêmicas

Submitted by Martha Martínez Silveira ([email protected]) on 2015-03-31T16:41:50Z No. of bitstreams: 1 Artigo Marcos Vannier final 2 (1) (2).pdf: 4840804 bytes, checksum: a4d5cb5bb1f45f8803f5931b9f79052d (MD5)Approved for entry into archive by Martha Martínez Silveira ([email protected]) on 2015-03-31T17:05:42Z (GMT) No. of bitstreams: 1 Artigo Marcos Vannier final 2 (1) (2).pdf: 4840804 bytes, checksum: a4d5cb5bb1f45f8803f5931b9f79052d (MD5)Made available in DSpace on 2015-03-31T17:05:42Z (GMT). No. of bitstreams: 1 Artigo Marcos Vannier final 2 (1) (2).pdf: 4840804 bytes, checksum: a4d5cb5bb1f45f8803f5931b9f79052d (MD5) Previous issue date: 2010Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Biomorfologia Parasitária. Salvador, BA, Brasil / Conselho Nacional de Desenvolvimento Científico e Tecnológico. Instituto Nacional para Pesquisa Translacional em Saúde e Ambiente na Região Amazônica. BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Biomorfologia Parasitária. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Biomorfologia Parasitária. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Biomorfologia Parasitária. Salvador, BA, Brasil / Conselho Nacional de Desenvolvimento Científico e Tecnológico. Instituto Nacional para Pesquisa Translacional em Saúde e Ambiente na Região Amazônica. BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Biomorfologia Parasitária. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Biomorfologia Parasitária. Salvador, BA, Brasil / Conselho Nacional de Desenvolvimento Científico e Tecnológico. Instituto Nacional para Pesquisa Translacional em Saúde e Ambiente na Região Amazônica. BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Biomorfologia Parasitária. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Biomorfologia Parasitária. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Biomorfologia Parasitária. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Biomorfologia Parasitária. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Biomorfologia Parasitária. Salvador, BA, Brasil / Conselho Nacional de Desenvolvimento Científico e Tecnológico. Instituto Nacional para Pesquisa Translacional em Saúde e Ambiente na Região Amazônica. BrasilO projeto “ciência na estrada: educação e cidadania” www.bahia.fiocruz.br/ciencianaestrada) é um programa itinerante de educação científica que difunde informações sobre saúde e prevenção de doenças, bem como sobre temas científicos gerais. As atividades do projeto são principalmente dirigidas à populações de baixa renda, onde as doenças infecciosas e parasitárias tendem a ser muito mais comuns, devido às condições sanitárias e de habitação inadequadas. A maioria das atividades vem sendo realizada na Bahia, mas, recentemente, também estamos participando de eventos e estudos na Região Amazônica através do INCT–INPeTAm, CNPq/MCT. Nossa equipe conta com um laboratório itinerante construído dentro de um ônibus equipado com microscópios, câmeras, computadores etc. A intervenção inclui palestras, minicursos e debates sobre doenças parasitárias e sexualmente transmissíveis, entre outras infecções e hábitos de higiene. São empregados cartazes, cartilhas, jogos eletrônicos educativos, vídeos, modelos em resina de parasitos, micróbios, células e incrustações exibindo vetores de doenças parasitárias. Performances teatrais e atividades lúdicas são freqüentemente usadas para esclarecer o público sobre saúde e ciência. Eventualmente exames parasitológicos de fezes, aferição de pressão arterial e testes de grupos sanguíneos são realizados não apenas como serviços para a população, mas também para melhor entender a saúde da comunidade, permitindo o planejamento de uma abordagem mais efetiva de nossas ações. As piores condições de saúde pública foram observadas na periferia e subúrbios das grandes cidades, que a falta de conhecimento científico e saúde foi encontrado principalmente nas áreas rurais. Os alunos abordados em comunidades revisitados apresentaram compreensão de saúde consideravelmente promovida e os pais e professores relataram melhores hábitos de higiene. Estas observações reforçam a idéia de que iniciativas de promoção da saúde e de educação científica itinerantes podem melhorar a saúde pública, apoiando a inclusão social em regiões pobresThe “Science on the Road: education and citizenship” (‘Ciência na Estrada: educação e cidadania’, www.bahia.fiocruz.br/ciencianaestrada) project is an itinerant science education program bringing information on health and disease prevention as well as on general scientific topics. The project activities are mainly directed to low-income populations where parasitic and infectious diseases tend to be much more prevalent, due to inadequate sanitary and housing conditions. Most of the activities were held in Bahia state, but recently we are also taking part in events and studies in the Amazon region via the National Institute for Translational Research on Health and Environment in the Amazon Region, INCT-INPeTAm, CNPq/MCT. Our team counts on an itinerant laboratory built within a bus equipped with microscopes, cameras, computers etc. The intervention includes lectures, short courses and debates on parasitic and sexually-transmitted diseases, among other infections and hygiene habits. We employ posters, booklets, educative electronic games, videos, resin-made models of parasites, microbes and cells and incrustations displaying parasitic disease vectors. Theatrical performances and ludic activities are often used to enlighten the public about health and science. Eventually parasitological stool examinations, blood pressure measurement and blood group tests are performed not only as services for the population, but also to better understand the community health, enabling the planning of a more effective approach for our actions. The worst public health conditions were observed in the suburban periphery of the larger cities, whereas lack of scientific and health knowledge was mainly found in the rural areas. The students approached in communities revisited presented considerably enhanced health understanding and parents/teachers reported better hygienic habits. These observations reinforce the idea that health promotion and science education itinerant initiatives may improve public health, supporting social inclusion in poor region

Table_1_Neuroprotective effects of crude extracts, compounds, and isolated molecules obtained from plants in the central nervous system injuries: a systematic review.DOCX

The number of people with central nervous system (CNS) injuries increases worldwide and only a few therapies are used to mitigate neurological damage. Crude extracts, compounds, and isolated molecules obtained from plants have neuroprotective effects; however, their actions on the central nervous system are still not fully understood. This systematic review investigated the neuroprotective effects of crude extracts, compound, and isolated molecules obtained from plants in different CNS lesions. This PICO (Population/Problem, Intervention, Control, Outcome) systematic review included in vivo and in vitro studies that used small rodents as experimental models of CNS injuries (P) treated with crude extracts, compounds, and/or isolated molecules obtained from plants (I), compared to non-intervention conditions (C), and that showed a neuroprotective effect (O). Fourteen out of 5,521 studies were selected for qualitative analysis. Several neuroprotective effects (improvement of antioxidant activity, modulation of the inflammatory response, tissue preservation, motor and cognitive recovery) in the brain and spinal cord were reported after treatment with different doses of crude extracts (10 studies), compounds (2 studies), and isolated molecules (2 studies). Crude extracts, compounds, or isolated molecules obtained from plants showed promising neuroprotective effects against several CNS injuries in both the brain and spinal cord, regardless of gender and age, through the modulation of inflammatory activity and oxidative biochemistry, tissue preservation, and recovery of motor and cognitive activity.</p

Table_2_Neuroprotective effects of crude extracts, compounds, and isolated molecules obtained from plants in the central nervous system injuries: a systematic review.XLSX

The number of people with central nervous system (CNS) injuries increases worldwide and only a few therapies are used to mitigate neurological damage. Crude extracts, compounds, and isolated molecules obtained from plants have neuroprotective effects; however, their actions on the central nervous system are still not fully understood. This systematic review investigated the neuroprotective effects of crude extracts, compound, and isolated molecules obtained from plants in different CNS lesions. This PICO (Population/Problem, Intervention, Control, Outcome) systematic review included in vivo and in vitro studies that used small rodents as experimental models of CNS injuries (P) treated with crude extracts, compounds, and/or isolated molecules obtained from plants (I), compared to non-intervention conditions (C), and that showed a neuroprotective effect (O). Fourteen out of 5,521 studies were selected for qualitative analysis. Several neuroprotective effects (improvement of antioxidant activity, modulation of the inflammatory response, tissue preservation, motor and cognitive recovery) in the brain and spinal cord were reported after treatment with different doses of crude extracts (10 studies), compounds (2 studies), and isolated molecules (2 studies). Crude extracts, compounds, or isolated molecules obtained from plants showed promising neuroprotective effects against several CNS injuries in both the brain and spinal cord, regardless of gender and age, through the modulation of inflammatory activity and oxidative biochemistry, tissue preservation, and recovery of motor and cognitive activity.</p

Table_3_Neuroprotective effects of crude extracts, compounds, and isolated molecules obtained from plants in the central nervous system injuries: a systematic review.XLSX

The number of people with central nervous system (CNS) injuries increases worldwide and only a few therapies are used to mitigate neurological damage. Crude extracts, compounds, and isolated molecules obtained from plants have neuroprotective effects; however, their actions on the central nervous system are still not fully understood. This systematic review investigated the neuroprotective effects of crude extracts, compound, and isolated molecules obtained from plants in different CNS lesions. This PICO (Population/Problem, Intervention, Control, Outcome) systematic review included in vivo and in vitro studies that used small rodents as experimental models of CNS injuries (P) treated with crude extracts, compounds, and/or isolated molecules obtained from plants (I), compared to non-intervention conditions (C), and that showed a neuroprotective effect (O). Fourteen out of 5,521 studies were selected for qualitative analysis. Several neuroprotective effects (improvement of antioxidant activity, modulation of the inflammatory response, tissue preservation, motor and cognitive recovery) in the brain and spinal cord were reported after treatment with different doses of crude extracts (10 studies), compounds (2 studies), and isolated molecules (2 studies). Crude extracts, compounds, or isolated molecules obtained from plants showed promising neuroprotective effects against several CNS injuries in both the brain and spinal cord, regardless of gender and age, through the modulation of inflammatory activity and oxidative biochemistry, tissue preservation, and recovery of motor and cognitive activity.</p