In Search of Lost Terms: Constructing a yoga taxonomy and thesaurus

The subject of the thesaurus is the practice and teaching of yoga. This vocabulary was created for the completion of an assignment for module INM303 Information Organisation. The thesaurus is not based on existing resources to index and is therefore entirely artificial. In this document, you will find a taxonomy structure with one section developed to the lowest level - other sections are shown up to three levels below the first terms - the thesaurus fragment for this section, and a short reflection on the building process

How to Tell a Story with Lyrics: A case study of the British Library's display Paul McCartney: the Lyrics (2021) to explore the creation of an inspiring exhibit of song words.

From November 2021 to March 2022, lyrics and memorabilia from Paul McCartney’s personal archive went on display at the British Library. It is rare to go to libraries to access song lyrics, so this study investigated why the library and Paul McCartney created a display following the release of a lyric book. As inspiration was one of the aims behind this project, inspiring visitors by design was also explored. Firstly, desk research was conducted on the issue of song words, lyric collections, and principles of exhibition design. Secondly, a case study of the display Paul McCartney: the Lyrics (2021) was done to understand the creation of a lyric display. As such, the literature review and interviews with staff illuminated the challenges of collecting lyrics due to a lack of awareness from songwriters to keep their work and a lack of rules in lyric publications. Consequently, a lot of inaccurate lyrics are discoverable on unofficial websites. In addition, the analysis of the findings revealed that cultural institutions can have an impact on how artists and listeners value and consume lyrics. Speaking with stakeholders of the display also highlighted how exhibition makers include their audience in the design of an exhibit. Ultimately, this study concluded that a successful display of lyrics inspires visitors to appreciate lyrics as an artform and to explore the library in new ways

Carbohydrates for Soccer: A Focus on Skilled Actions and Half-Time Practices.

Carbohydrate consumption is synonymous with soccer performance due to the established effects on endogenous energy store preservation, and physical capacity maintenance. For performance-enhancement purposes, exogenous energy consumption (in the form of drinks, bars, gels and snacks) is recommended on match-day; specifically, before and during match-play. Akin to the demands of soccer, limited opportunities exist to consume carbohydrates outside of scheduled breaks in competition, such as at half-time. The link between cognitive function and blood glucose availability suggests that carbohydrates may influence decision-making and technical proficiency (e.g., soccer skills). However, relatively few reviews have focused on technical, as opposed to physical, performance while also addressing the practicalities associated with carbohydrate consumption when limited in-play feeding opportunities exist. Transient physiological responses associated with reductions in activity prevalent in scheduled intra-match breaks (e.g., half-time) likely have important consequences for practitioners aiming to optimize match-day performance. Accordingly, this review evaluated novel developments in soccer literature regarding (1) the ergogenic properties of carbohydrates for skill performance; and (2) novel considerations concerning exogenous energy provision during half-time. Recommendations are made to modify half-time practices in an aim to enhance subsequent performance. Viable future research opportunities exist regarding a deeper insight into carbohydrate provision on match-day

Prenatal phenotyping: A community effort to enhance the Human Phenotype Ontology.

Technological advances in both genome sequencing and prenatal imaging are increasing our ability to accurately recognize and diagnose Mendelian conditions prenatally. Phenotype-driven early genetic diagnosis of fetal genetic disease can help to strategize treatment options and clinical preventive measures during the perinatal period, to plan in utero therapies, and to inform parental decision-making. Fetal phenotypes of genetic diseases are often unique and at present are not well understood; more comprehensive knowledge about prenatal phenotypes and computational resources have an enormous potential to improve diagnostics and translational research. The Human Phenotype Ontology (HPO) has been widely used to support diagnostics and translational research in human genetics. To better support prenatal usage, the HPO consortium conducted a series of workshops with a group of domain experts in a variety of medical specialties, diagnostic techniques, as well as diseases and phenotypes related to prenatal medicine, including perinatal pathology, musculoskeletal anomalies, neurology, medical genetics, hydrops fetalis, craniofacial malformations, cardiology, neonatal-perinatal medicine, fetal medicine, placental pathology, prenatal imaging, and bioinformatics. We expanded the representation of prenatal phenotypes in HPO by adding 95 new phenotype terms under the Abnormality of prenatal development or birth (HP:0001197) grouping term, and revised definitions, synonyms, and disease annotations for most of the 152 terms that existed before the beginning of this effort. The expansion of prenatal phenotypes in HPO will support phenotype-driven prenatal exome and genome sequencing for precision genetic diagnostics of rare diseases to support prenatal care

Comparison of Hepatic-like Cell Production from Human Embryonic Stem Cells and Adult Liver Progenitor Cells: CAR Transduction Activates a Battery of Detoxification Genes

In vitro production of human hepatocytes is of primary importance in basic research, pharmacotoxicology and biotherapy of liver diseases. We have developed a protocol of differentiation of human embryonic stem cells (ES) towards hepatocyte-like cells (ES-Hep). Using a set of human adult markers including CAAT/enhancer binding protein (C/EBPalpha), hepatocyte nuclear factor 4/7 ratio (HNF4alpha1/HNF4alpha7), cytochrome P450 7A1 (CYP7A1), CYP3A4 and constitutive androstane receptor (CAR), and fetal markers including alpha-fetoprotein, CYP3A7 and glutathione S-transferase P1, we analyzed the expression of a panel of 41 genes in ES-Hep comparatively with human adult primary hepatocytes, adult and fetal liver. The data revealed that after 21 days of differentiation, ES-Hep are representative of fetal hepatocytes at less than 20 weeks of gestation. The glucocorticoid receptor pathway was functional in ES-Hep. Extending protocols of differentiation to 4 weeks did not improve cell maturation. When compared with hepatocyte-like cells derived from adult liver non parenchymal epithelial (NPE) cells (NPE-Hep), ES-Hep expressed several adult and fetal liver makers at much greater levels (at least one order of magnitude), consistent with greater expression of liver-enriched transcription factors Forkhead box A2, C/EBPalpha, HNF4alpha and HNF6. It therefore seems that ES-Hep reach a better level of differentiation than NPE-Hep and that these cells use different lineage pathways towards the hepatic phenotype. Finally we showed that lentivirus-mediated expression of xenoreceptor CAR in ES-Hep induced the expression of several detoxification genes including CYP2B6, CYP2C9, CYP3A4, UDP-glycosyltransferase 1A1, solute carriers 21A6, as well as biotransformation of midazolam, a CYP3A4-specific substrate

Effet d'un exercice sous-maximal prolongé sur la perfomance cognitive

TOULON-BU Centrale (830622101) / SudocSudocFranceF

Parental Divorce and Attitudes and Feelings toward Marriage and Divorce in Emerging Adulthood: New Insights from a Multiway-Frequency Analysis

Experiencing parental divorce can exert long-term consequences on children’s attitudes toward marriage and divorce. Participants’ opinions on marriage and divorce were qualitatively coded and two themes selected based on Willoughby’s theoretical framework. Multiway frequency analyses (MFA) were used to investigate associations between empirically based factors (derived from previous empirical studies) and participants’ endorsement of the two themes. Four hundred and forty six participants between 18 and 25 years-old, including 217 participants from divorced households, were interviewed. Young adults’ optimism toward marital relationships was related to more proximal factors and a lesser number of factors than young adults’ positive attitude toward divorce. Religious affiliation and parental conflict stood out as important factors. Recommendations are offered for future research.</p

Les lésions hépatiques dans la maladie de Rendu-Osler (description et corrélations anatomocliniques)

LYON1-BU Santé (693882101) / SudocSudocFranceF