Distribution of Farey Fractions in Residue Classes and Lang--Trotter Conjectures on Average

We prove that the set of Farey fractions of order $T$, that is, the set \{\alpha/\beta \in \Q : \gcd(\alpha, \beta) = 1, 1 \le \alpha, \beta \le T\}, is uniformly distributed in residue classes modulo a prime $p$ provided T \ge p^{1/2 +\eps} for any fixed \eps>0. We apply this to obtain upper bounds for the Lang--Trotter conjectures on Frobenius traces and Frobenius fields ``on average'' over a one-parametric family of elliptic curves

The role of multimodal neuromonitoring during anesthesia for ablation of giant endocranial tumors

Catedra de anesteziologie și reanimatologie nr.2, Catedra de anesteziologie și reanimatologie nr.1 „Valeriu Ghereg”, Catedra de neurochirurgie, USMF „Nicolae Testemițanu”, Chișinău, Republica Moldova, Conferința stiințifică „Nicolae Anestiadi – nume etern al chirurgiei basarabene” consacrată centenarului de la nașterea profesorului Nicolae Anestiadi 26 august 2016Material şi metode. În studiu au fost incluse 2 loturi de pacienţi: I lot– 6 pacienţi cărora li s-a administrat anestezie combinată (i/v + pivot inhalator cu sevofluran); lotul II– 5 pacienţi cărora li s-a administrat anestezie totală intravenoasă (propofol+fentanil). Monitoring: TAs, TAd, TAm (invaziv), PVC, echilibru acidobazic, gazos (arteră şi venă periferică, bulbul jugular), electrolitic, acidul lactic, diurezei orară, PESS. Discuţii. În lotul pacienţilor cu anestezie inhalatorie s-a determinat o incidenţă înaltă a depresiei hemodinamice profunde (Tam - 74,3 mmHg, p= 0,02). Tot aici s-a determinat: utilizarea dozelor mai mici de analgetice şi miorelaxante (sol. atracurium bromid 0,35-0,4mg/kg) , trezire mai rapidă, incidenţă mai scăzută a greții şi tremorului postoperator. S-a reuşit efectuarea mai veridică a neuromonitorigului, datorită cantităţii mai mici de miorelaxante utilizate. La pacienţii cu anestezie intravenoasă s-a determinat o stabilitate hemodinamică (Tam - 82,7 mmHg, p ≤ 0,05), hemoragie intraoperatorie nesemnificativă. În lotul dat s-a reuşit efectuarea neuromonitorigului, cu doze obişnuite de miorelaxante (sol. atracurium bromid 0,5 mg/kg). Concluzii. Tehnicile descrise pot fi utilizate pentru neuromonitorizare multimodală în ablaţia de tumori endocraniene. Tehnica de anestezie inhalatorie, respectând farmacocinetica preparatelor, ar putea fi de preferat, din cauza evitării riscurilor de supra - sau sub dozare de medicamente anestezice, oferind o trezire mai rapidă, cu o evaluarea neurologică imediată, care este extrem de importantă.Materials and methods. The study included two groups of patients: I-st group - 6 patients receiving combined anesthesia (i / v + inhaled sevoflurane); II-nd group - 5 patients who received intravenous anesthesia (propofol + fentanyl).Monitoring: sBP, dBP, mBP (invasive), CVP, acid-base, gas (peripheral artery and vein, jugular bulb) and electrolytic balances, lactic acid, hourly diuresis, neurology evoked potentials. Discussion. In the group of patients with inhalation anesthesia was determined a higher incidence of hemodynamic depression (Tam - 74,3 mmHg, p= 0,02). Also it was determined: use of lower doses of analgetics and muscle relaxants (sol. atracurium bromid 0,35-0,4mg/kg), faster awakening, lower incidence of postoperative nausea and tremors. We managed a more accurate recording of evoked potentials due to the small amount of muscle relaxant used. In patients with intravenous anesthesia was determined a more stable BP (mBP - 82,7 mmHg, p ≤ 0,05), less intraoperative bleeding. In the group given was carrying neuromonitorigului managed with dose of muscle relaxant common (ground. atracurium aromide 0.5 mg / kg). Conclusions. The techniques described can be used for multimodal neuromonitoring in ablation of tumor endocranial. Inhalational anesthesia technique, respecting the pharmacokinetics preparations could be preferable because avoid the risks of over - or under dosage of anesthetic agents, providing an awakening faster with immediate neurological evaluation, which is extremely important

Kuwait: Fostering Sustainable Investment through Modern Commercial Law Systems

The Government of Kuwait (GOK) is now moving decisively to reform its insolvency and creditor/debtor regime (ICR). Stakeholders recognize that Kuwait's ICR system had fallen behind that required for a modern economy. The GOK's effort to establish a modern insolvency and creditor rights system is driven by several considerations: first, consistent with its traditional strengths, Kuwait is seeking to transform itself into a regional financial and trading center, as expressed in the Amiri vision 2030 and the GOK's most-recent five-year development plan. Second, many of the difficulties afflicting the country's investment company sector, which started surfacing in 2008, still await fundamental resolution. Third, development of small and medium enterprises (SMEs) is essential to help the GOK meet its goals of diversifying the sources of income and encouraging young people to work in the private sector, in order to reduce the burden of the public sector. The GOK's reform agenda aspires to world-class standards, balancing international norms with solutions rooted in Kuwait's unique local customs. The consensus among stakeholders is that an effective insolvency regime would benefit the Kuwait economy

Effects of cold-rolling deformation on texture evolution and mechanical properties of Ti-29Nb-9Ta-10Zr alloy

International audienceThe crystallographic texture of Ti-29Nb-9Ta-10Zr alloy is studied after cold-rolling with different amounts of thickness reduction, up to 60%. The major texture components developed during cold-rolling were: γ-fibre components: {111}〈View the MathML source〉, {111}〈View the MathML source〉, {111}〈View the MathML source〉 and {111}〈View the MathML source〉; texture component: {112}〈View the MathML source〉 and texture components: {001}〈View the MathML source〉 and {010}〈001〉. Besides crystallographic texture the resulted mechanical properties were studied by nanoindentation. It was showed that the decrease in Young's modulus after different cold-rolling stages is mainly attributed to the stress-induced α″-Ti phase formation. At 60% cold-rolling thickness reduction obtained an elastic modulus close to 45.29±3.81 GPa, coupled with an average Vickers microhardness close to 279.83±4.28 HV

Field Localization and Enhancement of Phase Locked Second and Third Harmonic Generation in Absorbing Semiconductor Cavities

We predict and experimentally observe the enhancement by three orders of magnitude of phase mismatched second and third harmonic generation in a GaAs cavity at 650nm and 433nm, respectively, well above the absorption edge. Phase locking between the pump and the harmonics changes the effective dispersion of the medium and inhibits absorption. Despite hostile conditions the harmonics become localized inside the cavity leading to relatively large conversion efficiencies. Field localization plays a pivotal role and ushers in a new class of semiconductor-based devices in the visible and UV ranges

The Philia project – for the successful integration of the young through their empowerment and social network development

The Philia+ project has been approved for funding within the Erasmus + Programme. Several partners from Belgium, France, Germany, Portugal and Romania (from higher education and social work institutions) have worked to support the academic success and social inclusion of (pre)adolescents aged 13-18 in foster care, and to enhance, preserve and develop their support networks. Training programmes were held for teachers, trainers and researchers involved in the project, as well as for students and social work professionals and young people in difficulty in the care of associations and organizations providing them social and psychological support. The aim has always been to change their position according to the theoretical DPAPC (empowerment of individuals and communities) framework and to the methodological RAC (collaborative research-action) framework, in order to enable them to understand the mechanism of the social determinism of success and failure and to enhance their support networks. We managed to create two training modules, teasers of experienced testimonies (focus groups, comprehensive conversations), educational films for the two modules, educational films on accompanying Roma and unaccompanied minors.info:eu-repo/semantics/publishedVersio

Nodular goiter: an indication for surgical treatment

Catedra Chirurgie nr.5 a facultăţii stomatologie, USMF „NicolaeTestemițanu”, Spitalul Clinic Central stația Chișinău, Chișinău, Republica Moldova, Conferința stiințifică „Nicolae Anestiadi – nume etern al chirurgiei basarabene” consacrată centenarului de la nașterea profesorului Nicolae Anestiadi 26 august 2016Guşile nodulare, în ultimii ani, prevalează printre patologiile ce necesită tratament chirurgical, afectând predominant persoanele de sex feminin cu vârsta fertilă. Tratamentul chirurgical al guşilor este prioritar datorită radicalităţii şi complicaţiilor reduse comparativ cu metodele conservative și minim-invazive utilizate ca hormonoterapia, terapia cu iod radioactiv, scleroterapia cu etanol și termoterapia. Scopul. Ameliorarea rezultatelor tratamentului chirurgical al guşilor nodulare. Material și metode. În perioada anilor 2011 – 2016, în cadrul clinicii de chirurgie a Spitalului Clinic Central, stația Chișinău, au fost efectuate 54 intervenții chirurgicale la pacienții cu diagnosticul de Guşă nodulară gr.IIIIV eutiroidiană sau hipertiroidiană compensată. Vârsta pacienţilor a variat de la 19 până la 63 ani. Tratamentul chirurgical aplicat a constat în tiroidectomii totale(4) şi subtotale(2), hemitiroidectomii unilaterale(38), enucleerea nodulilor tiroidieni(2), istmectomii(1) şi combinate – hemitiroidectomii unilaterale şi enucleerea nodulului din lobul contralateral, hemitiroidectomii unilaterale şi rezecţii parţiale de lob contralateral(7) în dependenţă de originea tumorală (adenom folicular, carcinom papilar, carcinom folicular) sau autoimună (struma Hashimoto) cu sau fără elemente de compresie a structurilor adiacente. La toți pacienții a fost efectuat examenul histologic extemporaneu al țesutului glandular. Rezultate. Complicaţii intra- și postoperatorii n-au fost depistate. Toți pacienții au fost externați la domiciliu în stare satisfăcătoare. În conformitate cu dozarea hormonilor tiroidieni la necesitate s-au indicat preparate hormonale. Rezultatele la distanță după un an au fost studiate la 47 pacienți, după 3 ani – la 35 pacienți, după 5 ani – la 12 pacienți. Recidive ale maladiei n-au fost depistate. Concluzii. Intervenţia chirurgicală este o metodă eficace în tratamentul radical al guşilor nodulare.Introduction. In the last few years nodular goiter dominates among the pathologies that require surgery and it occurs more often in women of childbearing age. Surgical treatment of goiters by its radicality and minimal complications has the priority in comparison with other conservative and minimally invasive methods such as hormone therapy, radioiodine therapy, ethanol sclerotherapy and thermotherapy. Objective. The improvement of surgical treatment results of goiters. Material and methods. During 2011-2016, inside the surgery clinic of Central Clinic Railway Hospital, were performed 54 surgeries to the patients with euthyroid or compensated hyperthyroid nodular goiter grade III-IV. The patients’ age varied from 19 to 63 years. Surgical treatment comprised: total thyroidectomies(4), subtotal thyroidectomies(2), unilateral thyroidectomies(38), simple enucleation of a nodule(2), isthmusectomy(1), hemithyroidectomy combined with contralateral nodule enucleation or hemithyroidectomy combined with contralateral partial lobe resection(7) according to tumoral (follicular adenoma, follicular carcinoma, papillary carcinoma) or autoimmune (Hashimoto’s goiter) root with or without compressive symptoms. All the patients were exposed to extemporaneous histological examination of the thyroid tissue. Results. Intra- and postoperative complications were not found. All the patients were discharged home in good conditions. Based on the thyroid hormones dosage some of patients were given hormone therapy. The remote results were studied after one year for 47 patients, after 3 years – for 35 patients, after 5 years - for 12 patients. The relapse of nodular goiter wasn’t detected. Conclusion. The surgery is an effective method in radical treatment of nodular goiters

Клинико-статистические аспекты наследственности, как фактора риска развития запоров у беременных

Department of Obstetrics and Gynecology, Department of Internal Medicine State University of Medicine and Pharmacy „Nicolae Testemitanu”, Chisinau, Republic of MoldovaConstipation, as the world goes, is the evacuation of the bowels less than three times per week. An objective criterion of constipation is considered to be stool weight decreased till 35 g per day. The clinico-genealogical method was used. The sampling size is 346 pregnant women who filled in the forms and were clinically examined 72.8 ± 2.4% of women live in the city area and 27.2 ± 4.6% of pregnant women live in the countryside. With the use of the clinico-genealogical investigation method, 364 pregnant women were examined: 164 pregnant women with a constipation problem (66 – with functional constipation, 98 – with gestational constipation) and 182 pregnant women without a constipation problem. In 53.66 ± 3.89% cases pregnant women with a constipation problem noted familial load by this feature while this feature’s frequency occurred in the families of women without this problem 33.52 ± 3.5% (p < 0.01). The results of the investigation showed that pregnant women who have first relation degree relatives with a constipation problem in anamnesis have a higher constipation development risk in comparison with pregnant women with a favorable inherited anamnesis.Запорами принято называть эвакуацию кала менее трех раз в неделю. Объективным критерием запоров является объем каловых масс менее 35 гр. в день. В исследовании был использован клинико-генеалогический метод. Нами было анкетировано и проведено клиническое обследование 346 беременных, из которых в городской местности проживает 72,8 ± 2,4% и в сельской – 27,2 ± 4,6%. Методом клинико-генеалогического исследования обследовано 346 беременных: 164 беременные, страдающими запорами (66 – функциональными, 98 – гестационными) и 182 – без запоров. Результаты исследования свидетельствуют о важной роли наследственного фактора в этиопатогенезе запоров у беременных, что дает основание отнести его к факторам риска развития запоров в процессе гестации. В 53,66 ± 3,89 % случаях у беременных женщин с запорами было отмечено наличие наследственного фактора, в то время как частота встречаемости у женщин без такой патологии составляет 33,52 ± 3,5% (p < 0,01). Результаты исследования продемонстрировали, что у беременных женщин с запорами, встречающимися в анамнезе у родственников первой линии родства, существует повышенный риск развития запоров в отличие от беременных без отягощенного семейного анамнеза

Скрининг дисфункций щитовидной железы у детей с синдромом Дауна. Наблюдение детей в условиях практики семейного врача

Department of Pediatrics, Research Institute for Maternal and Child Healthcare, Congresul III al Medicilor de Familie din Republica Moldova, 17–18 mai, 2012, Chişinău, Republica Moldova, Conferinţa Naţională „Maladii bronhoobstructive la copii”, consacrată profesorului universitar, doctor habilitat Victor Gheţeul, 27 aprilie, Chişinău, Republica MoldovaThyroid dysfunctions are detected significantly more frequently in children with Down syndrome (DS) compared to the group children with typical development. Our study conducted on a group of 52 children with DS aged 3 months – 3 years, beneficiaries of the Centre of Early Intervention “Voinicel” had shown an imbalance of thyroid hormones in the 36.5% of those surveyed, manifested by compensatory increased level of TSH in 89.4% of cases, and reduced levels of T3 and T4 – in 26.3% of children. The associated clinical signs frequently have been found: edemas in the cervical region and/or eyelids, dorsal parts of hands (42.8%), sweating (71.4%), sleep disturbances (57.1%), dry skin (50.0%), apathy (50.0%), clumsy, slow movements (64.2%), frequent infections (42.8%), low voice (35.7%). The correction of hypothyroidism by individually adjusted doses of L-Thyroxine has led to improvement in the clinical conditions of patients and the development of children. Based on the study results, an algorithm was proposed to monitor the children with DS in primary health care in order to identify hypothyroidism on the early stages and its correction to ensure a timely and optimal development of children with DS.Дисфункция щитовидной железы обнаруживается у детей с синдромом Дауна (СД) значительно чаще по сравнению с группой детей с типичным развитием. Наши исследования, проведенные на группе из 52 детей с СД в возрасте от 3 месяцев до 3 лет, посещающих Центр Раннего Вмешательства “Войничел”, выявили дисбаланс гормонов щитовидной железы у 36,5% исследованных, который проявлялся компенсаторным повышением уровня ТСГ в 89,4% случаев, снижением уровня Т3 и Т4 – в 26,3% случаев. Часто обнаруживались ассоциированные клинические признаки в виде отечности в области шеи и/или век, тыльной части рук (42,8%), потливость (71,4%), нарушение сна (57,1%), сухость кожи (50,0%), апатия (50,0%), неуклюжие, медленные движения (64,2%), предрасположенность к инфекциям (42,8%), низкий голос (35,7%). Коррекция гипотиреоза индивидуально регулированными дозами L-Тироксина привело к улучшению клинического состояния детей и к ускорению их развития. На основании результатов исследования был разработан алгоритм мониторинга детей с синдромом Дауна в условиях практики семейного врача с целью выявления гипотиреоза на ранней стадии и его коррекции в целях обеспечения оптимального развития детей с СД