1,546 research outputs found
BMQ
BMQ: Boston Medical Quarterly was published from 1950-1966 by the Boston University School of Medicine and the Massachusetts Memorial Hospitals
Models of Individual Blue Stragglers
This chapter describes the current state of models of individual blue
stragglers. Stellar collisions, binary mergers (or coalescence), and partial or
ongoing mass transfer have all been studied in some detail. The products of
stellar collisions retain memory of their parent stars and are not fully mixed.
Very high initial rotation rates must be reduced by an unknown process to allow
the stars to collapse to the main sequence. The more massive collision products
have shorter lifetimes than normal stars of the same mass, while products
between low mass stars are long-lived and look very much like normal stars of
their mass. Mass transfer can result in a merger, or can produce another binary
system with a blue straggler and the remnant of the original primary. The
products of binary mass transfer cover a larger portion of the colour-magnitude
diagram than collision products for two reasons: there are more possible
configurations which produce blue stragglers, and there are differing
contributions to the blended light of the system. The effects of rotation may
be substantial in both collision and merger products, and could result in
significant mixing unless angular momentum is lost shortly after the formation
event. Surface abundances may provide ways to distinguish between the formation
mechanisms, but care must be taking to model the various mixing mechanisms
properly before drawing strong conclusions. Avenues for future work are
outlined.Comment: Chapter 12, in Ecology of Blue Straggler Stars, H.M.J. Boffin, G.
Carraro & G. Beccari (Eds), Astrophysics and Space Science Library, Springe
The self-force on a static scalar test-charge outside a Schwarzschild black hole
The finite part of the self-force on a static scalar test-charge outside a
Schwarzschild black hole is zero. By direct construction of Hadamard's
elementary solution, we obtain a closed-form expression for the minimally
coupled scalar field produced by a test-charge held fixed in Schwarzschild
spacetime. Using the closed-form expression, we compute the necessary external
force required to hold the charge stationary. Although the energy associated
with the scalar field contributes to the renormalized mass of the particle (and
thereby its weight), we find there is no additional self-force acting on the
charge. This result is unlike the analogous electrostatic result, where, after
a similar mass renormalization, there remains a finite repulsive self-force
acting on a static electric test-charge outside a Schwarzschild black hole. We
confirm our force calculation using Carter's mass-variation theorem for black
holes. The primary motivation for this calculation is to develop techniques and
formalism for computing all forces - dissipative and non-dissipative - acting
on charges and masses moving in a black-hole spacetime. In the Appendix we
recap the derivation of the closed-form electrostatic potential. We also show
how the closed-form expressions for the fields are related to the infinite
series solutions.Comment: RevTeX, To Appear in Phys. Rev.
Dysregulated protocadherin-pathway activity as an intrinsic defect in induced pluripotent stem cell-derived cortical interneurons from subjects with schizophrenia.
We generated cortical interneurons (cINs) from induced pluripotent stem cells derived from 14 healthy controls and 14 subjects with schizophrenia. Both healthy control cINs and schizophrenia cINs were authentic, fired spontaneously, received functional excitatory inputs from host neurons, and induced GABA-mediated inhibition in host neurons in vivo. However, schizophrenia cINs had dysregulated expression of protocadherin genes, which lie within documented schizophrenia loci. Mice lacking protocadherin-α showed defective arborization and synaptic density of prefrontal cortex cINs and behavioral abnormalities. Schizophrenia cINs similarly showed defects in synaptic density and arborization that were reversed by inhibitors of protein kinase C, a downstream kinase in the protocadherin pathway. These findings reveal an intrinsic abnormality in schizophrenia cINs in the absence of any circuit-driven pathology. They also demonstrate the utility of homogenous and functional populations of a relevant neuronal subtype for probing pathogenesis mechanisms during development
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Validation of a culturally adapted Swedish-language version of the Death Literacy Index
The death literacy index (DLI) was developed in Australia to measure death literacy, a set of experience-based knowledge needed to understand and act on end-of-life (EOL) care options but has not yet been validated outside its original context. The aim of this study was to develop a culturally adapted Swedish-language version of the DLI, the DLI-S, and assess sources of evidence for its validity in a Swedish context. The study involved a multi-step process of translation and cultural adaptation and two validation phases: examining first content and response process validity through expert review (n = 10) and cognitive interviews (n = 10); and second, internal structure validity of DLI-S data collected from an online cross-sectional survey (n = 503). The psychometric evaluation involved analysis of descriptive statistics on item and scale-level, internal consistency and test-retest reliability, and confirmatory factor analysis. During translation and adaptation, changes were made to adjust items to the Swedish context. Additional adjustments were made following findings from the expert review and cognitive interviews. The content validity index exceeded recommended thresholds (S-CVIAve = 0.926). The psychometric evaluation provided support for DLI-S' validity. The hypothesized six-factor model showed good fit (χ2 = 1107.631 p<0.001, CFI = 0.993, TLI = 0.993, RMSEA = 0.064, SRMR = 0.054). High internal consistency reliability was demonstrated for the overall scale (Cronbach's α = 0.94) and each sub-scale (α 0.81-0.92). Test-retest reliability was acceptable, ICC ranging between 0.66-0.85. Through a comprehensive assessment of several sources of evidence, we show that the DLI-S demonstrates satisfactory validity and acceptability to measure death literacy in the Swedish context. There are, however, indications that the sub-scales measuring community capacity perform worse in comparison to other sca and may function differently in Sweden than in the original context. The DLI-S has potential to contribute to research on community-based EOL interventions
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