50 research outputs found
Influence of dietary n-6 and n-3 lipids upon the development of pulmonary granulomas induced by Schistosoma mansoni eggs
Pulmonary granuloma development was studied in mice injected with 2x103
Schistosoma mansoni eggs through the main tail vein. Mice were divided
into three groups and fed with a laboratory manipulated diet differing
among them only in the source of fatty acids. Control group (CT) was
fed with a soya oil diet; n-6 deficient animals (low n-6 group)
received a supplemented coconut fat diet; and the third group, high
n-3, was fed with a cod liver oil diet. The expected anti-inflammatory
actions associated with essential fatty acids deficiency was noticed in
our system. When compared with CT, animals fed with the n-6 deficient
diet presented significantly reduced pulmonary granulomas 32 days after
egg injection. Mice fed with high n-3 diet had pulmonary granulomas
reduced as soon as 16 days post egg injection. Mean granuloma
measurements for CT at days 8, 16 and 32 were, in 103μ2,
respectively 7.52 5.92, 32.70 18.09, 32.22 19.87; for n-6 deficient
animals 17.65 18.85, 36.14 29.14, 24.45 14.06; and for high n-3 group
were 11.60 12.67, 9.97 12.34, 25.54 16.66