Small scale structures in three-dimensional magnetohydrodynamic turbulence

We investigate using direct numerical simulations with grids up to 1536^3 points, the rate at which small scales develop in a decaying three-dimensional MHD flow both for deterministic and random initial conditions. Parallel current and vorticity sheets form at the same spatial locations, and further destabilize and fold or roll-up after an initial exponential phase. At high Reynolds numbers, a self-similar evolution of the current and vorticity maxima is found, in which they grow as a cubic power of time; the flow then reaches a finite dissipation rate independent of Reynolds number.Comment: 4 pages, 3 figure

Contribution of extracellular negatively charged residues to ATP action and zinc modulation of rat P2X 2 receptors

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/65506/1/j.1471-4159.2008.05228.x.pd

Magnetohydrodynamic activity inside a sphere

We present a computational method to solve the magnetohydrodynamic equations in spherical geometry. The technique is fully nonlinear and wholly spectral, and uses an expansion basis that is adapted to the geometry: Chandrasekhar-Kendall vector eigenfunctions of the curl. The resulting lower spatial resolution is somewhat offset by being able to build all the boundary conditions into each of the orthogonal expansion functions and by the disappearance of any difficulties caused by singularities at the center of the sphere. The results reported here are for mechanically and magnetically isolated spheres, although different boundary conditions could be studied by adapting the same method. The intent is to be able to study the nonlinear dynamical evolution of those aspects that are peculiar to the spherical geometry at only moderate Reynolds numbers. The code is parallelized, and will preserve to high accuracy the ideal magnetohydrodynamic (MHD) invariants of the system (global energy, magnetic helicity, cross helicity). Examples of results for selective decay and mechanically-driven dynamo simulations are discussed. In the dynamo cases, spontaneous flips of the dipole orientation are observed.Comment: 15 pages, 19 figures. Improved figures, in press in Physics of Fluid

Large scale flow effects, energy transfer, and self-similarity on turbulence

The effect of large scales on the statistics and dynamics of turbulent fluctuations is studied using data from high resolution direct numerical simulations. Three different kinds of forcing, and spatial resolutions ranging from 256^3 to 1024^3, are being used. The study is carried out by investigating the nonlinear triadic interactions in Fourier space, transfer functions, structure functions, and probability density functions. Our results show that the large scale flow plays an important role in the development and the statistical properties of the small scale turbulence. The role of helicity is also investigated. We discuss the link between these findings and intermittency, deviations from universality, and possible origins of the bottleneck effect. Finally, we briefly describe the consequences of our results for the subgrid modeling of turbulent flows

Hydrodynamic and magnetohydrodynamic computations inside a rotating sphere

Numerical solutions of the incompressible magnetohydrodynamic (MHD) equations are reported for the interior of a rotating, perfectly-conducting, rigid spherical shell that is insulator-coated on the inside. A previously-reported spectral method is used which relies on a Galerkin expansion in Chandrasekhar-Kendall vector eigenfunctions of the curl. The new ingredient in this set of computations is the rigid rotation of the sphere. After a few purely hydrodynamic examples are sampled (spin down, Ekman pumping, inertial waves), attention is focused on selective decay and the MHD dynamo problem. In dynamo runs, prescribed mechanical forcing excites a persistent velocity field, usually turbulent at modest Reynolds numbers, which in turn amplifies a small seed magnetic field that is introduced. A wide variety of dynamo activity is observed, all at unit magnetic Prandtl number. The code lacks the resolution to probe high Reynolds numbers, but nevertheless interesting dynamo regimes turn out to be plentiful in those parts of parameter space in which the code is accurate. The key control parameters seem to be mechanical and magnetic Reynolds numbers, the Rossby and Ekman numbers (which in our computations are varied mostly by varying the rate of rotation of the sphere) and the amount of mechanical helicity injected. Magnetic energy levels and magnetic dipole behavior are exhibited which fluctuate strongly on a time scale of a few eddy turnover times. These seem to stabilize as the rotation rate is increased until the limit of the code resolution is reached.Comment: 26 pages, 17 figures, submitted to New Journal of Physic

Convection-driven kinematic dynamos at low Rossby and magnetic Prandtl numbers

Most large-scale planetary magnetic fields are thought to be driven by low Rossby number convection of a low magnetic Prandtl number fluid. Here kinematic dynamo action is investigated with an asymptotic, rapidly rotating dynamo model for the plane layer geometry that is intrinsically low magnetic Prandtl number. The thermal Prandtl number and Rayleigh number are varied to illustrate fundamental changes in flow regime, ranging from laminar cellular convection to geostrophic turbulence in which an inverse energy cascade is present. A decrease in the efficiency of the convection to generate a dynamo, as determined by an increase in the critical magnetic Reynolds number, is observed as the buoyancy forcing is increased. This decreased efficiency may result from both the loss of correlations associated with the increasingly disordered states of flow that are generated, and boundary layer behavior that enhances magnetic diffusion locally. We find that the spatial characteristics of the large-scale magnetic field is dependent only weakly on changes in flow behavior. In contrast, the behavior of the small-scale magnetic field is directly dependent on, and therefore shows significant variations with, the small-scale convective flow field. However, our results are limited to the linear, kinematic dynamo regime; future simulations that include the Lorentz force are therefore necessary to assess the robustness of these results

Assumptions behind grammatical approaches to code-switching: when the blueprint is a red herring

Many of the so-called ‘grammars’ of code-switching are based on various underlying assumptions, e.g. that informal speech can be adequately or appropriately described in terms of ‘‘grammar’’; that deep, rather than surface, structures are involved in code-switching; that one ‘language’ is the ‘base’ or ‘matrix’; and that constraints derived from existing data are universal and predictive. We question these assumptions on several grounds. First, ‘grammar’ is arguably distinct from the processes driving speech production. Second, the role of grammar is mediated by the variable, poly-idiolectal repertoires of bilingual speakers. Third, in many instances of CS the notion of a ‘base’ system is either irrelevant, or fails to explain the facts. Fourth, sociolinguistic factors frequently override ‘grammatical’ factors, as evidence from the same language pairs in different settings has shown. No principles proposed to date account for all the facts, and it seems unlikely that ‘grammar’, as conventionally conceived, can provide definitive answers. We conclude that rather than seeking universal, predictive grammatical rules, research on CS should focus on the variability of bilingual grammars

Aromatase Is a Direct Target of FOXL2: C134W in Granulosa Cell Tumors via a Single Highly Conserved Binding Site in the Ovarian Specific Promoter

BACKGROUND: Granulosa cell tumors (GCT) of the ovary often express aromatase and synthesize estrogen, which in turn may influence their progression. Recently a specific point mutation (C134W) in the FOXL2 protein was identified in >94% of adult-type GCT and it is likely to contribute to their development. A number of genes are known to be regulated by FOXL2, including aromatase/CYP19A1, but it is unclear which are direct targets and whether the C134W mutation alters their regulation. Recently, it has been reported that FOXL2 forms a complex with steroidogenic factor 1 (SF-1) which is a known regulator of aromatase in granulosa cells. METHODOLOGY/PRINCIPAL FINDINGS: In this work, the human GCT-derived cell lines KGN and COV434 were heterozygous and wildtype for the FOXL2:C134W mutation, respectively. KGN had abundant FOXL2 mRNA expression but it was not expressed in COV434. Expression of exogenous FOXL2:C134W in COV434 cells induced higher expression of a luciferase reporter for the ovarian specific aromatase promoter, promoter II (PII) (-516bp) than expression of wildtype FOXL2, but did not alter induction of a similar reporter for the steroidogenic acute regulatory protein (StAR) promoter (-1300bp). Co-immunoprecipitation confirmed that FOXL2 bound SF-1 and that it also bound its homologue, liver receptor homologue 1 (LRH-1), however, the C134W mutation did not alter these interactions or induce a selective binding of the proteins. A highly conserved putative binding site for FOXL2 was identified in PII. FOXL2 was demonstrated to bind the site by electrophoretic mobility shift assays (EMSA) and site-directed mutagenesis of this element blocked its differential induction by wildtype FOXL2 and FOXL2:C134W. CONCLUSIONS/SIGNIFICANCE: These findings suggest that aromatase is a direct target of FOXL2:C134W in adult-type GCT via a single distinctive and highly conserved binding site in PII and therefore provide insight into the pathogenic mechanism of this mutation

Aromatase expression is increased in BRCA1 mutation carriers

<p>Abstract</p> <p>Background</p> <p>Until recently, the molecular mechanisms explaining increased incidence of ovarian and breast cancers in carriers of <it>BRCA1 </it>gene mutations had not been clearly understood. Of significance is the finding that BRCA1 negatively regulates aromatase expression <it>in vitro</it>. Our objective was to characterise aromatase gene <it>(CYP19A1) </it>and its promoter expression in breast adipose and ovarian tissue in <it>BRCA1 </it>mutation carriers and unaffected controls.</p> <p>Methods</p> <p>We measured aromatase transcripts, total and promoter-specific (PII, PI.3, PI.4) in prophylactic oophorectomy or mastectomy, therapeutic mastectomy, ovarian and breast tissue from unaffected women.</p> <p>Results</p> <p>We demonstrate that the lack of functional BRCA1 protein correlates to higher aromatase levels in 85% of <it>BRCA1 </it>mutation carriers. This increase is mediated by aberrant transcriptional regulation of aromatase; in breast adipose by increases in promoter II/I.3 and I.4-specific transcripts; and in the ovary with elevation in promoter I.3 and II-specific transcripts.</p> <p>Conclusion</p> <p>Understanding the link between BRCA1 and aromatase is significant in terms of understanding why carcinogenesis is restricted to estrogen-producing tissues in <it>BRCA1 </it>mutation carriers.</p

Language attitudes and use in a transplanted setting: Greek Cypriots in London

In this paper we explore language attitudes and use in the Greek Cypriot community in London, England. Our study is based on an earlier survey carried out in Nicosia, Cyprus and we compare attitudes to language and reported language use in the two communities. We thereby highlight the significance of sociolinguistic variables on similar groups of speakers. We further extend our investigation to include codeswitching practices in the London community. \ud Analysis of language attitudes and use within the Greek-Cypriot population of London, and comparisons with findings in Nicosia, reflect symbolic forces operating in the two contexts. Despite obvious differences between the two communities, (most obviously the official languages and distinct cultural backgrounds of the two nations), the Greek Cypriot Dialect continues to play an active role in both. English is however the ‘default choice‘ for young Cypriots in the UK and Standard Modern Greek occupies a much more limited role than in Cyprus. It is argued that differences in language attitudes and use can be interpreted in light of different market forces operating in the nation (i.e. Cyprus) and the Diaspora (i.e. UK)