Analytical Guidance Laws and Integrated Guidance/Autopilot for Homing Missiles

An approach to integrated guidance/autopilot design is considered in this study. It consists of two parts: 1) recognizing the importance of polar coordinates to describe the end game in terms of problem description and measurement acquisition, the terminal guidance problem is formulated in terms of polar coordinates; 2a) through the use of the state transition matrix of the intercept dynamics, a closed form solution for the transverse command acceleration is obtained; and 2b) through a commonly used approximation on time-to-go and a coordinate transformation, a family of proportional navigation optimal guidance laws is obtained in a closed form. A typical element of such a guidance law is combined with the autopilot dynamics to result in a feedback control law in terms of output variable

Low Energy Electron Point Projection Microscopy of Suspended Graphene, the Ultimate "Microscope Slide"

Point Projection Microscopy (PPM) is used to image suspended graphene using low-energy electrons (100-200eV). Because of the low energies used, the graphene is neither damaged or contaminated by the electron beam. The transparency of graphene is measured to be 74%, equivalent to electron transmission through a sheet as thick as twice the covalent radius of sp^2-bonded carbon. Also observed is rippling in the structure of the suspended graphene, with a wavelength of approximately 26 nm. The interference of the electron beam due to the diffraction off the edge of a graphene knife edge is observed and used to calculate a virtual source size of 4.7 +/- 0.6 Angstroms for the electron emitter. It is demonstrated that graphene can be used as both anode and substrate in PPM in order to avoid distortions due to strong field gradients around nano-scale objects. Graphene can be used to image objects suspended on the sheet using PPM, and in the future, electron holography

Ion measurements during Pioneer Venus reentry: Implications for solar cycle variation of ion composition and dynamics

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/95616/1/grl7044.pd

Characterization of the K2-18 multi-planetary system with HARPS: A habitable zone super-Earth and discovery of a second, warm super-Earth on a non-coplanar orbit

The bright M dwarf K2-18 at 34 pc is known to host a transiting super-Earth-sized planet orbiting within the star's habitable zone; K2-18b. Given the superlative nature of this system for studying an exoplanetary atmosphere receiving similar levels of insolation as the Earth, we aim to characterize the planet's mass which is required to interpret atmospheric properties and infer the planet's bulk composition. We obtain precision radial velocity measurements with the HARPS spectrograph and couple those measurements with the K2 photometry to jointly model the observed radial velocity variation with planetary signals and a radial velocity jitter model based on Gaussian process regression. We measure the mass of K2-18b to be $8.0 \pm 1.9$ M$_{\oplus}$ with a bulk density of $3.7 \pm 0.9$ g/cm$^3$ which may correspond to a predominantly rocky planet with a significant gaseous envelope or an ocean planet with a water mass fraction $\gtrsim 50$%. We also find strong evidence for a second, warm super-Earth K2-18c at $\sim 9$ days with a semi-major axis 2.4 times smaller than the transiting K2-18b. After re-analyzing the available light curves of K2-18 we conclude that K2-18c is not detected in transit and therefore likely has an orbit that is non-coplanar with K2-18b. A suite of dynamical integrations with varying simulated orbital eccentricities of the two planets are used to further constrain each planet's eccentricity posterior from which we measure $e_b < 0.43$ and $e_c < 0.47$ at 99% confidence. The discovery of the inner planet K2-18c further emphasizes the prevalence of multi-planet systems around M dwarfs. The characterization of the density of K2-18b reveals that the planet likely has a thick gaseous envelope which along with its proximity to the Solar system makes the K2-18 planetary system an interesting target for the atmospheric study of an exoplanet receiving Earth-like insolation.Comment: 13 pages, 8 figures including 4 interactive figures best viewed in Adobe Acrobat. Submitted to Astronomy & Astrophysics. Comments welcom

The critical velocity effect as a cause for the H\alpha emission from the Magellanic stream

Observations show significant H\alpha-emissions in the Galactic halo near the edges of cold gas clouds of the Magellanic Stream. The source for the ionization of the cold gas is still a widely open question. In our paper we discuss the critical velocity effect as a possible explanation for the observed H\alpha-emission. The critical velocity effect can yield a fast ionization of cold gas if this neutral gas passes through a magnetized plasma under suitable conditions. We show that for parameters that are typical for the Magellanic Stream the critical velocity effect has to be considered as a possible ionization source of high relevance.Comment: 9 pages, 2 figures. accepted, to appear in The Astrophysical Journa

Effects of intravenous theophylline on exercise-induced myocardial ischemia: II. A concentration-dependent phenomenon

AbstractObjectives. The effects of varying concentrations of theophylline on exercise-induced myocardial ischemia were evaluated in patients with stable coronary artery disease.Background. Theophylline is a competitive antagonist of adenosine and may have potential as an anti-ischemic medication. It is not known whether these effects on myocardial ischemia are concentration dependent.Methods. In a double-blind, randomized, crossover manner, 11 patients received, at 1-week intervals, placebo and each of three theophylline doses by intravenous infusion for 45 min. Graded exercise testing was performed before randomization and immediately after each infusion. Concurrent anti-ischemic medications were withheld for 24 h before each exercise test. Serum theophylline concentrations achieved were 3.9 ± 1.0 mg/liter (low), 8.2 ± 1.8 mg/liter (medium) and 13.2 ± 2.3 mg/liter (high).Results. Compared with placebo, none of the three theophylline infusions produced a significant alteration in rest heart rate, blood pressure, mean frequency or severity of ventricular ectopic activity or noncardiac symptoms. The time to onset of ischemia was progressively increased, with medium and high concentrations achieving statistical significance. Similar patterns were observed for oxygen uptake and the heart rate-systolic blood pressure product at the onset of ischemia. Total exercise duration was significantly prolonged with the medium and high concentrations.Conclusions. It is concluded that administration of varying doses of theophylline before exercise produces a clinically significant and concentration-dependent improvement in the indicators of myocardial ischemia in patients with chronic stable coronary artery disease

GJ 1252 b: A 1.2 R\u3csub\u3e⊕\u3c/sub\u3e Planet Transiting An M3 Dwarf At 20.4 pc

We report the discovery of GJ 1252 b, a planet with a radius of 1.193 ± 0.074 R⊕ and an orbital period of 0.52 days around an M3-type star (0.381 ± 0.019 M⊕, 0.391 ± 0.020 R⊕) located 20.385 ± 0.019 pc away. We use Transiting Exoplanet Survey Satellite (TESS) data, ground-based photometry and spectroscopy, Gaia astrometry, and high angular resolution imaging to show that the transit signal seen in the TESS data must originate from a transiting planet. We do so by ruling out all false-positive scenarios that attempt to explain the transit signal as originating from an eclipsing stellar binary. Precise Doppler monitoring also leads to a tentative mass measurement of 2.09 ± 0.56 M⊕. The host star proximity, brightness (V = 12.19 mag, K = 7.92 mag), low stellar activity, and the system\u27s short orbital period make this planet an attractive target for detailed characterization, including precise mass measurement, looking for other objects in the system, and planet atmosphere characterization

The Tyrosine Kinase Csk Dimerizes through Its SH3 Domain

The Src family kinases possess two sites of tyrosine phosphorylation that are critical to the regulation of kinase activity. Autophosphorylation on an activation loop tyrosine residue (Tyr 416 in commonly used chicken c-Src numbering) increases catalytic activity, while phosphorylation of a C-terminal tyrosine (Tyr 527 in c-Src) inhibits activity. The latter modification is achieved by the tyrosine kinase Csk (C-terminal Src Kinase), but the complete inactivation of the Src family kinases also requires the dephosphorylation of the activation loop tyrosine. The SH3 domain of Csk recruits the tyrosine phosphatase PEP, allowing for the coordinated inhibition of Src family kinase activity. We have discovered that Csk forms homodimers through interactions mediated by the SH3 domain in a manner that buries the recognition surface for SH3 ligands. The formation of this dimer would therefore block the recruitment of tyrosine phosphatases and may have important implications for the regulation of Src kinase activity

Engineering Design with Digital Thread

Digital Thread offers the opportunity to use information generated across the product lifecycle to design the next generation of products. In this paper, we introduce a mathematical methodology that establishes the data-driven design and decision problem associated with Digital Thread. Our objectives are twofold: 1) Provide a mathematical definition of Digital Thread in the context of conceptual and preliminary design and establish a methodology for how information along the Digital Thread enters into the design problem as well how design decisions affect the Digital Thread. 2) Develop a data-driven design method that incorporates data from different sources from across the product life cycle. We illustrate aspects of our methodology through an example design of a structural fiber-steered composite component.United States. Air Force. Office of Scientific Research (Grant FA9550-16-1-0108)SUTD-MIT International Design Centre (IDC

Executive Summary: The 2018 Academic Emergency Medicine Consensus Conference: Aligning the Pediatric Emergency Medicine Research Agenda to Reduce Health Outcome Gaps

Emergency care providers share a compelling interest in developing an effective patient‐centered, outcomes‐based research agenda that can decrease variability in pediatric outcomes. The 2018 Academic Emergency Medicine Consensus Conference “Aligning the Pediatric Emergency Medicine Research Agenda to Reduce Health Outcome Gaps (AEMCC)” aimed to fulfill this role. This conference convened major thought leaders and stakeholders to introduce a research, scholarship, and innovation agenda for pediatric emergency care specifically to reduce health outcome gaps. Planning committee and conference participants included emergency physicians, pediatric emergency physicians, pediatricians, and researchers with expertise in research dissemination and translation, as well as comparative effectiveness, in collaboration with patients, patient and family advocates from national advocacy organizations, and trainees. Topics that were explored and deliberated through subcommittee breakout sessions led by content experts included 1) pediatric emergency medical services research, 2) pediatric emergency medicine (PEM) research network collaboration, 3) PEM education for emergency medicine providers, 4) workforce development for PEM, and 5) enhancing collaboration across emergency departments (PEM practice in non–children’s hospitals). The work product of this conference is a research agenda that aims to identify areas of future research, innovation, and scholarship in PEM.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/146868/1/acem13667.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/146868/2/acem13667_am.pd