Puncture gauge formulation for Einstein-Gauss-Bonnet gravity and four-derivative scalar-tensor theories in d+1 spacetime dimensions

We develop a modified CCZ4 formulation of the Einstein equations in d + 1 spacetime dimensions for general relativity plus a Gauss-Bonnet term, as well as for the most general parity-invariant scalar-tensor theory of gravity up to four derivatives. We demonstrate well-posedness for both theories and provide full expressions for their implementation in numerical relativity codes. As a proof of concept, we study the so-called “stealth scalarization” induced by the spin of the remnant black hole after the merger. As in previous studies using alternative gauges, we find that the scalarization occurs too late after the merger to impact the tensor waveform, unless the parameters are finely tuned. Naively increasing the coupling to accelerate the growth of the scalar field risks a breakdown of the effective field theory, and therefore well-posedness, as the evolution is pushed into the strongly coupled regime. Observation of such an effect would therefore rely on the detection of the scalar radiation that is produced during scalarization. This work provides a basis on which further studies can be undertaken using codes that employ a moving-punctures approach to managing singularities in the numerical domain. It is therefore an important step forward in our ability to analyze modifications of general relativity in gravitational wave observations

Testing the limits of scalar-Gauss-Bonnet gravity through nonlinear evolutions of spin-induced scalarization

Quadratic theories of gravity with second order equations of motion provide an interesting model for testing deviations from general relativity in the strong gravity regime. However, they can suffer from a loss of hyperbolicity, even for initial data that is in the weak coupling regime and free from any obvious pathology. This effect has been studied in a variety of cases including isolated black holes and binaries. Here we explore the loss of hyperbolicity in spin-induced scalarization of isolated Kerr black holes in a scalar-Gauss-Bonnet theory of gravity, employing the modified CCZ4 formulation that has recently been developed. We find that, as in previous studies, hyperbolicity is lost when the scalar field and its gradients become large, and identify the breakdown in our evolutions with the physical modes of the purely gravitational sector. We vary the gauge parameters and find the results to be independent of their value. This, along with our use of a different gauge formulation to previous works, supports the premise that the loss of hyperbolicity is dominated by the physical modes. Since scalar-Gauss-Bonnet theories can be viewed as effective field theories (EFTs), we also examine the strength of the coupling during the evolution. We find that at the moment when hyperbolicity is lost the system is already well within the regime where the EFT is no longer valid. This reinforces the idea that the theories should only be applied within their regime of validity, and not treated as complete theories in their own right

Mechanisms of base selection by human single-stranded selective monofunctional uracil-DNA glycosylase

hSMUG1 (human single-stranded selective monofunctional uracil-DNA glyscosylase) is one of three glycosylases encoded within a small region of human chromosome 12. Those three glycosylases, UNG (uracil-DNA glycosylase), TDG (thymine-DNA glyscosylase), and hSMUG1, have in common the capacity to remove uracil from DNA. However, these glycosylases also repair other lesions and have distinct substrate preferences, indicating that they have potentially redundant but not overlapping physiological roles. The mechanisms by which these glycosylases locate and selectively remove target lesions are not well understood. In addition to uracil, hSMUG1 has been shown to remove some oxidized pyrimidines, suggesting a role in the repair of DNA oxidation damage. In this paper, we describe experiments in which a series of oligonucleotides containing purine and pyrimidine analogs have been used to probe mechanisms by which hSMUG1 distinguishes potential substrates. Our results indicate that the preference of hSMUG1 for mispaired uracil over uracil paired with adenine is best explained by the reduced stability of a duplex containing a mispair, consistent with previous reports with Escherichia coli mispaired uracil-DNA glycosylase. We have also extended the substrate range of hSMUG1 to include 5-carboxyuracil, the last in the series of damage products from thymine methyl group oxidation. The properties used by hSMUG1 to select damaged pyrimidines include the size and free energy of solvation of the 5-substituent but not electronic inductive properties. The observed distinct mechanisms of base selection demonstrated for members of the uracil glycosylase family help explain how considerable diversity in chemical lesion repair can be achieved

Metallic Conductivity in a Two-Dimensional Cobalt Dithiolene Metal-Organic Framework

Two-dimensional (2D) metal–organic frameworks (MOFs) have received a great deal of attention due to their relatively high charge carrier mobility and low resistivity. Here we report on the temperature-dependent charge transport properties of a 2D cobalt 2,3,6,7,10,11-triphenylenehexathiolate framework. Variable temperature resistivity studies reveal a transition from a semiconducting to a metallic phase with decreasing temperature, which is unprecedented in MOFs. We find this transition to be highly dependent on the film thickness and the amount of solvent trapped in the pores, with density functional theory calculations of the electronic-structure supporting the complex metallic conductivity of the material. These results identify the first experimentally observed MOF that exhibits band-like metallic conductivity

Nitric oxide sensing in plants is mediated by proteolytic control of group VII ERF transcription factors

Nitric oxide (NO) is an important signaling compound in prokaryotes and eukaryotes. In plants, NO regulates critical developmental transitions and stress responses. Here, we identify a mechanism for NO sensing that coordinates responses throughout development based on targeted degradation of plant-specific transcriptional regulators, the group VII ethylene response factors (ERFs). We show that the N-end rule pathway of targeted proteolysis targets these proteins for destruction in the presence of NO, and we establish them as critical regulators of diverse NO-regulated processes, including seed germination, stomatal closure, and hypocotyl elongation. Furthermore, we define the molecular mechanism for NO control of germination and crosstalk with abscisic acid (ABA) signaling through ERF-regulated expression of ABSCISIC ACID INSENSITIVE5 (ABI5). Our work demonstrates how NO sensing is integrated across multiple physiological processes by direct modulation of transcription factor stability and identifies group VII ERFs as central hubs for the perception of gaseous signals in plants

Reducing non-attendance rates for assessment at an eating disorders service: a quality improvement initiative

Rates of non-attendance at initial appointments within community eating disorder (ED) services are frequently high, although this has received relatively little research attention and no reports of interventions designed to address this. The current report describes outcomes following a change of procedure introducing a ‘partial booking’ system. Attendance rates at first appointments (N = 1260) were audited following introduction of a system designed to reduce non-attendance in January 2013 within a UK ED service. Rates were compared following implementation of the new system, using a historical control group for comparison, and showed a decline from 20.4 to 15.1%, a medium-sized effect. Use of a system asking patients to book an appointment reduced non-attendance at initial appointments and may be of use to similar services experiencing high non-attendance rates. Opt-in initiatives can reduce burden resulting from long waiting times and can be easily adapted to individual services

Metallic Conductivity in a Two-Dimensional Cobalt Dithiolene Metal-Organic Framework

Two-dimensional (2D) metal–organic frameworks (MOFs) have received a great deal of attention due to their relatively high charge carrier mobility and low resistivity. Here we report on the temperature-dependent charge transport properties of a 2D cobalt 2,3,6,7,10,11-triphenylenehexathiolate framework. Variable temperature resistivity studies reveal a transition from a semiconducting to a metallic phase with decreasing temperature, which is unprecedented in MOFs. We find this transition to be highly dependent on the film thickness and the amount of solvent trapped in the pores, with density functional theory calculations of the electronic-structure supporting the complex metallic conductivity of the material. These results identify the first experimentally observed MOF that exhibits band-like metallic conductivity

How should beta-diversity inform biodiversity conservation?

To design robust protected area networks, accurately measure species losses, or understand the processes that maintain species diversity, conservation science must consider the organization of biodiversity in space. Central is beta-diversity - the component of regional diversity that accumulates from compositional differences between local species assemblages. We review how beta-diversity is impacted by human activities, including farming, selective logging, urbanization, species invasions, overhunting, and climate change. Beta-diversity increases, decreases, or remains unchanged by these impacts, depending on the balance of processes that cause species composition to become more different (biotic heterogenization) or more similar (biotic homogenization) between sites. While maintaining high beta-diversity is not always a desirable conservation outcome, understanding beta-diversity is essential for protecting regional diversity and can directly assist conservation planning. Beta-diversity reveals the spatial scaling of diversity loss.Beta-diversity illuminates mechanisms of regional diversity maintenance.Human activities cause beta-diversity to increase, decrease, or remain unchanged.Conservation significance of beta-diversity shift depends on local diversity dynamics