45 research outputs found
Narrow-line Laser Cooling by Adiabatic Transfer
We propose and demonstrate a novel laser cooling mechanism applicable to
particles with narrow-linewidth optical transitions. By sweeping the frequency
of counter-propagating laser beams in a sawtooth manner, we cause adiabatic
transfer back and forth between the ground state and a long-lived optically
excited state. The time-ordering of these adiabatic transfers is determined by
Doppler shifts, which ensures that the associated photon recoils are in the
opposite direction to the particle's motion. This ultimately leads to a robust
cooling mechanism capable of exerting large forces via a weak transition and
with reduced reliance on spontaneous emission. We present a simple intuitive
model for the resulting frictional force, and directly demonstrate its efficacy
for increasing the total phase-space density of an atomic ensemble. We rely on
both simulation and experimental studies using the 7.5~kHz linewidth S
to P transition in Sr. The reduced reliance on spontaneous
emission may allow this adiabatic sweep method to be a useful tool for cooling
particles that lack closed cycling transitions, such as molecules.Comment: 5 pages, 4 figure
Systematic review of studies generating individual participant data on the efficacy of drugs for treating soil-transmitted helminthiases and the case for data-sharing
Preventive chemotherapy and transmission control (PCT) by mass drug administration is the cornerstone of the World Health Organization (WHO)’s policy to control soil-transmitted helminthiases (STHs) caused by Ascaris lumbricoides (roundworm), Trichuris trichiura (whipworm) and hookworm species (Necator americanus and Ancylostama duodenale) which affect over 1 billion people globally. Despite consensus that drug efficacies should be monitored for signs of decline that could jeopardise the effectiveness of PCT, systematic monitoring and evaluation is seldom implemented. Drug trials mostly report aggregate efficacies in groups of participants, but heterogeneities in design complicate classical meta-analyses of these data. Individual participant data (IPD) permit more detailed analysis of drug efficacies, offering increased sensitivity to identify atypical responses potentially caused by emerging drug resistance