Grupos de ayuda mutua en personas con problemas severos de salud mental en el modelo de la recuperación. La inclusión del cuerpo.

El modelo de la recuperación se basa en la incorporación de las propias personas con trastornos mentales de naturaleza psicótica a su proceso de mejoría. Trabajando en este paradigma surge una experiencia denominada plataforma terapéutica que se desarrolla en un dispositivo de salud mental comunitaria pública y que incluye intervenciones múltiples, multidisciplinares e integradas con la intención de fomentar el uso de los recursos sanos de todas las dimensiones identificadas. Los factores referidos cristalizan en una propuesta desde los propios integrantes para iniciar una actividad grupal de baile liderada por uno de ellos en un contexto extra-sanitario con la intención de fomentar los aspectos sanos sociales y normalizar las actividades al margen de la vivencia de la experiencia psicótica. Se señalan las dificultades desde la institución y la propia clínica psicótica para llevar a cabo actividades en el paradigma de la recuperación en encuadres comunitarios y desde la sanidad pública.Recovery model is based on the implication of the people who suffer psychosis in their own improvement process. We propose a therapeutical experience in a Community Mental Health. Team in the Andalusian Health Service. It includes integrated interventions from different professional roles (Social worker, nursery and psychiatrist) to increase healthy areas. This article exposes a 3-year evolution including a self-promoted movement from the users. It includes bodily aspects and mutual self-help. This experience is set in a non-medical environment to promote healthy social aspects and increase experience out from the psychosis. We also remark institutional and clinical difficulties to develop recovery activities in comunnity environment from public health settings

CtDNA from body fluids is an adequate source for EGFR biomarker testing in advanced lung adenocarcinoma

Objectives: Epidermal growth factor receptor (EGFR) biomarker testing using blood-based liquid biopsies remains challenging due to the low concentration of circulating tumor DNA (ctDNA) in certain plasma samples. The aim of this study is to evaluate the usefulness for EGFR biomarker testing of ctDNA from pleural effusions, cerebrospinal fluids, ascites and pericardial effusions obtained during the clinical management of lung adenocarcinoma patients. Methods: For comparison purposes, 23 paired plasma and body fluid samples were collected from 17 patients with EGFR-positive lung adenocarcinoma. After circulating free DNA (cfDNA) isolation, samples were evaluated for the initial EGFR-sensitizing mutation and the p.T790M resistance mutation by array-based digital PCR (dPCR). Results: Body fluids had more cfDNA than plasma samples (1.90 vs. 0.36 ng/µL; p=0.0130), and more samples tested positive for EGFR mutations (21 vs. 16 samples), with a total of 28 vs. 22 variants detected. Furthermore, mutant allele frequencies (MAFs) observed in body fluids were significantly higher than those assessed in the paired plasma samples for EGFR-sensitizing mutations (median MAFs = 15.8 vs. 0.8%; p=0.0004) as well as for the p.T790M resistance mutation (median MAFs = 8.69 vs. 0.16%; p=0.0390). Importantly, two patients who had progressed on first-generation EGFR-tyrosine kinase inhibitors with a dubious result for p.T790M plasma (MAFs = 0.11%) had an indisputably positive result in their respective body fluid samples (MAFs = 10.25 and 9.66%). Conclusions: ctDNA derived from body fluids is an informative source for EGFR biomarker testing, with greater sensitivity than plasma samples.MB is supported by an i-PFIS predoctoral fellowship (Grant Number IFI18/00051) from ISCIII. ES is funded by the Consejería de Ciencia, Universidades e Innovación de la Comunidad de Madrid (Doctorados Industriales de la Comunidad de Madrid IND2019/BMD-17258), Spain

Acciones docentes prácticas en Derecho penal, Derecho penitenciario y Criminología: experiencias didácticas fuera del aula

Con la implantación del Espacio Europeo de Educación Superior se han venido operando cambios importantes en los métodos y técnicas aplicados en la docencia del Derecho y, más concretamente, en las disciplinas jurídicas que conforman las Ciencias penales. Así, se ha ido avanzando en la dirección de promover una participación más activa del estudiante, mediante el empleo de herramientas y métodos innovadores que han contribuido a proporcionar una formación más integral, comprensiva de competencias genéricas, transversales y específicas. En esta línea de cambio del modelo educativo, la Red de Investigación sobre acciones docentes prácticas en Derecho penal, Derecho penitenciario y Criminología ha desarrollado nuevos recursos que giran en torno a la realización de salidas didácticas de los alumnos a instituciones y organizaciones directamente relacionadas con el sistema penal, fundamentalmente las que componen la judicatura, el aparato policial y el sistema penitenciario

Cartilage tissue engineering: adult human mesenchymal stromal cells and collagen biomaterials

Abstract presentado en el 2014 World Congress on Osteoarthritis: Promoting Clinical and Basic Research in Osteoarthriti

Walkability and socio-economic status in relation to walking, playing and sports practice in a representative Spanish sample of youth: The PASOS study

[Abstract] : Purpose Physical activity (PA) provides multiple health-related benefits in children and adolescents, however, at present, the majority of young people are insufficiently physically active. The aim of this study was to evaluate if neighborhood walkability and/or socio-economic status (SES) could affect the practice of walking, play outdoors and sports practice in a representative sample of Spanish children and adolescents. Methods A sample of 4092 youth (aged 8–16 years old) from 245 primary and secondary schools in 121 localities from each of the 17 Spanish autonomous communities participated in the study. Walk Score was used to evaluate walkability of the neighborhood and household income was used as an indicator of SES. A 7-item self-reported validated questionnaire, was used to assess PA levels, and in a subsample of 10% of the participants, randomly selected from the entire sample, PA was objectively measured by accelerometers. Results Youth from more walkable areas reported more minutes walking per day compared with those from less walkable neighborhoods (51.4 vs 48.8 minutes, respectively). The lowest average minutes spent in playing outdoors was found among participants from low-SES and low-walkable neighborhoods. Neighborhood SES influenced on the participation in team sports during the weekend, being this participation higher in high SES neighborhoods. Conclusion Providing high walkable environments seems a good strategy to promote PA regardless SES levels. It seems that improving the walkability is a key component to partially overcome the SES inequalities, especially in urban areas with low SES. High-SES environments can offer better sports facilities and more organized physical activities than low-SES ones

Estudo dos aspectos epidemiológicos que influenciam o aborto espontâneo

El aborto espontáneo es uno de los más frecuentes de su tipo, con el objetivo de determinar algunos aspectos epidemiológicos del aborto espontáneo y disminuir su incidencia se realizó el presente estudio. A través del método observacional, transversal, descriptivo y prospectivo; se investigaron pacientes atendidas en el Hospital Fe del Valle en el primer semestre del 2019. La muestra estuvo conformada por 109 pacientes con aborto espontáneo, de un universo de 342 remitidas por esta causa. Entre los resultados, se identificó que la edad media es de 27 años. De 88 gestantes, con parto anterior, 40.84% fueron eutócicos, de 111 con abortos anteriores 29.74% fueron espontáneos. La manifestación clínica más frecuente fue el sangrado transvaginal (79.81%). La mayoría de los abortos espontáneos ocurrieron en el primer trimestre del embarazo, la edad gestacional media al momento de ocurrencia del evento fue 9.3 semanas; los factores de riesgo más frecuentes fueron: consumo de café (62.39%), aborto previo (44.04%).  El consumo de cafeína, el tabaquismo y el aborto espontáneo precoz son factores de riesgo frecuentes en las pacientes estudiadas.Spontaneous abortion is one of the most frequent of its kind. In order to determine some epidemiological aspects of spontaneous abortion and reduce its incidence, the present study was carried out. Through the observational, transversal, descriptive and prospective method; Patients treated at the Hospital Fe del Valle in the first half of 2019 were investigated. The sample consisted of 109 patients with spontaneous abortion, out of a universe of 342 referred for this cause. Among the results, it was identified that the mean age is 27 years. Of 88 pregnant women, with previous delivery, 40.84% were eutocic, of 111 with previous abortions 29.74% were spontaneous. The most frequent clinical manifestation was transvaginal bleeding (79.81%). The majority of spontaneous abortions occurred in the first trimester of pregnancy, the mean gestational age at the time of occurrence of the event was 9.3 weeks; the most frequent risk factors were: coffee consumption (62.39%), previous abortion (44.04%). Caffeine consumption, smoking and early spontaneous abortion are frequent risk factors in the patients studied.O aborto espontâneo é um dos mais frequentes desse tipo e, com o objetivo de determinar alguns aspectos epidemiológicos do aborto espontâneo e reduzir sua incidência, foi realizado o presente estudo. Pelo método observacional, transversal, descritivo e prospectivo; Foram investigados pacientes atendidos no Hospital Fe del Valle no primeiro semestre de 2019. A amostra foi constituída por 109 pacientes com aborto espontâneo, de um universo de 342 encaminhados por essa causa. Dentre os resultados, identificou-se que a média de idade é de 27 anos. Das 88 gestantes, com parto anterior, 40,84% foram eutócicas, das 111 com abortos anteriores 29,74% foram espontâneos. A manifestação clínica mais frequente foi sangramento transvaginal (79,81%). A maioria dos abortos espontâneos ocorreu no primeiro trimestre da gravidez, a idade gestacional média no momento da ocorrência do evento era de 9,3 semanas; os fatores de risco mais frequentes foram: consumo de café (62,39%), aborto anterior (44,04%).  O consumo de cafeína, tabagismo e aborto espontâneo precoce são fatores de risco frequentes nas pacientes estudadas

Association of the toxigenic dinoflagellate Alexandrium ostenfeldii With spirolide accumulation in cultured mussels (Mytilus galloprovincialis) From Northwest Mexico

Spirolides are polyether cyclic imines considered as “fast acting toxins.” Long-term human health consequences of spirolide ingestion are uncertain, and hence regulatory limits for human consumption have not been established. Nevertheless, monitoring these toxins in shellfish is essential because they can interfere with detection by mouse bioassay of lipophilic regulated toxins. Todos Santos Bay (TSB), in the northwest of the Baja California Peninsula, is an important shellfish cultivation and fish-farming area in Mexico. The toxin analog 13-desmethyl spirolide C has been reported in cultivated mussels (Mytilus galloprovincialis) from TSB, but the causative species associated with accumulation of this toxin has not been previously identified. We assessed the occurrence of Alexandrium ostenfeldii, the unique known producer of spirolides, by inverted light microscopy and by PCR with species-specific oligonucleotides designed for the ITS and 18S rDNA. We determined the presence and abundance of this species at the surface and at the thermocline from samples collected over two annual sampling periods (2013–2014 and 2016–2017). During the 2013–2014 period, A. ostenfeldii was found in 50% of the samples analyzed by light microscopy. The highest cell abundance occurred in October 2013. During 2016–2017 the dinoflagellate was present in low cell abundances and was detected in only 20.9% of the samples. Cells of this species were usually found when sea surface temperature ranged from 17 to 20 C. We also evaluated spirolide accumulated in cultivated mussels from TSB by tandem mass spectrometry (LC-MS/MS). The only spirolide detected was 13-desmethyl spirolide C, found mainly during the 2013–2014 sampling period, with the highest concentration in June 2014. During winter, toxin concentration was at or below the detection limit. During 2016–2017,spirolides were below the detection limit, coinciding with the absence of the causative species. Cell abundance of A. ostenfeldii and spirolide concentration in mussels did not present a clear correlation. This study represents the first record of A. ostenfeldii in TSB and provides evidence that this species is the primary origin of spirolides accumulated in mussels

Cancer-associated fibroblasts modify lung cancer metabolism involving ROS and TGF-β signaling

Lung cancer is a major public health problem due to its high incidence and mortality rate. The altered metabolism in lung cancer is key for the diagnosis and has implications on both, the prognosis and the response to treatments. Although Cancer-associated fibroblasts (CAFs) are one of the major components of the tumor microenvironment, little is known about their role in lung cancer metabolism. We studied tumor biopsies from a cohort of 12 stage IIIA lung adenocarcinoma patients and saw a positive correlation between the grade of fibrosis and the glycolysis phenotype (Low PGC-1α and High GAPDH/MT-CO1 ratio mRNA levels). These results were confirmed and extended to other metabolism-related genes through the in silico data analysis from 73 stage IIIA lung adenocarcinoma patients available in TCGA. Interestingly, these relationships are not observed with the CAFs marker α-SMA in both cohorts. To characterize the mechanism, in vitro co-culture studies were carried out using two NSCLC cell lines (A549 and H1299 cells) and two different fibroblast cell lines. Our results confirm that a metabolic reprogramming involving ROS and TGF-β signaling occurs in lung cancer cells and fibroblasts independently of α-SMA induction. Under co-culture conditions, Cancer-Associated fibroblasts increase their glycolytic ability. On the other hand, tumor cells increase their mitochondrial function. Moreover, the differential capability among tumor cells to induce this metabolic shift and also the role of the basal fibroblasts Oxphos Phosphorylation (OXPHOS) function modifying this phenomenon could have implications on both, the diagnosis and prognosis of patients. Further knowledge in the mechanism involved may allow the development of new therapies.Work in the authors’ laboratories is supported by ‘‘Instituto de Salud Carlos III’’ PI13/01806 and PIE14/0064 to M.P. A.C-B, received a Spanish Lung Cancer Group fellowship. R.L-B, is supported by Comunidad Autónoma de Madrid “Garantía juvenil” contract