The impact of foreign aid on aggregate welfare measures : a panel data analysis

Does foreign aid enhance aggregate human welfare? This paper attempts to answer this question by using a panel of twenty-eight countries, covering the period from 1990 to 2014. It explores intra-country variation by splitting the sample into low-income and middle-income countries. Combined with the fixed effects estimator, these approaches sought to control for the heterogeneity of the effects of aid on welfare measures. Perhaps surprisingly, there was no evidence that foreign aid contributes to the reduction of infant mortality or increase of human development index.info:eu-repo/semantics/publishedVersio

Analysis of HFE And Non-HFE Gene Mutations in Brazilian Patients with Hemochromatosis

BACKGROUND: Approximately one-half of Brazilian patients with hereditary hemochromatosis (HH) are neither homozygous for the C282Y mutation nor compound heterozygous for the H63D and C282Y mutations that are associated with HH in Caucasians. Other mutations have been described in the HFE gene as well as in genes involved in iron metabolism, such as transferrin receptor 2 (TfR2) and ferroportin 1 (SCL40A1). AIMS: To evaluate the role of HFE, TfR2 and SCL40A1 mutations in Brazilian subjects with HH. PATIENTS AND METHODS: Nineteen male subjects (median age 42 [range: 20-72] years) with HH were evaluated using the Haemochromatosis StripAssay A®. This assay is capable of detecting twelve HFE mutations, which are V53M, V59M, H63D, H63H, S65C, Q127H, P160delC, E168Q, E168X, W169X, C282Y and Q283, four TfR2 mutations, which are E60X, M172K, Y250X, AVAQ594-597del, and two SCL40A1 mutations, which are N144H and V162del. RESULTS: In our cohort, nine (47%) patients were homozygous for the C282Y mutation, two (11%) were heterozygous for the H63D mutation, and one each (5%) was either heterozygous for C282Y or compound heterozygous for C282Y and H63D. No other mutations in the HFE, TfR2 or SCL40A1 genes were observed in the studied patients. CONCLUSIONS: One-third of Brazilian subjects with the classical phenotype of HH do not carry HFE or other mutations that are currently associated with the disease in Caucasians. This observation suggests a role for other yet unknown mutations in the aforementioned genes or in other genes involved in iron homeostasis in the pathogenesis of HH in Brazil

Os bastidores da produção de fogos de artifício em Santo Antônio do Monte: degradação das condições de trabalho e saúde dos pirotecnistas

A cidade de Santo Antônio do Monte é considerada o 2º maior polo mundial de produção de fogos de artifício, sendo a pirotecnia a principal atividade econômica da região. Entretanto, o trabalho na indústria pirotécnica tem suscitado sérias preocupações das entidades sindicais e dos pesquisadores, bem como dos trabalhadores e suas famílias. Os acidentes de trabalho nesse setor são, geralmente, fatais ou mutilantes, havendo, ainda, registros de doenças relacionadas ao trabalho. Por isso, neste estudo almejou-se analisar as repercussões do processo de produção de fogos de artifício sobre a saúde e segurança desses trabalhadores. Os estudos da Psicopatologia do Trabalho e da tradição francesa de análise ergonômica constituíram as principais referências deste estudo. Para a realização desta pesquisa, utilizou-se uma estratégia metodológica pluridimensional, que reuniu e articulou dados estatísticos, empíricos (fatos clínicos, relatos, observações) e documentais. Os resultados revelam que os trabalhadores estão sujeitos a acidentes decorrentes do exercício de funções para as quais não foram adequadamente treinados, bem como a uma atividade penosa e nociva, geradora de lesões por esforço repetitivo (LERs) e doenças osteomusculares relacionadas ao trabalho. As mulheres que trabalham nesse setor também enfrentam o assédio sexual praticado por prepostos dos empregadores.The town of Santo Antonio do Monte is deemed to be the 2nd largest center of fireworks production in the world, and pyrotechnics is the region's main economic activity. However, the work in the pyrotechnic industry has raised serious concerns from labor unions and researchers, as well as the workers and their families. Labor accidents in this sector are usually fatal or mutilating, and there're also reports of labor-related diseases. Thus, this study aimed to analyze the repercussions of the fireworks production process on these workers' health and safety. Studies on the Psychopathology of Work and those based on the French tradition of ergonomic analysis provided the main references for this study. To carry out this research, we used a pluridimensional methodological strategy, which gathered and connected statistical, empirical (clinical facts, reports, observations), and documental data. The results show that workers are exposed to accidents resulting from the performance of jobs for which they haven't been properly trained, as well as to a painful and harmful activity, which causes repetitive strain injuries (RSIs) and workrelated musculoskeletal diseases. Women who work in this sector also face sexual harassment practiced by their employer's representatives

Patient-physician discordance in assessment of adherence to inhaled controller medication: a cross-sectional analysis of two cohorts

We aimed to compare patient's and physician's ratings of inhaled medication adherence and to identify predictors of patient-physician discordance.(SFRH/BPD/115169/2016) funded by Fundação para a Ciência e Tecnologia (FCT); ERDF (European Regional Development Fund) through the operations: POCI-01-0145-FEDER-029130 ('mINSPIRERS—mHealth to measure and improve adherence to medication in chronic obstructive respiratory diseases—generalisation and evaluation of gamification, peer support and advanced image processing technologies') cofunded by the COMPETE2020 (Programa Operacional Competitividade e Internacionalização), Portugal 2020 and by Portuguese Funds through FCT (Fundação para a Ciência e a Tecnologia).info:eu-repo/semantics/publishedVersio

O PORTAL DO CADERNO DE CIDADANIA COMO FERRAMENTA DE INCLUSÃO DIGITAL

Este artigo trata do desenvolvimento de um portal digital para divulgar as ações executadas pelo projeto de extensão da UNIVALI/Cejurps - Programa de Formação e Assessoria em Cidadania Infanto-juvenil - que possui o objetivo de ser uma ferramenta de inclusão digital para crianças e adolescentes. No portal existe um espaço para divulgar novidades, eventos, publicação de artigos, novas parcerias e um fórum para manter contato com os administradores e esclarecer dúvidas na interação com as crianças e os adolescentes. No trabalho de extensão foi utilizado para elaboração do portal e do jogo digital o método indutivo, já que cada etapa foi elaborada e trabalhada detalhadamente para obter-se o resultado final, qual seja, o sítio na internet, com a criação de um jogo digital. O método de procedimento foi o empírico, já que se obteve o auxílio de crianças e adolescentes para a elaboração de cada etapa, fortalecendo o papel da criança como ator social, na busca de um resultado mais efetivo e condizendo com a realidade das crianças

Identification of clusters of asthma control: A preliminary analysis of the inspirers studies

This work was funded by ERDF (European Regional Development Fund) through the operations: POCI- -01-0145-FEDER-029130 (“mINSPIRERS—mHealth to measure and improve adherence to medication in chronic obstructive respiratory diseases - generalisation and evaluation of gamification, peer support and advanced image processing technologies”) co-funded by the COMPETE2020 (Programa Operacional Competitividade e Internacionalização), Portugal 2020 and by Portuguese Funds through FCT (Fundação para a Ciência e a Tecnologia).© 2020, Sociedade Portuguesa de Alergologia e Imunologia Clinica. All rights reserved. Aims: To identify distinct asthma control clusters based on Control of Allergic Rhinitis and Asthma Test (CARAT) and to compare patients’ characteristics among these clusters. Methods: Adults and adolescents (≥13 years) with persistent asthma were recruited at 29 Portuguese hospital outpatient clinics, in the context of two observational studies of the INSPIRERS project. Demographic and clinical characteristics, adherence to inhaled medication, beliefs about inhaled medication, anxiety and depression, quality of life, and asthma control (CARAT, >24 good control) were collected. Hierarchical cluster analysis was performed using CARAT total score (CARAT-T). Results: 410 patients (68% adults), with a median (percentile 25–percentile 75) age of 28 (16-46) years, were analysed. Three clusters were identified [mean CARAT-T (min-max)]: cluster 1 [27(24-30)], cluster 2 [19(14-23)] and cluster 3 [10(2-13)]. Patients in cluster 1 (34%) were characterised by better asthma control, better quality of life, higher inhaler adherence and use of a single inhaler. Patients in clusters 2 (50%) and 3 (16%) had uncontrolled asthma, lower inhaler adherence, more symptoms of anxiety and depression and more than half had at least one exacerbation in the previous year. Further-more, patients in cluster 3 were predominantly female, had more unscheduled medical visits and more anxiety symp-toms, perceived a higher necessity of their prescribed inhalers but also higher levels of concern about taking these inhalers. There were no differences in age, body mass index, lung function, smoking status, hospital admissions or specialist physician follow-up time among the three clusters. Conclusion: An unsupervised method based on CARAT--T, identified 3 clusters of patients with distinct, clinically meaningful characteristics. The cluster with better asthma control had a cut-off similar to the established in the validation study of CARAT and an additional cut-off seems to distinguish more severe disease. Further research is necessary to validate the asthma control clusters identified.publishersversionpublishe

Duffy blood group gene polymorphisms among malaria vivax patients in four areas of the Brazilian Amazon region

<p>Abstract</p> <p>Background</p> <p>Duffy blood group polymorphisms are important in areas where <it>Plasmodium vivax </it>predominates, because this molecule acts as a receptor for this protozoan. In the present study, Duffy blood group genotyping in <it>P. vivax </it>malaria patients from four different Brazilian endemic areas is reported, exploring significant associations between blood group variants and susceptibility or resistance to malaria.</p> <p>Methods</p> <p>The <it>P. vivax </it>identification was determined by non-genotypic and genotypic screening tests. The Duffy blood group was genotyped by PCR/RFLP in 330 blood donors and 312 malaria patients from four Brazilian Amazon areas. In order to assess the variables significance and to obtain independence among the proportions, the Fisher's exact test was used.</p> <p>Results</p> <p>The data show a high frequency of the <it>FYA/FYB </it>genotype, followed by <it>FYB/FYB, FYA/FYA</it>, <it>FYA/FYB-33 </it>and <it>FYB/FYB-33</it>. Low frequencies were detected for the <it>FYA/FY</it>^<it>X</it>, <it>FYB/FY</it>^<it>X</it>, <it>FYX/FY</it>^{<it>X </it>}and <it>FYB-33/FYB-33 </it>genotypes. Negative Duffy genotype (<it>FYB-33/FYB-33</it>) was found in both groups: individuals infected and non-infected (blood donors). No individual carried the <it>FY</it>^<it>X</it><it>/FYB-33 </it>genotype. Some of the Duffy genotypes frequencies showed significant differences between donors and malaria patients.</p> <p>Conclusion</p> <p>The obtained data suggest that individuals with the <it>FYA/FYB </it>genotype have higher susceptibility to malaria. The presence of the <it>FYB-33 </it>allele may be a selective advantage in the population, reducing the rate of infection by <it>P. vivax </it>in this region. Additional efforts may contribute to better elucidate the physiopathologic differences in this parasite/host relationship in regions endemic for <it>P. vivax </it>malaria, in particular the Brazilian Amazon region.</p

Compreensão das características fisiopatológicas da hipertensão arterial sistêmica em relação a senescência: uma revisão de literatura

Introdução: A Hipertensão Arterial Sistêmica (HAS) é uma doença prevalente nos diversos âmbitos sociais e devido ao processo de envelhecimento natural do organismo, os idosos são mais propensos a adquirir essa doença. Objetivo: compreender as principais características relatadas na Hipertensão Arterial Sistêmica em associação ao processo fisiológico de envelhecimento, evidenciando, portanto, a importância do controle de fatores de risco evitáveis. Metodologia: Trata-se de uma revisão integrativa da literatura, por proporcionar uma síntese dos resultados obtidos através de pesquisas publicadas. Para direcionar a pesquisa, adotou-se como pergunta norteadora: “Quais as principais características associadas entre a Hipertensão Arterial Sistêmica e a senescência?" Para construção da pesquisa, a coleta e análise de dados foi realizada através do Portal da Biblioteca Virtual da Saúde e das bases de dados Medical Literature Analysis and Retrievel System Online via PubMed e Google Acadêmico através dos seguintes Descritores em Ciências da Saúde (DeCS): “Hipertensão Arterial Sistêmica”, “Senescência” e “Sintomas locais” combinados entre si pelo operador booleano AND com seus respectivos correspondentes no Mesh Terms. Discussão: Segundo dados das Pesquisa Nacional de Saúde (PNS) de 2013, aproximadamente 22% da população considerava-se portador de HA, sendo que indivíduos em uso de medicamentos anti-hipertensivos e com pressão arterial ≥ 140 por 90 mmHg superou a média de 33%. Por certo, pacientes mais idosos contam com uma maior rigidez arterial, atuando como a principal condição predisponente para elevação da pressão arterial. Conclusão: Com o aumento da expectativa de vida, há a prevalência e incidência maior de doenças progressivas, como a hipertensão arterial. Com isso, é essencial conduzir o devido conhecimento sobre os fatores de risco da HAS para a população, em especial os idosos, a fim de destacar a importância da prevenção e estimular o tratamento da pessoa idosa com Hipertensão Arterial Sistêmica

MAMMALS IN PORTUGAL : A data set of terrestrial, volant, and marine mammal occurrences in P ortugal

Mammals are threatened worldwide, with 26% of all species being includedin the IUCN threatened categories. This overall pattern is primarily associatedwith habitat loss or degradation, and human persecution for terrestrial mam-mals, and pollution, open net fishing, climate change, and prey depletion formarine mammals. Mammals play a key role in maintaining ecosystems func-tionality and resilience, and therefore information on their distribution is cru-cial to delineate and support conservation actions. MAMMALS INPORTUGAL is a publicly available data set compiling unpublishedgeoreferenced occurrence records of 92 terrestrial, volant, and marine mam-mals in mainland Portugal and archipelagos of the Azores and Madeira thatincludes 105,026 data entries between 1873 and 2021 (72% of the data occur-ring in 2000 and 2021). The methods used to collect the data were: live obser-vations/captures (43%), sign surveys (35%), camera trapping (16%),bioacoustics surveys (4%) and radiotracking, and inquiries that represent lessthan 1% of the records. The data set includes 13 types of records: (1) burrowsjsoil moundsjtunnel, (2) capture, (3) colony, (4) dead animaljhairjskullsjjaws, (5) genetic confirmation, (6) inquiries, (7) observation of live animal (8),observation in shelters, (9) photo trappingjvideo, (10) predators dietjpelletsjpine cones/nuts, (11) scatjtrackjditch, (12) telemetry and (13) vocalizationjecholocation. The spatial uncertainty of most records ranges between 0 and100 m (76%). Rodentia (n=31,573) has the highest number of records followedby Chiroptera (n=18,857), Carnivora (n=18,594), Lagomorpha (n=17,496),Cetartiodactyla (n=11,568) and Eulipotyphla (n=7008). The data setincludes records of species classified by the IUCN as threatened(e.g.,Oryctolagus cuniculus[n=12,159],Monachus monachus[n=1,512],andLynx pardinus[n=197]). We believe that this data set may stimulate thepublication of other European countries data sets that would certainly contrib-ute to ecology and conservation-related research, and therefore assisting onthe development of more accurate and tailored conservation managementstrategies for each species. There are no copyright restrictions; please cite thisdata paper when the data are used in publications.info:eu-repo/semantics/publishedVersio

SARS-CoV-2 introductions and early dynamics of the epidemic in Portugal

Genomic surveillance of SARS-CoV-2 in Portugal was rapidly implemented by the National Institute of Health in the early stages of the COVID-19 epidemic, in collaboration with more than 50 laboratories distributed nationwide. Methods By applying recent phylodynamic models that allow integration of individual-based travel history, we reconstructed and characterized the spatio-temporal dynamics of SARSCoV-2 introductions and early dissemination in Portugal. Results We detected at least 277 independent SARS-CoV-2 introductions, mostly from European countries (namely the United Kingdom, Spain, France, Italy, and Switzerland), which were consistent with the countries with the highest connectivity with Portugal. Although most introductions were estimated to have occurred during early March 2020, it is likely that SARS-CoV-2 was silently circulating in Portugal throughout February, before the first cases were confirmed. Conclusions Here we conclude that the earlier implementation of measures could have minimized the number of introductions and subsequent virus expansion in Portugal. This study lays the foundation for genomic epidemiology of SARS-CoV-2 in Portugal, and highlights the need for systematic and geographically-representative genomic surveillance.We gratefully acknowledge to Sara Hill and Nuno Faria (University of Oxford) and Joshua Quick and Nick Loman (University of Birmingham) for kindly providing us with the initial sets of Artic Network primers for NGS; Rafael Mamede (MRamirez team, IMM, Lisbon) for developing and sharing a bioinformatics script for sequence curation (https://github.com/rfm-targa/BioinfUtils); Philippe Lemey (KU Leuven) for providing guidance on the implementation of the phylodynamic models; Joshua L. Cherry (National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health) for providing guidance with the subsampling strategies; and all authors, originating and submitting laboratories who have contributed genome data on GISAID (https://www.gisaid.org/) on which part of this research is based. The opinions expressed in this article are those of the authors and do not reflect the view of the National Institutes of Health, the Department of Health and Human Services, or the United States government. This study is co-funded by Fundação para a Ciência e Tecnologia and Agência de Investigação Clínica e Inovação Biomédica (234_596874175) on behalf of the Research 4 COVID-19 call. Some infrastructural resources used in this study come from the GenomePT project (POCI-01-0145-FEDER-022184), supported by COMPETE 2020 - Operational Programme for Competitiveness and Internationalisation (POCI), Lisboa Portugal Regional Operational Programme (Lisboa2020), Algarve Portugal Regional Operational Programme (CRESC Algarve2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF), and by Fundação para a Ciência e a Tecnologia (FCT).info:eu-repo/semantics/publishedVersio