Medication safety research by observational study design

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Databases in the Asia-Pacific Region: The Potential for a Distributed Network Approach

Background: This study describes the availability and characteristics of databases in Asian-Pacific countries and assesses the feasibility of a distributed network approach in the region. Methods: A web-based survey was conducted among investigators using healthcare databases in the Asia-Pacific countries. Potential survey participants were identified through the Asian Pharmacoepidemiology Network. Results: Investigators from a total of 11 databases participated in the survey. Database sources included four nationwide claims databases from Japan, South Korea, and Taiwan; two nationwide electronic health records from Hong Kong and Singapore; a regional electronic health record from western China; two electronic health records from Thailand; and cancer and stroke registries from Taiwan. Conclusions: We identified 11 databases with capabilities for distributed network approaches. Many country-specific coding systems and terminologies have been already converted to international coding systems. The harmonization of health expenditure data is a major obstacle for future investigations attempting to evaluate issues related to medical costs.postprin

The association between oral fluoroquinolones and incident seizure event

Poster Session C - Spotlight Session - Asian Pharmacoepidemiology Network (AsPEN) SIG: no. 820This journal suppl. entitled: Special Issue: Abstracts of the 30th International Conference on Pharmacoepidemiology and Therapeutic Risk Management ... 2014BACKGROUND: Fluoroquinolones are a class of antibiotics prescribed for various infections. Several case reports have indicated the potential association between the use of oral fluoroquinolones and the development of incident seizure event. OBJECTIVES: The objectives of this study were to: 1) investigate the association between the use of oral fluoroquinolones and the development of incident seizure event; 2) to estimate the crude absolute risk of developing incident seizure event whilst prescribed with oral fluoroquinolones. METHODS: A self-controlled case series study design was used to investigate the association. Patients were retrieved from an electronic patient record database called the Clinical Data Analysis and Reporting System in Hong Kong from the year of 2001 to 2013. Patients who had an incident seizure event and were prescribed with oral fluoroquinolones in the out-patients setting during the study period were included. Those with a history of post-traumatic or febrile convulsion were excluded. The rate of having incident seizure event during the exposure period was compared with the non-exposed period. Conditional Poisson regression was used to estimate the incidence rate ratio at a 5% significance level. A sensitivity analysis was conducted by excluding patients who died within 30 days after the incident seizure event. RESULTS: A total of 291,751 prescriptions of oral fluoroquinolones were identified among 166,325 patients. A total of 2,206 patients met the case definition and were included in the analysis. An incidence rate ratio of 0.89 (0.52, 1.53) was estimated. Fourteen cases of incident seizure event occurred during the exposure period. The crude absolute risk of having incident seizure event whilst prescribed with oral fluoroquinolones was approximately 4.8x10^-5 (2.9x10^-5, 8.1x10^-5). No statistically significant association was observed between the use of oral fluoroquinolones and the development of incident seizure event in the sensitivity analysis. CONCLUSIONS: This study does not support the association between the use of oral fluoroquinolones and the development of incident seizure event

The association between oral fluoroquinolone use and the development of retinal detachment: a systematic review and meta-analysis of observational studies

Conference Theme: New Ideas in Ancient Cultures: Advancing Pharmacovigilance in Asiapp. 831-891 of this journal issue entitled: International Society of Pharmacovigilance AbstractsPoster Presentatio

The association between proton pump inhibitors and myocardial infarction: a self-controlled case series study.

Poster presentatio

Association between oral fluoroquinolones and seizures: a self-controlled case series study

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