1,885 research outputs found
Obsessions in OCD Mimicking Capgras: A Case Report
Obsessive Compulsive Disorder (OCD) is a mentally debilitating condition that can present in a multitude of ways and its manifestations can vary within the diagnosed patient population. OCD can be diagnosed with the presence of either obsessions or compulsions and does not require both. Sometimes, OCD can affect a patient in a way that mimics delusional misidentification syndromes. In these cases, a patient\u27s ego-dystonia can be a key distinguishing feature in diagnosis. In one specific delusional misidentification syndrome, Capgras, a patient possesses fixed beliefs that a known person (or sometimes object) is an imposter. And even though the textbook OCD presentation differs from that of Capgras Delusion, there can be overlapping similarities. As such, a patient\u27s insight and ego-dystonia into these preoccupations may help to point the diagnosis towards an obsessional form of OCD, a critical recognition for proper treatment. This case will highlight the importance of recognizing the distinction between obsessions and delusions to appropriatelv treat a patient with OCD with primarily obsessions
Similarity measures for mid-surface quality evaluation
Mid-surface models are widely used in engineering analysis to simplify the analysis of thin-walled parts, but it can be difficult to ensure that the mid-surface model is representative of the solid part from which it was generated. This paper proposes two similarity measures that can be used to evaluate the quality of a mid-surface model by comparing it to a solid model of the same part. Two similarity measures are proposed; firstly a geometric similarity evaluation technique based on the Hausdorff distance and secondly a topological similarity evaluation method which uses geometry graph attributes as the basis for comparison. Both measures are able to provide local and global similarity evaluation for the models. The proposed methods have been implemented in a software demonstrator and tested on a selection of representative models. They have been found to be effective for identifying geometric and topological errors in mid-surface models and are applicable to a wide range of practical thin-walled designs
A follow-up study at the West End Creche Child and Family Clinic.
Paper copy at Leddy Library: Theses & Major Papers - Basement, West Bldg. / Call Number: Thesis1981 .W654. Source: Masters Abstracts International, Volume: 40-07, page: . Thesis (M.S.W.)--University of Windsor (Canada), 1981
The Application of Image Recognition and Machine Learning to Capture Readings of Traditional Blood Pressure Devices: A Platform to Promote Population Health Management to Prevent Cardiovascular Diseases
Digital solutions for Blood Pressure Monitoring (or Telemonitoring) have sprouted in recent years, innovative solutions are often connected to the Internet of Things (IoT), with mobile health (mHealth) platform. However, clinical validity, technology cost and cross-platform data integration remain as the major barriers for the application of these solutions. In this paper, we present an IoT-based and AI-embedded Blood Pressure Telemonitoring (BPT) system, which facilitates home blood pressure monitoring for individuals. The highlights of this system are the machine learning techniques to enable automatic digits recognition, with F1 score of 98.5%; and the cloud-based portal developed for automated data synchronization and risk stratification. Positive feedbacks on trial implementation are received from three clinics. The overall system architecture, development of machine learning model in digit identification and cloud-based telemonitoring are addressed in this paper, alongside the followed implications
An overview of the rare parotid gland cancer
Cancer of the parotid gland is relatively rare, but carries poor prognosis owing to its prevailing distant metastases. In addition to the disease's basic epidemiology and pathology, we review some current discoveries of its tumorigenesis molecular mechanism. Based on published salivary gland cancer clinical trial data, non-surgical antitumor efficacies amongst a range of chemotherapy, radiation, and concurrent therapy regimens are compared. We also present the current development status of novel radiation therapy and targeted therapeutics, focusing on intensity-modulated radiation therapy (IMRT), and epidermal growth factor receptor (EGFR) and vascular endothelial growth factor (VEGF) blockages, which are showing promise for improving parotid gland cancer management
Within- and between-person variability of exhaled breath condensate pH and NH4+ in never and current smokers
SummaryRecent studies have suggested that the collection of exhaled breath condensate (EBC) may be a viable method in occupational field studies to sample secretions of the lower airway because it is simple to perform and non-invasive. However, there are unresolved questions about whether certain laboratory conditions may influence the analysis of EBC biomarker measurements. A total of 12 subjects performed 116 EBC tests. The effect of short and long-term sample storage and sample volume on two biomarkers of acid stress, pH and NH4+, in EBC were investigated and did not significantly influence either marker measurement after argon deaeration. We also investigated the variability and the effect of smoking on the biomarkers by collecting six samples each from five adult never smokers and five adult current smokers over a period of 1 month (n=60 total). For pH, the within-person and between-person variability was larger in current smokers compared to never smokers. Similar results were found for NH4+. Cigarette packs smoked per day now was also associated with both pH (p=0.01) and NH4+ (p=0.04) using mixed effects regression analysis. The variability and smoking results suggest that repeated measurements of EBC pH and NH4+ from the same individual may accurately predict the biological state of the airways of current smokers when compared to never smokers
Monitoring the Effects of Anti-angiogenesis on the Radiation Sensitivity of Pancreatic Cancer Xenografts Using Dynamic Contrast-Enhanced CT
Purpose
To image the intra-tumor vascular physiological status of pancreatic
tumors xenografts and their response to anti-angiogenic therapy using
Dynamic Contrast-Enhanced CT (DCE-CT), and to identify parameters of
vascular physiology associated with tumor X-ray sensitivity following
anti-angiogenic therapy.
Methods and Materials
Nude mice bearing human BxPC-3 pancreatic tumor xenografts were
treated with 5Gy of radiation therapy (RT), either a low-dose (40mg/kg) or a
high-dose (150mg/kg) of DC101, the anti-VEGF receptor-2 anti-angiogenesis
antibody, or with combination of low or high dose DC101 and 5Gy RT
(DC101-plus-RT). DCE-CT scans were longitudinally
acquired over three week period post-DC101 treatment. Parametric maps of
tumor perfusion and fractional plasma volume (Fp) were calculated
and their averaged values and histogram distributions evaluated and compared
to controls, from which a more homogeneous physiological window was observed
1-week post-DC101. Mice receiving a combination of
DC101-plus-RT(5Gy) were imaged baseline prior to
receiving DC101 and 1-week after DC101 (prior to RT). Changes in perfusion
and Fp were compared with alternation in tumor growth delay for
RT and DC101-plus-RT(5Gy) treated tumors.
Results
Pretreatment with low or high doses of DC101 prior to RT
significantly delayed tumor growth by an average 7.9 days compared to RT
alone (p≤0.01). The increase in tumor growth delay for the
DC101-plus-RT treated tumors was strongly associated
with changes in tumor perfusion (ΔP>−15%)
compared to RT treated tumors alone (p=0.01). In addition, further
analysis revealed a trend linking the tumor’s increased growth delay
to its tumor volume-to-DC101 dose ratio.
Conclusions
DCE-CT is capable of monitoring changes in intra-tumor physiological
parameter of tumor perfusion in response to anti-angiogenic therapy of a
pancreatic human tumor xenograft that was associated with enhanced radiation
response
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