4,248 research outputs found
Second harmonic generation from strongly coupled localized and propagating phonon-polariton modes
We experimentally investigate second harmonic generation from strongly
coupled localized and propagative phonon polariton modes in arrays of silicon
carbide nanopillars. Our results clearly demonstrate the hybrid nature of the
system's eigenmodes and distinct manifestation of strong coupling in the linear
and nonlinear response. While in linear reflectivity the intensity of the two
strongly-coupled branches is essentially symmetric and well explained by their
respective localized or propagative components, the second harmonic signal
presents a strong asymmetry. Analyzing it in detail, we reveal the importance
of interference effects between the nonlinear polarization terms originating in
the bulk and in the phonon polariton modes, respectively.Comment: 7 pages, 4 figure
Strong Coupling of Epsilon-Near-Zero Phonon Polaritons in Polar Dielectric Heterostructures
We report the first observation of epsilon near zero (ENZ) phonon polaritons
in an ultrathin AlN film fully hybridized with surface phonon polaritons (SPhP)
supported by the adjacent SiC substrate. Employing a strong coupling model for
the analysis of the dispersion and electric field distribution in these
hybridized modes, we show that they share the most prominent features of the
two precursor modes. The novel ENZ-SPhP coupled polaritons with a highly
propagative character and deeply sub-wavelength light confinement can be
utilized as building blocks for future infrared and terahertz (THz)
nanophotonic integration and communication devices
Medida da proteÃna S-100B sérica para classificação de risco no trauma craniano leve: estudo piloto no Brasil
BACKGROUND: Release of the neuronal protein S-100B into the circulation has been suggested as a specific indication of neuronal damage. The hypothesis that S-100B is a useful and cost-effective screening tool for the management of minor head injuries was tested. METHODS: Fifty consecutive patients sustaining isolated minor head injury were prospectively evaluated in the emergency room of a Brazilian hospital by routine cranial computed tomography scan. Venous blood samples (processed to serum) were assssayed for S-100B using a newly developed immunoassay test kit. Twenty-one normal healthy individuals served as negative controls. Data are presented as median and 25 to 75 percentiles. RESULTS: Patients reached the emergency room an average of 45 minutes (range: 30-62 minutes) after minor head injury. Six of 50 patients (12%) showed relevant posttraumatic lesions in the initial cranial computed tomography scan and were counted as positive. The median systemic concentration of S-100B in those patients was 0.75 µg/L (range: 0.66-6.5 µg/L), which was significantly different (U-test, P < .05) from the median concentration of 0.26 µg/L (range: 0.12-0.65 µg/L), of patients without posttraumatic lesions as counted by the cranial computed tomography. A sensitivity of 100%, a specificity of 20%, a positive predictive value of 15%, and a negative predictive value of 100% was calculated for the detection of patients suffering from intracranial lesions. CONCLUSIONS: Protein S-100B had a very high sensitivity and negative predictive value and could have an important role in ruling out the need for cranial computed tomography scan after minor head injury. This appears to be of substantial clinical relevance, particularly in countries where trauma incidence is high and medical resources are limited, such as in Brazil.INTRODUÇÃO: A liberação da proteÃna neuronal S-100B na circulação tem sido sugerida como indicadora de dano neuronal. Foi testada a hipótese de que a S-100B é um marcador útil e custo efetivo para a triagem de pacientes com trauma craniano leve. MÉTODO: Cinqüenta pacientes consecutivos com trauma craniano isolado foram prospectivamente avaliados na sala de emergência de um Centro de Trauma brasileiro pela tomografia computadorizada de crânio e por amostras de sangue venoso, para a medida no soro da proteÃna S-100B utilizando um teste recentemente desenvolvido; 21 pessoas normais foram utilizadas como controles negativos. Os resultados são apresentados como mediana e percentis 25-75. RESULTADOS: Os pacientes chegaram ao Centro de Trauma em média 45 min (30-62) após o trauma craniano leve. Seis dos 50 pacientes tiveram lesões pós-traumáticas relevantes segundo a tomografia computadorizada de crânio inicial (12%) e foram considerados como positivos. A concentração mediana de S-100B nestes pacientes foi de 0,75µg/L (0,66-6,5), significativamente maior (U-teste,
Treatment recommendations for psoriatic arthritis
Objective: To develop comprehensive recommendations for the treatment of the various clinical manifestations of psoriatic arthritis (PsA) based on evidence obtained from a systematic review of the literature and from consensus opinion. Methods: Formal literature reviews of treatment for the most significant discrete clinical manifestations of PsA (skin and nails, peripheral arthritis, axial disease, dactylitis and enthesitis) were performed and published by members of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA). Treatment recommendations were drafted for each of the clinical manifestations by rheumatologists, dermatologists and PsA patients based on the literature reviews and consensus opinion. The level of agreement for the individual treatment recommendations among GRAPPA members was assessed with an online questionnaire. Results: Treatment recommendations were developed for peripheral arthritis, axial disease, psoriasis, nail disease, dactylitis and enthesitis in the setting of PsA. In rotal, 19 recommendations were drafted, and over 80% agreement was obtained on 16 of them. In addition, a grid that factors disease severity into each of the different disease manifestations was developed to help the clinician with treatment decisions for the individual patient from an evidenced-based perspective. Conclusions: Treatment recommendations for the cardinal physical manifestations of PsA were developed based on a literature review and consensus between rheumatologists and dermatologists. In addition, a grid was established to assist in therapeutic reasoning and decision making for individual patients. It is anticipated that periodic updates will take place using this framework as new data become available
Sperm selection in natural conception:what can we learn from Mother Nature to improve assisted reproduction outcomes?
BACKGROUND: In natural conception only a few sperm cells reach the ampulla or the site of fertilization. This population is a selected group of cells since only motile cells can pass through cervical mucus and gain initial entry into the female reproductive tract. In animals, some studies indicate that the sperm selected by the reproductive tract and recovered from the uterus and the oviducts have higher fertilization rates but this is not a universal finding. Some species show less discrimination in sperm selection and abnormal sperm do arrive at the oviduct. In contrast, assisted reproductive technologies (ART) utilize a more random sperm population. In this review we contrast the journey of the spermatozoon in vivo and in vitro and discuss this in the context of developing new sperm preparation and selection techniques for ART. METHODS: A review of the literature examining characteristics of the spermatozoa selected in vivo is compared with recent developments in in vitro selection and preparation methods. Contrasts and similarities are presented. RESULTS AND CONCLUSIONS: New technologies are being developed to aid in the diagnosis, preparation and selection of spermatozoa in ART. To date progress has been frustrating and these methods have provided variable benefits in improving outcomes after ART. It is more likely that examining the mechanisms enforced by nature will provide valuable information in regard to sperm selection and preparation techniques in vitro. Identifying the properties of those spermatozoa which do reach the oviduct will also be important for the development of more effective tests of semen quality. In this review we examine the value of sperm selection to see how much guidance for ART can be gleaned from the natural selection processes in vivo
History of Galaxy Interactions and their Impact on Star Formation over the Last 7 Gyr from GEMS
We perform a comprehensive estimate of the frequency of galaxy mergers and
their impact on star formation over z~0.24--0.80 (lookback time T_b~3--7 Gyr)
using 3698 (M*>=1e9 Msun) galaxies with GEMS HST, COMBO-17, and Spitzer data.
Our results are: (1) Among 790 high mass (M*>=2.5e10 Msun) galaxies, the
visually-based merger fraction over z~0.24--0.80, ranges from 9%+-5% to 8%+-2%.
Lower limits on the major and minor merger fractions over this interval range
from 1.1% to 3.5%, and 3.6% to 7.5%, respectively. This is the first
approximate empirical estimate of the frequency of minor mergers at z<1. For a
visibility timescale of ~0.5 Gyr, it follows that over T_b~3--7 Gyr, ~68% of
high mass systems have undergone a merger of mass ratio >1/10, with ~16%, 45%,
and 7% of these corresponding respectively to major, minor, and ambiguous
`major or minor' mergers. The mean merger rate is a few x 1e-4 Gyr-1 Mpc-3. (2)
We compare the empirical merger fraction and rate for high mass galaxies to a
suite of Lambda CDM-based models: halo occupation distribution models,
semi-analytic models, and hydrodynamic SPH simulations. We find qualitative
agreement between observations and models such that the (major+minor) merger
fraction or rate from different models bracket the observations, and show a
factor of five dispersion. Near-future improvements can now start to rule out
certain merger scenarios. (3) Among ~3698 M*>=1e9 Msun galaxies, we find that
the mean SFR of visibly merging systems is only modestly enhanced compared to
non-interacting galaxies over z~0.24--0.80. Visibly merging systems only
account for less than 30% of the cosmic SFR density over T_b~3--7 Gyr. This
suggests that the behavior of the cosmic SFR density over the last 7 Gyr is
predominantly shaped by non-interacting galaxies.Comment: Accepted for Publication in the Astrophysical Journal. 17 pages of
text, 21 figures, 3 tables. Uses emulateapj5.st
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