7 research outputs found

    Controlling the prison population: Procedures for anticipating the effects of alternative strategies

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    This paper has two aims: first, to familiarize the reader with statistics of imprisonment in the UK and Europe, the relationship between receptions into prison, prison population, implied prison population and effective sentence length; and second, to evaluate and analyse alternative stratagies for producing changes in the prison poulation

    A Formal Synthesis of (−)-Perhydrohistrionicotoxin Using a Cross Metathesis–Hydrogenation Approach

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    The development of an efficient, high yielding six-step convergent synthesis of the semisynthetic alkaloid (−)-perhydrohistrionicotoxin is described. The key transformations include the cross metathesis of a Brønsted-acid masked primary homoallylic amine with a vinyl cyclohexenone and a regioselective palladium catalyzed hydrogenation. This sequence generated the advanced Winterfeldt spirocyclic precursor in 47% overall yield, with a longest linear sequence of five steps

    Results of quality control, statistical, fold-change and overlap filtering.

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    a<p>Data were filtered to have signal above background in ≥13/15 samples</p>b<p>B&H FDR - Benjamini and Hochberg False Discovery Rate multiple testing correction</p>c<p>This statistical and fold-change cut-off was chosen so data could be compared to Vawter et al <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0002412#pone.0002412-Vawter2" target="_blank">[29]</a></p
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