Triazine herbicide prometryn alters epoxide hydrolase activity and increases cytochrome P450 metabolites in murine livers via lipidomic profiling

Oxylipins are a group of bioactive fatty acid metabolites generated via enzymatic oxygenation. They are notably involved in inflammation, pain, vascular tone, hemostasis, thrombosis, immunity, and coagulation. Oxylipins have become the focus of therapeutic intervention since they are implicated in many conditions, such as nonalcoholic fatty liver disease, cardiovascular disease, and aging. The liver plays a crucial role in lipid metabolism and distribution throughout the organism. Long-term exposure to pesticides is suspected to contribute to hepatic carcinogenesis via notable disruption of lipid metabolism. Prometryn is a methylthio-s-triazine herbicide used to control the growth of annual broadleaf and grass weeds in many cultivated plants. The amounts of prometryn documented in the environment, mainly waters, soil and plants used for human and domestic consumption are significantly high. Previous research revealed that prometryn decreased liver development during zebrafish embryogenesis. To understand the mechanisms by which prometryn could induce hepatotoxicity, the effect of prometryn (185 mg/kg every 48 h for seven days) was investigated on hepatic and plasma oxylipin levels in mice. Using an unbiased LC-MS/MS-based lipidomics approach, prometryn was found to alter oxylipins metabolites that are mainly derived from cytochrome P450 (CYP) and lipoxygenase (LOX) in both mice liver and plasma. Lipidomic analysis revealed that the hepatotoxic effects of prometryn are associated with increased epoxide hydrolase (EH) products, increased sEH and mEH enzymatic activities, and induction of oxidative stress. Furthermore, 9-HODE and 13-HODE levels were significantly increased in prometryn treated mice liver, suggesting increased levels of oxidation products. Together, these results support that sEH may be an important component of pesticide-induced liver toxicity

Two-dimensional flow of foam around an obstacle: force measurements

A Stokes experiment for foams is proposed. It consists in a two-dimensional flow of a foam, confined between a water subphase and a top plate, around a fixed circular obstacle. We present systematic measurements of the drag exerted by the flowing foam on the obstacle, \emph{versus} various separately controlled parameters: flow rate, bubble volume, bulk viscosity, obstacle size, shape and boundary conditions. We separate the drag into two contributions, an elastic one (yield drag) at vanishing flow rate, and a fluid one (viscous coefficient) increasing with flow rate. We quantify the influence of each control parameter on the drag. The results exhibit in particular a power-law dependence of the drag as a function of the bulk viscosity and the flow rate with two different exponents. Moreover, we show that the drag decreases with bubble size, and increases proportionally to the obstacle size. We quantify the effect of shape through a dimensioned drag coefficient, and we show that the effect of boundary conditions is small.Comment: 26 pages, 13 figures, resubmitted version to Phys. Rev.

Quantum oscillations and decoherence due to electron-electron interaction in metallic networks and hollow cylinders

We have studied the quantum oscillations of the conductance for arrays of connected mesoscopic metallic rings, in the presence of an external magnetic field. Several geometries have been considered: a linear array of rings connected with short or long wires compared to the phase coherence length, square networks and hollow cylinders. Compared to the well-known case of the isolated ring, we show that for connected rings, the winding of the Brownian trajectories around the rings is modified, leading to a different harmonics content of the quantum oscillations. We relate this harmonics content to the distribution of winding numbers. We consider the limits where coherence length $L_\varphi$ is small or large compared to the perimeter $L$ of each ring constituting the network. In the latter case, the coherent diffusive trajectories explore a region larger than $L$, whence a network dependent harmonics content. Our analysis is based on the calculation of the spectral determinant of the diffusion equation for which we have a simple expression on any network. It is also based on the hypothesis that the time dependence of the dephasing between diffusive trajectories can be described by an exponential decay with a single characteristic time $\tau_\varphi$ (model A) . At low temperature, decoherence is limited by electron-electron interaction, and can be modelled in a one-electron picture by the fluctuating electric field created by other electrons (model B). It is described by a functional of the trajectories and thus the dependence on geometry is crucial. Expressions for the magnetoconductance oscillations are derived within this model and compared to the results of model A. It is shown that they involve several temperature-dependent length scales.Comment: 35 pages, revtex4, 25 figures (34 pdf files

Extension of Bogoliubov theory to quasi-condensates

We present an extension of the well-known Bogoliubov theory to treat low dimensional degenerate Bose gases in the limit of weak interactions and low density fluctuations. We use a density-phase representation and show that a precise definition of the phase operator requires a space discretisation in cells of size $l$. We perform a systematic expansion of the Hamiltonian in terms of two small parameters, the relative density fluctuations inside a cell and the phase change over a cell. The resulting macroscopic observables can be computed in one, two and three dimensions with no ultraviolet or infrared divergence. Furthermore this approach exactly matches Bogoliubov's approach when there is a true condensate. We give the resulting expressions for the equation of state of the gas, the ground state energy, the first order and second order correlations functions of the field. Explicit calculations are done for homogeneous systems.Comment: 32 pages, 2 figures; typos corrected in revised versio

Lyapunov exponents, one-dimensional Anderson localisation and products of random matrices

The concept of Lyapunov exponent has long occupied a central place in the theory of Anderson localisation; its interest in this particular context is that it provides a reasonable measure of the localisation length. The Lyapunov exponent also features prominently in the theory of products of random matrices pioneered by Furstenberg. After a brief historical survey, we describe some recent work that exploits the close connections between these topics. We review the known solvable cases of disordered quantum mechanics involving random point scatterers and discuss a new solvable case. Finally, we point out some limitations of the Lyapunov exponent as a means of studying localisation properties.Comment: LaTeX, 23 pages, 3 pdf figures ; review for a special issue on "Lyapunov analysis" ; v2 : typo corrected in eq.(3) & minor change

Polarization state of the optical near-field

The polarization state of the optical electromagnetic field lying several nanometers above complex dielectric structures reveals the intricate light-matter interaction that occurs in this near-field zone. This information can only be extracted from an analysis of the polarization state of the detected light in the near-field. These polarization states can be calculated by different numerical methods well-suited to near--field optics. In this paper, we apply two different techniques (Localized Green Function Method and Differential Theory of Gratings) to separate each polarisation component associated with both electric and magnetic optical near-fields produced by nanometer sized objects. The analysis is carried out in two stages: in the first stage, we use a simple dipolar model to achieve insight into the physical origin of the near-field polarization state. In the second stage, we calculate accurate numerical field maps, simulating experimental near-field light detection, to supplement the data produced by analytical models. We conclude this study by demonstrating the role played by the near-field polarization in the formation of the local density of states.Comment: 9 pages, 11 figures, accepted for publication in Phys. Rev.

Synchrotron X-ray diffraction experiments with a prototype hybrid pixel detector

International audienceA prototype X-ray pixel area detector (XPAD3.1) has been used for X-ray diffraction experiments with synchrotron radiation. The characteristics of this detector are very attractive in terms of fast readout time, high dynamic range and high signal-to-noise ratio. The prototype XPAD3.1 enabled various diffraction experiments to be performed at different energies, sample-to-detector distances and detector angles with respect to the direct beam, yet it was necessary to perform corrections on the diffraction images according to the type of experiment. This paper is focused on calibration and correction procedures to obtain high-quality scientific results specifically developed in the context of three different experiments, namely mechanical characterization of nanostructured multilayers, elastic-plastic deformation of duplex steel and growth of carbon nanotubes

Kaigorodov spaces and their Penrose limits

Kaigorodov spaces arise, after spherical compactification, as near horizon limits of M2, M5, and D3-branes with a particular pp-wave propagating in a world volume direction. We show that the uncompactified near horizon configurations K\times S are solutions of D=11 or D=10 IIB supergravity which correspond to perturbed versions of their AdS \times S analogues. We derive the Penrose-Gueven limits of the Kaigorodov space and the total spaces and analyse their symmetries. An Inonu-Wigner contraction of the Lie algebra is shown to occur, although there is a symmetry enhancement. We compare the results to the maximally supersymmetric CW spaces found as limits of AdS\times S spacetimes: the initial gravitational perturbation on the brane and its near horizon geometry remains after taking non-trivial Penrose limits, but seems to decouple. One particuliar limit yields a time-dependent homogeneous plane-wave background whose string theory is solvable, while in the other cases we find inhomogeneous backgrounds.Comment: latex2e, 24 page