The spherically symmetric collapse of a massless scalar field

We report on a numerical study of the spherically symmetric collapse of a self-gravitating massless scalar field. Earlier results of Choptuik(1992, 1994) are confirmed. The field either disperses to infinity or collapses to a black hole, depending on the strength of the initial data. For evolutions where the strength is close to but below the strength required to form a black hole, we argue that there will be a region close to the axis where the scalar curvature and field energy density can reach arbitrarily large levels, and which is visible to distant observersComment: 23 pages, 16 figures, uuencoded gzipped postscript This version omits 2 pages of figures. This file, the two pages of figures and the complete paper are available at ftp://ftp.damtp.cam.ac.uk/pub/gr/rsh100

The ribosome and its role in protein folding: looking through a magnifying glass

Protein folding, a process that underpins cellular activity, begins co-translationally on the ribosome. During translation, a newly synthesized polypeptide chain enters the ribosomal exit tunnel and actively interacts with the ribosome elements – the r-proteins and rRNA that line the tunnel – prior to emerging into the cellular milieu. While understanding of the structure and function of the ribosome has advanced significantly, little is known about the process of folding of the emerging nascent chain (NC). Advances in cryo-electron microscopy are enabling visualization of NCs within the exit tunnel, allowing early glimpses of the interplay between the NC and the ribosome. Once it has emerged from the exit tunnel into the cytosol, the NC (still attached to its parent ribosome) can acquire a range of conformations, which can be characterized by NMR spectroscopy. Using experimental restraints within molecular-dynamics simulations, the ensemble of NC structures can be described. In order to delineate the process of co-translational protein folding, a hybrid structural biology approach is foreseeable, potentially offering a complete atomic description of protein folding as it occurs on the ribosome

Enhancement of the plant innate immunity as a means to reduce Salmonella colonization in plants

The aim of the present study was to examine whether improvement of plant innate immunity is capable of restricting Salmonella colonization in plants. To this purpose, we examined whether potential PAMPs are capable of limiting Salmonella growth on plant surfaces either by exogenous application to tobacco leaves or by transient expression via Agrobacterium. Preliminary results showing the effectiveness of both methods in restricting Salmonella colonization will be presented

On 2D Viscoelasticity with Small Strain

An exact two-dimensional rotation-strain model describing the motion of Hookean incompressible viscoelastic materials is constructed by the polar decomposition of the deformation tensor. The global existence of classical solutions is proved under the smallness assumptions only on the size of initial strain tensor. The proof of global existence utilizes the weak dissipative mechanism of motion, which is revealed by passing the partial dissipation to the whole system.Comment: Different contributions of strain and rotation of the deformation are studied for viscoelastic fluids of Oldroyd-B type in 2

The Cosmic No-Hair Theorem and the Nonlinear Stability of Homogeneous Newtonian Cosmological Models

The validity of the cosmic no-hair theorem is investigated in the context of Newtonian cosmology with a perfect fluid matter model and a positive cosmological constant. It is shown that if the initial data for an expanding cosmological model of this type is subjected to a small perturbation then the corresponding solution exists globally in the future and the perturbation decays in a way which can be described precisely. It is emphasized that no linearization of the equations or special symmetry assumptions are needed. The result can also be interpreted as a proof of the nonlinear stability of the homogeneous models. In order to prove the theorem we write the general solution as the sum of a homogeneous background and a perturbation. As a by-product of the analysis it is found that there is an invariant sense in which an inhomogeneous model can be regarded as a perturbation of a unique homogeneous model. A method is given for associating uniquely to each Newtonian cosmological model with compact spatial sections a spatially homogeneous model which incorporates its large-scale dynamics. This procedure appears very natural in the Newton-Cartan theory which we take as the starting point for Newtonian cosmology.Comment: 16 pages, MPA-AR-94-

A novel mutation in NDUFB11 unveils a new clinical phenotype associated with lactic acidosis and sideroblastic anemia

NDUFB11, a component of mitochondrial complex I, is a relatively small integral membrane protein, belonging to the 'supernumerary' group of subunits, but proved to be absolutely essential for the assembly of an active complex I. Mutations in in the X-linked nuclear encoded NDUFB11 gene have recently been discovered in association with two distinct phenotypes, i.e. microphthalmia with linear skin defects and histiocytoid cardiomyopathy. We report on a male with complex I deficiency, caused by a de novo mutation in NDUFB11 and displaying early onset sideroblastic anemia as the unique feature. This is the third report that describes a mutation in NDUFB11 but all are associated to a different phenotype. Our results further expand the molecular spectrum and associated clinical phenotype of NDUFB11 defects

Abnormal structural and functional brain connectivity in gray matter heterotopia

available in PMC 2013 June 01Purpose:  Periventricular nodular heterotopia (PNH) is a malformation of cortical development associated with epilepsy and dyslexia. Evidence suggests that heterotopic gray matter can be functional in brain malformations and that connectivity abnormalities may be important in these disorders. We hypothesized that nodular heterotopia develop abnormal connections and systematically investigated the structural and functional connectivity of heterotopia in patients with PNH. Methods:  Eleven patients were studied using diffusion tensor tractography and resting-state functional connectivity MRI with bold oxygenation level–dependent (BOLD) imaging. Fiber tracks with a terminus within heterotopic nodules were visualized to determine structural connectivity, and brain regions demonstrating resting-state functional correlations to heterotopic nodules were analyzed. Relationships between these connectivity results and measures of clinical epilepsy and cognitive disability were examined. Key Findings:  A majority of heterotopia (69%) showed structural connectivity to discrete regions of overlying cortex, and almost all (96%) showed functional connectivity to these regions (mean peak correlation coefficient 0.61). Heterotopia also demonstrated connectivity to regions of contralateral cortex, other heterotopic nodules, ipsilateral but nonoverlying cortex, and deep gray matter structures or the cerebellum. Patients with the longest durations of epilepsy had a higher degree of abnormal functional connectivity (p = 0.036). Significance:  Most heterotopic nodules in PNH are structurally and functionally connected to overlying cortex, and the strength of abnormal connectivity is higher among patients with the longest duration of epilepsy. Along with prior evidence that cortico-cortical tract defects underlie dyslexia in this disorder, the current findings suggest that altered connectivity is likely a critical substrate for neurologic dysfunction in brain malformations.National Institutes of Health (U.S.) (NIH/NINDS R01 NS073601)National Institutes of Health (U.S.) (NIH/NINDS K23 NS049159)Epilepsy Foundation of AmericaHarvard University (William F. Milton Fund

Relativistic Elasticity

Relativistic elasticity on an arbitrary spacetime is formulated as a Lagrangian field theory which is covariant under spacetime diffeomorphisms. This theory is the relativistic version of classical elasticity in the hyperelastic, materially frame-indifferent case and, on Minkowski space, reduces to the latter in the non-relativistic limit . The field equations are cast into a first -- order symmetric hyperbolic system. As a consequence one obtains local--in--time existence and uniqueness theorems under various circumstances.Comment: 23 page

Integration of gray matter nodules into functional cortical circuits in periventricular heterotopia

Alterations in neuronal circuitry are recognized as an important substrate of many neurological disorders, including epilepsy. Patients with the developmental brain malformation of periventricular nodular heterotopia (PNH) often have both seizures and dyslexia, and there is evidence to suggest that aberrant neuronal connectivity underlies both of these clinical features. We used task-based functional MRI (fMRI) to determine whether heterotopic nodules of gray matter in this condition are integrated into functional cortical circuits. Blood oxygenation level-dependent (BOLD) fMRI was acquired in eight participants with PNH during the performance of reading-related tasks. Evidence of neural activation within heterotopic gray matter was identified, and regions of cortical coactivation were then mapped systematically. Findings were correlated with resting-state functional connectivity results and with performance on the fMRI reading-related tasks. Six participants (75%) demonstrated activation within at least one region of gray matter heterotopia. Cortical areas directly overlying the heterotopia were usually coactivated (60%), as were areas known to have functional connectivity to the heterotopia in the task-free resting state (73%). Six of seven (86%) primary task contrasts resulted in heterotopia activation in at least one participant. Activation was most commonly seen during rapid naming of visual stimuli, a characteristic impairment in this patient population. Our findings represent a systematic demonstration that heterotopic gray matter can be metabolically coactivated in a neuronal migration disorder associated with epilepsy and dyslexia. Gray matter nodules were most commonly coactivated with the anatomically overlying cortex and other regions with resting-state connectivity to heterotopia. These results have broader implications for understanding the network pathogenesis of both seizures and reading disabilities