The Ursinus Weekly, May 7, 1962

Curtain Club\u27s The Girls in 509 scheduled Friday and Saturday • Fraser & Dingman selected head soph rulers to enliven \u2762 frosh customs program • Canterbury Club features speaker, CBS church film • Awards highlight waiters\u27 banquet • Dennis recovering from heart attack • Moyer attends ISC meeting at E-town • World traveler slated to address IRC tonight • Yippee-i-o theme of Spring Festival featuring queen, festivities Saturday • Campus politicers reconcile riffs at annual banquet • Hudnut & students plan jazz seminar • Cub & Key Society meets at Staigers • Editorial: Beauty versus popularity; Turning the tables • Shenanigan \u2762 senior show theme • Dozing technique requires practice • Sesquicentennial fetes continue in nearby Norristown • Obscurity, neglect & confusion mark UC\u27s undeveloped college museum • Tennismen win over LaSalle, drop PMC heartbreaker • Lacrossers swamp West Chesterettes • Baseballers smash Haverford, F&M, lose to E-Towners • Trackmen trounce PMC & Dickinson, upset by Hopkins • UC & West Chester swap wins to open softball season • Greek gleaningshttps://digitalcommons.ursinus.edu/weekly/1319/thumbnail.jp

The Ursinus Weekly, February 24, 1964

First Ursinus art show is extraordinary success • Thursday night concert of Four Freshmen proves that big names are possible here • Mr. Hudnut to lead Bible Study group • Kenneth Wells to speak Wed.; President of Freedoms Foundation • Miracles subject of vespers talk • Pi Nu to host national chapters • St. Andrews gives annual awards; Study in Scotland with stipend • Dr. Zucker to appear with Rutgers choir in Carnegie Hall concert • Curtain Club sets production date • Ursinus in three-way second place MAC tie • Bible Study fellowship to present film Tuesday • Pre-med and chemical groups hear Dr. Guarino • Editorial: No more doubt; Let\u27s go yell • Letters to the editor • Freedoms Foundation • Color Day program • The Lincoln - Ursinus visits described by participants • Greek gleanings • Human society and living cell linked • Impending crisis in our American railroads: Part three • Wrestlers hike mark to 5-2 • 2 wins, 1 loss: Playoff for UC courtmen • Ursinus drubs Juniata 83-69 • Bears tip Hopkins 61-55 • Dragons devour Bears 83-68 • Mermaids split; Beat Stroudsburg • Intramural basketballhttps://digitalcommons.ursinus.edu/weekly/1265/thumbnail.jp

The Ursinus Weekly, February 24, 1964

First Ursinus art show is extraordinary success • Thursday night concert of Four Freshmen proves that big names are possible here • Mr. Hudnut to lead Bible Study group • Kenneth Wells to speak Wed.; President of Freedoms Foundation • Miracles subject of vespers talk • Pi Nu to host national chapters • St. Andrews gives annual awards; Study in Scotland with stipend • Dr. Zucker to appear with Rutgers choir in Carnegie Hall concert • Curtain Club sets production date • Ursinus in three-way second place MAC tie • Bible Study fellowship to present film Tuesday • Pre-med and chemical groups hear Dr. Guarino • Editorial: No more doubt; Let\u27s go yell • Letters to the editor • Freedoms Foundation • Color Day program • The Lincoln - Ursinus visits described by participants • Greek gleanings • Human society and living cell linked • Impending crisis in our American railroads: Part three • Wrestlers hike mark to 5-2 • 2 wins, 1 loss: Playoff for UC courtmen • Ursinus drubs Juniata 83-69 • Bears tip Hopkins 61-55 • Dragons devour Bears 83-68 • Mermaids split; Beat Stroudsburg • Intramural basketballhttps://digitalcommons.ursinus.edu/weekly/1265/thumbnail.jp

Pennsylvania Folklife Vol. 42, No. 2

• Charles E. Starry, Adams County Chair Maker • Lewis Miller\u27s Chronicle of York: A Picture of Life in Early America • Family Anecdotes from a Georges Creek Home • The Pennsylvania-German Schrank • The Barns of Towamensing Township • A Review of Robert F. Ensminger\u27s The Pennsylvania Barnhttps://digitalcommons.ursinus.edu/pafolklifemag/1136/thumbnail.jp

The Lantern Vol. 30, No. 1, February 1963

• Mechanical Duplicity • The Practical Profits of Purism • \u27Tis Better • Misha • Manuel • An American Fairy Tale • The Christ of Christopher Street • Nocturne • Various Reflections • He Came and Gently Lifted Me • Poem, In a Minor Key • World Fell to Ruin • The Map • On Being Jilted • Manna • Traitor • The Leaves Cling • Oh Freedom! • The Insurance Man • Translation - The Vampire • Four Poems • Sanguis • Phoney is the Color of My Love\u27s Life • To a Barmaidhttps://digitalcommons.ursinus.edu/lantern/1083/thumbnail.jp

The Lantern Vol. 32, No. 1, January 1965

• The Wise Man • Of Men and Lobsters • Deliberate-Beyond Conception • Villanelle • Villanelle: Interlude • Rune Green Stones • Redemption • John Ten • Torch Ends • The General and the Birdnest • Not Quite Free • Hymn to the Morning • Walking Togetherhttps://digitalcommons.ursinus.edu/lantern/1087/thumbnail.jp

The Lantern Vol. 31, No. 1, December 1963

• Today\u27s Memory • The Realization • Life Fire • Come Sleep • The Ends Meet • Dawn of Darkness • Closed and Done: With Apologies to No One • A Search • Concern • Obvious Oblivion • Love\u27s Ashes • Silence • To My Dentist • Snow • Wisdom • Look Up • Nepenthe • With Apologies to Charles Schulz • Autumn and You • What is Optimism? • Agnostic? • Potpourri of Beinghttps://digitalcommons.ursinus.edu/lantern/1085/thumbnail.jp

The Lantern Vol. 31, No. 2, May 1964

• The High, Forbidding Wall • Sonnet One • Sceptic • The Witch, the Prince, and the Princess • Portrait in Gold and Black • The Music of the Drum • Sweat It, Jack • Cold Blue and the Moon • Another Carpenter: Circa 1963 • At a Conference of Colonial Historians • Pineland Places • Diasia to Death • Hey!... • The Hour • I\u27ll Not Returnhttps://digitalcommons.ursinus.edu/lantern/1086/thumbnail.jp

The Ursinus Weekly, May 11, 1964

New Lost City Ramblers to perform Friday: Agency sponsors blue grass group • Bombers bombed by MSGA, faculty reviewing • UC scholar wins St. Andrews scholarship • Survey supports APO projects • Loved you Conrad : Spring festival succeeds with new program • Bible fellowship • Two classes elect officers today • Pi Nu Epsilon inducts members • Ursinus Circle • Obituary • Editorial: Attention administration • Mr. Pennypacker stages a remarkable performance: Robbins, Sinclair, Auchincloss and Matusow star in production • Spring hits UC campus with sun, fun and studies • Next President: Johnson • Letter to the Editor • Ursinus thinclads retain MAC crown: Cooper wins two, Dunn ties 440 record; Gladstone, Robart, Walter, relay take 1st • Softballers win; Season undefeated • Batsmen even for week: Defeated Drexel, split with Haverford and lost to LaSalle • Tennis loses 3rd; Bryn Mawr takes 4 • Lacrosse wins 4th; Swamp E-burg 13-3 • MAC summary • Greek gleaningshttps://digitalcommons.ursinus.edu/weekly/3110/thumbnail.jp

Modulation of Wnt5a Expression by Periodontopathic Bacteria

Wingless proteins, termed Wnt, are involved in embryonic development, blood cell differentiation, and tumorigenesis. In mammalian hematopoiesis, Wnt signaling is essential for stem-cell homeostasis and lymphocyte differentiation. Recent studies have suggested that these molecules are associated with cardiovascular diseases, rheumatoid arthritis, and osteoarthritis. Furthermore, Wnt5a signaling is essential for the general inflammatory response of human macrophages. Periodontitis is a chronic inflammatory disease caused by gram-negative periodontopathic bacteria and the resultant host immune response. Periodontitis is characterized by loss of tooth-supporting structures and alveolar bone resorption. There have been no previous reports on Wnt5a expression in periodontitis tissue, and only few study reported the molecular mechanisms of Wnt5a expression in LPS-stimulated monocytic cells. Using RT-PCR, we demonstrated that Wnt5a mRNA expression was up-regulated in chronic periodontitis tissue as compared to healthy control tissue. P. gingivalis LPS induced Wnt5a mRNA in the human monocytic cell line THP-1 with a peak at 4 hrs after stimulation. P. gingivalis LPS induced higher up-regulation of Wnt5a mRNA than E. coli LPS. The LPS receptors TLR2 and TLR4 were equally expressed on the surface of THP-1 cells. P. gingivalis LPS induced IκBα degradation and was able to increase the NF-κB binding activity to DNA. P. gingivalis LPS-induced Wnt5a expression was inhibited by NF-κB inhibitors, suggesting NF-κB involvement. Furthermore, IFN-γ synergistically enhanced the P. gingivalis LPS-induced production of Wnt5a. Pharmacological investigation and siRNA experiments showed that STAT1 was important for P. gingivalis LPS-induced Wnt5a expression. These results suggest that the modulation of Wnt5a expression by P. gingivalis may play an important role in the periodontal inflammatory process and serve a target for the development of new therapies