Associations with moderate or severe ARDS susceptibility.

<p>Multivariate logistic regression adjusted for age, sex, APACHE III score, alcohol abuse, smoking status, and history of chronic renal failure and diabetes mellitus. n = 414 (126 with ARDS).</p

Associations with ALI susceptibility.

<p>Multivariate logistic regression adjusted for age, sex, APACHE III score, alcohol abuse, smoking status, and history of chronic renal failure and diabetes mellitus.</p

Genotype frequencies in at-risk controls versus ALI cases.

<p>HWE Hardy-Weinberg equilibrium;</p>a<p>p value for the Fisher's exact test comparing genotypes for at risk controls and ALI cases.</p

Genetic variants studied.

*<p>MAF, minor allele frequency in the HapMap;</p>**<p>CEU population; EA, European American; AA, African American; Number refers to number of subjects in group of the referenced study.</p

Associations with VFDs.

<p>Multivariate linear regression adjusted for age, sex, APACHE III score, alcohol abuse, smoking status, and history of chronic renal failure and diabetes mellitus. n = 224.</p

HMC SIRS cohort population characteristics.

<p>Data is presented as mean ± SD for continuous variables and n (%) for categorical variables. P values represent results of t test comparison for difference of means for continuous variables and Fisher's exact test for frequency counts for categorical variables. IQR, interquartile range; VFD, ventilator free days; AKI, presence of acute kidney injury by AKIN score >/ = 1 with lowest creatinine during hospitalization used as baseline; Death, subject death within 28 days of admission.</p

Flow diagram for Study design.

<p>Subjects with suspected systemic inflammatory response syndrome (SIRS), n = 1327, were enrolled at Harborview Medical Center (HMC), Seattle, WA during the period December 2006–December 2010. In this study, we excluded non-Caucasian subjects, subjects who were found to have previous enrollment or missing data, and subjects that did not meet 3 SIRS criteria present concurrently within a 24 hour period.</p