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The occipital lateral plate mesoderm is a novel source for vertebrate neck musculature
In vertebrates, body musculature originates from somites, whereas head muscles originate from the cranial mesoderm. Neck muscles are located in the transition between these regions. We show that the chick occipital lateral plate mesoderm has myogenic capacity and gives rise to large muscles located in the neck and thorax. We present molecular and genetic evidence to show that these muscles not only have a unique origin, but additionally display a distinct temporal development, forming later than any other muscle group described to date. We further report that these muscles, found in the body of the animal, develop
like head musculature rather than deploying the programme used by the trunk muscles. Using mouse genetics we reveal that these muscles are formed in trunk muscle mutants but are absent in head muscle mutants. In concordance with this conclusion, their connective tissue is neural crest in origin. Finally, we provide evidence that the mechanism by which these neck muscles develop is conserved in vertebrates
Prospects for a lattice computation of rare kaon decay amplitudes. II. K →π ν ν ¯ decays
The rare kaon decays are strongly suppressed in the
standard model and widely regarded as processes in which new phenomena, not
predicted by the standard model, may be observed. Recognizing such new
phenomena requires precise standard model prediction for the braching ratio of
with controlled uncertainty for both short-distance and
long-distance contributions. In this work we demonstrate the feasibility of
lattice QCD calculation of the long-distance contribution to rare kaon decays
with the emphasis on . Our methodology covers the
calculation of both - and -exchange diagrams. We discuss the
estimation of the power-law, finite-volume corrections and two methods to
consistently combine the long distance contribution determined by the lattice
methods outlined here with the short distance parts that can be reliably
determined using perturbation theory. It is a subsequent work of our first
methodology paper on , where the focus was made on the
-exchange diagrams.Comment: 47 pages, 5 figure
Roundtable On Feminist Ideology And Religious Diversity, Part 5: Feminist Theology, Religiously Diverse Neighborhood Or Christian Ghetto?
Hepatic progenitor cells from adult human livers for cell transplantation.
Objective: Liver regeneration is mainly based on cellular
self-renewal including progenitor cells. Efforts have been
made to harness this potential for cell transplantation, but
shortage of hepatocytes and premature differentiated
progenitor cells from extra-hepatic organs are limiting
factors. Histological studies implied that resident cells in
adult liver can proliferate, have bipotential character and
may be a suitable source for cell transplantation.
Methods: Particular cell populations were isolated after
adequate tissue dissociation. Single cell suspensions were
purified by Thy-1 positivity selection, characterised in vitro
and transplanted in immunodeficient Pfp/Rag2 mice.
Results: Thy-1+ cells that are mainly found in the portal
tract and the surrounding parenchyma, were isolated from
surgical liver tissue with high yields from specimens with
histological signs of regeneration. Thy-1+ cell populations
were positive for progenitor (CD34, c-kit, CK14, M2PK,
OV6), biliary (CK19) and hepatic (HepPar1) markers
revealing their progenitor as well as hepatic and biliary
nature. The potential of Thy-1+ cells for differentiation in
vitro was demonstrated by increased mRNA and protein
expression for hepatic (CK18, HepPar1) and biliary (CK7)
markers during culture while progenitor markers CK14,
chromogranin A and nestin were reduced. After
transplantation of Thy-1+ cells into livers of immunodeficient
mice, engraftment was predominantly seen in the
periportal portion of the liver lobule. Analysis of in situ
material revealed that transplanted cells express human
hepatic markers HepPar1 and albumin, indicating functional
engraftment.
Conclusion: Bipotential progenitor cells from human
adult livers can be isolated using Thy-1 and might be a
potential candidate for cell treatment in liver diseases
Anomalous Chiral Symmetry Breaking above the QCD Phase Transition
We study the anomalous breaking of U_A(1) symmetry just above the QCD phase
transition for zero and two flavors of quarks, using a staggered fermion,
lattice discretization. The properties of the QCD phase transition are expected
to depend on the degree of U_A(1) symmetry breaking in the transition region.
For the physical case of two flavors, we carry out extensive simulations on a
16^3 x 4 lattice, measuring a difference in susceptibilities which is sensitive
to U_A(1) symmetry and which avoids many of the staggered fermion
discretization difficulties. The results suggest that anomalous effects are at
or below the 15% level.Comment: 10 pages including 2 figures and 1 tabl
Correlations in the Sine-Gordon Model with Finite Soliton Density
We study the sine-Gordon (SG) model at finite densities of the topological
charge and small SG interaction constant, related to the one-dimensional
Hubbard model near half-filling. Using the modified WKB approach, we find that
the spectrum of the Gaussian fluctuations around the classical solution
reproduces the results of the Bethe ansatz studies. The modification of the
collective coordinate method allows us to write down the action, free from
infra-red divergencies. The behaviour of the density-type correlation functions
is non-trivial and we demonstrate the existence of leading and sub-leading
asymptotes. A consistent definition of the charge-raising operator is
discussed. The superconducting-type correlations are shown to decrease slowly
at small soliton densities, while the spectral weight of right (left) moving
fermions is spread over neighboring "4k_F" harmonics.Comment: 12 pages, 3 eps figures, REVTEX; a discussion of fermions is adde
Critical State Behaviour in a Low Dimensional Metal Induced by Strong Magnetic Fields
We present the results of magnetotransport and magnetic torque measurements
on the alpha-(BEDT-TTF)2KHg(SCN)4 charge-transfer salt within the high magnetic
field phase, in magnetic fields extending to 33 T and temperatures as low as 27
mK. While the high magnetic field phase (at fields greater than ~ 23 T) is
expected, on theoretical grounds, to be either a modulated charge-density wave
phase or a charge/spin-density wave hybrid, the resistivity undergoes a
dramatic drop below ~ 3 K within the high magnetic field phase, falling in an
approximately exponential fashion at low temperatures, while the magnetic
torque exhibits pronounced hysteresis effects. This hysteresis, which occurs
over a broad range of fields, is both strongly temperature-dependent and has
several of the behavioural characteristics predicted by critical-state models
used to describe the pinning of vortices in type II superconductors in strong
magnetic fields. Thus, rather than exhibiting the usual behaviour expected for
a density wave ground state, both the transport and the magnetic properties of
alpha-(BEDT-TTF)2KHg(SCN)4, at high magnetic fields, closely resembles those of
a type II superconductor
Effect of propranolol on facial processing in autism spectrum disorder
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by social interaction deficits, communication impairments, and restricted, repetitive behaviors. ASD, with estimates of incidence as high as 1 in 88 individuals, has a largely unknown etiology. Pharmacological intervention is currently being explored to improve symptoms of ASD, including those in the social domain. Social interaction deficits in this population may include facial processing abnormalities, such as reduced eye contact, and increased fixation on less socially-salient facial regions, such as the mouth. However, there is variability in the degree of these deficits in the current literature. Additionally, it has been previously hypothesized that stress mediates poor facial processing in individuals with ASD. This pilot study examines the effect of propranolol, a nonselective beta-adrenergic antagonist anxiolytic, on facial processing in individuals with ASD and typically developing controls
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