The kinematic history of the Khlong Marui and Ranong Faults, southern Thailand

The Khlong Marui Fault (KMF) and Ranong Fault (RF) are major NNE-trending strike-slip faults which dissect peninsular Thailand. They have been assumed to be conjugate to the NW-trending Three Pagodas Fault (TPF) and Mae Ping Fault (MPF) in Northern Thailand, which experienced a diachronous reversal in shear sense during India–Eurasia collision. It follows that the KMF and RF are expected to show the opposite shear sense and a slip sense reversal at a similar time to the TPF and MPF. New field data from the KMF and RF reveal two phases of ductile dextral shear separated by Campanian magmatism. Paleocene to Eocene post-kinematic granites date the end of this phase, while a brittle sinistral phase deforms the granites, and has exhumed the ductile fault rocks. The timing of these movements precludes formation of the faults in response to Himalayan extrusion tectonics. Instead, they formed near the southern margin of a Late Cretaceous–Paleocene orogen, and may have been influenced by variations in the rate of subduction ahead of India and Australia. North-south compression prior to reactivation of the subduction zone around southern Sundaland in the Eocene caused widespread deformation in the overriding plate, including sinistral transpression on the KMF and RF

Regional seismic stratigraphic framework and depositional history of the post- : Valanginian passive margin sequences in the Northern Carnarvon Basin, North West Shelf of Australia

Acknowledgements We would like to express our gratitude to Geoscience Australia for the provision of public domain seismic and well log data. All available datasets used in this research are open source, can be accessed through the National Offshore Petroleum Information Management System (NOPIMS; https://nopims.dmp.wa.gov.au/nopims). Schlumberger are thanked for the provision of Petrel software. Mulky Winata is supported by a collaborative PhD scholarship under the Aberdeen – Curtin Alliance (http://aberdeencurtinalliance.org/) namely between Curtin University (Perth, Australia) and the University of Aberdeen (Aberdeen, Scotland). Diego Kietzmann, Victorian Paumard, Marina Rabineau and two anonymous referees are thanked for their thoughtful reviews of earlier versions of this manuscript.Peer reviewedPublisher PD

The Association of Cardiometabolic, Diet and Lifestyle Parameters With Plasma Glucagon-like Peptide-1:An IMI DIRECT Study

ContextThe role of glucagon-like peptide-1 (GLP-1) in type 2 diabetes (T2D) and obesity is not fully understood.ObjectiveWe investigate the association of cardiometabolic, diet, and lifestyle parameters on fasting and postprandial GLP-1 in people at risk of, or living with, T2D.MethodsWe analyzed cross-sectional data from the two Innovative Medicines Initiative (IMI) Diabetes Research on Patient Stratification (DIRECT) cohorts, cohort 1 (n = 2127) individuals at risk of diabetes; cohort 2 (n = 789) individuals with new-onset T2D.ResultsOur multiple regression analysis reveals that fasting total GLP-1 is associated with an insulin-resistant phenotype and observe a strong independent relationship with male sex, increased adiposity, and liver fat, particularly in the prediabetes population. In contrast, we showed that incremental GLP-1 decreases with worsening glycemia, higher adiposity, liver fat, male sex, and reduced insulin sensitivity in the prediabetes cohort. Higher fasting total GLP-1 was associated with a low intake of wholegrain, fruit, and vegetables in people with prediabetes, and with a high intake of red meat and alcohol in people with diabetes.ConclusionThese studies provide novel insights into the association between fasting and incremental GLP-1, metabolic traits of diabetes and obesity, and dietary intake, and raise intriguing questions regarding the relevance of fasting GLP-1 in the pathophysiology T2D

The timing of strike-slip shear along the Ranong and Khlong Marui faults, Thailand

The timing of shear along many important strike-slip faults in Southeast Asia, such as the Ailao Shan-Red River, Mae Ping and Three Pagodas faults, is poorly understood. We present 40Ar/39Ar, U-Pb SHRIMP and microstructural data from the Ranong and Khlong Marui faults of Thailand to show that they experienced a major period of ductile dextral shear during the middle Eocene (48–40 Ma, centered on 44 Ma) which followed two phases of dextral shear along the Ranong Fault, before the Late Cretaceous (>81 Ma) and between the late Paleocene and early Eocene (59–49 Ma). Many of the sheared rocks were part of a pre-kinematic crystalline basement complex, which partially melted and was intruded by Late Cretaceous (81–71 Ma) and early Eocene (48 Ma) tin-bearing granites. Middle Eocene dextral shear at temperatures of ~300–500°C formed extensive mylonite belts through these rocks and was synchronous with granitoid vein emplacement. Dextral shear along the Ranong and Khlong Marui faults occurred at the same time as sinistral shear along the Mae Ping and Three Pagodas faults of northern Thailand, a result of India-Burma coupling in advance of India-Asia collision. In the late Eocene (<37 Ma) the Ranong and Khlong Marui faults were reactivated as curved sinistral branches of the Mae Ping and Three Pagodas faults, which were accommodating lateral extrusion during India-Asia collision and Himalayan orogenesis

Seismic geomorphology of cretaceous megaslides offshore Namibia (Orange Basin):Insights into segmentation and degradation of gravity-driven linked systems

This study applies modern seismic geomorphology techniques to deep-water collapse features in the Orange Basin (Namibian margin, Southwest Africa) in order to provide unprecedented insights into the segmentation and degradation processes of gravity-driven linked systems. The seismic analysis was carried out using a high-quality, depth-migrated 3D volume that images the Upper Cretaceous post-rift succession of the basin, where two buried collapse features with strongly contrasting seismic expression are observed. The lower Megaslide Complex is a typical margin-scale, extensional-contractional gravity-driven linked system that deformed at least 2 km of post-rift section. The complex is laterally segmented into scoop-shaped megaslides up to 20 km wide that extend downdip for distances in excess of 30 km. The megaslides comprise extensional headwall fault systems with associated 3D rollover structures and thrust imbricates at their toes. Lateral segmentation occurs along sidewall fault systems which, in the proximal part of the megaslides, exhibit oblique extensional motion and define horst structures up to 6 km wide between individual megaslides. In the toe areas, reverse slip along these same sidewall faults, creates lateral ramps with hanging wall thrust-related folds up to 2 km wide. Headwall rollover anticlines, sidewall horsts and ramp anticlines may represent novel traps for hydrocarbon exploration on the Namibian margin.The Megaslide Complex is unconformably overlain by few hundreds of metres of highly contorted strata which define an upper Slump Complex. Combined seismic attributes and detailed seismic facies analysis allowed mapping of headscarps, thrust imbrications and longitudinal shear zones within the Slump Complex that indicate a dominantly downslope movement of a number of coalesced collapse systems. Spatial and stratal relationships between these shallow failures and the underlying megaslides suggest that the Slump Complex was likely triggered by the development of topography created by the activation of the main structural elements of the lower Megaslide Complex. This study reveals that gravity-driven linked systems undergo lateral segmentation during their evolution, and that their upper section can become unstable, favouring the initiation of a number of shallow failures that produce widespread degradation of the underlying megaslide structures. Gravity-driven linked systems along other margins are likely to share similar processes of segmentation and degradation, implying that the megaslide-related, hydrocarbon trapping structures discovered in the Namibian margin may be common elsewhere, making megaslides an attractive element of deep-water exploration along other gravitationally unstable margins

World Health Organization cardiovascular disease risk charts: revised models to estimate risk in 21 global regions

BACKGROUND: To help adapt cardiovascular disease risk prediction approaches to low-income and middle-income countries, WHO has convened an effort to develop, evaluate, and illustrate revised risk models. Here, we report the derivation, validation, and illustration of the revised WHO cardiovascular disease risk prediction charts that have been adapted to the circumstances of 21 global regions. METHODS: In this model revision initiative, we derived 10-year risk prediction models for fatal and non-fatal cardiovascular disease (ie, myocardial infarction and stroke) using individual participant data from the Emerging Risk Factors Collaboration. Models included information on age, smoking status, systolic blood pressure, history of diabetes, and total cholesterol. For derivation, we included participants aged 40-80 years without a known baseline history of cardiovascular disease, who were followed up until the first myocardial infarction, fatal coronary heart disease, or stroke event. We recalibrated models using age-specific and sex-specific incidences and risk factor values available from 21 global regions. For external validation, we analysed individual participant data from studies distinct from those used in model derivation. We illustrated models by analysing data on a further 123 743 individuals from surveys in 79 countries collected with the WHO STEPwise Approach to Surveillance. FINDINGS: Our risk model derivation involved 376 177 individuals from 85 cohorts, and 19 333 incident cardiovascular events recorded during 10 years of follow-up. The derived risk prediction models discriminated well in external validation cohorts (19 cohorts, 1 096 061 individuals, 25 950 cardiovascular disease events), with Harrell's C indices ranging from 0·685 (95% CI 0·629-0·741) to 0·833 (0·783-0·882). For a given risk factor profile, we found substantial variation across global regions in the estimated 10-year predicted risk. For example, estimated cardiovascular disease risk for a 60-year-old male smoker without diabetes and with systolic blood pressure of 140 mm Hg and total cholesterol of 5 mmol/L ranged from 11% in Andean Latin America to 30% in central Asia. When applied to data from 79 countries (mostly low-income and middle-income countries), the proportion of individuals aged 40-64 years estimated to be at greater than 20% risk ranged from less than 1% in Uganda to more than 16% in Egypt. INTERPRETATION: We have derived, calibrated, and validated new WHO risk prediction models to estimate cardiovascular disease risk in 21 Global Burden of Disease regions. The widespread use of these models could enhance the accuracy, practicability, and sustainability of efforts to reduce the burden of cardiovascular disease worldwide. FUNDING: World Health Organization, British Heart Foundation (BHF), BHF Cambridge Centre for Research Excellence, UK Medical Research Council, and National Institute for Health Research

Thin-section detrital zircon geochronology mitigates bias in provenance investigations

Detrital zircon U–Pb geochronology has enabled advances in the understanding of sediment provenance, transportation pathways, and the depositional age of sedimentary packages. However, sample selection and processing can result in biasing of detrital zircon age spectra. This paper presents a novel approach using in situ detrital zircon U–Pb measurements on thin-sections to provide greater confidence in maximum depositional ages and provenance interpretations. New U–Pb age data of 310 detrital zircon grains from 16 thin-sections of the Triassic Mungaroo Formation from two wells in the Northern Carnarvon Basin, Australia, are presented. Whilst detrital zircon age modes are consistent with previous work, there are some differences in the relative proportions of age modes, which are partly attributed to a lack of small grains in handpicked grain mounts. The relative sample bias is quantified via grain size comparison of dated zircon (in thin-sections or handpicked mounts) relative to all zircons identified in bulk-mounts and thin-sections. The youngest age mode (c. 320–195 Ma) is consistent with an active margin to the north. The dated zircons reveal a single grain defined maximum depositional age of 197 Ma for the upper part of the Mungaroo Formation, suggesting deposition may have continued into the Early Jurassic