High fundamental-repetition-rate bound solitons in carbon nanotube-based fiber lasers

© 2015 IEEE.We demonstrate bound solitons formation with a high fundamental-repetition-rate of 211.8 MHz from an all-fiber linear-configuration mode-locked laser incorporating a carbon-nanotube-based saturable absorber for the first time. By adjusting the polarization state of laser cavity, bound solitons exhibit a large change of pulse separation in a range of 3.5-73 times longer than the pulsewidth, while the phase difference of the tightly bound solitons switches between pm π 2. Numerical simulations confirm the experimental observations about the dependence of spectral profile of bound solitons on the pulse separation and the phase difference

Operation-Switchable Bidirectional Pulsed Fiber Laser Incorporating Carbon-Nanotube-Based Saturable Absorber

© 1995-2012 IEEE.We present an operation-switchable bidirectional ring-cavity pulsed fiber laser incorporating a carbon-nanotube-based saturable absorber and a polarization-dependent four-port circulator. By manipulating the intra-cavity polarization state of light, two sets of mode-locked pulses in terms of fundamental repetition rate and pulse width can be achieved separately from the same laser cavity. In clockwise direction, the laser generates mode-locked output pulse train with a pulse width of 600 fs and a fundamental repetition rate of 12.68 MHz. While in counter-clockwise direction, the laser generates mode-locked pulses with a pulse width of 480 fs and a fundamental repetition rate of 16.46 MHz. Furthermore, the same laser cavity can produce bidirectional Q-switched output pulse trains with synchronized repetition rate. Such synchronized repetition rate is linearly proportional to pump power. The results show a multi-functional pulsed fiber laser with selectable output pulse trains

Dark pulse generation in fiber lasers incorporating carbon nanotubes

© 2014 Optical Society of America.We demonstrate the generation of dark pulses from carbon nanotube (CNT) incorporated erbium-doped fiber ring lasers with net anomalous dispersion. A side-polished fiber coated with CNT layer by optically-driven deposition method is embedded into the laser in order to enhance the birefringence and nonlinearity of the laser cavity. The dual-wavelength domain-wall dark pulses are obtained from the developed CNT-incorporated fiber laser at a relatively low pump threshold of 50.6 mW. Dark pulses repeated at the fifth-order harmonic of the fundamental cavity frequency are observed by adjusting the intra-cavity polarization state

Enhanced stability of dispersion-managed mode-locked fiber lasers with near-zero net cavity dispersion by high-contrast saturable absorbers

We experimentally investigate the stability of dispersion-managed mode-locked fiber lasers using carbon-nanotubebased saturable absorbers (SAs) with different modulation depths. An unstable operation region of the mode-locked fiber laser with near-zero net cavity dispersion is observed, where the laser produces random pulse burst rather than stable pulse train. Through the implementation of high-contrast SAs in the laser, the unstable region is found to be shrunk by ?31.3% when the modulation depth of the SAs increases from 6.4% to 12.5%. The numerical simulation is consistent with the experimental observation. © 2013 Optical Society of America

The Clinical Utility of SUDOSCAN in Chronic Kidney Disease in Chinese Patients with Type 2 Diabetes

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Respiratory viral infections in exacerbation of chronic airway inflammatory diseases: novel mechanisms and insights from the upper airway epithelium.

Respiratory virus infection is one of the major sources of exacerbation of chronic airway inflammatory diseases. These exacerbations are associated with high morbidity and even mortality worldwide. The current understanding on viral-induced exacerbations is that viral infection increases airway inflammation which aggravates disease symptoms. Recent advances in in vitro air-liquid interface 3D cultures, organoid cultures and the use of novel human and animal challenge models have evoked new understandings as to the mechanisms of viral exacerbations. In this review, we will focus on recent novel findings that elucidate how respiratory viral infections alter the epithelial barrier in the airways, the upper airway microbial environment, epigenetic modifications including miRNA modulation, and other changes in immune responses throughout the upper and lower airways. First, we reviewed the prevalence of different respiratory viral infections in causing exacerbations in chronic airway inflammatory diseases. Subsequently we also summarized how recent models have expanded our appreciation of the mechanisms of viral-induced exacerbations. Further we highlighted the importance of the virome within the airway microbiome environment and its impact on subsequent bacterial infection. This review consolidates the understanding of viral induced exacerbation in chronic airway inflammatory diseases and indicates pathways that may be targeted for more effective management of chronic inflammatory diseases

Metrics with Prescribed Ricci Curvature near the Boundary of a Manifold

Suppose $M$ is a manifold with boundary. Choose a point $o\in\partial M$. We investigate the prescribed Ricci curvature equation \Ric(G)=T in a neighborhood of $o$ under natural boundary conditions. The unknown $G$ here is a Riemannian metric. The letter $T$ in the right-hand side denotes a (0,2)-tensor. Our main theorems address the questions of the existence and the uniqueness of solutions. We explain, among other things, how these theorems may be used to study rotationally symmetric metrics near the boundary of a solid torus $\mathcal T$. The paper concludes with a brief discussion of the Einstein equation on $\mathcal T$.Comment: 13 page

The statistical analysis of a clinical trial when a protocol amendment changed the inclusion criteria

Abstract Background Sometimes, protocol amendments that change the inclusion and exclusion criteria are required in clinical trials. Then, the patient populations before and after the amendment may differ. Methods We propose to perform separate statistical tests for the different phases, i.e. for the patients recruited before and after the amendment, and to combine the tests using Fisher's combination test. After a significant combination test a multiple testing procedure can be applied to identify the phase(s) to which a proof of efficacy refers. We assume that the amendment(s) are not based on any type of unblinded data. The proposed method is investigated within a simulation study. Results The proposed combination approach is superior to the 'naïve' strategy to ignore the differences between the phases and pooling the data to perform just one statistical test. This superiority disappears when there are hardly any differences between the two phases. Conclusion When one or more protocol amendments change the inclusion and exclusion criteria, one should realize that the populations may differ. In this case, separate tests for the different phases together with a combination test are a powerful method that can be applied in a variety of settings. The (first) amendment should specify the combination test to be applied in order to combine the different phases.</p

Pregnancy and oral health in Hong Kong

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Levothyrox® new and old formulations: are they switchable for millions of patients?

International audienceIn France, more than 2.5 million patients are currently treated with levothyroxine, mainly as the marketed product Levothyrox ®. In March 2017, at the request of French authorities, a new formulation of Levothyrox ® was licensed, with the objective of avoiding stability deficiencies of the old formulation. Before launching this new formulation, an average bioequivalence trial, based on European Union recommended guidelines, was performed. The implicit rationale was the assumption that the two products, being bioequivalent, would also be switchable, allowing substitution of the new for the old formulation, thus avoiding the need for individual calibration of the dosage regimen of thyroxine, using the thyroid-stimulating hormone level as the endpoint, as required for a new patient on initiating treatment. Despite the fact that both formulations were shown to be bioequivalent, adverse drug reactions were reported in several thousands of patients after taking the new formulation. In this opinion paper, we report that more than 50% of healthy volunteers enrolled in a successful regulatory average bioequivalence trial were actually outside the a priori bioequivalence range. Therefore, we question the ability of an average bioequivalence trial to guarantee the switchability within patients of the new and old levothyroxine formulations. We further propose an analysis of this problem using the conceptual framework of individual bioequivalence. This involves investigating the bioavailability of the two formulations within a subject, by comparing not only the population means (as established by average bioequivalence) but also by assessing two variance terms, namely the within-subject variance and the variance estimating subject-by-formulation interaction. A higher within individual variability for the new formulation would lead to reconsideration of the appropriateness of the new formulation. Alternatively, a possible subject-by-formulation interaction would allow a judgement on the ability, or not, of doctors to manage patients effectively during transition from the old to the new formulation