Evaluation of different teaching-learning methods according to students’ preference and perception

Background: Improved teaching methodology is prerequisite for education systems so that students learn effectively. The present study was done with the objectives of evaluation of different teaching-learning methods according to students’ preference and perception.Methods: It was observational, non-interventional questionnaire based study. Total 100 students were selected randomly from second MBBS as participants of it. They filled questionnaires with 11 questions, by selecting appropriate options.Results: All students were interested in Pharmacology. Cardio-Vascular System and autocoids were the most interesting topics according to 40% of students. Total 53% of students preferred combination of chalk and board with PowerPoint presentation for understanding, while chalk and board alone (65%) as more interactive teaching method. Total 80% of students preferred interactive lecture session. Clinical case/bed side study was preferred by 89% of students. Total 40% of students preferred combination of teachers’ note and standard textbooks as reading materials. Total 80% of students mentioned that revision at the end of lecture is necessary. One and half year as ideal time to learn second MBBS, has been selected by 60% of students. Teaching with more clinical orientation is one of the changes suggested by 28% of students.Conclusions: Combination of traditional chalk and board method with modern powerpoint method, wherever necessary, is ideal for interactive and understandable lecture session. Integration/correlation of clinical cases with clinical Pharmacology will be more helpful in understanding and learning. Proper and effective management of time is essential for maximum utilization of MBBS duration with optimum output for students

Prescribing pattern and drug utilization study in inpatients of department of Orthopaedics in a rural teaching hospital of Ujjain, Madhya Pradesh, India

Background: Drug utilization study can increase our understanding of how drugs are being used. This study was done to evaluate the current drug prescribing trend in management of indoor patient of orthopaedic department and to comment on rationality of the prescribed medicines.Methods: This is a prospective observational study conducted for 12 months, in Chandrikaben Rashmikant Gardi Hospital, a 600 bedded tertiary care rural based, teaching hospital. Total 611 patients were included in this study.Results: Total 5416 drugs were prescribed in 611 prescriptions. Average number of drugs per prescription was 8.86. Average duration of prescription was 10.7 days. Percentage of drugs prescribed by generic name was 28.8%. Percentage of encounter with an Antibiotic prescribed was 60.23% i.e. out of 611 prescriptions antibiotics were prescribed in 368. Percentage of encounter with an Injection prescribed was 63% which means out of 611 prescriptions, injectables were prescribed in 385. Percentage of drugs prescribed from National Essential Medicine List was 52.63%. Percentage of drugs prescribed from WHO model List was 32.46%. Diclofenac (14.25%) was most commonly prescribed drug. Incidence of polypharmacy was quite high in context of Analgesics. Almost 40% of prescriptions had 2 drugs. Orally prescribed Analgesics were 62.6%, Injectables 34.38% and Topical 3.02%.Conclusions: This study reveals that the pattern of prescription in terms of rationality is poor. Special attention needs to be given to the irrational prescribing in terms of polypharmacy and long duration. Continuing medical education regarding appropriate use of drugs, knowledge of adverse effects and standard prescription guidelines will play pivotal role in rational prescription of drugs

Collection and analysis of adverse drug reactions of antiretroviral therapy in a tertiary care hospital in central India

Background: The main objective of study is to monitor and analyze the adverse drug reactions (ADRs) of ART and to assess causality and severity of the ADRs detected.Methods: It is a prospective observational study conducted in the ART centre of a tertiary care teaching hospital in central India. The data collected were recorded on standard ADR reporting forms. Causality was assessed by Naranjo’s algorithm. Severity of ADR’s was assessed by modified Hartwig and Seigel scale. Modified Shumock and Thorton criteria used for preventability assessment.Results: In twelve months duration 351 patients on ART were observed for ADRs. Total 166 ADRs detected in 96 patients. Incidence of ADRs was slightly more in female. The common systems involved were gastrointestinal 42.77% followed by nervous system 18.07%, musculoskeletal 15.06% skin/mucous membrane 07.83%, metabolic and nutritional 04.82%, red blood cell disorders 01.20 %, endocrinal 00.60 % and others 09.64%. The causality assessment as per Naranjo’s scale showed that out of 166 ADRs, 28.92% were probable and 71.08% were possible. Severity assessment by modified Hartwig and Siegel scale showed that 83.34% ADRs were mild and 15.66% were moderate. 46.39 % ADRs were probably preventable.Conclusions: Considering the magnitude of ADR related problems, there is a need for greater awareness among health care professionals, to detect and report them. These ADRs if recognized in time and managed properly can prevent treatment interruption

Role of Antioxidants in Male Reproduction: Review

To counter oxidative stress, cells constitutively express enzymes that detoxify the reactive oxygen species and repair the damage. An antioxidant is any substance that when present at low concentrations compared to those of an oxidizable substrate significantly delays or prevents oxidation of that substrate. The antioxidant enzymes are major cell defense against acute oxygen toxicity. The functions of these antioxidant enzymes are to protect the membrane and cytosolic components against damage caused by free radicals. Glutathione peroxidase, Superoxide dismutase, glutathione-s-transferase, catalase, xanthine oxidase. Amongst a variety of antioxidants; vitamin E antioxidant use is essential because it travels through the body in molecules called lipoproteins and protect them from oxidation. For Many years, vitamin E considered as an anti-sterility factor. In the male reproductive system, vitamin C is known to protect spermatogenesis, and it plays a major role in semen integrity and fertility in men. It increases testosterone levels and prevents sperm agglutination. It is an important chain-breaking antioxidant, contributing up to 65 % of the total antioxidant capacity of seminal plasma found intracellularly and extracellularly. N-Acetyl cysteine reacts with highly oxidizing radicals such as ˙OH, ˙NO2, CO3˙‑, and also bind redox-active metal ions. Thiosl can also afford radioprotection through the donation of reducing equivalents. Keywords: Antioxidants; Male fertility; Sperm quality

Role of Antioxidants in Male Reproduction: Review

To counter oxidative stress, cells constitutively express enzymes that detoxify the reactive oxygen species and repair the damage. An antioxidant is any substance that when present at low concentrations compared to those of an oxidizable substrate significantly delays or prevents oxidation of that substrate. The antioxidant enzymes are major cell defense against acute oxygen toxicity. The functions of these antioxidant enzymes are to protect the membrane and cytosolic components against damage caused by free radicals. Glutathione peroxidase, Superoxide dismutase, glutathione-s-transferase, catalase, xanthine oxidase. Amongst a variety of antioxidants; vitamin E antioxidant use is essential because it travels through the body in molecules called lipoproteins and protect them from oxidation. For Many years, vitamin E considered as an anti-sterility factor. In the male reproductive system, vitamin C is known to protect spermatogenesis, and it plays a major role in semen integrity and fertility in men. It increases testosterone levels and prevents sperm agglutination. It is an important chain-breaking antioxidant, contributing up to 65 % of the total antioxidant capacity of seminal plasma found intracellularly and extracellularly. N-Acetyl cysteine reacts with highly oxidizing radicals such as ˙OH, ˙NO2, CO3˙‑, and also bind redox-active metal ions. Thiosl can also afford radioprotection through the donation of reducing equivalents. Keywords: Antioxidants; Male fertility; Sperm quality

Evaluation of different teaching-learning methods according to students’ preference and perception

Background: Improved teaching methodology is prerequisite for education systems so that students learn effectively. The present study was done with the objectives of evaluation of different teaching-learning methods according to students’ preference and perception.Methods: It was observational, non-interventional questionnaire based study. Total 100 students were selected randomly from second MBBS as participants of it. They filled questionnaires with 11 questions, by selecting appropriate options.Results: All students were interested in Pharmacology. Cardio-Vascular System and autocoids were the most interesting topics according to 40% of students. Total 53% of students preferred combination of chalk and board with PowerPoint presentation for understanding, while chalk and board alone (65%) as more interactive teaching method. Total 80% of students preferred interactive lecture session. Clinical case/bed side study was preferred by 89% of students. Total 40% of students preferred combination of teachers’ note and standard textbooks as reading materials. Total 80% of students mentioned that revision at the end of lecture is necessary. One and half year as ideal time to learn second MBBS, has been selected by 60% of students. Teaching with more clinical orientation is one of the changes suggested by 28% of students.Conclusions: Combination of traditional chalk and board method with modern powerpoint method, wherever necessary, is ideal for interactive and understandable lecture session. Integration/correlation of clinical cases with clinical Pharmacology will be more helpful in understanding and learning. Proper and effective management of time is essential for maximum utilization of MBBS duration with optimum output for students

EFEECT OF PRANAYAMA (YOGA) ON PULMONARY FUNCTION TEST OF YOUNG HEALTHY STUDENTS.

Several studies had been undertaken to prove the role of pranayama (yoga) for the improvement of pulmonary functions in various disease conditions as well as in healthy individuals. The main objective of this study was to assess the effect of pranayama on pulmonary function test in 75 medical students of both sexes (50males, 25 females) ranging in age from 18 to25 years. All the participants were given training for 15 days by certified trained yoga teacher and after that they were allowed to practice the pranayama for 30 minutes everyday for the duration of three months. Spirometry was done before and after completion of three months pranayama practice. The results were analyzed by ‘paired t test’. There were significant improvement in tidal volume (p<.0001), vital capacity (VC) p<.0001, Maximum voluntary ventilation (MVV) p<.001, peak expiratory flow rate (PEFR) p<.001, forced expiratory volume in the first second (FEV1) p<.001, forced vital capacity (FVC), p<.005, forced mid expiratory flow in 0.25– 0.75 seconds (FEF25- 75) p<0.0001. The present study indicates that pranayama has positive physiological benefits on respiratory system as evidenced by improvement of pulmonary function