Inflammasomes: Molecular Regulation and Implications for Metabolic and Cognitive Diseases

Inflammasomes are specialized signaling platforms critical for the regulation of innate immune and inflammatory responses. Various NLR family members (i.e., NLRP1, NLRP3, and IPAF) as well as the PYHIN family member AIM2 can form inflammasome complexes. These multi-protein complexes activate inflammatory caspases (i.e., caspase-1) which in turn catalyze the maturation of select pro-inflammatory cytokines, including interleukin (IL)-1β and IL-18. Activation of the NLRP3 inflammasome typically requires two initiating signals. Toll-like receptor (TLR) and NOD-like receptor (NLR) agonists activate the transcription of pro-inflammatory cytokine genes through an NF-κB-dependent priming signal. Following exposure to extracellular ATP, stimulation of the P2X purinoreceptor-7 (P2X7R), which results in K+ efflux, is required as a second signal for NLRP3 inflammasome formation. Alternative models for NLRP3 activation involve lysosomal destabilization and phagocytic NADPH oxidase and/or mitochondria-dependent reactive oxygen species (ROS) production. In this review we examine regulatory mechanisms that activate the NLRP3 inflammasome pathway. Furthermore, we discuss the potential roles of NLRP3 in metabolic and cognitive diseases, including obesity, type 2 diabetes mellitus, Alzheimer’s disease, and major depressive disorder. Novel therapeutics involving inflammasome activation may result in possible clinical applications in the near future

Determining tan(beta) in \tau\tau Fusion to SUSY Higgs Bosons at a Photon Collider

We investigate \tau\tau fusion to light h and heavy H and A Higgs bosons in the Minimal Supersymmetric Standard Model (MSSM) at a photon collider as a promising channel for measuring large values of tan(beta). For standard design parameters of a photon collider an error \Delta tan(beta) \sim 1, uniformly for tan(beta) \gsim 10, may be expected, improving on complementary measurements at the LHC and e+e- linear colliders.Comment: 12 pages, 5 figure

Angular dependent magnetothermopower of α-(ET)₂KHg(SCN)₄

The magnetic field and angular dependences of the thermopower and Nernst effect of the quasi-twodimensional (q2D) organic conductor α-(ET)₂KHg(SCN)₄ are experimentally measured at temperatures below (4 K) and above (9 K) the transition temperature to fields of 31 T. In addition, a theoretical model which involves a magnetic breakdown effect between the q1D and q2D bands is proposed in order to simulate the data. Analysis of the background components of the thermopower and Nernst effect imply that at low temperatures, in the CDW state, the properties of α-(ET)₂KHg(SCN)₄ are determined mostly by the orbits on the new open Fermi sheets. Quantum oscillations observed in the both thermoelectric effects, at fields above 8 T, originate only from the α orbit

Subthreshold characteristics of pentacene field-effect transistors influenced by grain boundaries.

Grain boundaries in polycrystalline pentacene films significantly affect the electrical characteristics of pentacene field-effect transistors (FETs). Upon reversal of the gate voltage sweep direction, pentacene FETs exhibited hysteretic behaviours in the subthreshold region, which was more pronounced for the FET having smaller pentacene grains. No shift in the flat-band voltage of the metal-insulator-semiconductor capacitor elucidates that the observed hysteresis was mainly caused by the influence of localized trap states existing at pentacene grain boundaries. From the results of continuous on/off switching operation of the pentacene FETs, hole depletion during the off period is found to be limited by pentacene grain boundaries. It is suggested that the polycrystalline nature of a pentacene film plays an important role on the dynamic characteristics of pentacene FETs

Cost consideration in closing the nuclear fuel cycle

This study evaluates the economic aspect of closing the nuclear fuel cycle. It compares the fuel cycle costs of the direct disposal and the self-generated recycle fuel cycles to determine the justifiable fuel-reprocessing costs. Previous fuel cycle cost studies cited the low natural uranium prices, due to soft demand, as the reason for low incentive of fuel reprocessing. This study calculated fuel- reprocessing costs as functions of the spent-fuel disposal costs and the natural uranium prices to illustrate that spent-fuel disposal economics could also play an important role in fuel reprocessing and the closing of the nuclear fuel cycle

Sequential soil washing techniques using hydrochloric acid and sodium hydroxide for remediating arsenic-contaminated soils in abandoned iron-ore mines

Sequential washing techniques using single or dual agents sodium hydroxide (NaOH) and hydrochloric acid (HCl) solutions were applied to arsenic-contaminated soils in an abandoned iron-ore mine area. We investigated the best remediation strategies to maximize arsenic removal efficiency for both soils and arsenic-containing washing solution through conducting a series of batch experiments. Based on the results of a sequential extraction procedure, most arsenic prevails in Fe-As precipitates or coprecipitates, and iron exists mostly in the crystalline forms of iron oxide. Soil washing by use of a single agent was not effective in remediating arsenic-contaminated soils because arsenic extractions determined by the Korean standard test (KST) methods for washed soils were not lower than 6 mg kg-1 in all experimental conditions. The results of X-ray diffraction (XRD) indicated that iron-ore fines produced mobile colloids through coagulation and flocculation in water contacting the soils, containing dissolved arsenic and fine particles of ferric arsenate-coprecipitated silicate. The first washing step using 0.2 M HCl was mostly effective in increasing the cationic hydrolysis of amorphous ferrihydrite, inducing high removal of arsenic. Thus, the removal step of arsenic-containing flocs can lower arsenic extractions (KST methods) of washed soils. Among several washing trials, alternative sequential washing using 0.2 M HCl followed by 1 M HCl (second step) and 1 M NaOH solution (third step) showed reliable and lower values of arsenic extractions (KST methods) of washed soils. This washing method can satisfy the arsenic regulation of washed soil for reuse or safe disposal application. The kinetic data of washing tests revealed that dissolved arsenic was easily readsorbed into remaining soils at a low pH. This result might have occurred due to dominant species of positively charged crystalline iron oxides characterized through the sequential extraction procedure. However, alkaline extraction using NaOH was effective in removing arsenic readsorbed onto the surface of crystalline minerals. This is because of the ligand displacement reaction of hydroxyl ions with arsenic species and high pH conditions that can prevent readsorption of arsenic. © 2006 Elsevier Ltd. All rights reserved

Highly reproducible alkali metal doping system for organic crystals through enhanced diffusion of alkali metal by secondary thermal activation

In this paper, we report an efficient alkali metal doping system for organic single crystals. Our system employs an enhanced diffusion method for the introduction of alkali metal into organic single crystals by controlling the sample temperature to induce secondary thermal activation. Using this system, we achieved intercalation of potassium into picene single crystals with closed packed crystal structures. Using optical microscopy and Raman spectroscopy, we confirmed that the resulting samples were uniformly doped and became K2picene single crystal, while only parts of the crystal are doped and transformed into K2picene without secondary thermal activation. Moreover, using a customized electrical measurement system, the insulator-to-semiconductor transition of picene single crystals upon doping was confirmed by in situ electrical conductivity and ex situ temperature-dependent resistivity measurements. X-ray diffraction studies showed that potassium atoms were intercalated between molecular layers of picene, and doped samples did not show any KH- nor KOH-related peaks, indicating that picene molecules are retained without structural decomposition. During recent decades, tremendous efforts have been exerted to develop high-performance organic semiconductors and superconductors, whereas as little attention has been devoted to doped organic crystals. Our method will enable efficient alkali metal doping of organic crystals and will be a resource for future systematic studies on the electrical property changes of these organic crystals upon doping. © 2018 The Author(s

CPsuperH: a Computational Tool for Higgs Phenomenology in the Minimal Supersymmetric Standard Model with Explicit CP Violation

We provide a detailed description of the Fortran code CPsuperH, a newly--developed computational package that calculates the mass spectrum and decay widths of the neutral and charged Higgs bosons in the Minimal Supersymmetric Standard Model with explicit CP violation. The program is based on recent renormalization-group-improved diagrammatic calculations that include dominant higher--order logarithmic and threshold corrections, b-quark Yukawa-coupling resummation effects and Higgs-boson pole-mass shifts. The code CPsuperH is self--contained (with all subroutines included), is easy and fast to run, and is organized to allow further theoretical developments to be easily implemented. The fact that the masses and couplings of the charged and neutral Higgs bosons are computed at a similar high-precision level makes it an attractive tool for Tevatron, LHC and LC studies, also in the CP-conserving case.Comment: 46 pages, LaTeX, 4 eps figures; the code may be obtained from http://theory.ph.man.ac.uk/~jslee/CPsuperH.html (version as to appear in Comput. Phys. Commun.

Time and Amplitude of Afterpulse Measured with a Large Size Photomultiplier Tube

We have studied the afterpulse of a hemispherical photomultiplier tube for an upcoming reactor neutrino experiment. The timing, the amplitude, and the rate of the afterpulse for a 10 inch photomultiplier tube were measured with a 400 MHz FADC up to 16 \ms time window after the initial signal generated by an LED light pulse. The time and amplitude correlation of the afterpulse shows several distinctive groups. We describe the dependencies of the afterpulse on the applied high voltage and the amplitude of the main light pulse. The present data could shed light upon the general mechanism of the afterpulse.Comment: 11 figure