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    Energy Flux, Lactate Shuttling, Mitochondrial Dynamics, and Hypoxia

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    Our understanding of what happens in working muscle and at the whole-body level at sea level and at high altitude is different from that a few years ago. If dietary CHO and nutrition are adequate, at sea level metabolism shifts from a mix of lipid and CHO-derived fuels toward carbohydrate (glycogen, glucose, and lactate) oxidation at moderate and greater exercise intensities. As given by the Crossover Concept, a percentage to total energy expenditure, lipid oxidation is greatest at exercise power outputs eliciting 45-50 % of VO2max with greater intensities requiring relatively more CHO and lesser lipid oxidation. At altitude, a given exercise power output is achieved at a greater relative intensity expressed as % VO2max. Hence, exercise under conditions of hypoxia requires greater glycolytic flux, and lactate production than does the same effort at sea level, normoxic conditions. Glycolytic flux is further augmented at altitude by the effect of hypoxemia on sympathetic nervous system activity. Hence, augmented lactate production during exercise is adaptive. Over the short term, accelerated lactate flux provides ATP supporting muscle contraction and balances cytosolic redox. As well, lactate provides and energy substrate and gluconeogenic precursor. Over a longer term, via redox and ROS-generating mechanisms, lactate may affect adaptations in mitochondrial biogenesis and solute (glucose and lactate) transport. While important, the energy substrate, gluconeogenic, and signaling qualities of lactate production and disposal at altitude need to be considered within the context of overall dietary energy intake and expenditure during exercise at sea level and high altitude

    Vacuumless kinks systems from vacuum ones, an example

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    Some years ago, Cho and Vilenkin, introduced a model which presents topological solutions, despite not having degenerate vacua as is usually expected. Here we present a new model with topological defects, connecting degenerate vacua but which in a certain limit recovers precisely the one proposed originally by Cho and Vilenkin. In other words, we found a kind of parent model for the so called vacuumless model. Then the idea is extended to a model recently introduced by Bazeia et al. Finally, we trace some comments the case of the Liouville model.Comment: 11 pages, 4 figure

    Teores de matéria seca, proteína bruta, carboidratos solúveis e extrato etéreo das silagens de tres genótipos de girassol (Helianthus annuus L.) com aditivos em sete diferentes épocas de abertura.

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    O objetivo deste experimento foi avaliar os teores de materia seca (MS), proteĂ­na bruta (PB), carboidratos soluveis (CHO) e extrato etereo (EE) das silagens de tres genotipos: M 734, Rumbosol 91 e a variedade V2000, enriquecidas com ureia (U), carbonato de calcio (CC), ureia mais carbonato de calcio (U*CC); e inoculante bacteriano (IB), sendo tambem ensilado material original sem aditivo que serviu como silagem testemunha (T). Foram utilizados silos de laboratorio de PVC, abertos com um, tres, cinco, sete, 14, 28 e 56 dias de ensilados. As silagens de genotipos M734 foram as que apresentaram os maiores teores de MS comparadas as silagens do Rumbosol 91 e este maior que o V2000. A adicao somente de U resultou em silagens com teores de PB superiores as silagens T e foram semelhantes entre si nos diferentes dias de abertura. Os teores de CHO soluveis variaram de 0,03% a 3,86%, sendo que as silagens T e com aditivos do genotipo M734 apresentaram no dia de abertura um teores significativamente superiores ao Rumbosol 91 e ao V2000. O IB nao promoveu uma rapida queda nos teores de CHO soluveis como esperado. os teores de EE foram estatisticamente superiores para os genotipos V2000 e M734 em relacao ao Rumbosol 91 e nao apresentaram diferenca com a utilizacao dos aditivos. Concluindo, as silagens de girassol avaliadas apresentaram baixos teores de MS e apenas o uso de ureia promoveu alteracoes aumentando o teor de proteina bruta das silagens dentro dos parametros avaliados
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