Clump Development by the Nickel Bubble Effect in Supernovae

We used one-dimensional radiative-transport radiation hydrodynamical (RHD) simulations to investigate the formation of clumping in freely-expanding supernova ejecta due to the radioactive heating from the Ni56 -> Co56 -> Fe56 decay sequence. The heating gives rise to an inflated Nickel bubble, which induces a forward shock that compresses the outer ambient gas into a shell. The radiative energy deposited by the radioactivity leaks out across the shock by radiative diffusion, and we investigate its effect on the evolution of the ejecta structure. Compared to the hydrodynamical adiabatic approximation with gamma =4/3, the preshock gas becomes accelerated by the radiation outflow. The shock is thus weakened and the shell becomes broader and less dense. The thickness of the shell takes up <~ 4 % of the radius of the bubble, and the structure of the shell can be approximately described by a self-similar solution. We compared the properties of the shell components with those of the ejecta clumps indicated by our previous hydrodynamical simulations for the later interaction of clumps with the outer supernova remnant. The high density contrast across the shell, chi ~ 100, is compatible with that of ejecta clumps as indicated for Tycho's knots, but there is insufficient dense gas to cause a pronounced protrusion on the outline of a core collapse supernova remnant, like the bullets in the Vela remnant.Comment: accepted by Ap

3D Magneto-Hydrodynamic Simulations of Parker Instability with Cosmic Rays

This study investigates Parker instability in an interstellar medium (ISM) near the Galactic plane using three-dimensional magneto-hydrodynamic simulations. Parker instability arises from the presence of a magnetic field in a plasma, wherein the magnetic buoyant pressure expels the gas and cause the gas to move along the field lines. The process is thought to induce the formation of giant molecular clouds in the Galaxy. In this study, the effects of cosmic-ray (CR) diffusion are examined. The ISM at equilibrium is assumed to comprise a plasma fluid and a CR fluid at various temperatures, with a uniform magnetic field passing through it in the azimuthal direction of the Galactic disk. After a small perturbation, the unstable gas aggregates at the footpoint of the magnetic fields and forms dense blobs. The growth rate of the instability increases with the strength of the CR diffusion. The formation of dense clouds is enhanced by the effect of cosmic rays (CRs), whereas the shape of the clouds depends sensitively on the initial conditions of perturbation.Comment: 4 pages, Computer Physics Communications 2011, 182, p177-17

Instabilities and Clumping in Type Ia Supernova Remnants

We present two-dimensional high-resolution hydrodynamical simulations in spherical polar coordinates of a Type Ia supernova interacting with a constant density interstellar medium. The ejecta are assumed to be freely expanding with an exponential density profile. The interaction gives rise to a double-shocked structure susceptible to hydrodynamic instabilities. The Rayleigh-Taylor instability initially grows, but the Kelvin-Helmholtz instability takes over, producing vortex rings. The nonlinear instability initially evolves toward longer wavelengths and eventually fades away when the reverse shock front is in the flatter part of the supernova density distribution. Based on observations of X-ray knots and the protrusion in the southeast outlin of Tycho's supernova remnant, we include clumping in the ejecta. The clump interaction with the reverse shock induces Rayleigh-Taylor and Kelvin-Helmholtz instabilities on the clump surface that facilitate fragmentation. In order to survive crushing and to have a bulging effect on the forward shock, the clump's initial density ratio to the surrounding ejecta must be at least 100 for the conditions in Tycho's remnant. The 56Ni bubble effect may be important for the development of clumpiness in the ejecta. The observed presence of an Fe clump would then require a non-radioactive origin for this Fe, possibly 54Fe. The large radial distance of the X-ray emitting Si and S ejecta from the remnant center indicates that they were initially in clumps.Comment: 27 pages, 4 postscript figures, 5 GIF figures submitted to Astrophysical Journa

Trends and predictors of changes in pulmonary function after treatment for pulmonary tuberculosis

OBJECTIVES: The present study aimed to investigate the trends in changes in pulmonary function and the risk factors for pulmonary function deterioration in patients with pulmonary tuberculosis after completing treatment. INTRODUCTION: Patients usually have pulmonary function abnormalities after completing treatment for pulmonary tuberculosis. The time course for changes in pulmonary function and the risk factors for deterioration have not been well studied. METHODS: A total of 115 patients with 162 pulmonary function results were analyzed. We retrieved demographic and clinical data, radiographic scores, bacteriological data, and pulmonary function data. A generalized additive model with a locally weighted scatterplot smoothing technique was used to evaluate the trends in changes in pulmonary function. A generalized estimating equation model was used to determine the risk factors associated with deterioration of pulmonary function. RESULTS: The median interval between the end of anti-tuberculosis treatment and the pulmonary function test was 16 months (range: 0 to 112 months). The nadir of pulmonary function occurred approximately 18 months after the completion of the treatment. The risk factors associated with pulmonary function deterioration included smear-positive disease, extensive pulmonary involvement prior to anti-tuberculosis treatment, prolonged anti-tuberculosis treatment, and reduced radiographic improvement after treatment. CONCLUSIONS: After the completion of anti-tuberculosis TB treatment, several risk factors predicted pulmonary function deterioration. For patients with significant respiratory symptoms and multiple risk factors, the pulmonary function test should be followed up to monitor the progression of functional impairment, especially within the first 18 months after the completion of anti-tuberculosis treatment

Rayleigh-Taylor Instabilities in Type Ia Supernova Remnants undergoing Cosmic-Ray Particle Acceleration - Low Adiabatic Index Solutions

This study investigates the evolution of Rayleigh-Taylor (R-T) instabilities in Type Ia supernova remnants that are associated with a low adiabatic index gamma, where gamma < 5/3, which reflects the expected change in the supernova shock structure as a result of cosmic-ray particle acceleration. Extreme cases, such as the case with the maximum compression ratio that corresponds to gamma=1.1, are examined. As gamma decreases, the shock compression ratio rises, and an increasingly narrow inter shock region with a more pronounced initial mixture of R-T unstable gas is produced. Consequently, the remnant outline may be perturbed by small-amplitude, small-wavelength bumps. However, as the instability decays over time, the extent of convective mixing in terms of the ratio of the radius of the R-T fingers to the blast wave does not strongly depend on the value of gamma for gamma >= 1.2. As a result of the age of the remnant, the unstable gas cannot extend sufficiently far to form metal-enriched filaments of ejecta material close to the periphery of Tycho's supernova remnant. The consistency of the dynamic properties of Tycho's remnant with the adiabatic model gamma=5/3 reveals that the injection of cosmic rays is too weak to alter the shock structure. Even with very efficient acceleration of cosmic rays at the shock, significantly enhanced mixing is not expected in Type Ia supernova remnants.Comment: 11 pages, 10 figures, MNRAS, accepte

Neuron Regeneration and Proliferation Effects of Danshen and Tanshinone IIA

This study evaluates the proliferative effects of danshen and its monomer extract, tanshinone IIA, on Schwann cell proliferation. A piece of silicone rubber was guided across a 15-mm gap in the sciatic nerve of a rat. This nerve gap was then filled with different concentrations of danshen (0–100 mg/mL). The results showed that danshen increased the expressions of uPA, cyclin D1, E and ERK, JNK, and P38 MAP kinases via the FGF-2 signaling pathway in a dose-dependent manner. RSC96, Schwann cells were also administered with danshen (0, 20, 40, 60, 80, and 100 μg/mL) and tanshinone IIA (0, 2, 4, 6, 8, and 10 μg/mL). In lower concentrations, danshen and tanshinone IIA exhibited an apparent effect on Schwann cells. Similar effects were also demonstrated in the FGF-2-uPA regulating cascade and cell cycle proliferative protein results. Schwann cell migration was elevated as well. We used MAPK-signaling chemical inhibitors and identified the proliferative effects of danshen and tanshinone IIA as MAPK-signaling dependent. The results from the in vitro systems indicate that danshen and tanshinone IIA can be used to induce Schwann cell proliferation, and in vivo results potentially suggest that danshen and tanshinone IIA might enhance neuron regeneration